Abstract:
:Numerical models of the mitral valve have been used to elucidate mitral valve function and mechanics. These models have evolved from simple two-dimensional approximations to complex three-dimensional fully coupled fluid structure interaction models. However, to date these models lack direct one-to-one experimental validation. As computational solvers vary considerably, experimental benchmark data are critically important to ensure model accuracy. In this study, a novel left heart simulator was designed specifically for the validation of numerical mitral valve models. Several distinct experimental techniques were collectively performed to resolve mitral valve geometry and hemodynamics. In particular, micro-computed tomography was used to obtain accurate and high-resolution (39 μm voxel) native valvular anatomy, which included the mitral leaflets, chordae tendinae, and papillary muscles. Three-dimensional echocardiography was used to obtain systolic leaflet geometry. Stereoscopic digital particle image velocimetry provided all three components of fluid velocity through the mitral valve, resolved every 25 ms in the cardiac cycle. A strong central filling jet (V ~ 0.6 m/s) was observed during peak systole with minimal out-of-plane velocities. In addition, physiologic hemodynamic boundary conditions were defined and all data were synchronously acquired through a central trigger. Finally, the simulator is a precisely controlled environment, in which flow conditions and geometry can be systematically prescribed and resultant valvular function and hemodynamics assessed. Thus, this work represents the first comprehensive database of high fidelity experimental data, critical for extensive validation of mitral valve fluid structure interaction simulations.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Rabbah JP,Saikrishnan N,Yoganathan APdoi
10.1007/s10439-012-0651-zsubject
Has Abstractpub_date
2013-02-01 00:00:00pages
305-15issue
2eissn
0090-6964issn
1573-9686journal_volume
41pub_type
杂志文章abstract::A mathematical model of heat, water and soluble gas exchange in the airways and alveoli was used to predict the location of soluble gas exchange in the lung. A previously published model of heat, water and soluble gas exchange in the airways was improved by incorporating anatomical data on the airway wall to better de...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.1630600
更新日期:2003-12-01 00:00:00
abstract::Induced pluripotent stem cell derived cardiomyocytes (iPSC-CM) provide a powerful platform for disease modeling and drug development in vitro. Traditionally, electrophysiological methods or fluorescent dyes (e.g. calcium) have been used in their functional characterization. Recently, video microscopy has enabled non-i...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-017-1933-2
更新日期:2018-01-01 00:00:00
abstract::The longitudinal assessment of joint health is a long-standing issue in the management of musculoskeletal injuries. The acoustic emissions (AEs) produced by joint articulation could serve as a biomarker for joint health assessment, but their use has been limited by a lack of mechanistic understanding of their creation...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-019-02333-x
更新日期:2020-01-01 00:00:00
abstract::Opportunities to provide clinical immersion experiences to bioengineering undergraduate students have expanded over the last several years. These programs allow students to observe the clinical environment in order to better understand workflow processes, the context in which medical equipment is used, and identify un...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-020-02508-x
更新日期:2020-09-01 00:00:00
abstract::Soft collagenous tissue features many hierarchies of structure, starting from tropocollagen molecules that form fibrils, and proceeding to a bundle of fibrils that form fibers. Here we report the development of an atomistically informed continuum model of collagenous tissue. Results from full atomistic and molecular m...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-009-9679-0
更新日期:2009-06-01 00:00:00
abstract::Pressure ulcers (PUs) can occur in any situations where people are subjected to non-uniform distribution of pressure over a prolonged period. They can have devastating effects on the patients' well-being and in extreme conditions can prove fatal. In addition to traditional wisdom implicating mechanically induced ischa...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/s10439-014-1233-z
更新日期:2015-02-01 00:00:00
abstract::The emerging field of micro-technology has opened up new possibilities for exploring cellular chemotaxis in real space and time, and at single cell resolution. Chemotactic cells sense and move in response to chemical gradients and play important roles in a number of physiological and pathological processes, including ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/s10439-011-0489-9
更新日期:2012-06-01 00:00:00
abstract::Abdominal aortic aneurysms occur in as much as 2-3% of the population, and their rupture produces a mortality rate of 78-94% (1), causing 15,000 deaths per year in the U.S. alone. As an investigation into the mechanical factors that lead to aneurysm rupture, flow field measurements are presented for steady flow throug...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02368298
更新日期:1995-01-01 00:00:00
abstract::Fibroblasts are abundant in cardiac tissue. Experimental studies suggested that fibroblasts are electrically coupled to myocytes and this coupling can impact cardiac electrophysiology. In this work, we present a novel approach for mathematical modeling of electrical conduction in cardiac tissue composed of myocytes, f...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-009-9667-4
更新日期:2009-05-01 00:00:00
abstract::The concept of body force (force per unit volume) is introduced to account for the effect of the force generated in the radial direction by the active state of the myocardium in an elastic model of the left ventricle represented as a thick-walled cylinder contracting symmetrically. Experimental evidence for the validi...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02368077
更新日期:1991-01-01 00:00:00
abstract::The left-right asymmetry in the potential amplitude on the scalp was studied in poststroke patients by using flash visual evoked potential (VEP) and a numerical two-dimensional model of the head. The left-right asymmetry of the VEP was measured in three patients after thrombosis, in one after hemorrhage, and in one he...
journal_title:Annals of biomedical engineering
pub_type: 临床试验,杂志文章
doi:10.1007/BF02770997
更新日期:1996-01-01 00:00:00
abstract::The pulmonary microvasculature offers a heterogeneous barrier to the motion of large solutes as they pass between blood and lymph. While this barrier has been approximated by a few discrete pathways or by statistical ensembles of many pathways, these descriptions only partly capture the structural and functional prope...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02368425
更新日期:1990-01-01 00:00:00
abstract::A study that customizes the feature generator parameters of an asynchronous Brain Interface (BI) is discussed. The goal is to detect the presence of a certain pattern, in the ongoing EEG, associated with a specific movement and to improve the system's performance. Results of this study show that customization mostly b...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-006-9097-5
更新日期:2006-06-01 00:00:00
abstract::Further understanding of the mechanical deformation and tear behavior of kidney during suturing helps to enhance surgical task execution that requires fine suture manipulation. This paper aims to develop a model to describe the relationship between the tensile force acting on suture line and the resulted kidney deform...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-012-0722-1
更新日期:2013-04-01 00:00:00
abstract::The study was to explore the effects of BMP-2 gene modified canine bone marrow stromal cells (bMSCs) mediated by a nonviral PEI derivative (GenEscort™ II) in promoting bone formation in vitro and in vivo. Canine bMSCs were cultured and transfected with plasmids containing bone morphogenetic protein-2 gene (pBMP-2) or ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-011-0276-7
更新日期:2011-06-01 00:00:00
abstract::A search for robust noninvasive methods permitting to discern the respiration subtle peculiarities in mammals is a topical issue. A novel approach called "sorption-enhanced infrared thermography" (SEIRT), helping to solve this problem, is described. Its benefits spring from the integration of the infrared thermography...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-018-2018-6
更新日期:2018-07-01 00:00:00
abstract::The appropriateness of integrated information systems to the description of integrated biological systems is discussed. An integrated information system in the physiology of the regulation of respiration is argued to be a structural mathematical model of the system and the relational data base, which it can compute. I...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02363292
更新日期:1983-01-01 00:00:00
abstract::Poor vascular homeostasis drives many clinical disorders including diabetes, arthritis, atherosclerosis, and peripheral artery disease. Local tissue ischemia resultant of insufficient blood flow is a potent stimulus for recruitment of endothelial progenitor cells (EPCs). This mobilization and homing is a multi-step pr...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/s10439-015-1400-x
更新日期:2015-10-01 00:00:00
abstract::This paper reviews the applications of accelerometers on the detection of physiological acoustic signals such as heart sounds, respiratory sounds, and gastrointestinal sounds. These acoustic signals contain a rich reservoir of vital physiological and pathological information. Accelerometer-based systems enable continu...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/s10439-014-1111-8
更新日期:2014-11-01 00:00:00
abstract::Classically, the primary tool for quantifying the dynamics of vergence and other eye movements has been the main sequence. The main sequence is a plot of peak velocity versus response amplitude and is particularly useful for comparing the dynamics of a large number of eye movements over a range of response amplitudes....
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.162
更新日期:1999-05-01 00:00:00
abstract::In this study, we introduce the fast wavelet transform as a method for characterizing maturational changes in electrocortical activity, respiratory activity, and blood pressure in fetal lambs in early (110-122 days), mid (123-135 days), and late (136-144 days) third trimester (term 145 days). Each recording was 2 hr i...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02584457
更新日期:1995-09-01 00:00:00
abstract::The effects of facet wiring procedure commonly used for stabilizing cervical spines after laminectomy or bilateral facet dislocation on the motion behavior of whole cervical spines are investigated using a Selspot II system. A fresh human ligamentous intact specimen was potted at T1/T2 vertebra and clinically relevant...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02368022
更新日期:1989-01-01 00:00:00
abstract::We propose a novel method to reconstruct the hypothetical geometry of the healthy vasculature prior to intracranial aneurysm (IA) formation: a Frenet frame is calculated along the skeletonization of the arterial geometry; upstream and downstream boundaries of the aneurysmal segment are expressed in terms of the local ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-013-0794-6
更新日期:2013-07-01 00:00:00
abstract::Numerous head injury models exist that vary in mesh density by orders of magnitude. A careful study of the mesh convergence behavior is necessary, especially in terms of strain most relevant to brain injury. To this end, as well as to investigate the effect of element integration scheme on simulated strains, we re-mes...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-018-02159-z
更新日期:2019-02-01 00:00:00
abstract::A wide range of length and time scales are relevant to pharmacology, especially in drug development, drug design and drug delivery. Therefore, multiscale computational modeling and simulation methods and paradigms that advance the linkage of phenomena occurring at these multiple scales have become increasingly importa...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/s10439-016-1563-0
更新日期:2016-09-01 00:00:00
abstract::We propose a mathematical model for analyses of the elastic properties of the wall of the outer hair cell (OHC) in the inner ear. The model reflects the properties of the major components of the OHC wall: the subsurface cisternae, the cortical lattice, the plasma membrane, and the radial pillars. The wall is treated a...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.87
更新日期:1998-01-01 00:00:00
abstract::A two-dimensional sheet model was used to study the dynamics of reentry around a zone of functional block. The sheet is a set of parallel, continuous, and uniform cables, transversely interconnected by a brick-wall arrangement of fixed resistors. In accord with experimental observations on cardiac tissue, longitudinal...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02368286
更新日期:1994-11-01 00:00:00
abstract::Functional outcomes, such as joint flexion and gait, are important indicators of efficacy in musculoskeletal research. Current technologies that objectively assess these parameters, including visual tracking systems and force plates, are challenging to deploy in long-term translational and clinical studies. To that en...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-018-2105-8
更新日期:2018-12-01 00:00:00
abstract::Gap junctions play a fundamental role in intercellular communication in cardiac tissue. Various types of heart disease including hypertrophy and ischemia are associated with alterations of the spatial arrangement of gap junctions. Previous studies applied two-dimensional optical and electron-microscopy to visualize ga...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-011-0369-3
更新日期:2011-11-01 00:00:00
abstract::In this study we present a novel, robust method to couple finite element (FE) models of cardiac mechanics to systems models of the circulation (CIRC), independent of cardiac phase. For each time step through a cardiac cycle, left and right ventricular pressures were calculated using ventricular compliances from the FE...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-006-9212-7
更新日期:2007-01-01 00:00:00