The role of nanomedicine in growing tissues.

abstract：:Pathologic vascular adaptation following local injury is the primary driver for accelerated intimal hyperplasia and an occlusive phenotype. Smooth muscle cell (SMC) proliferation within the wall, and migration into the developing intima, is a major component of this remodeling response. The primary objective in the cu...

journal_title：Annals of biomedical engineering

authors： Klein B,Destephens A,Dumeny L,Hu Q,He Y,O'Malley K,Jiang Z,Tran-Son-Tay R,Berceli S

更新日期：2017-03-01 00:00:00

abstract：:Cochlear implantation consists in electrically stimulating the auditory nerve by inserting an electrode array inside the cochlea, a bony structure of the inner ear. In the absence of any visual feedback, the insertion results in many cases of damages of the internal structures. This paper presents a feasibility study ...

journal_title：Annals of biomedical engineering

authors： Lavenir L,Zemiti N,Akkari M,Subsol G,Venail F,Poignet P

更新日期：2020-10-30 00:00:00

abstract：:The field of tissue engineering promises to deliver biological substitutes to repair or replace tissues in the body that have been injured or diseased. The clinical demand for musculoskeletal tissues is particularly high, especially for cartilage and bone defects. Although they are generally considered biologically si...

journal_title：Annals of biomedical engineering

authors： Sharma B,Elisseeff JH

更新日期：2004-01-01 00:00:00

abstract：:Effects of hyperthermia on transport of low-density lipoprotein (LDL) through a stenosed arterial wall are analyzed comprehensively in the present work. The realistic and pertinent aspects of an arterial wall is represented by a multi-layer model, with a proper representation of the thickened intima region due to the ...

journal_title：Annals of biomedical engineering

authors： Iasiello M,Vafai K,Andreozzi A,Bianco N,Tavakkoli F

更新日期：2015-07-01 00:00:00

abstract：:Induced pluripotent stem cell derived cardiomyocytes (iPSC-CM) provide a powerful platform for disease modeling and drug development in vitro. Traditionally, electrophysiological methods or fluorescent dyes (e.g. calcium) have been used in their functional characterization. Recently, video microscopy has enabled non-i...

journal_title：Annals of biomedical engineering

authors： Ahola A,Pölönen RP,Aalto-Setälä K,Hyttinen J

更新日期：2018-01-01 00:00:00

abstract：:Left ventricular (LV) diastolic filling is limited by the constraining effects exerted by the pericardium (PE) and the lung/chest wall. The aim of the present study was to assess the validity of various estimates of external cardiac constraint, compared to pericardial surface pressure (Ppe) measured lateral to the LV ...

journal_title：Annals of biomedical engineering

authors： Kingma I,Smiseth OA,Frais MA,Smith ER,Tyberg JV

更新日期：1987-01-01 00:00:00

abstract：:Continuous measurement of arterial blood density after bolus injection of fluids of different density into the right atrium has been used to measure cardiac output and mean transit time through the central circulation. The transit time distribution for density, however, differs from that for plasma-phase tracers such ...

journal_title：Annals of biomedical engineering

authors： Ligas JR,Moslehi F,Epstein MA

更新日期：1993-07-01 00:00:00

abstract：:For highly diffusive solutes the kinetics of blood-tissue exchange is only poorly represented by a model consisting of sets of independent parallel capillary-tissue units. We constructed a more realistic multicapillary network model conforming statistically to morphometric data. Flows through the tortuous paths in the...

journal_title：Annals of biomedical engineering

authors： Beard DA,Bassingthwaighte JB

更新日期：2000-03-01 00:00:00

abstract：:The strength between the cortical screw and bone following an orthopaedic implant surgery is an important determinant for the success of osteosynthesis. An excessive axial cutting force during drilling produces microcracks in the bone surface, resulting in reduced strength between the screw and bone, resulting in loos...

journal_title：Annals of biomedical engineering

authors： Singh RP,Gupta V,Pandey PM,Mridha AR

更新日期：2021-01-01 00:00:00

abstract：:In vitro stent-induced thromboembolism was altered by the presence of residual stenoses placed upstream or placed upstream and downstream of the stent. Heparinized (3 micro/ml) bovine blood was gravity fed through a conduit with a deployed coronary stent. Embolism was continuously monitored using a light-scattering mi...

journal_title：Annals of biomedical engineering

authors： Sukavaneshvar S,Rosa GM,Solen KA

更新日期：2000-02-01 00:00:00

abstract：:Of the many models of peripheral nerve in the literature, essentially all have relied on experimentally derived values for the anisotropic resistivity of the nerve bundle interstitial space. This paper is a comprehensive mathematical analysis of the most referenced experiment for the longitudinal and radial resistivit...

journal_title：Annals of biomedical engineering

authors： Altman KW,Plonsey R

更新日期：1989-01-01 00:00:00

abstract：:Continuous flow left ventricular devices (CF-LVADs) support the failing heart at a constant speed and alters the loads on the aortic valve. This may cause insufficiency in the aortic valve under long-term CF-LVAD support. The aim of this study is to assess the aortic valve function under varying speed CF-LVAD support....

journal_title：Annals of biomedical engineering

authors： Bozkurt S,van de Vosse FN,Rutten MC

更新日期：2015-08-01 00:00:00

abstract：:Validation is a critical step in finite element model (FEM) development. This study focuses on the validation of the Global Human Body Models Consortium full body average male occupant FEM in five localized loading regimes-a chest impact, a shoulder impact, a thoracoabdominal impact, an abdominal impact, and a pelvic ...

journal_title：Annals of biomedical engineering

authors： Vavalle NA,Davis ML,Stitzel JD,Gayzik FS

更新日期：2015-09-01 00:00:00

abstract：:One goal of large scale clinical trials is to determine how a drug is processed by, and cleared from, the human body [i.e., its pharmacokinetic (PK) properties] and how these PK properties differ between individuals in a population (i.e., its population PK properties). Due to the high cost of these studies and the lim...

journal_title：Annals of biomedical engineering

authors： Hooker AC,Foracchia M,Dodds MG,Vicini P

更新日期：2003-01-01 00:00:00

abstract：:Mechanical ventilation is a life-support therapy for intensive care patients suffering from respiratory failure. To reduce the current rate of ventilator-induced lung injury requires ventilator settings that are patient-, time-, and disease-specific. A common lung protective strategy is to optimise the level of positi...

journal_title：Annals of biomedical engineering

authors： Morton SE,Knopp JL,Chase JG,Möller K,Docherty P,Shaw GM,Tawhai M

更新日期：2019-07-01 00:00:00

abstract：:Hemodynamic forces are known to be able to induce an inflammatory phenotype in endothelial cells (ECs). The EC glycocalyx (GCX) is a dynamic structure which is regulated in response to different stimuli and hypothesized as an important contributor to the mechanotransduction of wall shear stresses (WSS). In this work, ...

journal_title：Annals of biomedical engineering

authors： Cooper S,McDonald K,Burkat D,Leask RL

更新日期：2017-09-01 00:00:00

abstract：:Pelvic floor muscle (PFM) strength measurement provides useful information for the study of pelvic floor dysfunctions. Vaginal digital palpation, intravaginal pressure measurements, and the use of a dynamometric speculum represent currently available clinical methods for evaluating PFM strength. However, none of these...

journal_title：Annals of biomedical engineering

authors： Saleme CS,Rocha DN,Del Vecchio S,Silva Filho AL,Pinotti M

更新日期：2009-08-01 00:00:00

abstract：:A method of investigating head acceleration and intracranial dynamics from stick impacts in girls' and women's lacrosse was developed using headform impact experiments and a finite element head model. Assessing the likelihood of head injury due to stick-head impacts is of interest in girls' and women's lacrosse due to...

journal_title：Annals of biomedical engineering

authors： Morse JD,Franck JA,Wilcox BJ,Crisco JJ,Franck C

更新日期：2014-12-01 00:00:00

abstract：:A model predictive control strategy to simultaneously regulate hemodynamic and anesthetic variables in critical care patients is presented. A nonlinear canine circulatory model, which has been used to study the effect of inotropic and vasoactive drugs on hemodynamic variables, has been extended to include propofol pha...

journal_title：Annals of biomedical engineering

authors： Rao RR,Bequette BW,Roy RJ

更新日期：2000-01-01 00:00:00

abstract：:In uniaxial tensile testing, load preconditioning is used to generate repeatable load/elongation curves and set a "reference state" for subsequent tensile tests. We have observed however, that for porcine aortic valve (PAV) tissues, preconditioning does not lead to repeatable stress relaxation curves. We thus investig...

journal_title：Annals of biomedical engineering

authors： Carew EO,Garg A,Barber JE,Vesely I

更新日期：2004-04-01 00:00:00

abstract：:A novel apparatus for the multifaceted evaluation of artery function was developed. It measures endothelial and smooth muscle functions and the pressure-strain elastic modulus (E p). A rigid airtight chamber with an ultrasound probe was attached to the upper arm to manipulate the transmural pressure of the brachial ar...

journal_title：Annals of biomedical engineering

authors： Yaguchi T,Cong Y,Shimo K,Kurokawa T,Sugita S,Nagayama K,Masuda H,Matsumoto T

更新日期：2017-06-01 00:00:00

abstract：:A goal of the Human Research Program at National Aeronautics and Space Administration (NASA) is to analyze and mitigate the risk of occupant injury due to dynamic loads. Experimental tests of human subjects and biofidelic anthropomorphic test devices provide valuable kinematic and kinetic data related to injury risk e...

journal_title：Annals of biomedical engineering

authors： Gaewsky JP,Jones DA,Ye X,Koya B,McNamara KP,Gayzik FS,Weaver AA,Putnam JB,Somers JT,Stitzel JD

更新日期：2019-02-01 00:00:00

abstract：:A mathematical model has been developed to investigate previously obtained experimental findings relating to the activation of factor X by surface-bound tissue factor--factor VIIa (TF:VIIa) in a tubular flow reactor. In those experiments, factor X was perfused through a microcapillary tube over a range of flow (shear)...

journal_title：Annals of biomedical engineering

authors： Gir S,Slack SM,Turitto VT

更新日期：1996-05-01 00:00:00

abstract：:While considerable efforts have been expended to develop snore-driven markers for detecting obstructive sleep apnea (OSA), there is little emphasis on the relationship between the human upper airway (UA) dimensions and the attributes of snores. This paper aims to investigate the acoustical and perceptual impacts of ch...

journal_title：Annals of biomedical engineering

authors： Ng AK,Koh TS,Baey E,Puvanendran K

更新日期：2009-09-01 00:00:00

abstract：:Microencapsulation of recombinant cells is a novel promising approach to tumor therapy in which therapeutic protein is sustainable and long-term delivered by microencapsulated cells. The semi-permeable membrane of microcapsule can protect cell from host's immune rejection, increase the chemical stability of therapeuti...

journal_title：Annals of biomedical engineering

authors： Zhang Y,Wang W,Zhou J,Yu W,Zhang X,Guo X,Ma X

更新日期：2007-04-01 00:00:00

abstract：:Accurate assessment of blood platelet function is essential in understanding thrombus formation which plays a central role in cardiovascular disease. Parallel plate flow chambers have been widely used as they allow for platelet adhesion on a collagen surface at physiologically relevant fluid mechanical forces. Standar...

journal_title：Annals of biomedical engineering

authors： Sarvepalli DP,Schmidtke DW,Nollert MU

更新日期：2009-07-01 00:00:00

abstract：:Femoral neck fractures are a relevant clinical and social problem. The aim of this study was to improve the prediction of patients at-risk of femoral neck fracture with respect to the current densitometric-based methods. In particular, finite element models were used to assess the prediction accuracy obtained by combi...

journal_title：Annals of biomedical engineering

authors： Testi D,Viceconti M,Cappello A,Gnudi S

更新日期：2002-06-01 00:00:00

abstract：:Electrospinning was used in innovative electrospinning rigs to obtain tubular and flat fibrous structures with controlled fiber orientation with the aim to be used as scaffolds for biomedical applications, more specifically in the tissue engineering of vascular and orthopedic grafts. Gelatine and hydroxyapatite (HA)-g...

journal_title：Annals of biomedical engineering

authors： Salifu AA,Nury BD,Lekakou C

更新日期：2011-10-01 00:00:00

abstract：:Dual X-ray absorptiometry (DXA) measures areal bone mineral density (aBMD) by simplifying a complex 3D bone structure to a 2D projection and is not equally effective for explaining fracture strength in women and men. Unlike DXA, subject-specific quantitative computed tomography-based finite element analysis (QCT/FEA) ...

journal_title：Annals of biomedical engineering

authors： Rezaei A,Giambini H,Rossman T,Carlson KD,Yaszemski MJ,Lu L,Dragomir-Daescu D

更新日期：2017-12-01 00:00:00

abstract：:Typical inverse dynamics approaches to the calculation of muscle, ligament, and joint contact forces are based on a step-wise solution of the equations of motion. This approach is therefore limited in its ability to provide insight as to the muscular, ligamentous, and articular interactions that create joint stability...

journal_title：Annals of biomedical engineering

authors： Cleather DJ,Bull AM

更新日期：2011-07-01 00:00:00