Abstract：
:Understanding the complex spatiotemporal dynamics of action potential propagation in the heart during arrhythmia is exceedingly difficult. This study applies nonlinear dynamics tools to simplify this task. Using the results of a simulation of an electrical induction of reentry in a sheet of myocardium represented as a bidomain, transmembrane voltage maps are processed to obtain: (i) spatial maps of phase angle and phase singularity trajectories, (ii) state scatter plots, and (iii) spatial maps of even phase resetting, wave fronts and wave tails. Tracking the phase singularities allows us to identify the "seeds" of reentry before the reentrant circuit is formed and to characterize the spatiotemporal evolution of the organizing center of the reentrant circuit. The state scatter plots demonstrate the effect of the shock on the instantaneous state of the system. The spatial maps of even phase resetting allow us to identify the shock-induced excitable gaps (regions of regenerative repolarization) as well as the regions directly activated by the shock. These nontraditional approaches to the analysis of electrophysiological phenomena greatly enhance our ability to conceptualize the dynamics of arrhythmias.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Larson C,Dragnev L,Trayanova Ndoi
10.1114/1.1581289subject
Has Abstractpub_date
2003-07-01 00:00:00pages
768-80issue
7eissn
0090-6964issn
1573-9686journal_volume
31pub_type
杂志文章abstract：:There are recent reports of hybrid tissue-fabric materials with good performance-high biocompatibility and high mechanical strength. In this study, we demonstrate the capability of a hybrid material as a long-term filter for blood proteins. Polyester fabrics were implanted into rats to fabricate hybrid tissue-fabric m...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1781-5
更新日期：2017-05-01 00:00:00
abstract：:This project was undertaken to establish if the integral circulation had any effects upon the mechanical behavior of bone. The influence of blood flow in the rabbit tibia on the strain induced at the bone surface when under load was assessed. Recordings were taken from three adult and three immature New Zealand White ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02390377
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abstract：:An intelligent multichannel stimulator (IMS) has been designed and built for use in a cardiac research environment. The device is capable of measuring and responding to cardiac electrophysiological phenomena in real time with carefully timed and placed electrical stimuli. The system consists of 16 channels of sense/st...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1451077
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abstract：:Literature review articles provide a valuable mechanism for remaining informed amidst an ever-increasing body of scientific work. Condensing current advances into this disseminatable form is a critical activity for any research trainee. To systematize this multifaceted process, we present the "why, when, who, what, ho...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-019-02290-5
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abstract：:We attempted to estimate in living adherent epithelial alveolar cells, the degree of structural and mechanical heterogeneity by considering two individualized cytoskeleton components, i.e., a submembranous "cortical" cytoskeleton and a "deep" cytoskeleton (CSK). F-actin structure characterizing each CSK component was ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1616932
更新日期：2003-11-01 00:00:00
abstract：:A major drawback in the operation of mechanical heart valve prostheses is thrombus formation in the near valve region. Detailed flow analysis in this region during the valve closure phase is of interest in understanding the relationship between shear stress and platelet activation. A fixed-grid Cartesian mesh flow sol...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-006-9194-5
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02537-6
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-012-0626-0
更新日期：2013-01-01 00:00:00
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1431-3
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.110
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-017-1967-5
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-0111-6
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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