Abstract:
:This study investigated the effect of mechanical strain on solute diffusion in human TMJ discs (mean cadaver age 77.8) using the electrical conductivity method. The electrical conductivity, as well as small ion diffusivity, of male and female TMJ discs was determined under three compressive strains. In the male group, the average disc electrical conductivity (mean ± SD) at 0% strain was 5.14 ± 0.97 mS/cm, decreased to 4.50 ± 0.91 mS/cm (-12.3%) at 10% strain, and 3.93 ± 0.81 mS/cm (-23.5%) at 20% compressive strain. Correspondingly, the average disc relative ion diffusivity at 0% strain was 0.44 ± 0.08, decreased to 0.40 ± 0.08 (-8.9%) at 10% strain, and 0.36 ± 0.08 (-16.7%) at 20% compressive strain. In the female group, the average disc electrical conductivity at 0% strain was 5.84 ± 0.59 mS/cm, decreased to 5.01 ± 0.50 mS/cm (-14.2%) at 10% strain, and 4.33 ± 0.46 mS/cm (-25.8%) at 20% compressive strain. Correspondingly, the average disc relative ion diffusivity at 0% strain was 0.49 ± 0.05, decreased to 0.43 ± 0.04 (-11.3%) at 10% strain, and 0.39 ± 0.04 (-19.9%) at 20% compressive strain. The results indicated that mechanical strain significantly impeded solute diffusion through the disc. This mechanical strain effect was larger in the female than in the male human TMJ disc. This study may provide new insights into TMJ pathophysiology.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Wright GJ,Kuo J,Shi C,Bacro TR,Slate EH,Yao Hdoi
10.1007/s10439-013-0840-4subject
Has Abstractpub_date
2013-11-01 00:00:00pages
2349-57issue
11eissn
0090-6964issn
1573-9686journal_volume
41pub_type
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