Abstract：
:The advantages of photoacoustic (PA) imaging, including low cost, non-ionizing operation, and sub-mm spatial resolution at centimeters depth, make it a promising modality to probe nanoparticle-targeted abnormalities in real time at cellular and molecular levels. However, detecting rare cell types in a heterogeneous background with strong optical scattering and absorption remains a big challenge. For example, differentiating circulating tumor cells in vivo (typically fewer than 10 cells/mL for an active tumor) among billions of erythrocytes in the blood is nearly impossible. In this paper, a newly developed technique, magnetomotive photoacoustic (mmPA) imaging, which can greatly increase the sensitivity and specificity of sensing targeted cells or molecular interactions, is reviewed. Its primary advantage is suppression of background signals through magnetic enrichment/manipulation with simultaneous PA detection of magnetic contrast agent targeted objects. Results from phantom and in vitro studies demonstrate the capability of mmPA imaging to differentiate regions targeted with magnetic nanoparticles from the background, and to trap and sensitively detect targeted cells at a concentration of a single cell per milliliter in a flow system mimicking a human peripheral artery. This technique provides an example of the ways in which molecular imaging can potentially enable robust molecular diagnosis and treatment, and accelerate the translation of molecular medicine into the clinic.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
O'Donnell M,Wei CW,Xia J,Pelivanov I,Jia C,Huang SW,Hu X,Gao Xdoi
10.1007/s10439-013-0901-8subject
Has Abstractpub_date
2013-11-01 00:00:00pages
2237-47issue
11eissn
0090-6964issn
1573-9686journal_volume
41pub_type
杂志文章,评审abstract：:In 12 dogs anesthetised with alpha-chloralose and urethane, and beta-adrenergic blocked with propranolol, the cervical vagi were stimulated for 60 seconds with supramaximal constant current pulses at frequencies between 2.0 and 10 Hz. The time course of the recovery of the cardiac period response, after cessation of v...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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abstract：:Conventional nanoporous hydrogels often lead to slow cartilage deposition by MSCs in 3D due to physical constraints and requirement for degradation. Our group has recently reported macroporous gelatin microribbon (μRB) hydrogels, which substantially accelerate MSC-based cartilage formation in vitro compared to convent...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02522-z
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1593-7
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-014-1224-0
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.47
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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更新日期：2012-08-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.110
更新日期：1998-09-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02565-2
更新日期：2021-01-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.96
更新日期：1998-05-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
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更新日期：2002-03-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-007-9303-0
更新日期：2007-06-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1114/1.1312187
更新日期：2000-08-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584258
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-013-0939-7
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journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
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journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
