Abstract：
:Much effort is expended in developing biomimetic scaffolds that provide the micro-architecture of native tissue with appropriate cellular niches. Such scaffolds are often seeded with progenitor cells to generate engineered replacements for diseased or damaged tissues. An alternative approach relies on biology, rather than technology, to provide scaffolds containing progenitor cells in authentic niches. This article describes the use of accessible living tissues containing endogenous progenitor cells in their native, physiological environments. Such tissues also possess scaffolding properties, and can be readily harvested, manipulated and returned to the patient intra-operatively to facilitate repair and regeneration. Our group has explored the in situ genetic manipulation of cells within these tissues before they are reimplanted, although other means of modulation are certainly possible. Examples of suitable donor tissues include marrow, skeletal muscle and fat. In the case of marrow, clotting produces a moldable, autologous fibrin matrix containing endogenous cells; if necessary, exogenous cells can be added prior to clotting. These approaches have been studied experimentally in orthopaedic contexts, particularly for the healing and regeneration of bone and cartilage.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Evans CHdoi
10.1007/s10439-014-1174-6subject
Has Abstractpub_date
2015-03-01 00:00:00pages
787-95issue
3eissn
0090-6964issn
1573-9686journal_volume
43pub_type
杂志文章,评审abstract：:We present a method for the localized statistical discrimination of class populations based on the Karhunen-Loève and Fukunaga-Koontz transforms. These transforms provide features that model the variance of a sample distribution. The spatial series of a 196 channel epicardial electrogram recording from an arrythmogeni...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02367084
更新日期：1994-09-01 00:00:00
abstract：:In physiological conditions, joint function involves continuously moving contact areas over the tissue surface. Such moving contacts play an important role for the durability of the tissue. It is known that in pathological joints these motion paths and contact mechanics change. Nevertheless, limited information exists...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1543-9
更新日期：2016-08-01 00:00:00
abstract：:The concept of body force (force per unit volume) is introduced to account for the effect of the force generated in the radial direction by the active state of the myocardium in an elastic model of the left ventricle represented as a thick-walled cylinder contracting symmetrically. Experimental evidence for the validi...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368077
更新日期：1991-01-01 00:00:00
abstract：:Impedance data, e.g., system responses, from perturbing small amplitude applied sinusoid signals of near DC to high kilohertz frequencies, give chemical information. Analysis of frequency-dependent imaginary and real impedance proceeds from equivalent analog circuit elements to chemical and physical significance deter...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368537
更新日期：1992-01-01 00:00:00
abstract：:For the esophageal contractile activity recorded during swallowing, a feature extraction scheme has been developed. It recognizes the time, duration, and amplitudes of local peaks for each peristaltic wave. The method is based on the Tauberian approximation for modeling waveforms as a sum of identically shaped pulses ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02367607
更新日期：1993-03-01 00:00:00
abstract：:In this paper, an intelligent proportional-integral-derivative (PID) control method is introduced to the robotic testing system for the biomechanical study of human musculoskeletal joints. For the testing system, the robot is a highly nonlinear and heavily coupled complicated system, and the human spinal specimen also...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1023/b:abme.0000030759.80354.e8
更新日期：2004-06-01 00:00:00
abstract：:The bioinspired, microscale tissue engineering approach has emerged in recent years as a promising alternative to preformed scaffolds. Using this approach, complex tissues and organs can be efficiently engineered from microscale modules to replicate the intricate architecture and physiology of vascularized organs and ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-018-02192-y
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:This work explores for the first time the effects of temperature increments on the development of high shear stresses between plaque and arterial wall due to their different dilatational properties. Data from the literature report febrile reactions prior to myocardial infarction in patients with normal coron...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-007-9397-4
更新日期：2008-01-01 00:00:00
abstract：:To study pulsatile pressure-flow rate relationships in the intact pulmonary vascular network of mice, we developed a protocol for measuring pulmonary vascular resistance and impedance in isolated, ventilated, and perfused mouse lungs. We used pulmonary emboli to validate the effect of vascular obstruction on resistanc...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-9050-z
更新日期：2006-04-01 00:00:00
abstract：:Hemodynamic parameters play an important role in regulating vascular remodeling in arterio-venous fistula (AVF) maturation. Investigating the changes in hemodynamic parameters during AVF maturation is expected to improve our understanding of fistula failure, but very little data on actual temporal changes in human AVF...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-012-0703-4
更新日期：2013-04-01 00:00:00
abstract：:The effects of facet wiring procedure commonly used for stabilizing cervical spines after laminectomy or bilateral facet dislocation on the motion behavior of whole cervical spines are investigated using a Selspot II system. A fresh human ligamentous intact specimen was potted at T1/T2 vertebra and clinically relevant...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368022
更新日期：1989-01-01 00:00:00
abstract：:We propose a multifrequency energy transmission scheme for annular phased arrays in deep-body hyperthermia. The problem of frequency dependent resonance effects reported in hyperthermia phantom calibration studies, leading to skewed energy deposition patterns and unwanted energy maxima (hot spots), is addressed by com...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1430749
更新日期：2002-01-01 00:00:00
abstract：:This discussion and review article focuses on the possible use of regenerative techniques applied to the interfaces between skin and medical implants. As is widely known, the area of contact between an implant and the skin--the skin-implant interface--is prone to recurrent and persistent problems originated from the l...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-010-9937-1
更新日期：2010-06-01 00:00:00
abstract：:An intelligent multichannel stimulator (IMS) has been designed and built for use in a cardiac research environment. The device is capable of measuring and responding to cardiac electrophysiological phenomena in real time with carefully timed and placed electrical stimuli. The system consists of 16 channels of sense/st...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1451077
更新日期：2002-02-01 00:00:00
abstract：:Despite the clinical effectiveness of coronary artery stenting, percutaneous coronary intervention or "stenting" is not free of complications. Stent malapposition (SM) is a common feature of "stenting" particularly in challenging anatomy, such as that characterized by long, tortuous and bifurcated segments. SM is an i...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-014-1237-8
更新日期：2015-08-01 00:00:00
abstract：:Computational modeling and simulation has become more common in design and development of bioprosthetic heart valves. To have a reliable computational model, considering accurate mechanical properties of biological soft tissue is one of the most important steps. The goal of this study was to present a non-invasive mat...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-018-02129-5
更新日期：2019-01-01 00:00:00
abstract：:This paper describes a finite volume method for modeling electrical activation in a sample of cardiac tissue using the bidomain equations. Microstructural features to the level of cleavage planes between sheets of myocardial fibers in the tissue are explicitly represented. The key features of this implementation compa...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-005-1434-6
更新日期：2005-05-01 00:00:00
abstract：:Biomaterial-based tissue engineering strategies hold great promise for osteochondral tissue repair. Yet significant challenges remain in joining highly dissimilar materials to achieve a biomimetic, mechanically robust design for repairing interfaces between soft tissue and bone. This study sought to improve interfacia...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1337-0
更新日期：2015-11-01 00:00:00
abstract：:To better understand the relationship between kinetic processes of contraction and the dynamic features of an isometric twitch, studies were conducted using a mathematical model that included: (1) kinetics of cross bridge (XB) cycling; (2) kinetics of thin filament regulatory processes; (3) serial and feedback interac...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1366669
更新日期：2001-05-01 00:00:00
abstract：:A python computer package is developed to segment and analyze scanning electron microscope (SEM) images of scaffolds for bone tissue engineering. The method requires only a portion of an SEM image to be labeled and used for training. The algorithm is then able to detect the pore characteristics for other SEM images ac...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02638-2
更新日期：2020-10-15 00:00:00
abstract：:Mechanical ventilation is a life-support therapy for intensive care patients suffering from respiratory failure. To reduce the current rate of ventilator-induced lung injury requires ventilator settings that are patient-, time-, and disease-specific. A common lung protective strategy is to optimise the level of positi...
journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
doi：10.1007/s10439-019-02253-w
更新日期：2019-07-01 00:00:00
abstract：:Classically, the primary tool for quantifying the dynamics of vergence and other eye movements has been the main sequence. The main sequence is a plot of peak velocity versus response amplitude and is particularly useful for comparing the dynamics of a large number of eye movements over a range of response amplitudes....
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.162
更新日期：1999-05-01 00:00:00
abstract：:The neutrophil has developed into one of the most efficient vertebrate motile cells. It migrates through tissues, where it encounters multiple chemoattractant signals with complex spatial and temporal characteristics. The directional movement of the neutrophil is signaled by the binding of chemoattractants and chemoki...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1114/1.1477446
更新日期：2002-03-01 00:00:00
abstract：:A cable model is formulated to estimate the spatial distribution of intracellular electric potential and current, from the cement line to the lumen of an osteon, as the frequency of the loading and the conductance of the gap junction are altered. The model predicts that the characteristic diffusion time for the spread...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02648049
更新日期：1997-03-01 00:00:00
abstract：:In order to increase the probability of having a successful cataract post-surgery, the customisation of the haptic design of the intraocular lens (IOL) according to the characteristics of the patient is recommended. In this study, we present two prediction models based on deep neural networks (DNNs). One is capable of...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02636-4
更新日期：2020-12-01 00:00:00
abstract：:Early stage changes in hypertensive arteries have a significant effect on the long-term adaptation of the arteries. Compared to the long-term adaptation, little is known about the early dimensional and functional changes in hypertensive arteries in the first few days of hypertension. To study the early stage changes i...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1376391
更新日期：2001-06-01 00:00:00
abstract：:Nanomedicine (a division of nanotechnology) is an interdisciplinary research field incorporating biology, chemistry, engineering and medicine with the intention to improve disease prevention, diagnosis, and treatment. Specifically, there have been great strides made in using nanomedicine to enhance the functions of ce...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-009-9722-1
更新日期：2009-10-01 00:00:00
abstract：:Collagen, the most commonly used extra-cellular matrix protein for tissue engineering applications, displays poor mechanical properties. Here, we report on the preparation and characterization of novel multi-component composite systems that incorporate a genetically engineered, biocompatible polymer (elastin-like poly...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-013-0825-3
更新日期：2013-10-01 00:00:00
abstract：:Spine musculoskeletal models used to estimate loads and displacements require many simplifying assumptions. We examined how assumptions about subject size and vertebral positions can affect the model outcomes. Head and neck models were developed to represent 30 subjects (15 males and 15 females) in neutral posture and...
journal_title：Annals of biomedical engineering
pub_type： 临床试验,杂志文章
doi：10.1007/s10439-018-2084-9
更新日期：2018-11-01 00:00:00
abstract：:Acute cerebral ischemic events and thrombosis are associated with the rupture/erosion of carotid atherosclerotic plaques. The aim of the present study was to determine the impact of calcification deposition on the wall shear stress (WSS) and stresses within the plaques using 3D fluid-structure interaction (FSI) models...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02655-1
更新日期：2020-10-20 00:00:00
