Abstract:
:The oscillometric fixed-ratio method is widely employed for non-invasive measurement of systolic and diastolic pressures (SP and DP) but is heuristic and prone to error. We investigated the accuracy of this method using an established mathematical model of oscillometry. First, to determine which factors materially affect the errors of the method, we applied a thorough parametric sensitivity analysis to the model. Then, to assess the impact of the significant parameters, we examined the errors over a physiologically relevant range of those parameters. The main findings of this model-based error analysis of the fixed-ratio method are that: (1) SP and DP errors drastically increase as the brachial artery stiffens over the zero trans-mural pressure regime; (2) SP and DP become overestimated and underestimated, respectively, as pulse pressure (PP) declines; (3) the impact of PP on SP and DP errors is more obvious as the brachial artery stiffens over the zero trans-mural pressure regime; and (4) SP and DP errors can be as large as 58 mmHg. Our final and main contribution is a comprehensive explanation of the mechanisms for these errors. This study may have important implications when using the fixed-ratio method, particularly in subjects with arterial disease.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Liu J,Hahn JO,Mukkamala Rdoi
10.1007/s10439-012-0700-7subject
Has Abstractpub_date
2013-03-01 00:00:00pages
587-97issue
3eissn
0090-6964issn
1573-9686journal_volume
41pub_type
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