A preliminary physiologically based pharmacokinetic model for naphthalene and naphthalene oxide in mice and rats.

abstract：:A cohesive zone model (CZM) approach is applied to simulate atherosclerotic plaque delamination experiments in mouse abdominal aorta specimens. A three-dimensional finite element model is developed for the experiments. The aortic wall is treated as a fiber-reinforced, highly deformable, incompressible material, and th...

journal_title：Annals of biomedical engineering

authors： Leng X,Chen X,Deng X,Sutton MA,Lessner SM

更新日期：2015-12-01 00:00:00

abstract：:Left ventricular (LV) diastolic filling is limited by the constraining effects exerted by the pericardium (PE) and the lung/chest wall. The aim of the present study was to assess the validity of various estimates of external cardiac constraint, compared to pericardial surface pressure (Ppe) measured lateral to the LV ...

journal_title：Annals of biomedical engineering

authors： Kingma I,Smiseth OA,Frais MA,Smith ER,Tyberg JV

更新日期：1987-01-01 00:00:00

abstract：:It is widely recognized that the bacteria sequestered in a biofilm on a medical implant are much more resistant to antibiotics than their planktonic counterparts. Recent studies have shown that application of antibiotic along with low power ultrasound significantly increases the killing of planktonic bacteria by the a...

journal_title：Annals of biomedical engineering

authors： Qian Z,Sagers RD,Pitt WG

更新日期：1997-01-01 00:00:00

abstract：:We describe a system for real-time control of biological and other experiments. This device, based around the Real-Time Linux operating system, was tested specifically in the context of dynamic clamping, a demanding real-time task in which a computational system mimics the effects of nonlinear membrane conductances in...

journal_title：Annals of biomedical engineering

authors： Dorval AD,Christini DJ,White JA

更新日期：2001-10-01 00:00:00

abstract：:This paper describes the development and use of a direct compression stimulator for culturing explants from the meniscus of the knee and articular cartilage. Following design and fabrication of the instrument along with its data acquisition system, the function of the machine was verified by both mechanical means and ...

journal_title：Annals of biomedical engineering

authors： Aufderheide AC,Athanasiou KA

更新日期：2006-09-01 00:00:00

abstract：:The longitudinal assessment of joint health is a long-standing issue in the management of musculoskeletal injuries. The acoustic emissions (AEs) produced by joint articulation could serve as a biomarker for joint health assessment, but their use has been limited by a lack of mechanistic understanding of their creation...

journal_title：Annals of biomedical engineering

authors： Whittingslow DC,Jeong HK,Ganti VG,Kirkpatrick NJ,Kogler GF,Inan OT

更新日期：2020-01-01 00:00:00

abstract：:We attempted to estimate in living adherent epithelial alveolar cells, the degree of structural and mechanical heterogeneity by considering two individualized cytoskeleton components, i.e., a submembranous "cortical" cytoskeleton and a "deep" cytoskeleton (CSK). F-actin structure characterizing each CSK component was ...

journal_title：Annals of biomedical engineering

authors： Laurent VM,Fodil R,Cañadas P,Féréol S,Louis B,Planus E,Isabey D

更新日期：2003-11-01 00:00:00

abstract：:Membrane introduction mass spectrometry has been applied to inert gas measurements in blood and tissue, but gases with low blood solubility are associated with reduced sensitivity. Countercurrent extraction of inert gases from a blood sample into a water carrier phase has the potential to extract most of the gas sampl...

journal_title：Annals of biomedical engineering

authors： Baumgardner JE,Neufeld GR

更新日期：1997-09-01 00:00:00

abstract：:In uniaxial tensile testing, load preconditioning is used to generate repeatable load/elongation curves and set a "reference state" for subsequent tensile tests. We have observed however, that for porcine aortic valve (PAV) tissues, preconditioning does not lead to repeatable stress relaxation curves. We thus investig...

journal_title：Annals of biomedical engineering

authors： Carew EO,Garg A,Barber JE,Vesely I

更新日期：2004-04-01 00:00:00

abstract：:In order to increase the probability of having a successful cataract post-surgery, the customisation of the haptic design of the intraocular lens (IOL) according to the characteristics of the patient is recommended. In this study, we present two prediction models based on deep neural networks (DNNs). One is capable of...

journal_title：Annals of biomedical engineering

authors： Cabeza-Gil I,Ríos-Ruiz I,Calvo B

更新日期：2020-12-01 00:00:00

abstract：:The function of a chamber depends on its hydrodynamic properties: isometric pressures it can exert in the operating range of distensions, compliances in the operating range of distensions, and wall-displacement resistances in the operating range of distensions. Wall-displacement resistance is the departure of pressure...

journal_title：Annals of biomedical engineering

authors： Regen DM

更新日期：1988-01-01 00:00:00

abstract：:Rod photoreceptors express a unique type of noninactivating potassium channels, Kx channels, which play an important role in setting the dark potential and participate in shaping the light response. Biophysical studies of Kx channels are limited. For example, the effects of a conventional blocker of potassium channels...

journal_title：Annals of biomedical engineering

authors： Liu XD,Kourennyi DE

更新日期：2004-10-01 00:00:00

abstract：:The manner in which energy from an explosion is transmitted into the brain is currently a highly debated topic within the blast injury community. This study was conducted to investigate the injury biomechanics causing blast-related neurotrauma in the rat. Biomechanical responses of the rat head under shock wave loadin...

journal_title：Annals of biomedical engineering

authors： Bolander R,Mathie B,Bir C,Ritzel D,VandeVord P

更新日期：2011-10-01 00:00:00

abstract：:The effects of tissue hydration and fixed charge density on hydraulic permeability and creep behavior of cartilaginous tissues have been investigated using the triphasic theory and finite element methods. The empirical model for hydraulic permeability of uncharged gels and Mackie and Meares (1955) model for ion diffus...

journal_title：Annals of biomedical engineering

authors： Gu WY,Yao H

更新日期：2003-11-01 00:00:00

abstract：:Osteoarthritis (OA) is a progressive, degenerative disease of articulating joints that not only affects the elderly, but also involves younger, more active individuals with prolonged participation in high physical-demand activities. Thus, effective therapies that are easy to adopt clinically are critical in limiting t...

journal_title：Annals of biomedical engineering

authors： Holyoak DT,Tian YF,van der Meulen MC,Singh A

更新日期：2016-06-01 00:00:00

abstract：:Deep tissue injury (DTI) is a type of pressure ulcer in which tissue breakdown initiates at the bone-muscle interface under intact skin. Excessive deformation in the soft tissue, particularly around bony prominences, is believed to be one of the causes leading to the development of DTI. The main goal of this study was...

journal_title：Annals of biomedical engineering

authors： Solis LR,Liggins AB,Seres P,Uwiera RR,Poppe NR,Pehowich E,Thompson RB,Mushahwar VK

更新日期：2012-08-01 00:00:00

abstract：:The influence of scaffold compliance on blood vessel tissue engineering remains unclear and compliance mismatch issues are important to an in vivo tissue-engineering approach. We have designed and constructed a modular bioreactor system that is capable of imparting pulsatile fluid flow while simultaneously measuring v...

journal_title：Annals of biomedical engineering

authors： Webb AR,Macrie BD,Ray AS,Russo JE,Siegel AM,Glucksberg MR,Ameer GA

更新日期：2007-08-01 00:00:00

abstract：:Children with cerebral palsy frequently experience foot dragging and tripping during walking due to a lack of adequate knee flexion in swing (stiff-knee gait). Stiff-knee gait is often accompanied by an overly flexed knee during stance (crouch gait). Studies on stiff-knee gait have mostly focused on excessive knee mus...

journal_title：Annals of biomedical engineering

authors： van der Krogt MM,Bregman DJ,Wisse M,Doorenbosch CA,Harlaar J,Collins SH

更新日期：2010-04-01 00:00:00

abstract：:Basic fibroblast growth factor (FGF-2) is a potent angiogenic growth factor involved in the development of diseases such as cancer, atherosclerosis, and heart and limb ischemia, as well as normal wound healing and tissue development. Despite being one of the most heavily studied angiogenic growth factors, the binding ...

journal_title：Annals of biomedical engineering

authors： Filion RJ,Popel AS

更新日期：2004-05-01 00:00:00

abstract：:Coronary artery bypass graft (CABG) failure has been linked to graft hemodynamics, in particular wall shear stress. This study characterizes the morphology, geometry and wall shear stress patterns in human CABGs. The intimal thickness (IT) in 49 human saphenous vein CABGs was measured by digital light microscopy. The ...

journal_title：Annals of biomedical engineering

authors： Leask RL,Butany J,Johnston KW,Ethier CR,Ojha M

更新日期：2005-03-01 00:00:00

abstract：:Rapid screening of biomarkers, with high specificity and accuracy, is critical for many point-of-care diagnostics. Microfluidics, the use of microscale channels to manipulate small liquid samples and carry reactions in parallel, offers tremendous opportunities to address fundamental questions in biology and provide a ...

journal_title：Annals of biomedical engineering

authors： Ng E,Chen K,Hang A,Syed A,Zhang JX

更新日期：2016-04-01 00:00:00

abstract：:A number of human head finite element (FE) models have been developed from different research groups over the years to study the mechanisms of traumatic brain injury. These models can vary substantially in model features and parameters, making it important to evaluate whether simulation results from one model are read...

journal_title：Annals of biomedical engineering

authors： Ji S,Ghadyani H,Bolander RP,Beckwith JG,Ford JC,McAllister TW,Flashman LA,Paulsen KD,Ernstrom K,Jain S,Raman R,Zhang L,Greenwald RM

更新日期：2014-01-01 00:00:00

abstract：:In physiological conditions, joint function involves continuously moving contact areas over the tissue surface. Such moving contacts play an important role for the durability of the tissue. It is known that in pathological joints these motion paths and contact mechanics change. Nevertheless, limited information exists...

journal_title：Annals of biomedical engineering

authors： Schätti OR,Gallo LM,Torzilli PA

更新日期：2016-08-01 00:00:00

abstract：:Impedance data, e.g., system responses, from perturbing small amplitude applied sinusoid signals of near DC to high kilohertz frequencies, give chemical information. Analysis of frequency-dependent imaginary and real impedance proceeds from equivalent analog circuit elements to chemical and physical significance deter...

journal_title：Annals of biomedical engineering

authors： Buck RP

更新日期：1992-01-01 00:00:00

abstract：:To study the effects of compressive straining on muscle cell deformation and damage an in vitro model system was developed. Myoblasts were seeded in agarose constructs and cultured in growth medium for 4 days. Subsequently, the cells were allowed to fuse into multinucleated myotubes for 8 days in differentiation mediu...

journal_title：Annals of biomedical engineering

authors： Bouten CV,Knight MM,Lee DA,Bade DL

更新日期：2001-02-01 00:00:00

abstract：:The statistical distribution of von Mises stress in the trabeculae of human vertebral cancellous bone was estimated using large-scale finite element models. The goal was to test the hypothesis that average trabecular von Mises stress is correlated to the maximum trabecular level von Mises stress. The hypothesis was pr...

journal_title：Annals of biomedical engineering

authors： Fyhrie DP,Hoshaw SJ,Hamid MS,Hou FJ

更新日期：2000-01-01 00:00:00

abstract：:For several years, Virginia Tech and other schools have measured the frequency and severity of head impacts sustained by collegiate American football players in real time using the Head Impact Telemetry (HIT) System of helmet-mounted accelerometers. In this study, data from 37,128 head impacts collected at Virginia Te...

journal_title：Annals of biomedical engineering

authors： Funk JR,Rowson S,Daniel RW,Duma SM

更新日期：2012-01-01 00:00:00

abstract：:Irreversible electroporation (IRE), is a new non-thermal tissue ablation technology in which brief high electric field pulses are delivered across the target tissue to induce cell death by irreversible permeabilization of the cell membrane. A deficiency of conventional IRE is that the ablation zone is relatively small...

journal_title：Annals of biomedical engineering

authors： Lv Y,Yao C,Rubinsky B

更新日期：2019-07-01 00:00:00

abstract：:We describe a model for the Compound Action Currents (CACs) and Compound Action Potentials (CAPs) produced by a peripheral nerve bundle in vitro. The Single Fiber Action Currents (SFACs) and the extracellular Single Fiber Action Potentials (SFAPs) are calculated using a generalized volume conduction model. Frequency-d...

journal_title：Annals of biomedical engineering

authors： Wijesinghe RS,Gielen FL,Wikswo JP Jr

更新日期：1991-01-01 00:00:00

abstract：:We examine the influence of the added mass effect (fluid inertia) on mitral valve leaflet stress during isovolumetric phases. To study this effect, oscillating flow is applied to a flexible membrane at various frequencies to control inertia. Resulting membrane strain is calculated through a three-dimensional reconstru...

journal_title：Annals of biomedical engineering

authors： Bark DL Jr,Dasi LP

更新日期：2016-05-01 00:00:00