Electrophysiological modeling of fibroblasts and their interaction with myocytes.

abstract：:In order to obtain the first quantitative measurements of the in vivo stresses in early-stage amphibian embryos, we developed a novel instrument that uses a pair of parallel wires that are glued to the surface of an embryo normal to the direction in which the stress is to be determined. When a slit is made parallel to...

journal_title：Annals of biomedical engineering

authors： Benko R,Brodland GW

更新日期：2007-04-01 00:00:00

abstract：:Previous research in cellular adhesion has focused primarily on studying isolated cells under conditions where cells do not interact with each other. However, in vivo cells form sheets where both cell-substratum and cell-cell interactions contribute to the overall adhesive behavior. Our understanding of how cell-cell ...

journal_title：Annals of biomedical engineering

authors： Peel MM,DiMilla PA

更新日期：1999-03-01 00:00:00

abstract：:An algorithm to track a rat swimming in a Morris Water Maze has been developed. The system is automatically configured to any pool and relative suitable light conditions. It tracks the rat's position and head pose 10 times per second. The output data is displayed in a bitmap and also in a text file. The system was tes...

journal_title：Annals of biomedical engineering

authors： Hval ES,Barrett SF,Wilcox M,Bailey TA

更新日期：2004-08-01 00:00:00

abstract：:Based on mathematical expressions governing the electric field, the extracellular potentials generated by a single active fiber in a restricted circular cylindrical volume conductor are evaluated. This paper examines the effect of the extent of the volume conductor, with radius b, on the extracellular potentials at di...

journal_title：Annals of biomedical engineering

authors： Trayanova N,Henriquez CS,Plonsey R

更新日期：1990-01-01 00:00:00

abstract：:Viscous shear stress and Reynolds stress are often used to predict hemolysis and thrombosis due to flow-induced stress on blood elements in cardiovascular devices. These macroscopic stresses are distinct from the true stress on an individual cell, which is determined by the local microscale flow field. In this paper t...

journal_title：Annals of biomedical engineering

authors： Quinlan NJ,Dooley PN

更新日期：2007-08-01 00:00:00

abstract：:This study proposes magnetic resonance (MR)-measurement-integrated (MR-MI) simulation, in which the difference between the computed velocity field and the phase-contrast MRI measurement data is fed back to the numerical simulation. The computational accuracy and the fundamental characteristics, such as steady characte...

journal_title：Annals of biomedical engineering

authors： Funamoto K,Suzuki Y,Hayase T,Kosugi T,Isoda H

更新日期：2009-06-01 00:00:00

abstract：:Proper replacement or repair of damaged tendons or ligaments requires functionally engineered tissue that mimics their native mechanical properties. While tendon structure-function relationships are generally assumed, there exists little quantitative evidence of the roles of distinct tendon components in tendon functi...

journal_title：Annals of biomedical engineering

authors： Robinson PS,Lin TW,Jawad AF,Iozzo RV,Soslowsky LJ

更新日期：2004-07-01 00:00:00

abstract：:Pressure ulcers (PUs) can occur in any situations where people are subjected to non-uniform distribution of pressure over a prolonged period. They can have devastating effects on the patients' well-being and in extreme conditions can prove fatal. In addition to traditional wisdom implicating mechanically induced ischa...

journal_title：Annals of biomedical engineering

authors： Mirtaheri P,Gjøvaag T,Worsley PR,Bader DL

更新日期：2015-02-01 00:00:00

abstract：:Wiener static nonlinear system identification was used to study the linear dynamics and static nonlinearities in the response of skin and underlying tissue under indentation in vivo. A device capable of measuring the dynamic mechanical properties of bulk skin tissue was developed and it incorporates a custom-built Lor...

journal_title：Annals of biomedical engineering

authors： Chen Y,Hunter IW

更新日期：2012-10-01 00:00:00

abstract：:Parameters of physiological models are commonly associated in an input-output experiment with a specific pattern of the system response. This association is often made on an intuitive basis by traditional sensitivity analysis, i.e., by inspecting the variations of model output trajectories with respect to parameter va...

journal_title：Annals of biomedical engineering

authors： Thomaseth K,Cobelli C

更新日期：1999-09-01 00:00:00

abstract：:Some investigators have attempted to estimate the Reynolds shear stress on the basis of a single component of velocity. The purpose of this investigation is to determine the validity of such estimates in a complex flow field, such as occurs in the cardiovascular system in the region of the aortic valve. Turbulent velo...

journal_title：Annals of biomedical engineering

authors： Walburn FJ,Sabbah HN,Stein PD

更新日期：1985-01-01 00:00:00

abstract：:A number of human head finite element (FE) models have been developed from different research groups over the years to study the mechanisms of traumatic brain injury. These models can vary substantially in model features and parameters, making it important to evaluate whether simulation results from one model are read...

journal_title：Annals of biomedical engineering

authors： Ji S,Ghadyani H,Bolander RP,Beckwith JG,Ford JC,McAllister TW,Flashman LA,Paulsen KD,Ernstrom K,Jain S,Raman R,Zhang L,Greenwald RM

更新日期：2014-01-01 00:00:00

abstract：:Congenital heart disease is the leading cause of infant death in the United States with over 36,000 newborns affected each year. Despite this growing problem there are few mechanical circulatory support devices designed specifically for pediatric and neonate patients. Previous research has been done investigating pedi...

journal_title：Annals of biomedical engineering

authors： Good BC,Deutsch S,Manning KB

更新日期：2016-04-01 00:00:00

abstract：:To study pulsatile pressure-flow rate relationships in the intact pulmonary vascular network of mice, we developed a protocol for measuring pulmonary vascular resistance and impedance in isolated, ventilated, and perfused mouse lungs. We used pulmonary emboli to validate the effect of vascular obstruction on resistanc...

journal_title：Annals of biomedical engineering

authors： Tuchscherer HA,Webster EB,Chesler NC

更新日期：2006-04-01 00:00:00

abstract：:We propose a mathematical model for analyses of the elastic properties of the wall of the outer hair cell (OHC) in the inner ear. The model reflects the properties of the major components of the OHC wall: the subsurface cisternae, the cortical lattice, the plasma membrane, and the radial pillars. The wall is treated a...

journal_title：Annals of biomedical engineering

authors： Spector AA,Brownell WE,Popel AS

更新日期：1998-01-01 00:00:00

abstract：:Nanomedicine (a division of nanotechnology) is an interdisciplinary research field incorporating biology, chemistry, engineering and medicine with the intention to improve disease prevention, diagnosis, and treatment. Specifically, there have been great strides made in using nanomedicine to enhance the functions of ce...

journal_title：Annals of biomedical engineering

authors： Chun YW,Webster TJ

更新日期：2009-10-01 00:00:00

abstract：:In this work, we propose an analog electrical model of the coronary circulation for patients with obstructive disease undergoing revascularization. In this clinical situation, the collateral circulation to the occluded artery is difficult to ascertain via preoperative measurements and well-developed collaterals might ...

journal_title：Annals of biomedical engineering

authors： Maasrani M,Verhoye JP,Corbineau H,Drochon A

更新日期：2008-07-01 00:00:00

abstract：:This study aimed to quantify the elongation patterns of the collateral ligaments following TKA during functional activities of daily living. Using mobile video-fluoroscopy to capture radiographic images of the knee in a group of six patients, each with an ultra-congruent knee implant, tibiofemoral kinematics were reco...

journal_title：Annals of biomedical engineering

authors： Hosseini Nasab SH,Smith CR,Schütz P,Damm P,Trepczynski A,List R,Taylor WR

更新日期：2020-04-01 00:00:00

abstract：:In previous shoulder impact studies, the 50th-percentile male GHBMC human body finite-element model was shown to have good biofidelity regarding impact force, but under-predicted shoulder deflection by 80% compared to those observed in the experiment. The goal of this study was to validate the response of the GHBMC M5...

journal_title：Annals of biomedical engineering

authors： Park G,Kim T,Panzer MB,Crandall JR

更新日期：2016-08-01 00:00:00

abstract：:Recent advances in angioplasty have involved the application of polymer coatings to stent surfaces for purposes of drug delivery. Given the high levels of deformation developed in the plastic hinge of a stent during deployment, the achievement of an intact bond between the coating and the stent presents a significant ...

journal_title：Annals of biomedical engineering

authors： Hopkins CG,McHugh PE,McGarry JP

更新日期：2010-07-01 00:00:00

abstract：:Perfusion bioreactors are known to exert shear stresses on cultured cells, leading to cell differentiation and enhanced extracellular matrix deposition on scaffolds. The influence of the scaffold's porous microstructure is investigated for a polycaprolactone (PCL) scaffold with a regular microarchitecture and a silk f...

journal_title：Annals of biomedical engineering

authors： Zermatten E,Vetsch JR,Ruffoni D,Hofmann S,Müller R,Steinfeld A

更新日期：2014-05-01 00:00:00

abstract：:Gas transfer through hollow fiber membranes (HFMs) can be increased via fiber oscillation. Prior work, however, does not directly translate to present-day, full-scale artificial lungs. This in vitro study characterized the effects of HFM oscillations on oxygenation and hemolysis for a pediatric-sized HFM bundle. Effec...

journal_title：Annals of biomedical engineering

authors： Orizondo RA,Gino G,Sultzbach G,Madhani SP,Frankowski BJ,Federspiel WJ

更新日期：2018-05-01 00:00:00

abstract：:Membrane introduction mass spectrometry has been applied to inert gas measurements in blood and tissue, but gases with low blood solubility are associated with reduced sensitivity. Countercurrent extraction of inert gases from a blood sample into a water carrier phase has the potential to extract most of the gas sampl...

journal_title：Annals of biomedical engineering

authors： Baumgardner JE,Neufeld GR

更新日期：1997-09-01 00:00:00

abstract：:The planar fibrous connective tissues of the body are composed of a dense extracellular network of collagen and elastin fibers embedded in a ground matrix, and thus can be thought of as biocomposites. Thus, the quantification of fiber architecture is an important step in developing an understanding of the mechanics of...

journal_title：Annals of biomedical engineering

authors： Sacks MS,Smith DB,Hiester ED

更新日期：1997-07-01 00:00:00

abstract：:Dual X-ray absorptiometry (DXA) measures areal bone mineral density (aBMD) by simplifying a complex 3D bone structure to a 2D projection and is not equally effective for explaining fracture strength in women and men. Unlike DXA, subject-specific quantitative computed tomography-based finite element analysis (QCT/FEA) ...

journal_title：Annals of biomedical engineering

authors： Rezaei A,Giambini H,Rossman T,Carlson KD,Yaszemski MJ,Lu L,Dragomir-Daescu D

更新日期：2017-12-01 00:00:00

abstract：:Deformational loading represents a primary component of the chondrocyte physical environment in vivo. This review summarizes our experience with physiologic deformational loading of chondrocyte-seeded agarose hydrogels to promote development of cartilage constructs having mechanical properties matching that of the par...

journal_title：Annals of biomedical engineering

authors： Hung CT,Mauck RL,Wang CC,Lima EG,Ateshian GA

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:This work explores for the first time the effects of temperature increments on the development of high shear stresses between plaque and arterial wall due to their different dilatational properties. Data from the literature report febrile reactions prior to myocardial infarction in patients with normal coron...

journal_title：Annals of biomedical engineering

authors： Guinea GV,Atienza JM,Fantidis P,Rojo FJ,Ortega A,Torres M,Gonzalez P,Elices ML,Hayashi K,Elices M

更新日期：2008-01-01 00:00:00

abstract：:The blood-brain barrier (BBB) is a major obstacle for drug delivery to the brain. To seek for in vitro BBB models that are more accessible than animals for investigating drug transport across the BBB, we compared four in vitro cultured cell models: endothelial monoculture (bEnd3 cell line), coculture of bEnd3 and prim...

journal_title：Annals of biomedical engineering

authors： Li G,Simon MJ,Cancel LM,Shi ZD,Ji X,Tarbell JM,Morrison B 3rd,Fu BM

更新日期：2010-08-01 00:00:00

abstract：:An MR image-based computational model of a murine KHT sarcoma is presented that allows the calculation of plasma fluid and solute transport within tissue. Such image-based models of solid tumors may be used to optimize patient-specific therapies. This model incorporates heterogeneous vasculature and tissue porosity to...

journal_title：Annals of biomedical engineering

authors： Pishko GL,Astary GW,Mareci TH,Sarntinoranont M

更新日期：2011-09-01 00:00:00

abstract：:The traditional auscultatory technique and current methodologies for measuring human blood pressure are limited when used in situations where extreme vibration or acoustic noise is present. In this study, human subjects were used to establish the effectiveness of a novel adaptive blood pressure monitoring (ABPM) syste...

journal_title：Annals of biomedical engineering

authors： Pinto L,Dhanantwari A,Wong W,Stergiopoulos S,Maris M

更新日期：2002-05-01 00:00:00