Analog electrical model of the coronary circulation in case of multiple revascularizations.

Abstract:

:In this work, we propose an analog electrical model of the coronary circulation for patients with obstructive disease undergoing revascularization. In this clinical situation, the collateral circulation to the occluded artery is difficult to ascertain via preoperative measurements and well-developed collaterals might induce long-term restenosis of the revascularized artery due to flow competition mechanisms. The proposed model allows an original biomechanical analysis of per-operative hemodynamic data in order to assess quantitative evaluation of pressures and flows inside the native stenosed arteries, the collateral network and the bypass grafts. Average cardiac cycle values are analysed. In the case of 3-vessel disease and chronic occlusion of the right coronary artery, the quantitative results confirm the protective effects of the collateral flows in the pathological situation, but also show that the revascularization of the occluded right artery is fully justified since the collateral flows remain low, even when the left territory is revascularized. The model thus provides a computational tool to evaluate therapeutic strategies for each patient.

journal_name

Ann Biomed Eng

authors

Maasrani M,Verhoye JP,Corbineau H,Drochon A

doi

10.1007/s10439-008-9500-5

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

1163-74

issue

7

eissn

0090-6964

issn

1573-9686

journal_volume

36

pub_type

杂志文章
  • Effects of training on human tracking of electrocutaneous signals.

    abstract::The effects of training on a person's ability to perceive, interpret and utilize information presented via the tactile sense were examined by using a dual-channel electrocutaneous tracking approach. The electrocutaneous code studied was linear pulse rate encoding of information. The stimulus had a pulse width of 200 m...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/BF02367409

    authors: Szeto AY,Chung YM

    更新日期:1986-01-01 00:00:00

  • Do increased electrogastrographic frequencies always correspond to internal tachygastria?

    abstract::This study was undertaken to investigate the possible origin of some cutaneously recorded higher frequency electrogastrographic signals. Computer modeling of gastric electrical uncoupling was performed using previously described conoidal dipole model. Cutaneous electrogastrograms were simulated after uncoupling was in...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:

    authors: Mintchev MP,Bowes KL

    更新日期:1997-11-01 00:00:00

  • Left-right asymmetry of visual evoked potentials in brain-damaged patients: a mathematical model and experimental results.

    abstract::The left-right asymmetry in the potential amplitude on the scalp was studied in poststroke patients by using flash visual evoked potential (VEP) and a numerical two-dimensional model of the head. The left-right asymmetry of the VEP was measured in three patients after thrombosis, in one after hemorrhage, and in one he...

    journal_title:Annals of biomedical engineering

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02770997

    authors: Abboud S,Bar L,Rosenfeld M,Ring H,Glass I

    更新日期:1996-01-01 00:00:00

  • Hemodynamic Influence on Smooth Muscle Cell Kinetics and Phenotype During Early Vein Graft Adaptation.

    abstract::Pathologic vascular adaptation following local injury is the primary driver for accelerated intimal hyperplasia and an occlusive phenotype. Smooth muscle cell (SMC) proliferation within the wall, and migration into the developing intima, is a major component of this remodeling response. The primary objective in the cu...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-016-1725-0

    authors: Klein B,Destephens A,Dumeny L,Hu Q,He Y,O'Malley K,Jiang Z,Tran-Son-Tay R,Berceli S

    更新日期:2017-03-01 00:00:00

  • Quantitative Validation of a Human Body Finite Element Model Using Rigid Body Impacts.

    abstract::Validation is a critical step in finite element model (FEM) development. This study focuses on the validation of the Global Human Body Models Consortium full body average male occupant FEM in five localized loading regimes-a chest impact, a shoulder impact, a thoracoabdominal impact, an abdominal impact, and a pelvic ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-015-1286-7

    authors: Vavalle NA,Davis ML,Stitzel JD,Gayzik FS

    更新日期:2015-09-01 00:00:00

  • Low Impedance Carbon Adhesive Electrodes with Long Shelf Life.

    abstract::A novel electrocardiogram (ECG) electrode film is developed by mixing carbon black powder and a quaternary salt with a visco-elastic polymeric adhesive. Unlike traditional wet gel-based electrodes, carbon/salt/adhesive (CSA) electrodes should theoretically have an infinite shelf life as they do not dehydrate even afte...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-015-1282-y

    authors: Posada-Quintero HF,Reyes BA,Burnham K,Pennace J,Chon KH

    更新日期:2015-10-01 00:00:00

  • Design Optimisation of Coronary Artery Stent Systems.

    abstract::In recent years, advances in computing power and computational methods have made it possible to perform detailed simulations of the coronary artery stenting procedure and of related virtual tests of performance (including fatigue resistance, corrosion and haemodynamic disturbance). Simultaneously, there has been a gro...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审

    doi:10.1007/s10439-015-1373-9

    authors: Bressloff NW,Ragkousis G,Curzen N

    更新日期:2016-02-01 00:00:00

  • Novel Balloon Surface Scanning Device for Intraoperative Breast Endomicroscopy.

    abstract::Recent advances in fluorescence confocal endomicroscopy have allowed real-time identification of residual tumour cells on the walls of the cavity left by breast conserving surgery. However, it is difficult to systematically survey the surgical site because of the small imaging field-of-view of these probes, compounded...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-015-1493-2

    authors: Zuo S,Hughes M,Yang GZ

    更新日期:2016-07-01 00:00:00

  • Role of Rac and Rho-GDI alpha in the frequency-dependent expression of h1-calponin in vascular smooth muscle cells under cyclic mechanical strain.

    abstract::Phenotype transformation of vascular smooth muscle cells (VSMCs) has been reported to be directly influenced by the frequency of mechanical strain. This study explored the effects of different frequencies of mechanical strain on expression of phenotype marker h1-calponin and the possible mechanism. VSMCs were subjecte...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-008-9521-0

    authors: Qu MJ,Liu B,Qi YX,Jiang ZL

    更新日期:2008-09-01 00:00:00

  • Can molecular imaging enable personalized diagnostics? An example using magnetomotive photoacoustic imaging.

    abstract::The advantages of photoacoustic (PA) imaging, including low cost, non-ionizing operation, and sub-mm spatial resolution at centimeters depth, make it a promising modality to probe nanoparticle-targeted abnormalities in real time at cellular and molecular levels. However, detecting rare cell types in a heterogeneous ba...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审

    doi:10.1007/s10439-013-0901-8

    authors: O'Donnell M,Wei CW,Xia J,Pelivanov I,Jia C,Huang SW,Hu X,Gao X

    更新日期:2013-11-01 00:00:00

  • Emerging Brain Morphologies from Axonal Elongation.

    abstract::Understanding the characteristic morphology of our brain remains a challenging, yet important task in human evolution, developmental biology, and neurosciences. Mathematical modeling shapes our understanding of cortical folding and provides functional relations between cortical wavelength, thickness, and stiffness. Ye...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-015-1312-9

    authors: Holland MA,Miller KE,Kuhl E

    更新日期:2015-07-01 00:00:00

  • Effects of Chemically Doped Bioactive Borate Glass on Neuron Regrowth and Regeneration.

    abstract::Peripheral nerve injuries present challenges to regeneration. Currently, the gold standard for nerve repair is an autograft that results in another region of the body suffering nerve damage. Previously, bioactive borate glass (BBG) has been studied in clinical trials to treat patients with non-healing wounds, and we h...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-016-1689-0

    authors: Gupta B,Papke JB,Mohammadkhah A,Day DE,Harkins AB

    更新日期:2016-12-01 00:00:00

  • Hemoglobin glycation rate constant in non-diabetic Individuals.

    abstract::The objectives were as follows: (1) estimating mean value of the overall hemoglobin glycation rate constant (k); (2) analyzing inter-individual variability of k; (3) verifying ability of the hemoglobin A1c (HbA1c) formation model to predict changes of HbA1c during red blood cells cultivation in vitro and to reproduce ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-011-0366-6

    authors: Ladyżyński P,Wójcicki JM,Bąk MI,Sabalińska S,Kawiak J,Foltyński P,Krzymień J,Karnafel W

    更新日期:2011-11-01 00:00:00

  • Intelligent multichannel stimulator for the study of cardiac arrhythmias.

    abstract::An intelligent multichannel stimulator (IMS) has been designed and built for use in a cardiac research environment. The device is capable of measuring and responding to cardiac electrophysiological phenomena in real time with carefully timed and placed electrical stimuli. The system consists of 16 channels of sense/st...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1114/1.1451077

    authors: Johnson PL,Newton JC,Rollins DL,Knisley SB,Ideker RE,Smith WM

    更新日期:2002-02-01 00:00:00

  • Static magnetic fields promote osteoblast-like cells differentiation via increasing the membrane rigidity.

    abstract::The aim of this study was to test the differentiative effects of osteoblasts after treatment with a static magnetic field (SMF). MG63 osteoblast-like cells were exposed to a 0.4-T SMF. The differentiation markers were assessed by observing the changes in alkaline phosphatase activity and electron microscopy images. Me...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-007-9370-2

    authors: Chiu KH,Ou KL,Lee SY,Lin CT,Chang WJ,Chen CC,Huang HM

    更新日期:2007-11-01 00:00:00

  • In situ Microrheological Determination of Neutrophil Stiffening Following Adhesion in a Model Capillary.

    abstract::There has been considerable debate on the relative importance of biochemical stimuli and mechanical deformation in neutrophil adhesion in lung capillaries, a process observed following bacterial infection in the body. In contrast to venules, where the vessel diameter is larger than the leukocyte diameter (6-9 microm) ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-008-9437-8

    authors: Pai A,Sundd P,Tees DF

    更新日期:2008-04-01 00:00:00

  • Net change in periosteal strain during stance shift loading after surgery correlates to rapid de novo bone generation in critically sized defects.

    abstract::In an ovine femur model, proliferative woven bone fills critically sized defects enveloped by periosteum within 2 weeks of treatment with the one-stage bone-transport surgery. We hypothesize that mechanical loading modulates this process. Using high-definition optical strain measurements we determined prevailing perio...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-010-0242-9

    authors: McBride SH,Dolejs S,Brianza S,Knothe U,Knothe Tate ML

    更新日期:2011-05-01 00:00:00

  • Inverse parameter fitting of biological tissues: a response surface approach.

    abstract::In this paper, we present the application of a semi-global inverse method for determining material parameters of biological tissues. The approach is based on the successive response surface method, and is illustrated by fitting constitutive parameters to two nonlinear anisotropic constitutive equations, one for aortic...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-005-8338-3

    authors: Einstein DR,Freed AD,Stander N,Fata B,Vesely I

    更新日期:2005-12-01 00:00:00

  • Pixel-Based DXA-Derived Structural Properties Strongly Correlate with pQCT Measures at the One-Third Distal Femur Site.

    abstract::While bone mineral density has been traditionally used to quantify fracture risk for individuals with spinal cord injuries, recent studies are including engineering measurements such as section modulus and cross sectional moment of inertia. These are almost exclusively calculated by peripheral QCT scanners which, unli...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-017-1796-6

    authors: Baker AM,Wagner DW,Kiratli BJ,Beaupre GS

    更新日期:2017-05-01 00:00:00

  • A visualization-based analysis method for multiparameter models of capillary tissue-exchange.

    abstract::In order to successfully use a model for parameter identification, it must be carefully analyzed. Current analysis methods, however, are ad hoc and provide only partial information. We extended these methods through the application of stacked dimensions, a scientific visualization method. The end result of our extensi...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/BF02771001

    authors: Bosan S,Harris TR

    更新日期:1996-01-01 00:00:00

  • On the Impact of Intraluminal Thrombus Mechanical Behavior in AAA Passive Mechanics.

    abstract::Intraluminal thrombus (ILT) is a pseudo-tissue that develops from coagulated blood, and is found in most abdominal aortic aneurysms (AAAs) of clinically relevant size. A number of studies have suggested that ILT mechanical characteristics may be related to AAA risk of rupture, even though there is still great controve...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-015-1267-x

    authors: Riveros F,Martufi G,Gasser TC,Rodriguez-Matas JF

    更新日期:2015-09-01 00:00:00

  • Stenosis Hemodynamics Disrupt the Endothelial Cell Glycocalyx by MMP Activity Creating a Proinflammatory Environment.

    abstract::Hemodynamic forces are known to be able to induce an inflammatory phenotype in endothelial cells (ECs). The EC glycocalyx (GCX) is a dynamic structure which is regulated in response to different stimuli and hypothesized as an important contributor to the mechanotransduction of wall shear stresses (WSS). In this work, ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-017-1846-0

    authors: Cooper S,McDonald K,Burkat D,Leask RL

    更新日期:2017-09-01 00:00:00

  • Chest Wall Kinematics Using Triangular Cosserat Point Elements in Healthy and Neuromuscular Subjects.

    abstract::Optoelectronic plethysmography (OEP) is a noninvasive method for assessing lung volume variations and the contributions of different anatomical compartments of the chest wall (CW) through measurements of the motion of markers attached to the CW surface. The present study proposes a new method for analyzing the local C...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-017-1840-6

    authors: Solav D,Meric H,Rubin MB,Pradon D,Lofaso F,Wolf A

    更新日期:2017-08-01 00:00:00

  • Modeling of Experimental Atherosclerotic Plaque Delamination.

    abstract::A cohesive zone model (CZM) approach is applied to simulate atherosclerotic plaque delamination experiments in mouse abdominal aorta specimens. A three-dimensional finite element model is developed for the experiments. The aortic wall is treated as a fiber-reinforced, highly deformable, incompressible material, and th...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-015-1357-9

    authors: Leng X,Chen X,Deng X,Sutton MA,Lessner SM

    更新日期:2015-12-01 00:00:00

  • Two methods for recommending bat weights.

    abstract::Baseball players swung very light and very heavy bats through our instrument and the speed of the bat was recorded. These data were used to make mathematical models for each person. Then these models were coupled with equations of physics for bat-ball collisions to compute the Ideal Bat Weight for each individual. How...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/BF02584443

    authors: Bahill AT,Freitas MM

    更新日期:1995-07-01 00:00:00

  • Osteoarthritis: Pathology, Mouse Models, and Nanoparticle Injectable Systems for Targeted Treatment.

    abstract::Osteoarthritis (OA) is a progressive, degenerative disease of articulating joints that not only affects the elderly, but also involves younger, more active individuals with prolonged participation in high physical-demand activities. Thus, effective therapies that are easy to adopt clinically are critical in limiting t...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审

    doi:10.1007/s10439-016-1600-z

    authors: Holyoak DT,Tian YF,van der Meulen MC,Singh A

    更新日期:2016-06-01 00:00:00

  • Impedances of thin and layered systems: cells with even or odd numbers of interfaces.

    abstract::Impedance data, e.g., system responses, from perturbing small amplitude applied sinusoid signals of near DC to high kilohertz frequencies, give chemical information. Analysis of frequency-dependent imaginary and real impedance proceeds from equivalent analog circuit elements to chemical and physical significance deter...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/BF02368537

    authors: Buck RP

    更新日期:1992-01-01 00:00:00

  • Identification of static and dynamic components of reflex sensitivity in spastic elbow flexors using a muscle activation model.

    abstract::Static and dynamic components of the stretch reflex were studied in elbow flexors of 13 hemiparetic brain-injured individuals. Constant-velocity joint rotations were applied to the elbow, and the resulting stretch reflex torque and electromyographic responses were recorded in the biceps brachii and brachioradialis mus...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1114/1.1359496

    authors: Schmit BD,Rymer WZ

    更新日期:2001-04-01 00:00:00

  • Hydrodynamic shear and tethering through E-selectin signals phosphorylation of p38 MAP kinase and adhesion of human neutrophils.

    abstract::Recently, we reported that tethering and rolling of neutrophils in shear flow over a substrate of E-selectin signals activation of beta 2-integrins and firm adhesion via an intracellular signaling pathway involving phosphorylation of p38 MAP kinase. In the current study the objective was to examine the molecular mecha...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1114/1.1511240

    authors: Hentzen E,McDonough D,McIntire L,Smith CW,Goldsmith HL,Simon SI

    更新日期:2002-09-01 00:00:00

  • Reporter Scaffolds for Clinically Relevant Cell Transplantation Studies.

    abstract::There are a number of cell therapies that are either in clinical trials or moving toward clinical trials, particularly for diseases of the retina. One of the challenges with cell therapies is tracking the status of cells over time. Genetic manipulation can facilitate this, but it can limit the clinical application of ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-019-02393-z

    authors: Bolger M,Groynom R,Bogie K,Lavik E

    更新日期:2020-07-01 00:00:00