Stochasticity in membrane-localized "ligand-receptor-G protein" binding: consequences for leukocyte movement behavior.


:The signal that governs the chemotactic response of mammalian white blood cells and tissue cells arises from membrane-localized binding events involving chemotactic factor ligands and receptors and G proteins. Fluctuations in this signal have been traditionally attributed to significant "noise" in receptor-ligand binding owing to a limited number of receptors. This paper examines the validity and consequences of a new hypothesis which states that the noise could be associated with a limited number of G proteins as well as receptors. This work characterizes via stochastic analysis and simulation the effects of the relative sizes of G protein and receptor populations on the variance of fluctuations of receptor states and consequently on the directional persistence behavior of cells in uniform chemotactic factor concentrations under the assumptions of the model used to link a G protein-mediated receptor signal to cell turning. Our results suggest that there may exist an optimal number of G proteins through which chemotactic receptors can signal that maximizes cell orientation accuracy in a chemotactic factor gradient.


Ann Biomed Eng


Moghe PV,Tranquillo RT




Has Abstract


1995-05-01 00:00:00












  • A computerized mass spectrometer and flowmeter system for respiratory gas measurements.

    abstract::Instrumentation systems for breath-to-breath analysis of respiratory gas exchange have been faulted by phase lags between various flow and composition signals and by difficulties in gathering and processing large amounts of data. The system described here represents an attempt to overcome these problems. Phase delays ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Sodal IE,Swanson GD,Micco AJ,Sprague F,Ellis DG

    更新日期:1983-01-01 00:00:00

  • The effect of head rotation on the geometry and hemodynamics of healthy vertebral arteries.

    abstract::The geometric and hemodynamic characteristics of the left and right vertebral arteries (LVA, RVA) of six healthy volunteers were investigated for the supine (S) and the prone position (P) a common sleeping posture with head rotation. MRI images were used to reconstruct the subject specific three-dimensional solid mode...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Aristokleous N,Seimenis I,Georgiou GC,Nicolaides A,Anayiotos AS

    更新日期:2015-06-01 00:00:00

  • Conductance method for the measurement of cross-sectional areas of the aorta.

    abstract::A modified conductance method to determine the cross-sectional areas (CSAs) of arteries in piglets was evaluated in vivo. The method utilized a conductance catheter having four electrodes. Between the outer electrodes an alternating current was applied and between the inner electrodes the induced voltage difference wa...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Kornet L,Jansen JR,Gussenhoven EJ,Hardeman MR,Hoeks AP,Versprille A

    更新日期:1999-03-01 00:00:00

  • Investigating tendon fascicle structure-function relationships in a transgenic-age mouse model using multiple regression models.

    abstract::Proper replacement or repair of damaged tendons or ligaments requires functionally engineered tissue that mimics their native mechanical properties. While tendon structure-function relationships are generally assumed, there exists little quantitative evidence of the roles of distinct tendon components in tendon functi...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Robinson PS,Lin TW,Jawad AF,Iozzo RV,Soslowsky LJ

    更新日期:2004-07-01 00:00:00

  • Prediction of Post-Concussive Behavioral Changes in a Rodent Model Based on Head Rotational Acceleration Characteristics.

    abstract::Quantifying injury tolerance for concussion is complicated by variability in the type, severity, and time course of post-injury physiological and behavioral changes. The current study outlined acute and chronic changes in behavioral metrics following rotational acceleration-induced concussion in rats. The Medical Coll...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Stemper BD,Shah AS,Chiariello R,Olsen CM,Budde MD,Glavaski-Joksimovic A,McCrea M,Kurpad SN,Pintar FA

    更新日期:2016-11-01 00:00:00

  • Segmentation and Pore Structure Estimation in SEM Images of Tissue Engineering Scaffolds Using Genetic Algorithm.

    abstract::A python computer package is developed to segment and analyze scanning electron microscope (SEM) images of scaffolds for bone tissue engineering. The method requires only a portion of an SEM image to be labeled and used for training. The algorithm is then able to detect the pore characteristics for other SEM images ac...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Rouhollahi A,Ilegbusi O,Foroosh H

    更新日期:2020-10-15 00:00:00

  • Creating living cellular machines.

    abstract::Development of increasingly complex integrated cellular systems will be a major challenge for the next decade and beyond, as we apply the knowledge gained from the sub-disciplines of regenerative medicine, synthetic biology, micro-fabrication and nanotechnology, systems biology, and developmental biology. In this pros...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审


    authors: Kamm RD,Bashir R

    更新日期:2014-02-01 00:00:00

  • Changes of flow characteristics by stenting in aneurysm models: influence of aneurysm geometry and stent porosity.

    abstract::An endovascular technique using a stent has been developed and successfully applied in the treatment of wide neck aneurysms. A stent can facilitate thrombosis in the aneurysm pouch while maintaining biocompatible passage of the parent artery. Insertion of the stent changes the flow characteristics inside the aneurysm ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Rhee K,Han MH,Cha SH

    更新日期:2002-07-01 00:00:00

  • Novel organotypic cultures of human skin explants with an implant-tissue biomaterial interface.

    abstract::A novel in vitro culture system of organotypic human skin explants interfacing with external fixator pins is presented. The system was used to observe changes in skin morphology on the skin at the pin interface. To evaluate the performance of this novel system, histological analysis of human skin explants cultured for...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Peramo A,Marcelo CL,Goldstein SA,Martin DC

    更新日期:2009-02-01 00:00:00

  • In-Vitro Detection of Small Isolated Cartilage Defects: Intravascular Ultrasound Vs. Optical Coherence Tomography.

    abstract::This experimental work focused on the sensor selection for the development of a needle-like instrument to treat small isolated cartilage defects with hydrogels. The aim was to identify the most accurate and sensitive imaging method to determine the location and size of defects compared to a gold standard (µCT). Only i...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Horeman T,Buiter EC,Pouran B,Stijntjes M,Dankelman J,Tuijthof GJM

    更新日期:2018-11-01 00:00:00

  • A single equivalent moving dipole model: an efficient approach for localizing sites of origin of ventricular electrical activation.

    abstract::We propose a new method for guiding catheter ablation procedures to abolish sites of origin of arrhythmias. This method models both cardiac electrical activity and current pulses delivered from the tip of the ablation catheter with a single equivalent moving dipole (SEMD). The SEMD parameters are obtained from analysi...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Armoundas AA,Feldman AB,Mukkamala R,Cohen RJ

    更新日期:2003-05-01 00:00:00

  • Computational study of proteolysis-driven single cell migration in a three-dimensional matrix.

    abstract::Cell migration is a fundamental process that is crucial to a variety of physiological events. While traditional approaches have focused on two-dimensional (2D) systems, recent efforts have shifted to studying migration in three-dimensional (3D) matrices. A major distinction that has emerged is the increased importance...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Harjanto D,Zaman MH

    更新日期:2010-05-01 00:00:00

  • Intrinsic oscillations and discharge regularity of units in the dorsal cochlear nucleus (DCN) of the barbiturate anesthetized gerbil.

    abstract::Spike discharge patterns showing intrinsic oscillations (IOs) have been reported in units in the dorsal cochlear nucleus (DCN) of the decerebrate cat. These oscillations are related to the regularity of a unit's discharge rate and may be important for pitch perception. A DCN unit's regularity can be affected by severa...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Gdowski GT,Voigt HF

    更新日期:1998-05-01 00:00:00

  • Accuracy of Functional and Predictive Methods to Calculate the Hip Joint Center in Young Non-pathologic Asymptomatic Adults with Dual Fluoroscopy as a Reference Standard.

    abstract::Predictions from biomechanical models of gait may be sensitive to joint center locations. Most often, the hip joint center (HJC) is derived from locations of reflective markers adhered to the skin. Here, predictive techniques use regression equations of pelvic anatomy to estimate the HJC, whereas functional methods tr...

    journal_title:Annals of biomedical engineering

    pub_type: 临床试验,杂志文章


    authors: Fiorentino NM,Kutschke MJ,Atkins PR,Foreman KB,Kapron AL,Anderson AE

    更新日期:2016-07-01 00:00:00

  • Vascular remodeling in autogenous arterio-venous fistulas by MRI and CFD.

    abstract::Hemodynamic parameters play an important role in regulating vascular remodeling in arterio-venous fistula (AVF) maturation. Investigating the changes in hemodynamic parameters during AVF maturation is expected to improve our understanding of fistula failure, but very little data on actual temporal changes in human AVF...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Sigovan M,Rayz V,Gasper W,Alley HF,Owens CD,Saloner D

    更新日期:2013-04-01 00:00:00

  • User customization of the feature generator of an asynchronous brain interface.

    abstract::A study that customizes the feature generator parameters of an asynchronous Brain Interface (BI) is discussed. The goal is to detect the presence of a certain pattern, in the ongoing EEG, associated with a specific movement and to improve the system's performance. Results of this study show that customization mostly b...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Bashashati A,Fatourechi M,Ward RK,Birch GE

    更新日期:2006-06-01 00:00:00

  • Interstitial stress and fluid pressure within a growing tumor.

    abstract::A solid tumor is composed of a population of cells that is expanding as a result of cell division. With dense cell packing, the solid matrix of the interstitial tissue is subject to residual stress. In addition, elevated interstitial fluid pressure (IFP) has been reported by researchers for a number of solid tumors. T...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Sarntinoranont M,Rooney F,Ferrari M

    更新日期:2003-03-01 00:00:00

  • CareToy: Stimulation and Assessment of Preterm Infant's Activity Using a Novel Sensorized System.

    abstract::Early intervention programs aim at improving cognitive and motor outcomes of preterm infants. Intensive custom-tailored training activities are usually accompanied by assessment procedures, which have shortcomings, such as subjectivity, complex setups, and need for structured environments. A novel sensorized system, c...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Rihar A,Sgandurra G,Beani E,Cecchi F,Pašič J,Cioni G,Dario P,Mihelj M,Munih M

    更新日期:2016-12-01 00:00:00

  • Prediction of the biomechanical effects of compression therapy on deep veins using finite element modelling.

    abstract::Clinicians generally assume that Medical Compression Stockings (MCS) work by reducing vein luminal diameter and, in this way, help to prevent blood pooling. Conflicting results have been reported however in the case of lower leg deep veins which call into question this hypothesis. The purpose of this contribution is t...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Rohan PY,Badel P,Lun B,Rastel D,Avril S

    更新日期:2015-02-01 00:00:00

  • Three-dimensional modeling and quantitative analysis of gap junction distributions in cardiac tissue.

    abstract::Gap junctions play a fundamental role in intercellular communication in cardiac tissue. Various types of heart disease including hypertrophy and ischemia are associated with alterations of the spatial arrangement of gap junctions. Previous studies applied two-dimensional optical and electron-microscopy to visualize ga...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Lackey DP,Carruth ED,Lasher RA,Boenisch J,Sachse FB,Hitchcock RW

    更新日期:2011-11-01 00:00:00

  • Magnetic (eddy-current) electroventilation in the dog.

    abstract::Magnetic (eddy-current) stimulation of the inspiratory motor nerves in the neck of the anesthetized dog was achieved. Using a 10-turn coil wound around the base of the neck and a train of pulses (25/s), inspiration was produced by tetanic contraction of the inspiratory muscles. The volume of air inspired increased wit...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Geddes LA,Mouchawar G,Bourland JD,ElAbbady T,Nyenhuis J

    更新日期:1993-05-01 00:00:00

  • Human saphenous vein coronary artery bypass graft morphology, geometry and hemodynamics.

    abstract::Coronary artery bypass graft (CABG) failure has been linked to graft hemodynamics, in particular wall shear stress. This study characterizes the morphology, geometry and wall shear stress patterns in human CABGs. The intimal thickness (IT) in 49 human saphenous vein CABGs was measured by digital light microscopy. The ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Leask RL,Butany J,Johnston KW,Ethier CR,Ojha M

    更新日期:2005-03-01 00:00:00

  • Utilizing Atlas-Based Modeling to Predict Knee Joint Cartilage Degeneration: Data from the Osteoarthritis Initiative.

    abstract::Currently, there are no clinically available tools or applications which could predict osteoarthritis development. Some computational models have been presented to simulate cartilage degeneration, but they are not clinically feasible due to time required to build subject-specific knee models. Therefore, the objective ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Mononen ME,Liukkonen MK,Korhonen RK

    更新日期:2019-03-01 00:00:00

  • Development of gradient descent adaptive algorithms to remove common mode artifact for improvement of cardiovascular signal quality.

    abstract:BACKGROUND:Common-mode noise degrades cardiovascular signal quality and diminishes measurement accuracy. Filtering to remove noise components in the frequency domain often distorts the signal. METHOD:Two adaptive noise canceling (ANC) algorithms were tested to adjust weighted reference signals for optimal subtraction ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Ciaccio EJ,Micheli-Tzanakou E

    更新日期:2007-07-01 00:00:00

  • A novel left heart simulator for the multi-modality characterization of native mitral valve geometry and fluid mechanics.

    abstract::Numerical models of the mitral valve have been used to elucidate mitral valve function and mechanics. These models have evolved from simple two-dimensional approximations to complex three-dimensional fully coupled fluid structure interaction models. However, to date these models lack direct one-to-one experimental val...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Rabbah JP,Saikrishnan N,Yoganathan AP

    更新日期:2013-02-01 00:00:00

  • Functionalized biomicroelectromechanical systems sensors for force response study at local adhesion sites of single living cells on substrates.

    abstract::We present a method of measuring force response of a single living cell, attached to a substrate, in situ, by a functionalized microelectromechanical systems sensor that applies local deformation on the cell. The sensor is a single crystal silicon microcantilever beam with prescribed shape and geometry, and is coated ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Saif MT,Sager CR,Coyer S

    更新日期:2003-09-01 00:00:00

  • Human lumbar spine creep during cyclic and static flexion: creep rate, biomechanics, and facet joint capsule strain.

    abstract::There is a high incidence of low back pain (LBP) associated with occupations requiring sustained and/or repetitive lumbar flexion (SLF and RLF, respectively), which cause creep of the viscoelastic tissues. The purpose of this study was to determine the effect of creep on lumbar biomechanics and facet joint capsule (FJ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Little JS,Khalsa PS

    更新日期:2005-03-01 00:00:00

  • Numerical simulation of cell motion in tube flow.

    abstract::A theoretical model is presented for describing the motion of a deformable cell encapsulating a Newtonian fluid and enclosed by an elastic membrane in tube flow. In the mathematical formulation, the interior and exterior hydrodynamics are coupled with the membrane mechanics by means of surface equilibrium equations, a...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Pozrikidis C

    更新日期:2005-02-01 00:00:00

  • Biomechanical Characterisation of the Human Auricular Cartilages; Implications for Tissue Engineering.

    abstract::Currently, autologous cartilage provides the gold standard for auricular reconstruction. However, synthetic biomaterials offer a number of advantages for ear reconstruction including decreased donor site morbidity and earlier surgery. Critical to implant success is the material's mechanical properties as this affects ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Griffin MF,Premakumar Y,Seifalian AM,Szarko M,Butler PE

    更新日期:2016-12-01 00:00:00

  • Arterial wave propagation phenomena, ventricular work, and power dissipation.

    abstract::The effects of wave propagation phenomena, namely global reflection coefficient (gamma G[omega]) and pulse wave velocity (Cph), are studied in a model of the coupled left ventricle/arterial system. The left ventricle consists of a time-varying elastance, while the arterial system is modeled as a single, uniform, elast...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Berger DS,Li JK,Noordergraaf A

    更新日期:1995-11-01 00:00:00