Fetal Transcatheter Trileaflet Heart Valve Hemodynamics: Implications of Scaling on Valve Mechanics and Turbulence.

abstract：:Microfluidic devices fabricated using poly(dimethylsiloxane) (PDMS) polymer are routinely used for in vitro cell culture for a wide range of cellular assays. These assays typically involve the incubation of cultured cells with a drug molecule or a fluorescent marker while monitoring a cellular response. The accuracy o...

journal_title：Annals of biomedical engineering

authors： Wang JD,Douville NJ,Takayama S,ElSayed M

更新日期：2012-09-01 00:00:00

abstract：:Diabetic retinopathy is the leading cause of blindness in working age individuals in the United States. Breakdown of the blood-retinal barrier is one of the earliest events in the progression of diabetic retinopathy. Ideally, therapeutic measures would be directed at this early stage, but there are few sensitive, quan...

journal_title：Annals of biomedical engineering

authors： Russ PK,Gaylord GM,Haselton FR

更新日期：2001-08-01 00:00:00

abstract：:Induced pluripotent stem cell derived cardiomyocytes (iPSC-CM) provide a powerful platform for disease modeling and drug development in vitro. Traditionally, electrophysiological methods or fluorescent dyes (e.g. calcium) have been used in their functional characterization. Recently, video microscopy has enabled non-i...

journal_title：Annals of biomedical engineering

authors： Ahola A,Pölönen RP,Aalto-Setälä K,Hyttinen J

更新日期：2018-01-01 00:00:00

abstract：:Newborns with single ventricle physiology are usually palliated with a multi-staged procedure. When cardiovascular complications e.g., collateral vessel formation occur during the inter-stage periods, further treatments are required. An 8-month-old patient, who underwent second stage (i.e., bi-directional Glenn, BDG) ...

journal_title：Annals of biomedical engineering

authors： Corsini C,Baker C,Baretta A,Biglino G,Hlavacek AM,Hsia TY,Kung E,Marsden A,Migliavacca F,Vignon-Clementel I,Pennati G,Modeling of Congenital Hearts Alliance (MOCHA) Investigators.

更新日期：2015-06-01 00:00:00

abstract：:A model predictive control strategy to simultaneously regulate hemodynamic and anesthetic variables in critical care patients is presented. A nonlinear canine circulatory model, which has been used to study the effect of inotropic and vasoactive drugs on hemodynamic variables, has been extended to include propofol pha...

journal_title：Annals of biomedical engineering

authors： Rao RR,Bequette BW,Roy RJ

更新日期：2000-01-01 00:00:00

abstract：:Asymmetric 75% and 95% area reduction, transparent Sylgard stenotic models were operated under internal carotid artery (ICA) [Womersley parameter, alpha=5.36, Re(mean) =213 and 180, respectively, and Re(peak)=734 and 410, respectively] and left anterior descending coronary artery (LAD) flow wave forms (alpha=2.65, Re(...

journal_title：Annals of biomedical engineering

authors： Cao J,Rittgers SE

更新日期：1998-03-01 00:00:00

abstract：:The kidney is one of the most radiosensitive organs; it is the primary dose-limiting organ in radiotherapies for upper abdominal cancers. The role of mitochondrial redox state in the development and treatment of renal radiation injury, however, remains ill-defined. This study utilizes 3D optical cryo-imaging to quanti...

journal_title：Annals of biomedical engineering

authors： Mehrvar S,la Cour MF,Medhora M,Camara AKS,Ranji M

更新日期：2019-07-01 00:00:00

abstract：:We have studied the dependence of conduction velocity (theta) on extracellular potassium concentration ([K+]o) in a model of one-dimensional conduction using an idealized strand of human atrial cells. Elevated [K+]o in the 5-20 mM range shifts the resting potential (Vrest) in the depolarizing direction and reduces inp...

journal_title：Annals of biomedical engineering

authors： Nygren A,Giles WR

更新日期：2000-08-01 00:00:00

abstract：:We present an optical non-contact method for heart beat monitoring, based on the measurement of chest wall movements induced by the pumping action of the heart, which is eligible as a surrogate of electrocardiogram (ECG) in assessing both cardiac rate and heart rate variability (HRV). The method is based on the optica...

journal_title：Annals of biomedical engineering

authors： Morbiducci U,Scalise L,De Melis M,Grigioni M

更新日期：2007-01-01 00:00:00

abstract：:An endovascular technique using a stent has been developed and successfully applied in the treatment of wide neck aneurysms. A stent can facilitate thrombosis in the aneurysm pouch while maintaining biocompatible passage of the parent artery. Insertion of the stent changes the flow characteristics inside the aneurysm ...

journal_title：Annals of biomedical engineering

authors： Rhee K,Han MH,Cha SH

更新日期：2002-07-01 00:00:00

abstract：:Experimental studies have shown that cardiac fibroblasts are electrically inexcitable, but can contribute to electrophysiology of myocardium in various manners. The aim of this computational study was to give insights in the electrophysiological role of fibroblasts and their interaction with myocytes. We developed a m...

journal_title：Annals of biomedical engineering

authors： Sachse FB,Moreno AP,Abildskov JA

更新日期：2008-01-01 00:00:00

abstract：:Neuromuscular impairment associated with cerebral palsy (CP) often leads to life-long walking deficits. Our goal was to evaluate the ability of a novel untethered wearable ankle exoskeleton to reduce the severity of gait pathology from CP. In this clinical feasibility study of five individuals with CP, we used instrum...

journal_title：Annals of biomedical engineering

authors： Lerner ZF,Harvey TA,Lawson JL

更新日期：2019-06-01 00:00:00

abstract：:In order to obtain the first quantitative measurements of the in vivo stresses in early-stage amphibian embryos, we developed a novel instrument that uses a pair of parallel wires that are glued to the surface of an embryo normal to the direction in which the stress is to be determined. When a slit is made parallel to...

journal_title：Annals of biomedical engineering

authors： Benko R,Brodland GW

更新日期：2007-04-01 00:00:00

abstract：:Rapid technological advances have prompted the development of a wide range of telemonitoring systems to enable the prevention, early diagnosis and management, of chronic conditions. Remote monitoring can reduce the amount of recurring admissions to hospital, facilitate more efficient clinical visits with objective res...

journal_title：Annals of biomedical engineering

authors： Ní Scanaill C,Carew S,Barralon P,Noury N,Lyons D,Lyons GM

更新日期：2006-04-01 00:00:00

abstract：:In vitro and in vivo studies were conducted on omega-3 fatty acid-derived biomaterials to determine their utility as an implantable material for adhesion prevention following soft tissue hernia repair and as a means to allow for the local delivery of antimicrobial or antibiofilm agents. Naturally derived biomaterials ...

journal_title：Annals of biomedical engineering

authors： Faucher KM,Artzi N,Beck M,Beckerman R,Moodie G,Albergo T,Conroy S,Dale A,Corbeil S,Martakos P,Edelman ER

更新日期：2016-03-01 00:00:00

abstract：:The purpose of the study was to examine the effects of arterial coculture conditions on the transport properties of several in vitro endothelial cell (EC)-smooth muscle cell (SMC)-porous filter constructs in which SMC were grown to confluence first and then EC were inoculated. This order of culturing simulates the env...

journal_title：Annals of biomedical engineering

authors： Mathura RA,Russell-Puleri S,Cancel LM,Tarbell JM

更新日期：2016-05-01 00:00:00

abstract：:It is proposed that the maximum in cuff pressure oscillations during oscillometry is due to the buckling of the brachial artery under a cuff. This theory is investigated by means of a mathematical model of oscillatometry that includes the mechanics of the occlusive arm cuff, the arterial pressure pulse waveform, and t...

journal_title：Annals of biomedical engineering

authors： Drzewiecki G,Hood R,Apple H

更新日期：1994-01-01 00:00:00

abstract：:The objective of this work is to develop understanding of the local fluid dynamic mechanisms that underpin gas exchange in high-frequency oscillatory ventilation (HFOV). The flow field during HFOV was investigated experimentally using particle image velocimetry in idealized and realistic models of a single bifurcation...

journal_title：Annals of biomedical engineering

authors： Heraty KB,Laffey JG,Quinlan NJ

更新日期：2008-11-01 00:00:00

abstract：:We hypothesize that variations of body anthropometry, conjointly with the bone strength, determine the risk of hip fracture. To test the hypothesis, we compared, in a simulated sideways fall, the hip impact energy to the energy needed to fracture the femur. Ten femurs from elderly donors were tested using a novel drop...

journal_title：Annals of biomedical engineering

authors： Palanca M,Perilli E,Martelli S

更新日期：2020-11-12 00:00:00

abstract：:The study was to explore the effects of BMP-2 gene modified canine bone marrow stromal cells (bMSCs) mediated by a nonviral PEI derivative (GenEscort™ II) in promoting bone formation in vitro and in vivo. Canine bMSCs were cultured and transfected with plasmids containing bone morphogenetic protein-2 gene (pBMP-2) or ...

journal_title：Annals of biomedical engineering

authors： Lü K,Zeng D,Zhang Y,Xia L,Xu L,Kaplan DL,Jiang X,Zhang F

更新日期：2011-06-01 00:00:00

abstract：:Clinicians generally assume that Medical Compression Stockings (MCS) work by reducing vein luminal diameter and, in this way, help to prevent blood pooling. Conflicting results have been reported however in the case of lower leg deep veins which call into question this hypothesis. The purpose of this contribution is t...

journal_title：Annals of biomedical engineering

authors： Rohan PY,Badel P,Lun B,Rastel D,Avril S

更新日期：2015-02-01 00:00:00

abstract：:Millions of people worldwide are diagnosed each year with valvular heart disease, resulting in hundreds of thousands of valve replacement operations. Prosthetic valve replacements are designed to correct narrowing or backflow through the valvular orifice. Although commonly used, these therapies have serious disadvanta...

journal_title：Annals of biomedical engineering

authors： Berry JL,Steen JA,Koudy Williams J,Jordan JE,Atala A,Yoo JJ

更新日期：2010-11-01 00:00:00

abstract：:A vaccine that induces broadly neutralizing antibodies (bnAbs) against the human immunodeficiency virus (HIV) would be instrumental in controlling the disease. The membrane proximal external region (MPER) peptide is an appealing antigen candidate since it is conserved and is the target of several human bnAbs, such as ...

journal_title：Annals of biomedical engineering

authors： Shao S,Huang WC,Lin C,Hicar MD,LaBranche CC,Montefiori DC,Lovell JF

更新日期：2020-07-01 00:00:00

abstract：:The longitudinal assessment of joint health is a long-standing issue in the management of musculoskeletal injuries. The acoustic emissions (AEs) produced by joint articulation could serve as a biomarker for joint health assessment, but their use has been limited by a lack of mechanistic understanding of their creation...

journal_title：Annals of biomedical engineering

authors： Whittingslow DC,Jeong HK,Ganti VG,Kirkpatrick NJ,Kogler GF,Inan OT

更新日期：2020-01-01 00:00:00

abstract：:Impedance data, e.g., system responses, from perturbing small amplitude applied sinusoid signals of near DC to high kilohertz frequencies, give chemical information. Analysis of frequency-dependent imaginary and real impedance proceeds from equivalent analog circuit elements to chemical and physical significance deter...

journal_title：Annals of biomedical engineering

authors： Buck RP

更新日期：1992-01-01 00:00:00

abstract：:While bone mineral density has been traditionally used to quantify fracture risk for individuals with spinal cord injuries, recent studies are including engineering measurements such as section modulus and cross sectional moment of inertia. These are almost exclusively calculated by peripheral QCT scanners which, unli...

journal_title：Annals of biomedical engineering

authors： Baker AM,Wagner DW,Kiratli BJ,Beaupre GS

更新日期：2017-05-01 00:00:00

abstract：:Continuous measurement of arterial blood density after bolus injection of fluids of different density into the right atrium has been used to measure cardiac output and mean transit time through the central circulation. The transit time distribution for density, however, differs from that for plasma-phase tracers such ...

journal_title：Annals of biomedical engineering

authors： Ligas JR,Moslehi F,Epstein MA

更新日期：1993-07-01 00:00:00

abstract：:A novel apparatus for the multifaceted evaluation of artery function was developed. It measures endothelial and smooth muscle functions and the pressure-strain elastic modulus (E p). A rigid airtight chamber with an ultrasound probe was attached to the upper arm to manipulate the transmural pressure of the brachial ar...

journal_title：Annals of biomedical engineering

authors： Yaguchi T,Cong Y,Shimo K,Kurokawa T,Sugita S,Nagayama K,Masuda H,Matsumoto T

更新日期：2017-06-01 00:00:00

abstract：:Polymeric heart valves have the potential to reduce thrombogenic complications associated with current mechanical valves and overcome fatigue-related problems experienced by bioprosthetic valves. In this paper we characterize the in vitro velocity and Reynolds Shear Stress (RSS) fields inside and downstream of three d...

journal_title：Annals of biomedical engineering

authors： Leo HL,Dasi LP,Carberry J,Simon HA,Yoganathan AP

更新日期：2006-06-01 00:00:00

abstract：:Although medical specialties have recognized the importance of using ultrasonic imaging, dentistry is only beginning to discover its benefit. This has particularly been important in the field of periodontics which studies infections in the gum and bone tissues that surround the teeth. This study investigates the feasi...

journal_title：Annals of biomedical engineering

authors： Mahmoud AM,Ngan P,Crout R,Mukdadi OM

更新日期：2010-11-01 00:00:00