Through the microcirculatory maze with machete, molecule, and minicomputer (1986 Alza lecture).

abstract：:Past literature has provided evidence that a normal mechanical force environment of blood flow may guide normal development while an abnormal environment can lead to congenital malformations, thus warranting further studies on embryonic cardiovascular flow dynamics. In the current study, we developed a non-invasive 4D...

journal_title：Annals of biomedical engineering

authors： Ho S,Tan GXY,Foo TJ,Phan-Thien N,Yap CH

更新日期：2017-10-01 00:00:00

abstract：:Functional electrical stimulation (FES) to lower extremity (LE) muscles is used by individuals post-stroke as an alternative to mechanical orthotic devices during gait or as a training modality during rehabilitation. Technological developments which improve the feasibility, accessibility and effectiveness of FES syste...

journal_title：Annals of biomedical engineering

authors： Kafri M,Laufer Y

更新日期：2015-02-01 00:00:00

abstract：:We compare the influence of time-frequency methods on analysis of time-varying renal autoregulation properties. Particularly, we examine if detection probabilities are similar for amplitude and frequency modulation for a modulated simulation signal among five time-frequency approaches, and if time-varying changes in s...

journal_title：Annals of biomedical engineering

authors： Scully CG,Siu KL,Cupples WA,Braam B,Chon KH

更新日期：2013-01-01 00:00:00

abstract：:Extraction of the cardiac surfaces of interest from multi-detector computed tomographic (MDCT) data is a pre-requisite step for cardiac analysis, as well as for image guidance procedures. Most of the existing methods need manual corrections, which is time-consuming. We present a fully automatic segmentation technique ...

journal_title：Annals of biomedical engineering

authors： Antunes S,Esposito A,Palmisano A,Colantoni C,Cerutti S,Rizzo G

更新日期：2016-05-01 00:00:00

abstract：:In 12 dogs anesthetised with alpha-chloralose and urethane, and beta-adrenergic blocked with propranolol, the cervical vagi were stimulated for 60 seconds with supramaximal constant current pulses at frequencies between 2.0 and 10 Hz. The time course of the recovery of the cardiac period response, after cessation of v...

journal_title：Annals of biomedical engineering

authors： Celler BG,Lovell NH

更新日期：1991-01-01 00:00:00

abstract：:Pressure ulcer risk assessment might be optimized by incorporating the soft tissue reaction to mechanical loading in the currently used risk assessment scales. Cytokines, like IL-1alpha, IL-1RA, IL-8, and TNF-alpha, might be used to determine this tissue reaction, since they are released after 24 h of mechanical loadi...

journal_title：Annals of biomedical engineering

authors： Cornelissen LH,Bronneberg D,Bader DL,Baaijens FP,Oomens CW

更新日期：2009-05-01 00:00:00

abstract：:The identification of the insulin minimal model (MM) for the estimation of insulin secretion rate (ISR) and physiological indexes (e.g. beta-cell sensitivity) requires the knowledge of C-peptide (CP) kinetics. The four parameters of the two-compartment model of CP kinetics in a given individual can be derived either f...

journal_title：Annals of biomedical engineering

authors： Magni P,Sparacino G,Bellazzi R,Toffolo GM,Cobelli C

更新日期：2004-07-01 00:00:00

abstract：:Normal physiological mechanical forces cause constant tissue renewal in aortic valve leaflets (AVL) while altered mechanical forces incite changes in their structural and biological properties. The current study aims at characterizing the remodeling properties of AVL subjected to cyclic circumferential stretch in a st...

journal_title：Annals of biomedical engineering

authors： Balachandran K,Konduri S,Sucosky P,Jo H,Yoganathan AP

更新日期：2006-11-01 00:00:00

abstract：:A novel electrocardiogram (ECG) electrode film is developed by mixing carbon black powder and a quaternary salt with a visco-elastic polymeric adhesive. Unlike traditional wet gel-based electrodes, carbon/salt/adhesive (CSA) electrodes should theoretically have an infinite shelf life as they do not dehydrate even afte...

journal_title：Annals of biomedical engineering

authors： Posada-Quintero HF,Reyes BA,Burnham K,Pennace J,Chon KH

更新日期：2015-10-01 00:00:00

abstract：:Upon nerve injury, the body creates an environment consisting of permissive and non-permissive cues that instruct the function of cells involved in nerve repair. Among other roles, the developing extracellular matrix (ECM) acts as an underlying substrate to guide the union of neurites extending from the proximal stump...

journal_title：Annals of biomedical engineering

authors： Man AJ,Leach JK,Bannerman P

更新日期：2014-06-01 00:00:00

abstract：:Interstitial fluid flow, critical for macromolecular transport, was recently shown to drive fibroblast differentiation and perpendicular cell and matrix alignment in 3D collagen cultures. Here we explore the mechanisms underlying this flow-induced cell and collagen alignment. Cell and matrix alignment was assessed fro...

journal_title：Annals of biomedical engineering

authors： Ng CP,Swartz MA

更新日期：2006-03-01 00:00:00

abstract：:Currently, there are no clinically available tools or applications which could predict osteoarthritis development. Some computational models have been presented to simulate cartilage degeneration, but they are not clinically feasible due to time required to build subject-specific knee models. Therefore, the objective ...

journal_title：Annals of biomedical engineering

authors： Mononen ME,Liukkonen MK,Korhonen RK

更新日期：2019-03-01 00:00:00

abstract：:Vascular diseases are an increasing health issue, and common alloplastic, allogenic or autologous vascular grafts show frequent complications. The aim of this study is to develop an acellular, xenogenic bypass-graft from a bovine carotid artery (BAC) using detergent-based protocols. We compared decellularization with ...

journal_title：Annals of biomedical engineering

authors： Daugs A,Hutzler B,Meinke M,Schmitz C,Lehmann N,Markhoff A,Bloch O

更新日期：2017-11-01 00:00:00

abstract：:Diabetic retinopathy is the leading cause of blindness in working age individuals in the United States. Breakdown of the blood-retinal barrier is one of the earliest events in the progression of diabetic retinopathy. Ideally, therapeutic measures would be directed at this early stage, but there are few sensitive, quan...

journal_title：Annals of biomedical engineering

authors： Russ PK,Gaylord GM,Haselton FR

更新日期：2001-08-01 00:00:00

abstract：:We examine the influence of the added mass effect (fluid inertia) on mitral valve leaflet stress during isovolumetric phases. To study this effect, oscillating flow is applied to a flexible membrane at various frequencies to control inertia. Resulting membrane strain is calculated through a three-dimensional reconstru...

journal_title：Annals of biomedical engineering

authors： Bark DL Jr,Dasi LP

更新日期：2016-05-01 00:00:00

abstract：:One of the major functions of the cardiovascular system is to deliver blood to the microcirculation where exchange of mass and energy can take place. In the present article, we will provide an overview of the state-of-the-art computational methods for modeling of red blood cell (RBC) rheology and dynamics in the micro...

journal_title：Annals of biomedical engineering

authors： Cristini V,Kassab GS

更新日期：2005-12-01 00:00:00

abstract：:Icariin (Ic) has been demonstrated as a potent osteoinductive compound for bone tissue engineering. However, toxic side effects of the drug and poor biocompatibility of drug delivery systems (DDSs) still limit its application for bone repair in the clinic. To overcome these disadvantages and utilize the osteoinductivi...

journal_title：Annals of biomedical engineering

authors： Li M,Zhang C,Zhong Y,Zhao J

更新日期：2017-11-01 00:00:00

abstract：:Analysis and classification of esophageal motility records were investigated using signal processing and fuzzy-set pattern recognition techniques. A set of parameters has been extracted from the raw records and has previously been used as characterizing features. Improvements to these procedures were obtained by extra...

journal_title：Annals of biomedical engineering

authors： Abou-Chadi FE,Ezzat FA,Sif el-Din AA

更新日期：1994-01-01 00:00:00

abstract：:The advantages of photoacoustic (PA) imaging, including low cost, non-ionizing operation, and sub-mm spatial resolution at centimeters depth, make it a promising modality to probe nanoparticle-targeted abnormalities in real time at cellular and molecular levels. However, detecting rare cell types in a heterogeneous ba...

journal_title：Annals of biomedical engineering

authors： O'Donnell M,Wei CW,Xia J,Pelivanov I,Jia C,Huang SW,Hu X,Gao X

更新日期：2013-11-01 00:00:00

abstract：:Naphthalene is a toxicant with unusual species and tissue specificity that has been the subject of in vitro studies. We describe a preliminary physiologically based pharmacokinetic (PBPK) model for naphthalene constructed solely from in vitro data for comparison to animal data without the use of adjustable parameters....

journal_title：Annals of biomedical engineering

authors： Sweeney LM,Shuler ML,Quick DJ,Babish JG

更新日期：1996-03-01 00:00:00

abstract：:Recent advances in angioplasty have involved the application of polymer coatings to stent surfaces for purposes of drug delivery. Given the high levels of deformation developed in the plastic hinge of a stent during deployment, the achievement of an intact bond between the coating and the stent presents a significant ...

journal_title：Annals of biomedical engineering

authors： Hopkins CG,McHugh PE,McGarry JP

更新日期：2010-07-01 00:00:00

abstract：:Deformational loading represents a primary component of the chondrocyte physical environment in vivo. This review summarizes our experience with physiologic deformational loading of chondrocyte-seeded agarose hydrogels to promote development of cartilage constructs having mechanical properties matching that of the par...

journal_title：Annals of biomedical engineering

authors： Hung CT,Mauck RL,Wang CC,Lima EG,Ateshian GA

更新日期：2004-01-01 00:00:00

abstract：:Arterial restenosis following stent deployment may be influenced by the local flow environment within and around the stent. We have used computational fluid dynamics to investigate the flow field in the vicinity of model stents positioned within straight and curved vessels. Our simulations have revealed the presence o...

journal_title：Annals of biomedical engineering

authors： Seo T,Schachter LG,Barakat AI

更新日期：2005-04-01 00:00:00

abstract：:Bending stiffness of passive-dynamic ankle-foot orthoses (PD-AFOs) is a functional characteristic thought to restore lost ankle function due to weakened plantar flexors. However, lower extremity impairment profiles of patients are seldom limited to plantar flexion weakness, and PD-AFO characteristics often influence g...

journal_title：Annals of biomedical engineering

authors： Arch ES,Stanhope SJ

更新日期：2015-02-01 00:00:00

abstract：:Conventional nanoporous hydrogels often lead to slow cartilage deposition by MSCs in 3D due to physical constraints and requirement for degradation. Our group has recently reported macroporous gelatin microribbon (μRB) hydrogels, which substantially accelerate MSC-based cartilage formation in vitro compared to convent...

journal_title：Annals of biomedical engineering

authors： Barati D,Gegg C,Yang F

更新日期：2020-07-01 00:00:00

abstract：:Accurate identification of contracting muscles can help us to understand the muscle function in both physiological and pathological conditions. Conventional electromyography (EMG) have limited access to deep muscles, crosstalk, or instability in the recordings. Accordingly, a novel framework was developed to detect co...

journal_title：Annals of biomedical engineering

authors： Zheng Y,Shin H,Kamper DG,Hu X

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Common-mode noise degrades cardiovascular signal quality and diminishes measurement accuracy. Filtering to remove noise components in the frequency domain often distorts the signal. METHOD:Two adaptive noise canceling (ANC) algorithms were tested to adjust weighted reference signals for optimal subtraction ...

journal_title：Annals of biomedical engineering

authors： Ciaccio EJ,Micheli-Tzanakou E

更新日期：2007-07-01 00:00:00

abstract：:Dexterity of robots is highly required when it comes to integration for medical applications. Major efforts have been conducted to increase the dexterity at the distal parts of medical robots. This paper reports on developments toward integrating biocompatible conducting polymers (CP) into inherently dexterous concent...

journal_title：Annals of biomedical engineering

authors： Chikhaoui MT,Benouhiba A,Rougeot P,Rabenorosoa K,Ouisse M,Andreff N

更新日期：2018-10-01 00:00:00

abstract：:The extent to which sensorineural systems such as the auditory system are nonlinear depends on the type of stimulus that is used, and the part of the system from which recordings are made. An estimate of the first-order Wiener kernel of the evoked response from the inferior colliculus to amplitude-modulated tones and ...

journal_title：Annals of biomedical engineering

authors： Møller AR,Angelo RM

更新日期：1988-01-01 00:00:00

abstract：:The objective of this study was to develop a ferrocene mediated glucose biosensor for reverse iontophoresis. An amperometric ferrocene mediated glucose biosensor based on a three electrodes planar configuration was constructed using screen printing technique. Different combinations of glucose oxidase and ferrocene loa...

journal_title：Annals of biomedical engineering

authors： Ching CT,Sun TP,Huang SH,Shieh HL,Chen CY

更新日期：2010-04-01 00:00:00