Skull flexure as a contributing factor in the mechanism of injury in the rat when exposed to a shock wave.

abstract：:The longitudinal assessment of joint health is a long-standing issue in the management of musculoskeletal injuries. The acoustic emissions (AEs) produced by joint articulation could serve as a biomarker for joint health assessment, but their use has been limited by a lack of mechanistic understanding of their creation...

journal_title：Annals of biomedical engineering

authors： Whittingslow DC,Jeong HK,Ganti VG,Kirkpatrick NJ,Kogler GF,Inan OT

更新日期：2020-01-01 00:00:00

abstract：:Perfusion bioreactors are known to exert shear stresses on cultured cells, leading to cell differentiation and enhanced extracellular matrix deposition on scaffolds. The influence of the scaffold's porous microstructure is investigated for a polycaprolactone (PCL) scaffold with a regular microarchitecture and a silk f...

journal_title：Annals of biomedical engineering

authors： Zermatten E,Vetsch JR,Ruffoni D,Hofmann S,Müller R,Steinfeld A

更新日期：2014-05-01 00:00:00

abstract：:The measurement of CO2 volume exhaled per breath (VCO2.br) can be determined during anesthesia by the multiplication and integration of tidal flow (V) and PCO2. During side-stream capnometry, PCO2 must be advanced in time by transport delay (TD), the time to suction gas through the sampling tube. During ventilation, T...

journal_title：Annals of biomedical engineering

authors： Breen PH,Serina ER

更新日期：1997-01-01 00:00:00

abstract：:Rapid screening of biomarkers, with high specificity and accuracy, is critical for many point-of-care diagnostics. Microfluidics, the use of microscale channels to manipulate small liquid samples and carry reactions in parallel, offers tremendous opportunities to address fundamental questions in biology and provide a ...

journal_title：Annals of biomedical engineering

authors： Ng E,Chen K,Hang A,Syed A,Zhang JX

更新日期：2016-04-01 00:00:00

abstract：:Mechanical properties of the cardiac tissue play an important role in normal heart function. The goal of this study was to determine the passive mechanical properties of all heart chambers through a paired comparison study in an ovine model. Ovine heart was used due its physiological and anatomical similarities to hum...

journal_title：Annals of biomedical engineering

authors： Javani S,Gordon M,Azadani AN

更新日期：2016-11-01 00:00:00

abstract：:This paper presents the bispectral analysis of the ontogeny of the hippocampal EEG recorded from the dentate gyrus and CA1, the primary sites that generate theta (theta) rhythm. The hippocampal EEG was collected during the vigilance state of rapid eye movement (REM) sleep of freely moving rats at 15, 30 and 90 days of...

journal_title：Annals of biomedical engineering

authors： Ning T,Bronzino JD

更新日期：1998-07-01 00:00:00

abstract：:Biomaterial-based tissue engineering strategies hold great promise for osteochondral tissue repair. Yet significant challenges remain in joining highly dissimilar materials to achieve a biomimetic, mechanically robust design for repairing interfaces between soft tissue and bone. This study sought to improve interfacia...

journal_title：Annals of biomedical engineering

authors： Kinneberg KR,Nelson A,Stender ME,Aziz AH,Mozdzen LC,Harley BA,Bryant SJ,Ferguson VL

更新日期：2015-11-01 00:00:00

abstract：:Simulations are useful to study the heart's ability to generate flow and the interaction between contractility and loading conditions. The left ventricular pressure-volume (PV) relation has been shown to be nonlinear, but it is unknown whether a linear model is accurate enough for simulations. Six models were fitted t...

journal_title：Annals of biomedical engineering

authors： Lankhaar JW,Rövekamp FA,Steendijk P,Faes TJ,Westerhof BE,Kind T,Vonk-Noordegraaf A,Westerhof N

更新日期：2009-09-01 00:00:00

abstract：:Radiation applied for therapy and diagnostics damages molecular/atomic couples of biotissues, bones being among them. As a result, electron peculiarities and mechanical behavior of the latter are altered. Correlation between strength of the irradiated bone and its electron features explored due to photo- and exoelectr...

journal_title：Annals of biomedical engineering

authors： Dekhtyar Y

更新日期：2001-12-01 00:00:00

abstract：:This paper describes the development and use of a direct compression stimulator for culturing explants from the meniscus of the knee and articular cartilage. Following design and fabrication of the instrument along with its data acquisition system, the function of the machine was verified by both mechanical means and ...

journal_title：Annals of biomedical engineering

authors： Aufderheide AC,Athanasiou KA

更新日期：2006-09-01 00:00:00

abstract：:Mechanical cues arising from extracellular matrices greatly affect cellular properties, and hence, are of significance in designing biomaterials. In this study, a DNA crosslinked hydrogel was employed to examine cellular responses of spinal cord neurons to substrate compliances. Using DNA as crosslinkers in polymeric ...

journal_title：Annals of biomedical engineering

authors： Jiang FX,Yurke B,Firestein BL,Langrana NA

更新日期：2008-09-01 00:00:00

abstract：:The human thorax is commonly injured in motor vehicle crashes, and despite advancements in occupant safety rib fractures are highly prevalent. The objective of this study was to quantify the ability of gross and cross-sectional geometry, separately and in combination, to explain variation of human rib structural prope...

journal_title：Annals of biomedical engineering

authors： Murach MM,Kang YS,Goldman SD,Schafman MA,Schlecht SH,Moorhouse K,Bolte JH 4th,Agnew AM

更新日期：2017-09-01 00:00:00

abstract：:In an effort to share best practices in undergraduate engineering design education, we describe the origin, evolution and the current status of the undergraduate biomedical engineering design team program at Johns Hopkins University. Specifically, we describe the program and judge the quality of the pedagogy by relati...

journal_title：Annals of biomedical engineering

authors： Allen RH,Acharya S,Jancuk C,Shoukas AA

更新日期：2013-09-01 00:00:00

abstract：:Previous research in cellular adhesion has focused primarily on studying isolated cells under conditions where cells do not interact with each other. However, in vivo cells form sheets where both cell-substratum and cell-cell interactions contribute to the overall adhesive behavior. Our understanding of how cell-cell ...

journal_title：Annals of biomedical engineering

authors： Peel MM,DiMilla PA

更新日期：1999-03-01 00:00:00

abstract：:Newborns with single ventricle physiology are usually palliated with a multi-staged procedure. When cardiovascular complications e.g., collateral vessel formation occur during the inter-stage periods, further treatments are required. An 8-month-old patient, who underwent second stage (i.e., bi-directional Glenn, BDG) ...

journal_title：Annals of biomedical engineering

authors： Corsini C,Baker C,Baretta A,Biglino G,Hlavacek AM,Hsia TY,Kung E,Marsden A,Migliavacca F,Vignon-Clementel I,Pennati G,Modeling of Congenital Hearts Alliance (MOCHA) Investigators.

更新日期：2015-06-01 00:00:00

abstract：:The most widely implanted prosthetic valve is the mechanical bileaflet. Recent clinical experiences suggest that some designs are more prone to thromboembolic episodes than others. This study evaluated the hinge flow and near-field forward flow of the new St. Jude Medical Regent bileaflet mechanical heart valve. Laser...

journal_title：Annals of biomedical engineering

authors： Ellis JT,Travis BR,Yoganathan AP

更新日期：2000-05-01 00:00:00

abstract：:While considerable efforts have been expended to develop snore-driven markers for detecting obstructive sleep apnea (OSA), there is little emphasis on the relationship between the human upper airway (UA) dimensions and the attributes of snores. This paper aims to investigate the acoustical and perceptual impacts of ch...

journal_title：Annals of biomedical engineering

authors： Ng AK,Koh TS,Baey E,Puvanendran K

更新日期：2009-09-01 00:00:00

abstract：:Impedance data, e.g., system responses, from perturbing small amplitude applied sinusoid signals of near DC to high kilohertz frequencies, give chemical information. Analysis of frequency-dependent imaginary and real impedance proceeds from equivalent analog circuit elements to chemical and physical significance deter...

journal_title：Annals of biomedical engineering

authors： Buck RP

更新日期：1992-01-01 00:00:00

abstract：:Intra-cardiac flow has been explored for decades but there is still no consensus on whether or not healthy left ventricles (LV) may harbour turbulent-like flow despite its potential physiological and clinical relevance. The purpose of this study is to elucidate if a healthy LV could harbour flow instabilities, using i...

journal_title：Annals of biomedical engineering

authors： Chnafa C,Mendez S,Nicoud F

更新日期：2016-11-01 00:00:00

abstract：:Overexpressed receptors, characteristic of many cancers, have been targeted by various researchers to achieve a more specific treatment for cancer. A common approach is to use the natural ligand for the overexpressed receptor as a cancer-targeting agent which can deliver a chemically or genetically conjugated toxic mo...

journal_title：Annals of biomedical engineering

authors： Yoon DJ,Liu CT,Quinlan DS,Nafisi PM,Kamei DT

更新日期：2011-04-01 00:00:00

abstract：:Cell migration is a fundamental process that is crucial to a variety of physiological events. While traditional approaches have focused on two-dimensional (2D) systems, recent efforts have shifted to studying migration in three-dimensional (3D) matrices. A major distinction that has emerged is the increased importance...

journal_title：Annals of biomedical engineering

authors： Harjanto D,Zaman MH

更新日期：2010-05-01 00:00:00

abstract：:Tumor vasculature damage induced by various thermal treatments has been studied in vivo via laser confocal microscopy. Murine mammary carcinoma 4T1 was implanted in the nude mice dorsal skin fold window chamber. The implanted tumor was treated by alternate cooling and heating. Results showed that the treatment was muc...

journal_title：Annals of biomedical engineering

authors： Shen Y,Liu P,Zhang A,Xu LX

更新日期：2008-08-01 00:00:00

abstract：:Conventional nanoporous hydrogels often lead to slow cartilage deposition by MSCs in 3D due to physical constraints and requirement for degradation. Our group has recently reported macroporous gelatin microribbon (μRB) hydrogels, which substantially accelerate MSC-based cartilage formation in vitro compared to convent...

journal_title：Annals of biomedical engineering

authors： Barati D,Gegg C,Yang F

更新日期：2020-07-01 00:00:00

abstract：:Dexterity of robots is highly required when it comes to integration for medical applications. Major efforts have been conducted to increase the dexterity at the distal parts of medical robots. This paper reports on developments toward integrating biocompatible conducting polymers (CP) into inherently dexterous concent...

journal_title：Annals of biomedical engineering

authors： Chikhaoui MT,Benouhiba A,Rougeot P,Rabenorosoa K,Ouisse M,Andreff N

更新日期：2018-10-01 00:00:00

abstract：:Phenotype transformation of vascular smooth muscle cells (VSMCs) has been reported to be directly influenced by the frequency of mechanical strain. This study explored the effects of different frequencies of mechanical strain on expression of phenotype marker h1-calponin and the possible mechanism. VSMCs were subjecte...

journal_title：Annals of biomedical engineering

authors： Qu MJ,Liu B,Qi YX,Jiang ZL

更新日期：2008-09-01 00:00:00

abstract：:Recent studies have demonstrated the ability of magnetic resonance imaging (MRI) to provide anatomically realistic boundary conditions for computational fluid dynamics (CFD) simulations of arterial hemodynamics. To date, however, little is known about the overall reproducibility of such image-based CFD techniques. Tow...

journal_title：Annals of biomedical engineering

authors： Thomas JB,Milner JS,Rutt BK,Steinman DA

更新日期：2003-02-01 00:00:00

abstract：:Dual X-ray absorptiometry (DXA) measures areal bone mineral density (aBMD) by simplifying a complex 3D bone structure to a 2D projection and is not equally effective for explaining fracture strength in women and men. Unlike DXA, subject-specific quantitative computed tomography-based finite element analysis (QCT/FEA) ...

journal_title：Annals of biomedical engineering

authors： Rezaei A,Giambini H,Rossman T,Carlson KD,Yaszemski MJ,Lu L,Dragomir-Daescu D

更新日期：2017-12-01 00:00:00

abstract：:Children with cerebral palsy frequently experience foot dragging and tripping during walking due to a lack of adequate knee flexion in swing (stiff-knee gait). Stiff-knee gait is often accompanied by an overly flexed knee during stance (crouch gait). Studies on stiff-knee gait have mostly focused on excessive knee mus...

journal_title：Annals of biomedical engineering

authors： van der Krogt MM,Bregman DJ,Wisse M,Doorenbosch CA,Harlaar J,Collins SH

更新日期：2010-04-01 00:00:00

abstract：:We develop a mathematical model of nanoparticles depositing onto and penetrating into a biofilm grown in a parallel-plate flow cell. We carry out deposition experiments in a flow cell to support the modeling. The modeling and the experiments are motivated by the potential use of polymer nanoparticles as part of a trea...

journal_title：Annals of biomedical engineering

authors： Miller JK,Neubig R,Clemons CB,Kreider KL,Wilber JP,Young GW,Ditto AJ,Yun YH,Milsted A,Badawy HT,Panzner MJ,Youngs WJ,Cannon CL

更新日期：2013-01-01 00:00:00

abstract：:Recently, we reported that tethering and rolling of neutrophils in shear flow over a substrate of E-selectin signals activation of beta 2-integrins and firm adhesion via an intracellular signaling pathway involving phosphorylation of p38 MAP kinase. In the current study the objective was to examine the molecular mecha...

journal_title：Annals of biomedical engineering

authors： Hentzen E,McDonough D,McIntire L,Smith CW,Goldsmith HL,Simon SI

更新日期：2002-09-01 00:00:00