Abstract：
:In vitro stent-induced thromboembolism was altered by the presence of residual stenoses placed upstream or placed upstream and downstream of the stent. Heparinized (3 micro/ml) bovine blood was gravity fed through a conduit with a deployed coronary stent. Embolism was continuously monitored using a light-scattering microemboli detector, and the thrombus accumulated on the stent at the conclusion of the experiment was assessed gravimetrically. Gaussian stenoses (75% reduction in the cross-sectional area) were placed upstream or upstream and downstream of the stent to alter flow characteristics in the stent region. The presence of stenoses enhanced embolization from the stent in all cases, while end-point thrombus accumulation on the stent decreased with only an upstream stenosis present, and increased when upstream and downstream stenoses were present. Computational fluid dynamics with and without hypothetical model thrombi were used to ascertain the alterations in the flow environment caused by the stenoses and thrombi. Combining the computed hemodynamic parameters with experimental results indicated that increased radial transport of blood components and low wall shear stress provided by the stenoses and thrombi may explain the enhancement of end-point thrombus accumulation. Analysis further showed that thrombi growing at the stenosis-induced reattachment and separation points will be subjected to high shear forces which may explain the increased embolism when stenoses are present.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Sukavaneshvar S,Rosa GM,Solen KAdoi
10.1114/1.243subject
Has Abstractpub_date
2000-02-01 00:00:00pages
182-93issue
2eissn
0090-6964issn
1573-9686journal_volume
28pub_type
杂志文章abstract：:The development of brain interface (BI) technology continues to attract researchers with a wide range of backgrounds and expertise. Though the BI community is committed to accurate and objective evaluation of methods, systems, and technology, the very diversity of the methods and terminology used in the field hinders ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-7706-3
更新日期：2005-11-01 00:00:00
abstract：:Biologically active heart valves (tissue engineered and recellularized tissue-derived heart valves) have the potential to offer enhanced function when compared to current replacement value therapies since they can possibly remodel, and grow to meet the needs of the patient, and not require chronic medication. However,...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/b:abme.0000036640.11387.4b
更新日期：2004-08-01 00:00:00
abstract：:This study aimed to quantify the elongation patterns of the collateral ligaments following TKA during functional activities of daily living. Using mobile video-fluoroscopy to capture radiographic images of the knee in a group of six patients, each with an ultra-congruent knee implant, tibiofemoral kinematics were reco...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02459-3
更新日期：2020-04-01 00:00:00
abstract：:Percutaneous stent implantation has revolutionized the clinical treatment of occluded arteries. Nevertheless, there is still a large unmet need to prevent re-occlusion after implantation. Consequently, a niche exists for a cost-effective pre-clinical method of evaluating novel interventional devices in human models. T...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-009-9701-6
更新日期：2009-07-01 00:00:00
abstract：:The relationship between laboratory and on-field performance of football helmets was assessed for 31 football helmet models selected from those worn by players in the 2015-2019 National Football League (NFL) seasons. Linear impactor tests were conducted with helmets placed on an instrumented Hybrid III head and neck a...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02627-5
更新日期：2020-11-01 00:00:00
abstract：:Cells function based on a complex set of interactions that control pathways resulting in ultimate cell fates including proliferation, differentiation, and apoptosis. The inter-workings of this immensely dense network of intracellular molecules are influenced by more than random protein and nucleic acid distribution wh...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-005-9008-1
更新日期：2006-01-01 00:00:00
abstract：:Fractal time series analysis methods are commonly used for analyzing center of pressure (COP) signals with the goal of revealing the underlying neuromuscular processes for upright stance control. The use of fractal methods is often coupled with the assumption that the COP is an instance of fractional Gaussian noise (f...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-012-0646-9
更新日期：2013-08-01 00:00:00
abstract：:It is widely recognized that the bacteria sequestered in a biofilm on a medical implant are much more resistant to antibiotics than their planktonic counterparts. Recent studies have shown that application of antibiotic along with low power ultrasound significantly increases the killing of planktonic bacteria by the a...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02738539
更新日期：1997-01-01 00:00:00
abstract：:The influence of scaffold compliance on blood vessel tissue engineering remains unclear and compliance mismatch issues are important to an in vivo tissue-engineering approach. We have designed and constructed a modular bioreactor system that is capable of imparting pulsatile fluid flow while simultaneously measuring v...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-007-9304-z
更新日期：2007-08-01 00:00:00
abstract：:Overexpressed receptors, characteristic of many cancers, have been targeted by various researchers to achieve a more specific treatment for cancer. A common approach is to use the natural ligand for the overexpressed receptor as a cancer-targeting agent which can deliver a chemically or genetically conjugated toxic mo...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-011-0280-y
更新日期：2011-04-01 00:00:00
abstract：:The advantages of photoacoustic (PA) imaging, including low cost, non-ionizing operation, and sub-mm spatial resolution at centimeters depth, make it a promising modality to probe nanoparticle-targeted abnormalities in real time at cellular and molecular levels. However, detecting rare cell types in a heterogeneous ba...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-013-0901-8
更新日期：2013-11-01 00:00:00
abstract：:The material properties of normal cadaveric human cartilage in the ankle mortice (tibiotalar articulation) were evaluated to determine a possible etiologic mechanism of cartilage injury of the ankle when an obvious traumatic episode is not present. Using an automated indentation apparatus and the biphasic creep indent...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584467
更新日期：1995-09-01 00:00:00
abstract：:Förster resonance energy transfer (FRET) technology has been widely used in biological and biomedical research and is a very powerful tool in elucidating protein interactions in many cellular processes. Ubiquitination and SUMOylation are multi-step cascade reactions, involving multiple enzymes and protein-protein inte...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-0225-x
更新日期：2011-04-01 00:00:00
abstract：:The signal that governs the chemotactic response of mammalian white blood cells and tissue cells arises from membrane-localized binding events involving chemotactic factor ligands and receptors and G proteins. Fluctuations in this signal have been traditionally attributed to significant "noise" in receptor-ligand bind...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584427
更新日期：1995-05-01 00:00:00
abstract：:Diluted serum provides a model of interstitial fluid that can be used to study the response of smooth muscle cells (SMCs) to interstitial flow. The effect of serum and some of its components on SMC contraction (area reduction) and intracellular calcium ([Ca2+]i) response were characterized in rat aortic SMC in vitro. ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-004-7820-7
更新日期：2004-12-01 00:00:00
abstract：:Continuous flow left ventricular devices (CF-LVADs) support the failing heart at a constant speed and alters the loads on the aortic valve. This may cause insufficiency in the aortic valve under long-term CF-LVAD support. The aim of this study is to assess the aortic valve function under varying speed CF-LVAD support....
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-014-1204-4
更新日期：2015-08-01 00:00:00
abstract：:Three animal models were evaluated in this study involving head impacts of the rat, including the Marmarou drop-weight and two momentum-exchange techniques. In series 1, 36 Wistar rats were hit on the side of the free-moving head using Marmarou's 450 g impact mass at 4.4, 5.4, and 6.3 m/s. Head acceleration was measur...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0386-2
更新日期：2012-01-01 00:00:00
abstract：:Normalized maximal ventricular power (nPWRmax) is an index of cardiac function which measures the innate blood pumping ability, or contractility, of the left ventricle (LV), and its noninvasive assessment could prove useful in a variety of patients. nPWRmax is defined as the maximum instantaneous product of LV pressur...
journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
doi：10.1114/1.1415530
更新日期：2001-11-01 00:00:00
abstract：:We describe a system for real-time control of biological and other experiments. This device, based around the Real-Time Linux operating system, was tested specifically in the context of dynamic clamping, a demanding real-time task in which a computational system mimics the effects of nonlinear membrane conductances in...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1408929
更新日期：2001-10-01 00:00:00
abstract：:Currently, there are no clinically available tools or applications which could predict osteoarthritis development. Some computational models have been presented to simulate cartilage degeneration, but they are not clinically feasible due to time required to build subject-specific knee models. Therefore, the objective ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-018-02184-y
更新日期：2019-03-01 00:00:00
abstract：:Optoelectronic plethysmography (OEP) is a noninvasive method for assessing lung volume variations and the contributions of different anatomical compartments of the chest wall (CW) through measurements of the motion of markers attached to the CW surface. The present study proposes a new method for analyzing the local C...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-017-1840-6
更新日期：2017-08-01 00:00:00
abstract：:The concept of body force (force per unit volume) is introduced to account for the effect of the force generated in the radial direction by the active state of the myocardium in an elastic model of the left ventricle represented as a thick-walled cylinder contracting symmetrically. Experimental evidence for the validi...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368077
更新日期：1991-01-01 00:00:00
abstract：:During defecation, solid, semisolid or liquid stools are eliminated via the anus in a complex physiological process. Up to 25% of the population are affected by anorectal disorders that are poorly recognized and treated. We developed a new bionics device, a simulated stool named Fecobionics, to replace several current...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-018-02149-1
更新日期：2019-02-01 00:00:00
abstract：:Identifying the associations between head impact biomechanics and clinical recovery may inform better head impact monitoring procedures and identify athletes who may benefit from early treatments aimed to enhance recovery. The purpose of this study was to test whether head injury biomechanics are associated with clini...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02658-y
更新日期：2020-11-01 00:00:00
abstract：:Radiation applied for therapy and diagnostics damages molecular/atomic couples of biotissues, bones being among them. As a result, electron peculiarities and mechanical behavior of the latter are altered. Correlation between strength of the irradiated bone and its electron features explored due to photo- and exoelectr...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1114/1.1424911
更新日期：2001-12-01 00:00:00
abstract：:The most widely implanted prosthetic valve is the mechanical bileaflet. Recent clinical experiences suggest that some designs are more prone to thromboembolic episodes than others. This study evaluated the hinge flow and near-field forward flow of the new St. Jude Medical Regent bileaflet mechanical heart valve. Laser...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.297
更新日期：2000-05-01 00:00:00
abstract：:To study pulsatile pressure-flow rate relationships in the intact pulmonary vascular network of mice, we developed a protocol for measuring pulmonary vascular resistance and impedance in isolated, ventilated, and perfused mouse lungs. We used pulmonary emboli to validate the effect of vascular obstruction on resistanc...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-9050-z
更新日期：2006-04-01 00:00:00
abstract：:We have developed a method for quantifying the complexity of activation patterns observed during ventricular fibrillation (VF) that is based on our previously reported methodology for decomposing epicardial mapping data into a set of isolated wavefronts. One-half second datasets are acquired from a 21 x 24 array of un...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02684160
更新日期：1997-09-01 00:00:00
abstract：:Fibroblasts are abundant in cardiac tissue. Experimental studies suggested that fibroblasts are electrically coupled to myocytes and this coupling can impact cardiac electrophysiology. In this work, we present a novel approach for mathematical modeling of electrical conduction in cardiac tissue composed of myocytes, f...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-009-9667-4
更新日期：2009-05-01 00:00:00
abstract：:Literature review articles provide a valuable mechanism for remaining informed amidst an ever-increasing body of scientific work. Condensing current advances into this disseminatable form is a critical activity for any research trainee. To systematize this multifaceted process, we present the "why, when, who, what, ho...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-019-02290-5
更新日期：2019-11-01 00:00:00
