Abstract:
:This paper presents the bispectral analysis of the ontogeny of the hippocampal EEG recorded from the dentate gyrus and CA1, the primary sites that generate theta (theta) rhythm. The hippocampal EEG was collected during the vigilance state of rapid eye movement (REM) sleep of freely moving rats at 15, 30 and 90 days of age. In previous studies we demonstrated through bispectral analysis that significant quadratic phase coupling (QPC) of the EEG exists in the hippocampal formation of CA1 and the dentate gyrus during REM sleep, primarily in the theta (4-11 Hz) frequency range. In the present study we have examined whether QPC can be used as an effective measure of development, i.e., maturation of the hippocampal subfields CA1 and the dentate gyrus. We found that as animals mature from the age of 15 to 90 days, the occurrence of nonlinear QPC activities moves from (6.25 Hz, 6 Hz) to (7 Hz, 7 Hz) at CA1 and (6 Hz, 6 Hz) to (7.5 Hz, 7.5 Hz) at the dentate gyrus, respectively. The results indicate that bispectral analysis provides an additional and important description of the frequency characteristics of the hippocampal EEG and that the QPC measure is also a useful index to quantify the shift in the hippocampal theta frequency as animals mature.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Ning T,Bronzino JDdoi
10.1114/1.43subject
Has Abstractpub_date
1998-07-01 00:00:00pages
688-93issue
4eissn
0090-6964issn
1573-9686journal_volume
26pub_type
杂志文章abstract::This study is aimed at refining our understanding of the role of vortex formation at mitral mechanical heart valve (MHV) closure and its association with the high intensity transient signals (HITS) seen in echocardiographic studies with MHV recipients. Previously reported numerical results described a twofold process ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-007-9293-y
更新日期:2007-07-01 00:00:00
abstract::Numerous head injury models exist that vary in mesh density by orders of magnitude. A careful study of the mesh convergence behavior is necessary, especially in terms of strain most relevant to brain injury. To this end, as well as to investigate the effect of element integration scheme on simulated strains, we re-mes...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-018-02159-z
更新日期:2019-02-01 00:00:00
abstract::Recently, we reported that tethering and rolling of neutrophils in shear flow over a substrate of E-selectin signals activation of beta 2-integrins and firm adhesion via an intracellular signaling pathway involving phosphorylation of p38 MAP kinase. In the current study the objective was to examine the molecular mecha...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1511240
更新日期:2002-09-01 00:00:00
abstract::Similarities between photoreceptor Kx channels and EAG and KCNQ channels suggest that the Kx channel may be related to one or both of these families of potassium channels. To provide a basis for further comparison of these channels, as well as to reveal the role of zinc (endogenously present in photoreceptors) in Kx c...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1521415
更新日期:2002-01-01 00:00:00
abstract::Gas bubble motion in a blood vessel causes temporal and spatial gradients of shear stress at the cell surface lining the vessel wall as the bubble approaches the cell, moves over it and passes it by. Rapid reversals occur in the sign of the shear stress imparted to the cell surface during this motion. These may result...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-010-0120-5
更新日期:2010-12-01 00:00:00
abstract::Interstitial fluid flow, critical for macromolecular transport, was recently shown to drive fibroblast differentiation and perpendicular cell and matrix alignment in 3D collagen cultures. Here we explore the mechanisms underlying this flow-induced cell and collagen alignment. Cell and matrix alignment was assessed fro...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-005-9067-3
更新日期:2006-03-01 00:00:00
abstract::Optoelectronic plethysmography (OEP) is a noninvasive method for assessing lung volume variations and the contributions of different anatomical compartments of the chest wall (CW) through measurements of the motion of markers attached to the CW surface. The present study proposes a new method for analyzing the local C...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-017-1840-6
更新日期:2017-08-01 00:00:00
abstract::Collagen, the most commonly used extra-cellular matrix protein for tissue engineering applications, displays poor mechanical properties. Here, we report on the preparation and characterization of novel multi-component composite systems that incorporate a genetically engineered, biocompatible polymer (elastin-like poly...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-013-0825-3
更新日期:2013-10-01 00:00:00
abstract::Instrumentation systems for breath-to-breath analysis of respiratory gas exchange have been faulted by phase lags between various flow and composition signals and by difficulties in gathering and processing large amounts of data. The system described here represents an attempt to overcome these problems. Phase delays ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02367493
更新日期:1983-01-01 00:00:00
abstract::We propose a multifrequency energy transmission scheme for annular phased arrays in deep-body hyperthermia. The problem of frequency dependent resonance effects reported in hyperthermia phantom calibration studies, leading to skewed energy deposition patterns and unwanted energy maxima (hot spots), is addressed by com...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1430749
更新日期:2002-01-01 00:00:00
abstract::Microstructural characterization of cardiac tissue and its remodeling in disease is a crucial step in many basic research projects. We present a comprehensive approach for three-dimensional characterization of cardiac tissue at the submicrometer scale. We developed a compression-free mounting method as well as labelin...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-015-1465-6
更新日期:2016-05-01 00:00:00
abstract::A limitation of current tissue engineering vascular graft technology is the provision of an expandable, autologous cell source. By harnessing the multipotency of mesenchymal stem cells (MSC), it is hoped that functional vascular cells can be produced. To date, a range of 2D and 3D environments have been investigated f...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-010-9912-x
更新日期:2010-03-01 00:00:00
abstract::Femoral neck fractures are a relevant clinical and social problem. The aim of this study was to improve the prediction of patients at-risk of femoral neck fracture with respect to the current densitometric-based methods. In particular, finite element models were used to assess the prediction accuracy obtained by combi...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1495866
更新日期:2002-06-01 00:00:00
abstract::We present a method of measuring force response of a single living cell, attached to a substrate, in situ, by a functionalized microelectromechanical systems sensor that applies local deformation on the cell. The sensor is a single crystal silicon microcantilever beam with prescribed shape and geometry, and is coated ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1591189
更新日期:2003-09-01 00:00:00
abstract::Defining the constituent regulatory molecules in tendon is critical to understanding the process of tendon repair and instructive to the development of novel treatment modalities. The purpose of this study is to define the structural, expressional, and mechanical changes in the tendon injury response, and elucidate th...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-013-0915-2
更新日期:2014-03-01 00:00:00
abstract::The linear homeomorphic muscle model proposed by Enderle and coworkers for the rectus eye muscle is fitted to reflect the dynamics of muscles in the head-neck complex, specifically in muscles involved in gaze shifts. This parameterization of the model for different muscles in the neck region will serve to drive a 3D d...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-009-9851-6
更新日期:2010-02-01 00:00:00
abstract::Fingertips wrinkle due to long exposure to water. The biological reason for this morphological change is unclear and still not fully understood. There are two main hypotheses for the underlying mechanism of fingertip wrinkling: the 'shrink' model (in which the wrinkling is driven by the contraction of the lower layers...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-016-1764-6
更新日期:2017-04-01 00:00:00
abstract::Lung cancer is a leading cause of death worldwide. Radiation therapy (RT) is one method to treat this disease. A common side effect of RT for lung cancer is radiation-induced lung damage (RILD) which leads to loss of lung function. RILD often compounds pre-existing smoking-related regional lung function impairment. It...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-020-02697-5
更新日期:2020-11-30 00:00:00
abstract::Parameters of physiological models are commonly associated in an input-output experiment with a specific pattern of the system response. This association is often made on an intuitive basis by traditional sensitivity analysis, i.e., by inspecting the variations of model output trajectories with respect to parameter va...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.207
更新日期:1999-09-01 00:00:00
abstract::The design and operating characteristics of the first self-contained in-the-ear device to deliver altered auditory feedback is described for applications with those who stutter. The device incorporates a microdigital signal processor core that reproduces the high fidelity of unaided listening and auditory self-monitor...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1541014
更新日期:2003-02-01 00:00:00
abstract::In 12 dogs anesthetised with alpha-chloralose and urethane, and beta-adrenergic blocked with propranolol, the cervical vagi were stimulated for 60 seconds with supramaximal constant current pulses at frequencies between 2.0 and 10 Hz. The time course of the recovery of the cardiac period response, after cessation of v...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02584303
更新日期:1991-01-01 00:00:00
abstract::Linear compartmental models are useful, explanatory tools, that have been widely used to represent the dynamic behavior of complex biological systems. This paper addresses the problem of the numerical identification of such models, i.e., the estimation of the parameter values that will generate predictions closest to ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-009-9651-z
更新日期:2009-05-01 00:00:00
abstract::In this paper, an intelligent proportional-integral-derivative (PID) control method is introduced to the robotic testing system for the biomechanical study of human musculoskeletal joints. For the testing system, the robot is a highly nonlinear and heavily coupled complicated system, and the human spinal specimen also...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1023/b:abme.0000030759.80354.e8
更新日期:2004-06-01 00:00:00
abstract::For an optimal guidance of the rehabilitation therapy of stroke patients in an in-home setting, objective, and patient-specific performance assessment of arm movements is needed. In this study, metrics of hand movement relative to the pelvis and the sternum were estimated in 13 stroke subjects using a full body ambula...
journal_title:Annals of biomedical engineering
pub_type: 临床试验,杂志文章
doi:10.1007/s10439-014-1198-y
更新日期:2015-02-01 00:00:00
abstract::Collagen is known to be a viscoelastic material and therefore is an important source of time dependent behavior in soft tissue. Though there are material models for soft tissue that rely on properties and structure of constituent collagen fibers, such models generally utilize only the elastic properties of collagen, a...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-006-9124-6
更新日期:2006-07-01 00:00:00
abstract::The objective of this work is to develop understanding of the local fluid dynamic mechanisms that underpin gas exchange in high-frequency oscillatory ventilation (HFOV). The flow field during HFOV was investigated experimentally using particle image velocimetry in idealized and realistic models of a single bifurcation...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-008-9557-1
更新日期:2008-11-01 00:00:00
abstract::Correct development of neuronal tracts requires the coordination of multiple permissive and inhibitory signals. By generating an in vitro microenvironment using soft lithography and microfluidic techniques, multiple guidance cues can be presented in a spatially defined way. Here we evaluated how neurites of dorsal roo...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-008-9486-z
更新日期:2008-06-01 00:00:00
abstract::Conventional nanoporous hydrogels often lead to slow cartilage deposition by MSCs in 3D due to physical constraints and requirement for degradation. Our group has recently reported macroporous gelatin microribbon (μRB) hydrogels, which substantially accelerate MSC-based cartilage formation in vitro compared to convent...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-020-02522-z
更新日期:2020-07-01 00:00:00
abstract::The continuing lack of longitudinal histopathological and biomechanical data for human arteries in health and disease highlights the importance of studying the many genetic, pharmacological, and surgical models that are available in mice. As a result, there has been a significant increase in the number of reports on t...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-014-0988-6
更新日期:2014-06-01 00:00:00
abstract::Gap junctions play a fundamental role in intercellular communication in cardiac tissue. Various types of heart disease including hypertrophy and ischemia are associated with alterations of the spatial arrangement of gap junctions. Previous studies applied two-dimensional optical and electron-microscopy to visualize ga...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-011-0369-3
更新日期:2011-11-01 00:00:00