A fuzzy pattern recognition method to classify esophageal motility records.

abstract：:Correct development of neuronal tracts requires the coordination of multiple permissive and inhibitory signals. By generating an in vitro microenvironment using soft lithography and microfluidic techniques, multiple guidance cues can be presented in a spatially defined way. Here we evaluated how neurites of dorsal roo...

journal_title：Annals of biomedical engineering

authors： Li GN,Liu J,Hoffman-Kim D

更新日期：2008-06-01 00:00:00

abstract：:Ever-increasing demand for bone grafts necessitates the realization of clinical implementation of bone tissue engineered constructs. The predominant hurdle to implementation remains to be securing FDA approval, based on the lack of viable methods for the rigorous monitoring of said constructs. The study presented here...

journal_title：Annals of biomedical engineering

authors： Simmons AD,Sikavitsas VI

更新日期：2018-01-01 00:00:00

abstract：:Rapid screening of biomarkers, with high specificity and accuracy, is critical for many point-of-care diagnostics. Microfluidics, the use of microscale channels to manipulate small liquid samples and carry reactions in parallel, offers tremendous opportunities to address fundamental questions in biology and provide a ...

journal_title：Annals of biomedical engineering

authors： Ng E,Chen K,Hang A,Syed A,Zhang JX

更新日期：2016-04-01 00:00:00

abstract：:Deformational loading represents a primary component of the chondrocyte physical environment in vivo. This review summarizes our experience with physiologic deformational loading of chondrocyte-seeded agarose hydrogels to promote development of cartilage constructs having mechanical properties matching that of the par...

journal_title：Annals of biomedical engineering

authors： Hung CT,Mauck RL,Wang CC,Lima EG,Ateshian GA

更新日期：2004-01-01 00:00:00

abstract：:A model predictive control strategy to simultaneously regulate hemodynamic and anesthetic variables in critical care patients is presented. A nonlinear canine circulatory model, which has been used to study the effect of inotropic and vasoactive drugs on hemodynamic variables, has been extended to include propofol pha...

journal_title：Annals of biomedical engineering

authors： Rao RR,Bequette BW,Roy RJ

更新日期：2000-01-01 00:00:00

abstract：:The nonlinear dynamic properties of action potential encoding were studied in mechanosensory neurons innervating the slits of a slit-sense organ in the tropical wandering spider, Cupiennius salei. The organ contains two types of neurons that are morphologically similar but have different dynamic properties. Type A neu...

journal_title：Annals of biomedical engineering

authors： French AS,Sekizawa SI,Höger U,Torkkeli PH

更新日期：2001-03-01 00:00:00

abstract：:This paper reports the design, manufacturing, and characterization of a new bioreactor dedicated to the development of tissue-engineered heart valve substitutes. First, a comprehensive review of the state of the art in bioreactors is presented and a rigorous classification is put forward. The existing bioreactors foun...

journal_title：Annals of biomedical engineering

authors： Ruel J,Lachance G

更新日期：2009-04-01 00:00:00

abstract：:Mechanical interactions during angiogenesis, i.e., traction applied by neovessels to the extracellular matrix and the corresponding deformation, are important regulators of growth and neovascularization. We have previously designed, implemented, and validated a coupled model of angiogenesis in which a discrete microve...

journal_title：Annals of biomedical engineering

authors： Edgar LT,Hoying JB,Weiss JA

更新日期：2015-07-01 00:00:00

abstract：:Literature review articles provide a valuable mechanism for remaining informed amidst an ever-increasing body of scientific work. Condensing current advances into this disseminatable form is a critical activity for any research trainee. To systematize this multifaceted process, we present the "why, when, who, what, ho...

journal_title：Annals of biomedical engineering

authors： Koons GL,Schenke-Layland K,Mikos AG

更新日期：2019-11-01 00:00:00

abstract：:Human stem cells hold significant potential for the treatment of various diseases. However, their use as a therapy is hampered because of limited understanding of the mechanisms by which they respond to environmental stimuli. Efforts to understand extracellular biophysical cues have demonstrated the critical roles of ...

journal_title：Annals of biomedical engineering

authors： Piroli ME,Jabbarzadeh E

更新日期：2018-06-01 00:00:00

abstract：:Induced pluripotent stem cell derived cardiomyocytes (iPSC-CM) provide a powerful platform for disease modeling and drug development in vitro. Traditionally, electrophysiological methods or fluorescent dyes (e.g. calcium) have been used in their functional characterization. Recently, video microscopy has enabled non-i...

journal_title：Annals of biomedical engineering

authors： Ahola A,Pölönen RP,Aalto-Setälä K,Hyttinen J

更新日期：2018-01-01 00:00:00

abstract：:Proteoglycan 4 (PRG4) is a mucin-like glycoprotein present in synovial fluid and at the surface of articular cartilage. The objectives of this study were to (1) assess the articular cartilage surface adsorption and in vitro cartilage boundary lubricating ability of full-length recombinant human PRG4 (rhPRG4), and (2) ...

journal_title：Annals of biomedical engineering

authors： Abubacker S,Dorosz SG,Ponjevic D,Jay GD,Matyas JR,Schmidt TA

更新日期：2016-04-01 00:00:00

abstract：:A major benefit of computational modeling in biomechanics research is its ability to estimate internal muscular demands given limited input information. However, several assumptions regarding model parameters and constraints may influence model outputs. This research evaluated the influence of model parameter variabil...

journal_title：Annals of biomedical engineering

authors： Chopp-Hurley JN,Langenderfer JE,Dickerson CR

更新日期：2014-09-01 00:00:00

abstract：:Local hemodynamics are an important factor in atherosclerosis, from the development of early lesions, to the assessment of stroke risk, to determining the ultimate fate of a mature plaque. Until recently, our understanding of arterial fluid dynamics and their relationship to atherosclerosis was limited by the use of i...

journal_title：Annals of biomedical engineering

authors： Steinman DA

更新日期：2002-04-01 00:00:00

abstract：:Intracellular calcium oscillation caused by receptor activator of nuclear factor kappa-B ligand has been demonstrated to promote the differentiation of osteoclasts. Osteoclasts are recruited on the surface of trabeculae, and are exposed to fluid flow caused by the deformation of the bone matrix. However, the roles of ...

journal_title：Annals of biomedical engineering

authors： Li P,Hu M,Sun S,Zhang Y,Gao Y,Long M,Huo B,Zhang D

更新日期：2012-09-01 00:00:00

abstract：:Numerical models of the mitral valve have been used to elucidate mitral valve function and mechanics. These models have evolved from simple two-dimensional approximations to complex three-dimensional fully coupled fluid structure interaction models. However, to date these models lack direct one-to-one experimental val...

journal_title：Annals of biomedical engineering

authors： Rabbah JP,Saikrishnan N,Yoganathan AP

更新日期：2013-02-01 00:00:00

abstract：:In previous shoulder impact studies, the 50th-percentile male GHBMC human body finite-element model was shown to have good biofidelity regarding impact force, but under-predicted shoulder deflection by 80% compared to those observed in the experiment. The goal of this study was to validate the response of the GHBMC M5...

journal_title：Annals of biomedical engineering

authors： Park G,Kim T,Panzer MB,Crandall JR

更新日期：2016-08-01 00:00:00

abstract：:Biomaterial-based tissue engineering strategies hold great promise for osteochondral tissue repair. Yet significant challenges remain in joining highly dissimilar materials to achieve a biomimetic, mechanically robust design for repairing interfaces between soft tissue and bone. This study sought to improve interfacia...

journal_title：Annals of biomedical engineering

authors： Kinneberg KR,Nelson A,Stender ME,Aziz AH,Mozdzen LC,Harley BA,Bryant SJ,Ferguson VL

更新日期：2015-11-01 00:00:00

abstract：:A limitation of current tissue engineering vascular graft technology is the provision of an expandable, autologous cell source. By harnessing the multipotency of mesenchymal stem cells (MSC), it is hoped that functional vascular cells can be produced. To date, a range of 2D and 3D environments have been investigated f...

journal_title：Annals of biomedical engineering

authors： O'Cearbhaill ED,Murphy M,Barry F,McHugh PE,Barron V

更新日期：2010-03-01 00:00:00

abstract：:Diluted serum provides a model of interstitial fluid that can be used to study the response of smooth muscle cells (SMCs) to interstitial flow. The effect of serum and some of its components on SMC contraction (area reduction) and intracellular calcium ([Ca2+]i) response were characterized in rat aortic SMC in vitro. ...

journal_title：Annals of biomedical engineering

authors： Ainslie K,Shi ZD,Garanich JS,Tarbell JM

更新日期：2004-12-01 00:00:00

abstract：:We have developed poly(L: -lactide-co-glycolide) (PLGA) based composites using sol-gel derived bioactive glasses (S-BG), previously described by our group, as composite components. Two different composite types were manufactured that contained either S2-high content silica S-BG, or A2-high content lime S-BG. The compo...

journal_title：Annals of biomedical engineering

authors： Pamula E,Kokoszka J,Cholewa-Kowalska K,Laczka M,Kantor L,Niedzwiedzki L,Reilly GC,Filipowska J,Madej W,Kolodziejczyk M,Tylko G,Osyczka AM

更新日期：2011-08-01 00:00:00

abstract：:The unique resource constraints, urgency, and virulence of the coronavirus disease 2019 pandemic has sparked immense innovation in the development of barrier devices to protect healthcare providers from infectious airborne particles generated by patients during airway management interventions. Of the existing devices,...

journal_title：Annals of biomedical engineering

authors： Maloney LM,Yang AH,Princi RA,Eichert AJ,Hébert DR,Kupec TV,Mertz AE,Vasyltsiv R,Vijaya Kumar TM,Walker GJ,Peralta EJ,Hoffman JL,Yin W,Page CR

更新日期：2020-10-01 00:00:00

abstract：:A multifunctional FePt nanoparticle was developed that targets tumor microvasculature via "radiation-guided" peptides, and is detected by both near-infrared (NIR) fluorescence imaging and analytical mass spectrometry methods. Tumor specific binding was first measured by biotinylated peptide linked to fluorophore-conju...

journal_title：Annals of biomedical engineering

authors： Hariri G,Wellons MS,Morris WH 3rd,Lukehart CM,Hallahan DE

更新日期：2011-03-01 00:00:00

abstract：:This project was undertaken to establish if the integral circulation had any effects upon the mechanical behavior of bone. The influence of blood flow in the rabbit tibia on the strain induced at the bone surface when under load was assessed. Recordings were taken from three adult and three immature New Zealand White ...

journal_title：Annals of biomedical engineering

authors： McDonald F,Pitt Ford TR

更新日期：1994-03-01 00:00:00

abstract：:A recent analytical solution of the three-dimensional Stokes flow through a bumpy tube predicts that for a given bump area, there exists an optimal circumferential wavenumber which minimizes flow resistance. This study uses measurements of microvessel endothelial cell morphology to test whether this prediction holds i...

journal_title：Annals of biomedical engineering

authors： Sumagin R,Brown CW 3rd,Sarelius IH,King MR

更新日期：2008-04-01 00:00:00

abstract：:The emerging field of micro-technology has opened up new possibilities for exploring cellular chemotaxis in real space and time, and at single cell resolution. Chemotactic cells sense and move in response to chemical gradients and play important roles in a number of physiological and pathological processes, including ...

journal_title：Annals of biomedical engineering

authors： Kim BJ,Wu M

更新日期：2012-06-01 00:00:00

abstract：:Extraction of the cardiac surfaces of interest from multi-detector computed tomographic (MDCT) data is a pre-requisite step for cardiac analysis, as well as for image guidance procedures. Most of the existing methods need manual corrections, which is time-consuming. We present a fully automatic segmentation technique ...

journal_title：Annals of biomedical engineering

authors： Antunes S,Esposito A,Palmisano A,Colantoni C,Cerutti S,Rizzo G

更新日期：2016-05-01 00:00:00

abstract：:To study pulsatile pressure-flow rate relationships in the intact pulmonary vascular network of mice, we developed a protocol for measuring pulmonary vascular resistance and impedance in isolated, ventilated, and perfused mouse lungs. We used pulmonary emboli to validate the effect of vascular obstruction on resistanc...

journal_title：Annals of biomedical engineering

authors： Tuchscherer HA,Webster EB,Chesler NC

更新日期：2006-04-01 00:00:00

abstract：:Thorax injuries mainly due to rib fractures have been associated with high rates of morbidity and mortality in motor vehicle crashes. Thoracic biomechanics has been studied extensively, but there are no robust biomechanical response targets for ribs that consider age, sex, body size, and vulnerability factors. The obj...

journal_title：Annals of biomedical engineering

authors： Kang YS,Kwon HJ,Stammen J,Moorhouse K,Agnew AM

更新日期：2021-02-01 00:00:00

abstract：:Additive manufacturing, also known as 3D printing, has emerged over the past 3 decades as a disruptive technology for rapid prototyping and manufacturing. Vat polymerization, powder bed fusion, material extrusion, and binder jetting are distinct technologies of additive manufacturing, which have been used in a wide va...

journal_title：Annals of biomedical engineering

authors： Trombetta R,Inzana JA,Schwarz EM,Kates SL,Awad HA

更新日期：2017-01-01 00:00:00