Abstract：
:Dendritic cells (DCs) are crucial components of the immune response, strategically positioned as immune sentinels. Complex trafficking and accurate positioning of DCs are indispensable for both immunity and tolerance. This is particularly evident for their therapeutic application where an unmet clinical need exists for DCs with improved migratory capacity upon adoptive transfer into patients. One critical step that directs the trafficking of DCs throughout the body is their egress from the vasculature, starting with their adhesive interactions with vascular endothelium under shear flow. Both tethering and rolling rely on interactions mediated by specific glycans attached to glycoproteins and glycolipids present on the DC surface. In DCs, surface glycosylation, including the expression of selectin ligands, changes significantly depending on the local microenvironment and the functional state of the cells. These changes have been documented and have potential implications in important cell functions such as migration. In this article, we review the glycobiological aspects in the context of DC interaction with endothelium, and offer insights on how it can be applied to modulate DC applicability in therapy.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Silva Z,Konstantopoulos K,Videira PAdoi
10.1007/s10439-011-0448-5subject
Has Abstractpub_date
2012-04-01 00:00:00pages
777-89issue
4eissn
0090-6964issn
1573-9686journal_volume
40pub_type
杂志文章,评审abstract：:A computer-controlled optical electromechanical biaxial test system was employed to study the mechanical response of excised sheets of canine visceral pleura. Three classes of tests were performed: uniform biaxial stretching tests and tests in which the specimen was cyclically stretched along one axis while either the...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0329-y
更新日期：2011-09-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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doi：10.1007/s10439-014-1035-3
更新日期：2014-09-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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更新日期：2002-02-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-012-0625-1
更新日期：2013-01-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-009-9853-4
更新日期：2010-03-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
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journal_title：Annals of biomedical engineering
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doi：10.1007/s10439-008-9530-z
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1689-0
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journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
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更新日期：2014-01-01 00:00:00
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02684228
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journal_title：Annals of biomedical engineering
pub_type： 杂志文章
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journal_title：Annals of biomedical engineering
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