The Application of Digital Volume Correlation (DVC) to Evaluate Strain Predictions Generated by Finite Element Models of the Osteoarthritic Humeral Head.

Abstract:

:Continuum-level finite element models (FEMs) of the humerus offer the ability to evaluate joint replacement designs preclinically; however, experimental validation of these models is critical to ensure accuracy. The objective of the current study was to quantify experimental full-field strain magnitudes within osteoarthritic (OA) humeral heads by combining mechanical loading with volumetric microCT imaging and digital volume correlation (DVC). The experimental data was used to evaluate the accuracy of corresponding FEMs. Six OA humeral head osteotomies were harvested from patients being treated with total shoulder arthroplasty and mechanical testing was performed within a microCT scanner. MicroCT images (33.5 µm isotropic voxels) were obtained in a pre- and post-loaded state and BoneDVC was used to quantify full-field experimental strains (≈ 1 mm nodal spacing, accuracy = 351 µstrain, precision = 518 µstrain). Continuum-level FEMs with two types of boundary conditions (BCs) were simulated: DVC-driven and force-driven. Accuracy of the FEMs was found to be sensitive to the BC simulated with better agreement found with the use of DVC-driven BCs (slope = 0.83, r2 = 0.80) compared to force-driven BCs (slope = 0.22, r2 = 0.12). This study quantified mechanical strain distributions within OA trabecular bone and demonstrated the importance of BCs to ensure the accuracy of predictions generated by corresponding FEMs.

journal_name

Ann Biomed Eng

authors

Kusins J,Knowles N,Columbus M,Oliviero S,Dall'Ara E,Athwal GS,Ferreira LM

doi

10.1007/s10439-020-02549-2

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

2859-2869

issue

12

eissn

0090-6964

issn

1573-9686

pii

10.1007/s10439-020-02549-2

journal_volume

48

pub_type

杂志文章
  • Wall Shear Stress Topological Skeleton Independently Predicts Long-Term Restenosis After Carotid Bifurcation Endarterectomy.

    abstract::Wall Shear Stress (WSS) topological skeleton, composed by fixed points and the manifolds linking them, reflects the presence of blood flow features associated to adverse vascular response. However, the influence of WSS topological skeleton on vascular pathophysiology is still underexplored. This study aimed to identif...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-020-02607-9

    authors: Morbiducci U,Mazzi V,Domanin M,De Nisco G,Vergara C,Steinman DA,Gallo D

    更新日期:2020-12-01 00:00:00

  • Strategies to direct the enrichment, expansion, and recruitment of regulatory cells for the treatment of disease.

    abstract::Disease and injury perturb the balance of processes associated with inflammation and tissue remodeling, resulting in positive feedback loops, exacerbation of disease and compromised tissue repair. Conversely, under homeostatic healthy conditions, these processes are tightly regulated through the expansion and/or recru...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审

    doi:10.1007/s10439-014-1125-2

    authors: Glowacki AJ,Gottardi R,Yoshizawa S,Cavalla F,Garlet GP,Sfeir C,Little SR

    更新日期:2015-03-01 00:00:00

  • Historic and future development of high-frequency ventilation.

    abstract::High-frequency ventilation (HFV) has not one but several histories. Proceeding along largely independent pathways are techniques using frequencies of 1-5 Hz and techniques using 10-40 Hz, the former being introduced by Sjostrand in 1971, the latter by Lunkenheimer in 1972. It was nearly ten years before it was recogni...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/BF02407779

    authors: Bryan AC

    更新日期:1984-01-01 00:00:00

  • Partial Bone Formation in Additive Manufactured Porous Implants Reduces Predicted Stress and Danger of Fatigue Failure.

    abstract::New porous implant designs made possible by additive manufacturing allow for increased osseointegration, potentially improving implant performance and longevity for patients that require massive bone implants. The aim of this study was to evaluate how implantation and the strain distribution in the implant affect the ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-019-02369-z

    authors: Cheong VS,Fromme P,Coathup MJ,Mumith A,Blunn GW

    更新日期:2020-01-01 00:00:00

  • High fidelity virtual stenting (HiFiVS) for intracranial aneurysm flow diversion: in vitro and in silico.

    abstract::A flow diverter (FD) is a flexible, densely braided stent-mesh device placed endoluminally across an intracranial aneurysm to induce its thrombotic occlusion. FD treatment planning using computational virtual stenting and flow simulation requires accurate representation of the expanded FD geometry. We have recently de...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-013-0808-4

    authors: Ma D,Dumont TM,Kosukegawa H,Ohta M,Yang X,Siddiqui AH,Meng H

    更新日期:2013-10-01 00:00:00

  • Mechanical & cell culture properties of elastin-like polypeptide, collagen, bioglass, and carbon nanosphere composites.

    abstract::Collagen, the most commonly used extra-cellular matrix protein for tissue engineering applications, displays poor mechanical properties. Here, we report on the preparation and characterization of novel multi-component composite systems that incorporate a genetically engineered, biocompatible polymer (elastin-like poly...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-013-0825-3

    authors: Wheeler TS,Sbravati ND,Janorkar AV

    更新日期:2013-10-01 00:00:00

  • The placement of skin surface markers for non-invasive measurement of scapular kinematics affects accuracy and reliability.

    abstract::Abnormal scapular movement is widely believed to be an important factor in clinical pathology of the shoulder joint complex. Validated non-invasive techniques for measuring scapular movement have been developed, but the effect of marker placement on accuracy is unknown. The objective of this study was to determine the...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-010-0185-1

    authors: Bourne DA,Choo AM,Regan WD,MacIntyre DL,Oxland TR

    更新日期:2011-02-01 00:00:00

  • Progression of abdominal aortic aneurysm towards rupture: refining clinical risk assessment using a fully coupled fluid-structure interaction method.

    abstract::Rupture of abdominal aortic aneurysm (AAA) is associated with high mortality rates. Risk of rupture is multi-factorial involving AAA geometric configuration, vessel tortuosity, and the presence of intraluminal pathology. Fluid structure interaction (FSI) simulations were conducted in patient based computed tomography ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-014-1224-0

    authors: Xenos M,Labropoulos N,Rambhia S,Alemu Y,Einav S,Tassiopoulos A,Sakalihasan N,Bluestein D

    更新日期:2015-01-01 00:00:00

  • Sharing best practices in teaching biomedical engineering design.

    abstract::In an effort to share best practices in undergraduate engineering design education, we describe the origin, evolution and the current status of the undergraduate biomedical engineering design team program at Johns Hopkins University. Specifically, we describe the program and judge the quality of the pedagogy by relati...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-013-0781-y

    authors: Allen RH,Acharya S,Jancuk C,Shoukas AA

    更新日期:2013-09-01 00:00:00

  • Nonequilibrium facilitated transport of carbon dioxide in bicarbonate and bovine albumin solutions.

    abstract::The nonlinear diffusion-reaction equations describing the nonequilibrium transport of CO2 through flat layers of complex but homogeneous aqueous media were solved by an approximate analytical method called the "Combined Damköhler Number" (CDN) technique. Unlike other approximate analytical solutions, the CDN technique...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/BF02484468

    authors: Hoofd LJ,Tong RR,Stroeve P

    更新日期:1986-01-01 00:00:00

  • Dynamics of revolution time variability in cycling pattern: voluntary intent can alter the long-range autocorrelations.

    abstract::Long-range dependency has been found in most rhythmic motor signals. The origin of this property is unknown and largely debated. There is a controversy on the influence of voluntary control induced by requiring a pre-determined pace such as asking subjects to step to a metronome. We studied the cycle duration variabil...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10439-013-0834-2

    authors: Warlop TB,Bollens B,Crevecoeur F,Detrembleur C,Lejeune TM

    更新日期:2013-08-01 00:00:00

  • Generalized sensitivity functions in physiological system identification.

    abstract::Parameters of physiological models are commonly associated in an input-output experiment with a specific pattern of the system response. This association is often made on an intuitive basis by traditional sensitivity analysis, i.e., by inspecting the variations of model output trajectories with respect to parameter va...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1114/1.207

    authors: Thomaseth K,Cobelli C

    更新日期:1999-09-01 00:00:00

  • Predictive Virtual Patient Modelling of Mechanical Ventilation: Impact of Recruitment Function.

    abstract::Mechanical ventilation is a life-support therapy for intensive care patients suffering from respiratory failure. To reduce the current rate of ventilator-induced lung injury requires ventilator settings that are patient-, time-, and disease-specific. A common lung protective strategy is to optimise the level of positi...

    journal_title:Annals of biomedical engineering

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10439-019-02253-w

    authors: Morton SE,Knopp JL,Chase JG,Möller K,Docherty P,Shaw GM,Tawhai M

    更新日期:2019-07-01 00:00:00

  • Continuous blood density measurement for hemodynamic monitoring: an analysis of its accuracy and sensitivity.

    abstract::Continuous measurement of arterial blood density after bolus injection of fluids of different density into the right atrium has been used to measure cardiac output and mean transit time through the central circulation. The transit time distribution for density, however, differs from that for plasma-phase tracers such ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/BF02368628

    authors: Ligas JR,Moslehi F,Epstein MA

    更新日期:1993-07-01 00:00:00

  • Low strength static magnetic field inhibits the proliferation, migration, and adhesion of human vascular smooth muscle cells in a restenosis model through mediating integrins β1-FAK, Ca2+ signaling pathway.

    abstract::The proliferation, migration, and adhesion of vascular smooth muscle cells (VSMCs) and their interactions with extracellular matrix are key features of atherosclerosis and restenosis. Recently, there has been evidence that magnetic fields exert multiple effects on the biological performance of cells and may aid in the...

    journal_title:Annals of biomedical engineering

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10439-012-0602-8

    authors: Li Y,Song LQ,Chen MQ,Zhang YM,Li J,Feng XY,Li W,Guo W,Jia G,Wang H,Yu J

    更新日期:2012-12-01 00:00:00

  • Finite element modeling of coupled diffusion with partitioning in transdermal drug delivery.

    abstract::The finite element method is employed to simulate two-dimensional (axisymmetric) drug diffusion from a finite drug reservoir into the skin. The numerical formulation is based on a general mathematical model for multicomponent nonlinear diffusion that takes into account the coupling effects between the different compon...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-005-5788-6

    authors: Rim JE,Pinsky PM,van Osdol WW

    更新日期:2005-10-01 00:00:00

  • Sensor Anchoring Improves the Correlation Between Intramuscular Pressure and Muscle Tension in a Rabbit Model.

    abstract::Intramuscular pressure (IMP) shows promise for estimating individual muscle tension in vivo. However, previous pressure measurements show high variability during isometric contraction and poor correlation with tension during dynamic contraction. We hypothesized that enhanced sensor anchoring/orientation would improve ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-020-02633-7

    authors: O'Connor SM,Kaufman KR,Ward SR,Lieber RL

    更新日期:2021-02-01 00:00:00

  • Flow visualization in mechanical heart valves: occluder rebound and cavitation potential.

    abstract::High density particle image velocimetry, with spatial resolution of O(1 mm), was used to measure the effect of occluder rebound on the flow field near a Bjork-Shiley Monostrut tilting-disk mitral valve. The ability to measure two velocity components over an entire plane simultaneously provides a very different insight...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1114/1.281

    authors: Kini V,Bachmann C,Fontaine A,Deutsch S,Tarbell JM

    更新日期:2000-04-01 00:00:00

  • A finite volume method for modeling discontinuous electrical activation in cardiac tissue.

    abstract::This paper describes a finite volume method for modeling electrical activation in a sample of cardiac tissue using the bidomain equations. Microstructural features to the level of cleavage planes between sheets of myocardial fibers in the tissue are explicitly represented. The key features of this implementation compa...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-005-1434-6

    authors: Trew M,Le Grice I,Smaill B,Pullan A

    更新日期:2005-05-01 00:00:00

  • Predicting the responses of mechanoreceptor neurons to physiological inputs by nonlinear system identification.

    abstract::The nonlinear dynamic properties of action potential encoding were studied in mechanosensory neurons innervating the slits of a slit-sense organ in the tropical wandering spider, Cupiennius salei. The organ contains two types of neurons that are morphologically similar but have different dynamic properties. Type A neu...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1114/1.1355278

    authors: French AS,Sekizawa SI,Höger U,Torkkeli PH

    更新日期:2001-03-01 00:00:00

  • Genetics of energetics: transcriptional responses in cardiac metabolism.

    abstract::Recent evidence suggests that energy substrate metabolism forms the link between gene expression and contractile function of the heart. This hypothesis draws on three seemingly unconnected observations, made in 1941 by three different investigators. The first gave rise to the concept of the dynamic nature of body cons...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审

    doi:10.1114/1.1312187

    authors: Taegtmeyer H

    更新日期:2000-08-01 00:00:00

  • Mechanical analysis of atherosclerotic plaques based on optical coherence tomography.

    abstract::Finite element analysis is a powerful tool for investigating the biomechanics of atherosclerosis and has thereby provided an improved understanding of acute myocardial infarction. Structural analysis of arterial walls is traditionally performed using geometry contours derived from histology. In this paper we demonstra...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1114/b:abme.0000049034.75368.4a

    authors: Chau AH,Chan RC,Shishkov M,MacNeill B,Iftimia N,Tearney GJ,Kamm RD,Bouma BE,Kaazempur-Mofrad MR

    更新日期:2004-11-01 00:00:00

  • Automatized Patient-Specific Methodology for Numerical Determination of Biomechanical Corneal Response.

    abstract::This work presents a novel methodology for building a three-dimensional patient-specific eyeball model suitable for performing a fully automatic finite element (FE) analysis of the corneal biomechanics. The reconstruction algorithm fits and smooths the patient's corneal surfaces obtained in clinic with corneal topogra...

    journal_title:Annals of biomedical engineering

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10439-015-1426-0

    authors: Ariza-Gracia MÁ,Zurita J,Piñero DP,Calvo B,Rodríguez-Matas JF

    更新日期:2016-05-01 00:00:00

  • Mesh Convergence Behavior and the Effect of Element Integration of a Human Head Injury Model.

    abstract::Numerous head injury models exist that vary in mesh density by orders of magnitude. A careful study of the mesh convergence behavior is necessary, especially in terms of strain most relevant to brain injury. To this end, as well as to investigate the effect of element integration scheme on simulated strains, we re-mes...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-018-02159-z

    authors: Zhao W,Ji S

    更新日期:2019-02-01 00:00:00

  • Second harmonic generation imaging and Fourier transform spectral analysis reveal damage in fatigue-loaded tendons.

    abstract::Conventional histologic methods provide valuable information regarding the physical nature of damage in fatigue-loaded tendons, limited to thin, two-dimensional sections. We introduce an imaging method that characterizes tendon microstructure three-dimensionally and develop quantitative, spatial measures of damage for...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-010-9976-7

    authors: Fung DT,Sereysky JB,Basta-Pljakic J,Laudier DM,Huq R,Jepsen KJ,Schaffler MB,Flatow EL

    更新日期:2010-05-01 00:00:00

  • Mathematical models of the spatial distribution of retinal oxygen tension and consumption, including changes upon illumination.

    abstract::To better understand oxygen utilization by the retina, a mathematical model of oxygen diffusion and consumption in the cat outer, avascular retina was developed by analyzing previously recorded profiles of oxygen tension (PO2) as a function of retinal depth. Simple diffusion modelling of the oxygen distribution throug...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/BF02368415

    authors: Haugh LM,Linsenmeier RA,Goldstick TK

    更新日期:1990-01-01 00:00:00

  • Sensitivity analysis of an image-based solid tumor computational model with heterogeneous vasculature and porosity.

    abstract::An MR image-based computational model of a murine KHT sarcoma is presented that allows the calculation of plasma fluid and solute transport within tissue. Such image-based models of solid tumors may be used to optimize patient-specific therapies. This model incorporates heterogeneous vasculature and tissue porosity to...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-011-0349-7

    authors: Pishko GL,Astary GW,Mareci TH,Sarntinoranont M

    更新日期:2011-09-01 00:00:00

  • A Dual-Mode Bioreactor System for Tissue Engineered Vascular Models.

    abstract::In the past decades, vascular tissue engineering has made great strides towards bringing engineered vascular tissues to the clinics and, in parallel, obtaining in-lab tools for basic research. Herein, we propose the design of a novel dual-mode bioreactor, useful for the fabrication (construct mode) and in vitro stimul...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-017-1813-9

    authors: Bono N,Meghezi S,Soncini M,Piola M,Mantovani D,Fiore GB

    更新日期:2017-06-01 00:00:00

  • Consistent biomechanical phenotyping of common carotid arteries from seven genetic, pharmacological, and surgical mouse models.

    abstract::The continuing lack of longitudinal histopathological and biomechanical data for human arteries in health and disease highlights the importance of studying the many genetic, pharmacological, and surgical models that are available in mice. As a result, there has been a significant increase in the number of reports on t...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-014-0988-6

    authors: Bersi MR,Ferruzzi J,Eberth JF,Gleason RL Jr,Humphrey JD

    更新日期:2014-06-01 00:00:00

  • Why, When, Who, What, How, and Where for Trainees Writing Literature Review Articles.

    abstract::Literature review articles provide a valuable mechanism for remaining informed amidst an ever-increasing body of scientific work. Condensing current advances into this disseminatable form is a critical activity for any research trainee. To systematize this multifaceted process, we present the "why, when, who, what, ho...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-019-02290-5

    authors: Koons GL,Schenke-Layland K,Mikos AG

    更新日期:2019-11-01 00:00:00