Abstract：
:We propose a mathematical model for analyses of the elastic properties of the wall of the outer hair cell (OHC) in the inner ear. The model reflects the properties of the major components of the OHC wall: the subsurface cisternae, the cortical lattice, the plasma membrane, and the radial pillars. The wall is treated as a composite consisting of three elastic cylindrical shells. Two inner shells, isotropic and orthotropic/ are adjacent to each other, and the outermost isotropic shell is connected to the combined inner shell by elastic springs. We derive Flugge-type equations for the composite wall and apply the model to the interpretation of the experiments with axial loading and with inflation of the OHC. We derive expressions for the axial stiffness and the wall strains measured in these experiments in terms of the elastic properties of the wall components. We also consider a conceivable experiment with torsion of the OHC and obtain relations between the torque (the axial reaction) and the angle of torsion. These solutions provide necessary information for the future determination of the OHC elastic properties.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Spector AA,Brownell WE,Popel ASdoi
10.1114/1.87subject
Has Abstractpub_date
1998-01-01 00:00:00pages
157-65issue
1eissn
0090-6964issn
1573-9686journal_volume
26pub_type
杂志文章abstract：:Bone loss during long-term space flight is potentially a significant problem. Bone mineral density measurements show that bone is lost at a rate of about 1% per month from the lumbar spine, and 1.5% per month from the hip. Bone density changes are not uniform throughout the skeleton, and there is accumulating evidence...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章,评审
doi：10.1007/s10439-005-8967-6
更新日期：2005-01-01 00:00:00
abstract：:We have studied the dependence of conduction velocity (theta) on extracellular potassium concentration ([K+]o) in a model of one-dimensional conduction using an idealized strand of human atrial cells. Elevated [K+]o in the 5-20 mM range shifts the resting potential (Vrest) in the depolarizing direction and reduces inp...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1308489
更新日期：2000-08-01 00:00:00
abstract：:This paper presents the bispectral analysis of the ontogeny of the hippocampal EEG recorded from the dentate gyrus and CA1, the primary sites that generate theta (theta) rhythm. The hippocampal EEG was collected during the vigilance state of rapid eye movement (REM) sleep of freely moving rats at 15, 30 and 90 days of...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.43
更新日期：1998-07-01 00:00:00
abstract：:There is a significant clinical need for engineered bone graft substitutes that can quickly, effectively, and safely repair large segmental bone defects. One emerging field of interest involves the growth of engineered bone tissue in vitro within bioreactors, the most promising of which are perfusion bioreactors. Usin...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-016-1662-y
更新日期：2016-12-01 00:00:00
abstract：:Dynamic occlusal loading during mastication is clinically relevant in the design and functional assessment of dental restorations and removable dentures, and in evaluating temporomandibular joint dysfunction. The aim of this study was to develop a modelling framework to evaluate subject-specific dynamic occlusal loadi...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02688-6
更新日期：2021-01-06 00:00:00
abstract：:The long held assumption that sustained drug elution from stent coatings over weeks to months is imperative for clinical efficacy has limited the choice for stent coating materials. We developed and evaluated an omega-3 fatty acid (O3FA) based stent coating that is 85% absorbed and elutes 97% of its Sirolimus analog (...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1435-z
更新日期：2016-02-01 00:00:00
abstract：:Femoral neck fractures are a relevant clinical and social problem. The aim of this study was to improve the prediction of patients at-risk of femoral neck fracture with respect to the current densitometric-based methods. In particular, finite element models were used to assess the prediction accuracy obtained by combi...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1495866
更新日期：2002-06-01 00:00:00
abstract：:Articular cartilage is an avascular connective tissue responsible for bearing loads. Cell signaling plays a central role in cartilage homeostasis and tissue engineering by directing chondrocytes to synthesize/degrade the extracellular matrix or promote inflammatory responses. The aim of this paper was to investigate a...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-017-1964-8
更新日期：2018-02-01 00:00:00
abstract：:In order to obtain the first quantitative measurements of the in vivo stresses in early-stage amphibian embryos, we developed a novel instrument that uses a pair of parallel wires that are glued to the surface of an embryo normal to the direction in which the stress is to be determined. When a slit is made parallel to...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-006-9250-1
更新日期：2007-04-01 00:00:00
abstract：:Correct development of neuronal tracts requires the coordination of multiple permissive and inhibitory signals. By generating an in vitro microenvironment using soft lithography and microfluidic techniques, multiple guidance cues can be presented in a spatially defined way. Here we evaluated how neurites of dorsal roo...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-008-9486-z
更新日期：2008-06-01 00:00:00
abstract：:The unique resource constraints, urgency, and virulence of the coronavirus disease 2019 pandemic has sparked immense innovation in the development of barrier devices to protect healthcare providers from infectious airborne particles generated by patients during airway management interventions. Of the existing devices,...
journal_title：Annals of biomedical engineering
pub_type： 社论
doi：10.1007/s10439-020-02599-6
更新日期：2020-10-01 00:00:00
abstract：:Quantitative analysis of breast morphometry is critical to breast plastic surgery. Recently, three-dimensional (3D) photography has emerged as a strong new alternative for breast morphometry analysis in comparison to other existing techniques. 3D photography enables the capture of the entire breast surface topology vi...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-9971-z
更新日期：2010-05-01 00:00:00
abstract：:We hypothesize that variations of body anthropometry, conjointly with the bone strength, determine the risk of hip fracture. To test the hypothesis, we compared, in a simulated sideways fall, the hip impact energy to the energy needed to fracture the femur. Ten femurs from elderly donors were tested using a novel drop...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-020-02682-y
更新日期：2020-11-12 00:00:00
abstract：:Validation is a critical step in finite element model (FEM) development. This study focuses on the validation of the Global Human Body Models Consortium full body average male occupant FEM in five localized loading regimes-a chest impact, a shoulder impact, a thoracoabdominal impact, an abdominal impact, and a pelvic ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-015-1286-7
更新日期：2015-09-01 00:00:00
abstract：:A two-dimensional sheet model was used to study the dynamics of reentry around a zone of functional block. The sheet is a set of parallel, continuous, and uniform cables, transversely interconnected by a brick-wall arrangement of fixed resistors. In accord with experimental observations on cardiac tissue, longitudinal...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02368286
更新日期：1994-11-01 00:00:00
abstract：:The material properties of normal cadaveric human cartilage in the ankle mortice (tibiotalar articulation) were evaluated to determine a possible etiologic mechanism of cartilage injury of the ankle when an obvious traumatic episode is not present. Using an automated indentation apparatus and the biphasic creep indent...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02584467
更新日期：1995-09-01 00:00:00
abstract：:Despite cellular environments having dynamic characteristics, many laboratories utilized static polyacrylamide hydrogels to study the ECM-cell relationship. To attain a more in vivo like environment, we have developed a dynamic, DNA-crosslinked hydrogel (DNA gel). Through the controlled delivery of DNA, we can tempora...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0483-2
更新日期：2012-05-01 00:00:00
abstract：:Classically, the primary tool for quantifying the dynamics of vergence and other eye movements has been the main sequence. The main sequence is a plot of peak velocity versus response amplitude and is particularly useful for comparing the dynamics of a large number of eye movements over a range of response amplitudes....
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.162
更新日期：1999-05-01 00:00:00
abstract：:Effects of hyperthermia on transport of low-density lipoprotein (LDL) through a stenosed arterial wall are analyzed comprehensively in the present work. The realistic and pertinent aspects of an arterial wall is represented by a multi-layer model, with a proper representation of the thickened intima region due to the ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-014-1196-0
更新日期：2015-07-01 00:00:00
abstract：:Zebrafish is an emerging model system for cardiac conduction and regeneration. Zebrafish heart regenerates after 20% ventricular resection within 60 days. Whether cardiac conduction phenotype correlated with cardiomyocyte regeneration remained undefined. Longitudinal monitoring of the adult zebrafish heart (n = 12) wa...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-9993-6
更新日期：2010-07-01 00:00:00
abstract：:In this paper, an intelligent proportional-integral-derivative (PID) control method is introduced to the robotic testing system for the biomechanical study of human musculoskeletal joints. For the testing system, the robot is a highly nonlinear and heavily coupled complicated system, and the human spinal specimen also...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1023/b:abme.0000030759.80354.e8
更新日期：2004-06-01 00:00:00
abstract：:This article presents a computer-aided detection system for capsule endoscopy (CE) images using contourlet-based color textural features to recognize tumors in the digestive tract. As tumor exhibits rich information in color texture, a novel color texture feature based on contourlet transform is proposed to describe c...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0380-8
更新日期：2011-12-01 00:00:00
abstract：:Percutaneous stent implantation has revolutionized the clinical treatment of occluded arteries. Nevertheless, there is still a large unmet need to prevent re-occlusion after implantation. Consequently, a niche exists for a cost-effective pre-clinical method of evaluating novel interventional devices in human models. T...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-009-9701-6
更新日期：2009-07-01 00:00:00
abstract：:When cells and the matrix of a tissue remodel, the mechanical properties of the tissue do change. The mechanical properties are expressed by constitutive equations. In this article the remodeling of the constitutive equation of the pulmonary artery is studied. The remodeling was induced in a rat breathing a gas whose ...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1380417
更新日期：2001-01-01 00:00:00
abstract：:Using a three-dimensional propagation model of the human ventricular myocardium, we studied the role of fibrous structure in generating epicardial potential maps. This model represents the myocardium as an anisotropic bidomain with an equal anisotropy ratio, and it incorporates a realistic representation of anatomical...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.73
更新日期：1998-11-01 00:00:00
abstract：:We propose a multifrequency energy transmission scheme for annular phased arrays in deep-body hyperthermia. The problem of frequency dependent resonance effects reported in hyperthermia phantom calibration studies, leading to skewed energy deposition patterns and unwanted energy maxima (hot spots), is addressed by com...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1430749
更新日期：2002-01-01 00:00:00
abstract：:This study presents a novel approach to modeling the electrocardiogram (ECG): the Gaussian pulse decomposition. Constituent waves of the ECG are decomposed into and represented by Gaussian pulses using an iterative algorithm: the chip away decomposition (ChAD) algorithm. At each iteration, a nonlinear minimization met...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/BF02648039
更新日期：1997-03-01 00:00:00
abstract：:In the field of fluid flow within the human body, focus has been placed on the transportation of blood in the systemic circulation since the discovery of that system; but, other fluids and fluid flow phenomena pervade the body. Some of the most fascinating fluid flow phenomena within the human body involve fluids othe...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-010-9902-z
更新日期：2010-03-01 00:00:00
abstract：:We have developed poly(L: -lactide-co-glycolide) (PLGA) based composites using sol-gel derived bioactive glasses (S-BG), previously described by our group, as composite components. Two different composite types were manufactured that contained either S2-high content silica S-BG, or A2-high content lime S-BG. The compo...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1007/s10439-011-0307-4
更新日期：2011-08-01 00:00:00
abstract：:To study the effects of compressive straining on muscle cell deformation and damage an in vitro model system was developed. Myoblasts were seeded in agarose constructs and cultured in growth medium for 4 days. Subsequently, the cells were allowed to fuse into multinucleated myotubes for 8 days in differentiation mediu...
journal_title：Annals of biomedical engineering
pub_type： 杂志文章
doi：10.1114/1.1349698
更新日期：2001-02-01 00:00:00
