Stochasticity in membrane-localized "ligand-receptor-G protein" binding: consequences for leukocyte movement behavior.

abstract：:Proteoglycan 4 (PRG4) is a mucin-like glycoprotein present in synovial fluid and at the surface of articular cartilage. The objectives of this study were to (1) assess the articular cartilage surface adsorption and in vitro cartilage boundary lubricating ability of full-length recombinant human PRG4 (rhPRG4), and (2) ...

journal_title：Annals of biomedical engineering

authors： Abubacker S,Dorosz SG,Ponjevic D,Jay GD,Matyas JR,Schmidt TA

更新日期：2016-04-01 00:00:00

abstract：:There are a number of cell therapies that are either in clinical trials or moving toward clinical trials, particularly for diseases of the retina. One of the challenges with cell therapies is tracking the status of cells over time. Genetic manipulation can facilitate this, but it can limit the clinical application of ...

journal_title：Annals of biomedical engineering

authors： Bolger M,Groynom R,Bogie K,Lavik E

更新日期：2020-07-01 00:00:00

abstract：:The traditional auscultatory technique and current methodologies for measuring human blood pressure are limited when used in situations where extreme vibration or acoustic noise is present. In this study, human subjects were used to establish the effectiveness of a novel adaptive blood pressure monitoring (ABPM) syste...

journal_title：Annals of biomedical engineering

authors： Pinto L,Dhanantwari A,Wong W,Stergiopoulos S,Maris M

更新日期：2002-05-01 00:00:00

abstract：:Dendritic cells (DCs) are crucial components of the immune response, strategically positioned as immune sentinels. Complex trafficking and accurate positioning of DCs are indispensable for both immunity and tolerance. This is particularly evident for their therapeutic application where an unmet clinical need exists fo...

journal_title：Annals of biomedical engineering

authors： Silva Z,Konstantopoulos K,Videira PA

更新日期：2012-04-01 00:00:00

abstract：:To meet demands of vascular reconstruction, there is a need for prosthetic alternatives to natural blood vessels. Here we explored a new conduit fabrication approach. Macroporous, gelatin microcarriers laden with human umbilical vein endothelial cells and aortic smooth muscle cells were dispensed into tubular agarose ...

journal_title：Annals of biomedical engineering

authors： Twal WO,Klatt SC,Harikrishnan K,Gerges E,Cooley MA,Trusk TC,Zhou B,Gabr MG,Shazly T,Lessner SM,Markwald RR,Argraves WS

更新日期：2014-07-01 00:00:00

abstract：:A progressive reduction in muscle fiber conduction velocity is typically observed during fatiguing muscle contraction. Although the exact causes of the conduction velocity decrease have not yet been fully established, increasing evidence suggests that changes in extracellular potassium concentration may be largely res...

journal_title：Annals of biomedical engineering

authors： Fortune E,Lowery MM

更新日期：2009-10-01 00:00:00

abstract：:There is a high incidence of low back pain (LBP) associated with occupations requiring sustained and/or repetitive lumbar flexion (SLF and RLF, respectively), which cause creep of the viscoelastic tissues. The purpose of this study was to determine the effect of creep on lumbar biomechanics and facet joint capsule (FJ...

journal_title：Annals of biomedical engineering

authors： Little JS,Khalsa PS

更新日期：2005-03-01 00:00:00

abstract：:One goal of large scale clinical trials is to determine how a drug is processed by, and cleared from, the human body [i.e., its pharmacokinetic (PK) properties] and how these PK properties differ between individuals in a population (i.e., its population PK properties). Due to the high cost of these studies and the lim...

journal_title：Annals of biomedical engineering

authors： Hooker AC,Foracchia M,Dodds MG,Vicini P

更新日期：2003-01-01 00:00:00

abstract：:Crowding can substantially affect the transition of a protein between its native (N) and unfolded (U) states via volume exclusion effects. Also, it influences considerably the aggregation (A) of unfolded proteins. To examine the details, we developed an approach for computing the kinetic rates of the process N <--> U ...

journal_title：Annals of biomedical engineering

authors： Despa F,Orgill DP,Lee RC

更新日期：2005-08-01 00:00:00

abstract：:Gap junctions play a fundamental role in intercellular communication in cardiac tissue. Various types of heart disease including hypertrophy and ischemia are associated with alterations of the spatial arrangement of gap junctions. Previous studies applied two-dimensional optical and electron-microscopy to visualize ga...

journal_title：Annals of biomedical engineering

authors： Lackey DP,Carruth ED,Lasher RA,Boenisch J,Sachse FB,Hitchcock RW

更新日期：2011-11-01 00:00:00

abstract：:Collagen, the most commonly used extra-cellular matrix protein for tissue engineering applications, displays poor mechanical properties. Here, we report on the preparation and characterization of novel multi-component composite systems that incorporate a genetically engineered, biocompatible polymer (elastin-like poly...

journal_title：Annals of biomedical engineering

authors： Wheeler TS,Sbravati ND,Janorkar AV

更新日期：2013-10-01 00:00:00

abstract：:Polycrystalline silicon (poly-Si) micromechanical structures can be made by selectively etching an underlying sacrificial oxide layer. Advantages of this micromachining technique are its simplicity and compatibility with conventional integrated-circuit processing. Compressive internal stress in poly-Si films constrain...

journal_title：Annals of biomedical engineering

authors： Howe RT

更新日期：1986-01-01 00:00:00

abstract：:The effects of training on a person's ability to perceive, interpret and utilize information presented via the tactile sense were examined by using a dual-channel electrocutaneous tracking approach. The electrocutaneous code studied was linear pulse rate encoding of information. The stimulus had a pulse width of 200 m...

journal_title：Annals of biomedical engineering

authors： Szeto AY,Chung YM

更新日期：1986-01-01 00:00:00

abstract：:Early stage changes in hypertensive arteries have a significant effect on the long-term adaptation of the arteries. Compared to the long-term adaptation, little is known about the early dimensional and functional changes in hypertensive arteries in the first few days of hypertension. To study the early stage changes i...

journal_title：Annals of biomedical engineering

authors： Han HC,Ku DN

更新日期：2001-06-01 00:00:00

abstract：:We present a method for the localized statistical discrimination of class populations based on the Karhunen-Loève and Fukunaga-Koontz transforms. These transforms provide features that model the variance of a sample distribution. The spatial series of a 196 channel epicardial electrogram recording from an arrythmogeni...

journal_title：Annals of biomedical engineering

authors： Ciaccio EJ,Dunn SM,Akay M,Wit AL,Coromilas J,Costeas CA

更新日期：1994-09-01 00:00:00

abstract：:The bioinspired, microscale tissue engineering approach has emerged in recent years as a promising alternative to preformed scaffolds. Using this approach, complex tissues and organs can be efficiently engineered from microscale modules to replicate the intricate architecture and physiology of vascularized organs and ...

journal_title：Annals of biomedical engineering

authors： Annamalai RT,Matthew HWT

更新日期：2019-05-01 00:00:00

abstract：:The objective of this study was to develop a ferrocene mediated glucose biosensor for reverse iontophoresis. An amperometric ferrocene mediated glucose biosensor based on a three electrodes planar configuration was constructed using screen printing technique. Different combinations of glucose oxidase and ferrocene loa...

journal_title：Annals of biomedical engineering

authors： Ching CT,Sun TP,Huang SH,Shieh HL,Chen CY

更新日期：2010-04-01 00:00:00

abstract：:Rapid screening of biomarkers, with high specificity and accuracy, is critical for many point-of-care diagnostics. Microfluidics, the use of microscale channels to manipulate small liquid samples and carry reactions in parallel, offers tremendous opportunities to address fundamental questions in biology and provide a ...

journal_title：Annals of biomedical engineering

authors： Ng E,Chen K,Hang A,Syed A,Zhang JX

更新日期：2016-04-01 00:00:00

abstract：:3D bioprinting technology is a promising approach for corneal stromal tissue regeneration. In this study, gelatin methacrylate (GelMA) mixed with corneal stromal cells was used as a bioink. The visible light-based stereolithography (SLA) 3D bioprinting method was utilized to print the anatomically similar dome-shaped ...

journal_title：Annals of biomedical engineering

authors： Mahdavi SS,Abdekhodaie MJ,Kumar H,Mashayekhan S,Baradaran-Rafii A,Kim K

更新日期：2020-07-01 00:00:00

abstract：:Identifying the associations between head impact biomechanics and clinical recovery may inform better head impact monitoring procedures and identify athletes who may benefit from early treatments aimed to enhance recovery. The purpose of this study was to test whether head injury biomechanics are associated with clini...

journal_title：Annals of biomedical engineering

authors： Mihalik JP,Chandran A,Powell JR,Roby PR,Guskiewicz KM,Stemper BD,Shah AS,Rowson S,Duma S,Harezlak J,Riggen L,Broglio SP,McAllister TW,McCrea M,CARE Consortium Investigators.

更新日期：2020-11-01 00:00:00

abstract：:This project was undertaken to establish if the integral circulation had any effects upon the mechanical behavior of bone. The influence of blood flow in the rabbit tibia on the strain induced at the bone surface when under load was assessed. Recordings were taken from three adult and three immature New Zealand White ...

journal_title：Annals of biomedical engineering

authors： McDonald F,Pitt Ford TR

更新日期：1994-03-01 00:00:00

abstract：:High density particle image velocimetry, with spatial resolution of O(1 mm), was used to measure the effect of occluder rebound on the flow field near a Bjork-Shiley Monostrut tilting-disk mitral valve. The ability to measure two velocity components over an entire plane simultaneously provides a very different insight...

journal_title：Annals of biomedical engineering

authors： Kini V,Bachmann C,Fontaine A,Deutsch S,Tarbell JM

更新日期：2000-04-01 00:00:00

abstract：:High energy laser has emerged to be an important surgical tool in medical technology. However, the application of laser energy to drill or cut a bone is still in an experimental state. In order to estimate the adequacy of laser heating of bone surface and at the same time minimize the damage to the bone tissue, we dev...

journal_title：Annals of biomedical engineering

authors： Chen II,Saha S

更新日期：1987-01-01 00:00:00

abstract：:Microfluidic devices aim at miniaturizing, automating, and lowering the cost of chemical and biological sample manipulation and detection, hence creating new opportunities for lab-on-a-chip platforms. Recently, optofluidic devices have also emerged where optics is used to enhance the functionality and the performance ...

journal_title：Annals of biomedical engineering

authors： Bishara W,Isikman SO,Ozcan A

更新日期：2012-02-01 00:00:00

abstract：:Continued progress in the field of Brain Interface (BI) research has encouraged the rapid expansion of the BI community over the last two decades. As the number of BI researchers and organizations steadily increases, newer and more advanced technologies are constantly produced, evaluated, and reported. Though the BI c...

journal_title：Annals of biomedical engineering

authors： Jackson MM,Mason SG,Birch GE

更新日期：2006-05-01 00:00:00

abstract：:Understanding the characteristic morphology of our brain remains a challenging, yet important task in human evolution, developmental biology, and neurosciences. Mathematical modeling shapes our understanding of cortical folding and provides functional relations between cortical wavelength, thickness, and stiffness. Ye...

journal_title：Annals of biomedical engineering

authors： Holland MA,Miller KE,Kuhl E

更新日期：2015-07-01 00:00:00

abstract：:The identification of the input to, or kernels of, a system using nonparametric representations and least-squares estimation is becoming increasingly popular. Nonparametric representations avoid making a priori assumptions about the input or having detailed knowledge about the system, and only need to guarantee known ...

journal_title：Annals of biomedical engineering

authors： Verotta D

更新日期：1998-09-01 00:00:00

abstract：:In this paper, an intelligent proportional-integral-derivative (PID) control method is introduced to the robotic testing system for the biomechanical study of human musculoskeletal joints. For the testing system, the robot is a highly nonlinear and heavily coupled complicated system, and the human spinal specimen also...

journal_title：Annals of biomedical engineering

authors： Tian L

更新日期：2004-06-01 00:00:00

abstract：:Fingertips wrinkle due to long exposure to water. The biological reason for this morphological change is unclear and still not fully understood. There are two main hypotheses for the underlying mechanism of fingertip wrinkling: the 'shrink' model (in which the wrinkling is driven by the contraction of the lower layers...

journal_title：Annals of biomedical engineering

authors： Sáez P,Zöllner AM

更新日期：2017-04-01 00:00:00

abstract：:Left ventricular (LV) diastolic filling is limited by the constraining effects exerted by the pericardium (PE) and the lung/chest wall. The aim of the present study was to assess the validity of various estimates of external cardiac constraint, compared to pericardial surface pressure (Ppe) measured lateral to the LV ...

journal_title：Annals of biomedical engineering

authors： Kingma I,Smiseth OA,Frais MA,Smith ER,Tyberg JV

更新日期：1987-01-01 00:00:00