Stochasticity in membrane-localized "ligand-receptor-G protein" binding: consequences for leukocyte movement behavior.


:The signal that governs the chemotactic response of mammalian white blood cells and tissue cells arises from membrane-localized binding events involving chemotactic factor ligands and receptors and G proteins. Fluctuations in this signal have been traditionally attributed to significant "noise" in receptor-ligand binding owing to a limited number of receptors. This paper examines the validity and consequences of a new hypothesis which states that the noise could be associated with a limited number of G proteins as well as receptors. This work characterizes via stochastic analysis and simulation the effects of the relative sizes of G protein and receptor populations on the variance of fluctuations of receptor states and consequently on the directional persistence behavior of cells in uniform chemotactic factor concentrations under the assumptions of the model used to link a G protein-mediated receptor signal to cell turning. Our results suggest that there may exist an optimal number of G proteins through which chemotactic receptors can signal that maximizes cell orientation accuracy in a chemotactic factor gradient.


Ann Biomed Eng


Moghe PV,Tranquillo RT




Has Abstract


1995-05-01 00:00:00












  • Blood pressure measurement in noise intensive environments using adaptive interference cancellation.

    abstract::The traditional auscultatory technique and current methodologies for measuring human blood pressure are limited when used in situations where extreme vibration or acoustic noise is present. In this study, human subjects were used to establish the effectiveness of a novel adaptive blood pressure monitoring (ABPM) syste...

    journal_title:Annals of biomedical engineering

    pub_type: 临床试验,杂志文章


    authors: Pinto L,Dhanantwari A,Wong W,Stergiopoulos S,Maris M

    更新日期:2002-05-01 00:00:00

  • An optimization-based simultaneous approach to the determination of muscular, ligamentous, and joint contact forces provides insight into musculoligamentous interaction.

    abstract::Typical inverse dynamics approaches to the calculation of muscle, ligament, and joint contact forces are based on a step-wise solution of the equations of motion. This approach is therefore limited in its ability to provide insight as to the muscular, ligamentous, and articular interactions that create joint stability...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Cleather DJ,Bull AM

    更新日期:2011-07-01 00:00:00

  • Aortic Valve Function Under Support of a Left Ventricular Assist Device: Continuous vs. Dynamic Speed Support.

    abstract::Continuous flow left ventricular devices (CF-LVADs) support the failing heart at a constant speed and alters the loads on the aortic valve. This may cause insufficiency in the aortic valve under long-term CF-LVAD support. The aim of this study is to assess the aortic valve function under varying speed CF-LVAD support....

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Bozkurt S,van de Vosse FN,Rutten MC

    更新日期:2015-08-01 00:00:00

  • Continuous and noninvasive blood pressure measurement: a novel modeling methodology of the relationship between blood pressure and pulse wave velocity.

    abstract::In this paper, we aim to establish a new mathematical model that relates pulse wave velocity (PWV) to blood pressure (BP) for continuous and noninvasive BP measurement. For the first time, we derive an ordinary differential equation (ODE) expressing the fundamental relation between BP, elastic modulus G and PWV. The g...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Chen Y,Wen C,Tao G,Bi M,Li G

    更新日期:2009-11-01 00:00:00

  • MUlti-Dimensional Spline-Based Estimator (MUSE) for motion estimation: algorithm development and initial results.

    abstract::Image registration and motion estimation play central roles in many fields, including RADAR, SONAR, light microscopy, and medical imaging. Because of its central significance, estimator accuracy, precision, and computational cost are of critical importance. We have previously presented a highly accurate, spline-based ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Viola F,Coe RL,Owen K,Guenther DA,Walker WF

    更新日期:2008-12-01 00:00:00

  • Simulating Developmental Cardiac Morphology in Virtual Reality Using a Deformable Image Registration Approach.

    abstract::While virtual reality (VR) has potential in enhancing cardiovascular diagnosis and treatment, prerequisite labor-intensive image segmentation remains an obstacle for seamlessly simulating 4-dimensional (4-D, 3-D + time) imaging data in an immersive, physiological VR environment. We applied deformable image registratio...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Abiri A,Ding Y,Abiri P,Packard RRS,Vedula V,Marsden A,Kuo CJ,Hsiai TK

    更新日期:2018-12-01 00:00:00

  • Redirection of neurite outgrowth by coupling chondroitin sulfate proteoglycans to polymer membranes.

    abstract::Upon nerve injury, the body creates an environment consisting of permissive and non-permissive cues that instruct the function of cells involved in nerve repair. Among other roles, the developing extracellular matrix (ECM) acts as an underlying substrate to guide the union of neurites extending from the proximal stump...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Man AJ,Leach JK,Bannerman P

    更新日期:2014-06-01 00:00:00

  • Fibroblast morphology on dynamic softening of hydrogels.

    abstract::Despite cellular environments having dynamic characteristics, many laboratories utilized static polyacrylamide hydrogels to study the ECM-cell relationship. To attain a more in vivo like environment, we have developed a dynamic, DNA-crosslinked hydrogel (DNA gel). Through the controlled delivery of DNA, we can tempora...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Previtera ML,Trout KL,Verma D,Chippada U,Schloss RS,Langrana NA

    更新日期:2012-05-01 00:00:00

  • Magnetic (eddy-current) electroventilation in the dog.

    abstract::Magnetic (eddy-current) stimulation of the inspiratory motor nerves in the neck of the anesthetized dog was achieved. Using a 10-turn coil wound around the base of the neck and a train of pulses (25/s), inspiration was produced by tetanic contraction of the inspiratory muscles. The volume of air inspired increased wit...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Geddes LA,Mouchawar G,Bourland JD,ElAbbady T,Nyenhuis J

    更新日期:1993-05-01 00:00:00

  • Binary segmentation masks can improve intrasubject registration accuracy of bone structures in CT images.

    abstract::Registration of bone structures is a common problem in medical research as well as in clinical applications. Intrasubject rigid 3D monomodality registration of segmented bone structures of CT images and multimodality registration of muMR and segmented muCT bone images were performed with the multiresolution intensity-...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Museyko O,Eisa F,Hess A,Schett G,Kalender WA,Engelke K

    更新日期:2010-07-01 00:00:00

  • Functionalized biomicroelectromechanical systems sensors for force response study at local adhesion sites of single living cells on substrates.

    abstract::We present a method of measuring force response of a single living cell, attached to a substrate, in situ, by a functionalized microelectromechanical systems sensor that applies local deformation on the cell. The sensor is a single crystal silicon microcantilever beam with prescribed shape and geometry, and is coated ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Saif MT,Sager CR,Coyer S

    更新日期:2003-09-01 00:00:00

  • A computerized mass spectrometer and flowmeter system for respiratory gas measurements.

    abstract::Instrumentation systems for breath-to-breath analysis of respiratory gas exchange have been faulted by phase lags between various flow and composition signals and by difficulties in gathering and processing large amounts of data. The system described here represents an attempt to overcome these problems. Phase delays ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Sodal IE,Swanson GD,Micco AJ,Sprague F,Ellis DG

    更新日期:1983-01-01 00:00:00

  • Elastic properties of the composite outer hair cell wall.

    abstract::We propose a mathematical model for analyses of the elastic properties of the wall of the outer hair cell (OHC) in the inner ear. The model reflects the properties of the major components of the OHC wall: the subsurface cisternae, the cortical lattice, the plasma membrane, and the radial pillars. The wall is treated a...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Spector AA,Brownell WE,Popel AS

    更新日期:1998-01-01 00:00:00

  • Partitioning of cortical and deep cytoskeleton responses from transient magnetic bead twisting.

    abstract::We attempted to estimate in living adherent epithelial alveolar cells, the degree of structural and mechanical heterogeneity by considering two individualized cytoskeleton components, i.e., a submembranous "cortical" cytoskeleton and a "deep" cytoskeleton (CSK). F-actin structure characterizing each CSK component was ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Laurent VM,Fodil R,Cañadas P,Féréol S,Louis B,Planus E,Isabey D

    更新日期:2003-11-01 00:00:00

  • Rat aortic smooth muscle cells contract in response to serum and its components in a calcium independent manner.

    abstract::Diluted serum provides a model of interstitial fluid that can be used to study the response of smooth muscle cells (SMCs) to interstitial flow. The effect of serum and some of its components on SMC contraction (area reduction) and intracellular calcium ([Ca2+]i) response were characterized in rat aortic SMC in vitro. ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Ainslie K,Shi ZD,Garanich JS,Tarbell JM

    更新日期:2004-12-01 00:00:00

  • In Silico Investigation of Angiogenesis with Growth and Stress Generation Coupled to Local Extracellular Matrix Density.

    abstract::Mechanical interactions during angiogenesis, i.e., traction applied by neovessels to the extracellular matrix and the corresponding deformation, are important regulators of growth and neovascularization. We have previously designed, implemented, and validated a coupled model of angiogenesis in which a discrete microve...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Edgar LT,Hoying JB,Weiss JA

    更新日期:2015-07-01 00:00:00

  • An experimental evaluation of the use of an ensemble average for the calculation of turbulence in pulsatile flow.

    abstract::A comparison was made between turbulence calculated by subtracting an ensemble average from the instantaneous velocity and calculations made with a high pass digital filter. Velocity was measured with a laser Doppler anemometer in vitro in the region of a normal porcine aortic valve and in patients with a hot film ane...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Walburn FJ,Sabbah HN,Stein PD

    更新日期:1983-01-01 00:00:00

  • HFUS Imaging of the Cochlea: A Feasibility Study for Anatomical Identification by Registration with MicroCT.

    abstract::Cochlear implantation consists in electrically stimulating the auditory nerve by inserting an electrode array inside the cochlea, a bony structure of the inner ear. In the absence of any visual feedback, the insertion results in many cases of damages of the internal structures. This paper presents a feasibility study ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Lavenir L,Zemiti N,Akkari M,Subsol G,Venail F,Poignet P

    更新日期:2020-10-30 00:00:00

  • The Effects of 4%Fe on the Performance of Pure Zinc as Biodegradable Implant Material.

    abstract::The efforts to develop structural materials for biodegradable metal implants have lately shifted their focus from Magnesium and Iron base alloys towards Zinc. This was mainly due to the accelerated corrosion rate of Mg that is accompanied by hydrogen gas evolution, formation of voluminous iron oxide products with redu...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Kafri A,Ovadia S,Yosafovich-Doitch G,Aghion E

    更新日期:2019-06-01 00:00:00

  • Electrically active bioceramics: a review of interfacial responses.

    abstract::Electrical potentials in mechanically loaded bone have been implicated as signals in the bone remodeling cycle. Recently, interest has grown in exploiting this phenomenon to develop electrically active ceramics for implantation in hard tissue which may induce improved biological responses. Both polarized hydroxyapatit...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审


    authors: Baxter FR,Bowen CR,Turner IG,Dent AC

    更新日期:2010-06-01 00:00:00

  • Lensfree optofluidic microscopy and tomography.

    abstract::Microfluidic devices aim at miniaturizing, automating, and lowering the cost of chemical and biological sample manipulation and detection, hence creating new opportunities for lab-on-a-chip platforms. Recently, optofluidic devices have also emerged where optics is used to enhance the functionality and the performance ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审


    authors: Bishara W,Isikman SO,Ozcan A

    更新日期:2012-02-01 00:00:00

  • Characteristics of blood flow resistance under transverse vibration: red blood cell suspension in Dextran-40.

    abstract::Vibration under shear flow causes the reduction of flow resistance for shear-thinning fluids. The present study investigates the effect of vibration on the flow resistance of a nonaggregating red blood cell (RBC) suspension with a newly designed pressure-scanning capillary viscometer (PSCV). The PSCV was originally de...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Shin S,Ku Y,Suh JS,Moon SY,Jang JY

    更新日期:2003-10-01 00:00:00

  • Vortex ring formation in the left ventricle of the heart: analysis by 4D flow MRI and Lagrangian coherent structures.

    abstract::Recent studies suggest that vortex ring formation during left ventricular (LV) rapid filling is an optimized mechanism for blood transport, and that the volume of the vortex ring is an important measure. However, due to lack of quantitative methods, the volume of the vortex ring has not previously been studied. Lagran...

    journal_title:Annals of biomedical engineering

    pub_type: 临床试验,杂志文章


    authors: Töger J,Kanski M,Carlsson M,Kovács SJ,Söderlind G,Arheden H,Heiberg E

    更新日期:2012-12-01 00:00:00

  • The concept of using multifrequency energy transmission to reduce hot spots during deep-body hyperthermia.

    abstract::We propose a multifrequency energy transmission scheme for annular phased arrays in deep-body hyperthermia. The problem of frequency dependent resonance effects reported in hyperthermia phantom calibration studies, leading to skewed energy deposition patterns and unwanted energy maxima (hot spots), is addressed by com...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Jacobsen S,Melandsø F

    更新日期:2002-01-01 00:00:00

  • Reproducibility of image-based computational fluid dynamics models of the human carotid bifurcation.

    abstract::Recent studies have demonstrated the ability of magnetic resonance imaging (MRI) to provide anatomically realistic boundary conditions for computational fluid dynamics (CFD) simulations of arterial hemodynamics. To date, however, little is known about the overall reproducibility of such image-based CFD techniques. Tow...

    journal_title:Annals of biomedical engineering

    pub_type: 临床试验,杂志文章


    authors: Thomas JB,Milner JS,Rutt BK,Steinman DA

    更新日期:2003-02-01 00:00:00

  • Biomechanical Response Targets of Adult Human Ribs in Frontal Impacts.

    abstract::Thorax injuries mainly due to rib fractures have been associated with high rates of morbidity and mortality in motor vehicle crashes. Thoracic biomechanics has been studied extensively, but there are no robust biomechanical response targets for ribs that consider age, sex, body size, and vulnerability factors. The obj...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Kang YS,Kwon HJ,Stammen J,Moorhouse K,Agnew AM

    更新日期:2021-02-01 00:00:00

  • A Novel Apparatus for the Multifaceted Evaluation of Arterial Function Through Transmural Pressure Manipulation.

    abstract::A novel apparatus for the multifaceted evaluation of artery function was developed. It measures endothelial and smooth muscle functions and the pressure-strain elastic modulus (E p). A rigid airtight chamber with an ultrasound probe was attached to the upper arm to manipulate the transmural pressure of the brachial ar...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Yaguchi T,Cong Y,Shimo K,Kurokawa T,Sugita S,Nagayama K,Masuda H,Matsumoto T

    更新日期:2017-06-01 00:00:00

  • Stereolithography 3D Bioprinting Method for Fabrication of Human Corneal Stroma Equivalent.

    abstract::3D bioprinting technology is a promising approach for corneal stromal tissue regeneration. In this study, gelatin methacrylate (GelMA) mixed with corneal stromal cells was used as a bioink. The visible light-based stereolithography (SLA) 3D bioprinting method was utilized to print the anatomically similar dome-shaped ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Mahdavi SS,Abdekhodaie MJ,Kumar H,Mashayekhan S,Baradaran-Rafii A,Kim K

    更新日期:2020-07-01 00:00:00

  • A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading.

    abstract::Deformational loading represents a primary component of the chondrocyte physical environment in vivo. This review summarizes our experience with physiologic deformational loading of chondrocyte-seeded agarose hydrogels to promote development of cartilage constructs having mechanical properties matching that of the par...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审


    authors: Hung CT,Mauck RL,Wang CC,Lima EG,Ateshian GA

    更新日期:2004-01-01 00:00:00

  • A new pulsatile flow visualization method using a photochromic dye with application to Doppler ultrasound.

    abstract::A nonintrusive method for the visualization of pulsatile flow velocity profiles is described. The method is based on the use of a photochromic dye that is added to the fluid being studied and a nitrogen laser which excites the dye producing a marker "line" whose movement can be photographed. A microcomputer is used as...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Poots K,Cobbold RS,Johnston KW,Appugliese R,Kassam M,Zuech PE,Hummel RL

    更新日期:1986-01-01 00:00:00