Abstract:
:Finite element analysis is a powerful tool for investigating the biomechanics of atherosclerosis and has thereby provided an improved understanding of acute myocardial infarction. Structural analysis of arterial walls is traditionally performed using geometry contours derived from histology. In this paper we demonstrate the first use of a new imaging technique, optical coherence tomography (OCT), as a basis for finite element analysis. There are two primary benefits of OCT relative to histology: 1) imaging is performed without excessive tissue handling, providing a more realistic geometry than histology and avoiding structural artifacts common to histologic processing, and 2) OCT imaging can be performed in vivo, making it possible to study disease progression and the effect of therapeutic treatments in animal models and living patients. Patterns of mechanical stress and strain distributions computed from finite element analysis based on OCT were compared with those from modeling based on "gold standard" histology. Our results indicate that vascular structure and composition determined by OCT provides an adequate basis for investigating the biomechanical factors relevant to atherosclerosis and acute myocardial infarction.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Chau AH,Chan RC,Shishkov M,MacNeill B,Iftimia N,Tearney GJ,Kamm RD,Bouma BE,Kaazempur-Mofrad MRdoi
10.1114/b:abme.0000049034.75368.4asubject
Has Abstractpub_date
2004-11-01 00:00:00pages
1494-503issue
11eissn
0090-6964issn
1573-9686journal_volume
32pub_type
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