Abstract:
:Development of increasingly complex integrated cellular systems will be a major challenge for the next decade and beyond, as we apply the knowledge gained from the sub-disciplines of regenerative medicine, synthetic biology, micro-fabrication and nanotechnology, systems biology, and developmental biology. In this prospective, we describe the current state-of-the-art in the assembly of source cells, derived from pluripotent cells, into populations of a single cell type to produce the components or building blocks of higher order systems and finally, combining multiple cell types, possibly in combination with scaffolds possessing specific physical or chemical properties, to produce higher level functionality. We also introduce the issue, questions and ample research opportunities to be explored by others in the field. As these "living machines" increase in capabilities, exhibit emergent behavior and potentially reveal the ability for self-assembly, self-repair, and even self-replication, questions arise regarding the ethical implications of this work. Future prospects as well as ways of addressing these complex ethical questions will be discussed.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Kamm RD,Bashir Rdoi
10.1007/s10439-013-0902-7subject
Has Abstractpub_date
2014-02-01 00:00:00pages
445-59issue
2eissn
0090-6964issn
1573-9686journal_volume
42pub_type
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