Computational approach to estimating the effects of blood properties on changes in intra-stent flow.

abstract：:The temporal and spatial distribution of coronary blood flow, pressure, and volume are determined by the branching pattern and three-dimensional (3-D) geometry of the coronary vasculature, and by the mechanics of heart wall and vascular tone. Consequently, a realistic simulation of coronary blood flow requires, as a f...

journal_title：Annals of biomedical engineering

authors： Kaimovitz B,Lanir Y,Kassab GS

更新日期：2005-11-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is caused by extensive pulmonary vascular remodeling that increases right ventricular (RV) afterload and leads to RV failure. PAH predominantly affects women; paradoxically, female PAH patients have better outcomes than men. The roles of estrogen in PAH remain controversial, which...

journal_title：Annals of biomedical engineering

authors： Liu A,Hacker T,Eickhoff JC,Chesler NC

更新日期：2017-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is an irreversible brain disorder which represents the most common form of dementia in western countries. An early and accurate diagnosis of AD would enable to develop new strategies for managing the disease; however, nowadays there is no single test that can accurately predict the development...

journal_title：Annals of biomedical engineering

authors： Alonso JF,Poza J,Mañanas MA,Romero S,Fernández A,Hornero R

更新日期：2011-01-01 00:00:00

abstract：:"Smart" drug delivery systems should be selective and effective to ensure drug administration at the right time, at the right dosage, and anywhere in the body. Among the several administration routes and delivery systems that have been proposed, one of the most effective and promising is based on microfabricated parti...

journal_title：Annals of biomedical engineering

authors： Decuzzi P,Lee S,Decuzzi M,Ferrari M

更新日期：2004-06-01 00:00:00

abstract：:Lung cancer patients often suffer from severe airway stenosis, the symptoms of which can be relieved by the implantation of stents. Different respiratory stents are commercially available, but the impact of their mechanical performance on tissue responses is not well understood. Two novel laser-cut and hand-braided ni...

journal_title：Annals of biomedical engineering

authors： Thiebes AL,McGrath DJ,Kelly N,Sweeney CA,Kurtenbach K,Gesché VN,Clauser J,O'Brien B,Bruzzi M,McHugh PE,Jockenhoevel S,Cornelissen CG

更新日期：2019-08-01 00:00:00

abstract：:Tendon stem cells (TSCs) may be used to effectively repair or regenerate injured tendons. However, the fates of TSCs once implanted in vivo remain unclear. This study was aimed to determine the feasibility of labeling TSCs with super-paramagnetic iron oxide (SPIO) nano-particles to track TSCs in vivo using MRI. Rabbit...

journal_title：Annals of biomedical engineering

authors： Yang Y,Zhang J,Qian Y,Dong S,Huang H,Boada FE,Fu FH,Wang JH

更新日期：2013-10-01 00:00:00

abstract：:In physiological conditions, joint function involves continuously moving contact areas over the tissue surface. Such moving contacts play an important role for the durability of the tissue. It is known that in pathological joints these motion paths and contact mechanics change. Nevertheless, limited information exists...

journal_title：Annals of biomedical engineering

authors： Schätti OR,Gallo LM,Torzilli PA

更新日期：2016-08-01 00:00:00

abstract：:Patients with aortic stenosis present with calcium deposits on the native aortic valve, which can result in non-concentric expansion of Transcatheter Aortic Valve Replacement (TAVR) stents. The objective of this study is to evaluate whether eccentric deployment of TAVRs lead to turbulent blood flow and blood cell dama...

journal_title：Annals of biomedical engineering

authors： Gunning PS,Saikrishnan N,McNamara LM,Yoganathan AP

更新日期：2014-06-01 00:00:00

abstract：:Uncomplicated acute type B aortic dissections are usually treated medically, but they can become acutely complicated by rapid expansion, rupture and malperfusion syndromes and in the longer term by chronic dilatation and aortic aneurysm formation. The objective of this study is to use computational fluid dynamics reco...

journal_title：Annals of biomedical engineering

authors： Cheng Z,Wood NB,Gibbs RG,Xu XY

更新日期：2015-01-01 00:00:00

abstract：:Radiation applied for therapy and diagnostics damages molecular/atomic couples of biotissues, bones being among them. As a result, electron peculiarities and mechanical behavior of the latter are altered. Correlation between strength of the irradiated bone and its electron features explored due to photo- and exoelectr...

journal_title：Annals of biomedical engineering

authors： Dekhtyar Y

更新日期：2001-12-01 00:00:00

abstract：:User preferences need to be taken into account in order to be able to design devices that will gain acceptance both in a clinical and home setting. Sensor systems become redundant if patients or clinicians do not want to work with them. The aim of this systematic review was to determine both patients' and clinicians' ...

journal_title：Annals of biomedical engineering

authors： Bergmann JH,McGregor AH

更新日期：2011-09-01 00:00:00

abstract：:We have studied the interaction of high frequency jet ventilation with cardiovascular pressures and flows. Results in dogs show that the amplitude of all intrathoracic pressures and flows fluctuate with a frequency equal to the difference between the heart rate and ventilator rate. The magnitude of this amplitude vari...

journal_title：Annals of biomedical engineering

authors： Mitzner W,Gioia F,Weinmann GG,Robotham JL,Ehrlich W

更新日期：1987-01-01 00:00:00

abstract：:Current efforts to evaluate the performance of laparoscopic arterial fusion devices are limited to costly, time consuming, empirical studies. Thus, a finite element (FE) model, with the ability to predict device performance would improve device design and reduce development time and costs. This study introduces a mode...

journal_title：Annals of biomedical engineering

authors： Fankell DP,Kramer E,Cezo J,Taylor KD,Ferguson VL,Rentschler ME

更新日期：2016-11-01 00:00:00

abstract：:A major benefit of computational modeling in biomechanics research is its ability to estimate internal muscular demands given limited input information. However, several assumptions regarding model parameters and constraints may influence model outputs. This research evaluated the influence of model parameter variabil...

journal_title：Annals of biomedical engineering

authors： Chopp-Hurley JN,Langenderfer JE,Dickerson CR

更新日期：2014-09-01 00:00:00

abstract：:In this study we present a novel, robust method to couple finite element (FE) models of cardiac mechanics to systems models of the circulation (CIRC), independent of cardiac phase. For each time step through a cardiac cycle, left and right ventricular pressures were calculated using ventricular compliances from the FE...

journal_title：Annals of biomedical engineering

authors： Kerckhoffs RC,Neal ML,Gu Q,Bassingthwaighte JB,Omens JH,McCulloch AD

更新日期：2007-01-01 00:00:00

abstract：:The objective of this paper is to review the theoretical basis and clinical application of electrical impedance plethysmography in the noninvasive evaluation of peripheral arterial and venous disease. Theoretical, experimental and clinical studies have not demonstrated a direct relationship between electrical impedanc...

journal_title：Annals of biomedical engineering

authors： Zuech PE,Cobbold RS,Johnston KW,Kassam M

更新日期：1984-01-01 00:00:00

abstract：:Electromechanical reshaping (EMR) of cartilage provides an alternative to the classic surgical techniques of modifying the shape of facial cartilages. The original embodiment of EMR required surface electrodes to be in direct contact with the entire cartilage region being reshaped. This study evaluates the feasibility...

journal_title：Annals of biomedical engineering

authors： Manuel CT,Foulad A,Protsenko DE,Sepehr A,Wong BJ

更新日期：2010-11-01 00:00:00

abstract：:Traditionally, measurement of pulmonary O2 uptake uses mass balance of N2 to correct for differences between inspired and expired volume (V) due to temperature (T) and relative humidity (RH). Often during anesthesia, N2 balance cannot be invoked due to high inspired O2 fraction (FIO2) or nonsteady state conditions. Th...

journal_title：Annals of biomedical engineering

authors： Breen PH

更新日期：2000-09-01 00:00:00

abstract：:Collagen, the most commonly used extra-cellular matrix protein for tissue engineering applications, displays poor mechanical properties. Here, we report on the preparation and characterization of novel multi-component composite systems that incorporate a genetically engineered, biocompatible polymer (elastin-like poly...

journal_title：Annals of biomedical engineering

authors： Wheeler TS,Sbravati ND,Janorkar AV

更新日期：2013-10-01 00:00:00

abstract：:Lung cancer is a leading cause of death worldwide. Radiation therapy (RT) is one method to treat this disease. A common side effect of RT for lung cancer is radiation-induced lung damage (RILD) which leads to loss of lung function. RILD often compounds pre-existing smoking-related regional lung function impairment. It...

journal_title：Annals of biomedical engineering

authors： Dong Y,Kumar H,Tawhai M,Veiga C,Szmul A,Landau D,McClelland J,Lao L,Burrowes KS

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:This work explores for the first time the effects of temperature increments on the development of high shear stresses between plaque and arterial wall due to their different dilatational properties. Data from the literature report febrile reactions prior to myocardial infarction in patients with normal coron...

journal_title：Annals of biomedical engineering

authors： Guinea GV,Atienza JM,Fantidis P,Rojo FJ,Ortega A,Torres M,Gonzalez P,Elices ML,Hayashi K,Elices M

更新日期：2008-01-01 00:00:00

abstract：:Changes in fetal magnetocardiographic (fMCG) signals are indicators for fetal body movement. We propose a novel approach to reliably extract fetal body movements based on the field strength of the fMCG signal independent of its frequency. After attenuating the maternal MCG, we use a Hilbert transform approach to ident...

journal_title：Annals of biomedical engineering

authors： Govindan RB,Vairavan S,Ulusar UD,Wilson JD,McKelvey SS,Preissl H,Eswaran H

更新日期：2011-03-01 00:00:00

abstract：:Computing the numerical solution of the bidomain equations is widely accepted to be a significant computational challenge. In this study we extend a previously published semi-implicit numerical scheme with good stability properties that has been used to solve the bidomain equations (Whiteley, J.P. IEEE Trans. Biomed. ...

journal_title：Annals of biomedical engineering

authors： Whiteley JP

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:We present a fundamental theoretical framework for analysis of energy dissipation in any component of the circulatory system and formulate the full energy budget for both venous and arterial circulations. New indices allowing disease-specific subject-to-subject comparisons and disease-to-disease hemodynamic ...

journal_title：Annals of biomedical engineering

authors： Dasi LP,Pekkan K,de Zelicourt D,Sundareswaran KS,Krishnankutty R,Delnido PJ,Yoganathan AP

更新日期：2009-04-01 00:00:00

abstract：:Hemodynamic forces are known to be able to induce an inflammatory phenotype in endothelial cells (ECs). The EC glycocalyx (GCX) is a dynamic structure which is regulated in response to different stimuli and hypothesized as an important contributor to the mechanotransduction of wall shear stresses (WSS). In this work, ...

journal_title：Annals of biomedical engineering

authors： Cooper S,McDonald K,Burkat D,Leask RL

更新日期：2017-09-01 00:00:00

abstract：:A study that customizes the feature generator parameters of an asynchronous Brain Interface (BI) is discussed. The goal is to detect the presence of a certain pattern, in the ongoing EEG, associated with a specific movement and to improve the system's performance. Results of this study show that customization mostly b...

journal_title：Annals of biomedical engineering

authors： Bashashati A,Fatourechi M,Ward RK,Birch GE

更新日期：2006-06-01 00:00:00

abstract：:Acute cerebral ischemic events and thrombosis are associated with the rupture/erosion of carotid atherosclerotic plaques. The aim of the present study was to determine the impact of calcification deposition on the wall shear stress (WSS) and stresses within the plaques using 3D fluid-structure interaction (FSI) models...

journal_title：Annals of biomedical engineering

authors： Benitez J,Fontanarosa D,Wang J,Paritala PK,McGahan T,Lloyd T,Li Z

更新日期：2020-10-20 00:00:00

abstract：:A computer-controlled optical electromechanical biaxial test system was employed to study the mechanical response of excised sheets of canine visceral pleura. Three classes of tests were performed: uniform biaxial stretching tests and tests in which the specimen was cyclically stretched along one axis while either the...

journal_title：Annals of biomedical engineering

authors： Humphrey JD,Vawter DL,Vito RP

更新日期：1986-01-01 00:00:00

abstract：:Linear autoregressive (AR) model-based heart rate (HR) spectral analysis has been widely used to study HR dynamics. Owing to system and measurement noise, the parameters of an AR model have intrinsic statistical uncertainty. In this study, we evaluate how this AR parameter uncertainty can translate to uncertainty in H...

journal_title：Annals of biomedical engineering

authors： Christini DJ,Kulkarni A,Rao S,Stutman ER,Bennett FM,Hausdorff JM,Oriol N,Lutchen KR

更新日期：1995-03-01 00:00:00

abstract：:One goal of large scale clinical trials is to determine how a drug is processed by, and cleared from, the human body [i.e., its pharmacokinetic (PK) properties] and how these PK properties differ between individuals in a population (i.e., its population PK properties). Due to the high cost of these studies and the lim...

journal_title：Annals of biomedical engineering

authors： Hooker AC,Foracchia M,Dodds MG,Vicini P

更新日期：2003-01-01 00:00:00