Computational investigation of the delamination of polymer coatings during stent deployment.

Abstract:

:Recent advances in angioplasty have involved the application of polymer coatings to stent surfaces for purposes of drug delivery. Given the high levels of deformation developed in the plastic hinge of a stent during deployment, the achievement of an intact bond between the coating and the stent presents a significant mechanical challenge. Problems with coating delamination have been reported in recent experimental studies. In this paper, a cohesive zone model of the stent-coating interface is implemented in order to investigate coating debonding during stent deployment. Simulations reveal that coatings debond from the stent surface in tensile regions of the plastic hinge during deployment. The critical parameters governing the initiation of delamination include the coating thickness and stiffness, the interface strength between the coating and stent surface, and the curvature of the plastic hinge. The coating is also computed to debond from the stent surface in compressive regions of the plastic hinge by a buckling mechanism. Computed patterns of coating delamination correlate very closely with experimental images. This study provides insight into the critical factors governing coating delamination during stent deployment and offers a predictive framework that can be used to improve the design of coated stents.

journal_name

Ann Biomed Eng

authors

Hopkins CG,McHugh PE,McGarry JP

doi

10.1007/s10439-010-9972-y

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

2263-73

issue

7

eissn

0090-6964

issn

1573-9686

journal_volume

38

pub_type

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