Differential changes in the molecular stability of collagen from the pulmonary and aortic valves during the fetal-to-neonatal transition.

Abstract:

:During the fetal-to-neonatal transition, transvalvular pressures (TVPs) on the aortic and pulmonary valves change dramatically-but differently for each valve. We have examined changes in the molecular stability and crosslinking of collagen during this transition. Aortic and pulmonary valves were harvested from fetal and neonatal cattle. Using differential scanning calorimetry (DSC), denaturation of valvular collagen was examined and, using HPLC, the types and quantities of enzymatic crosslinks were examined. No difference in hydrothermal stability was found between the collagens in the fetal aortic and pulmonary valves; this was expected since the TVP is approximately the same across both valves before birth. Only in the neonatal samples was the collagen from aortic valves (higher TVP) less stable than that from pulmonary valves (lower TVP). Surprisingly, the enthalpy of denaturation did not differ either between valve type or with age, suggesting an entropic mechanism of altered molecular stability. A significant difference in immature-to-mature crosslink ratio was found between neonatal aortic and pulmonary valves: a difference absent in fetal valves. This ratio-indicative of remodeling rate-parallels (and may be a function of) the changing in vivo load. This study highlights the relationship between in vivo load and both (i) molecular stability and (ii) collagen remodeling in heart valves.

journal_name

Ann Biomed Eng

authors

Aldous IG,Lee JM,Wells SM

doi

10.1007/s10439-010-0061-z

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

3000-9

issue

9

eissn

0090-6964

issn

1573-9686

journal_volume

38

pub_type

杂志文章
  • Quantitative Validation of a Human Body Finite Element Model Using Rigid Body Impacts.

    abstract::Validation is a critical step in finite element model (FEM) development. This study focuses on the validation of the Global Human Body Models Consortium full body average male occupant FEM in five localized loading regimes-a chest impact, a shoulder impact, a thoracoabdominal impact, an abdominal impact, and a pelvic ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-015-1286-7

    authors: Vavalle NA,Davis ML,Stitzel JD,Gayzik FS

    更新日期:2015-09-01 00:00:00

  • Fluid shifts due to microgravity and their effects on bone: a review of current knowledge.

    abstract::Bone loss during long-term space flight is potentially a significant problem. Bone mineral density measurements show that bone is lost at a rate of about 1% per month from the lumbar spine, and 1.5% per month from the hip. Bone density changes are not uniform throughout the skeleton, and there is accumulating evidence...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审

    doi:10.1007/s10439-005-8967-6

    authors: McCarthy ID

    更新日期:2005-01-01 00:00:00

  • Mechanical & cell culture properties of elastin-like polypeptide, collagen, bioglass, and carbon nanosphere composites.

    abstract::Collagen, the most commonly used extra-cellular matrix protein for tissue engineering applications, displays poor mechanical properties. Here, we report on the preparation and characterization of novel multi-component composite systems that incorporate a genetically engineered, biocompatible polymer (elastin-like poly...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-013-0825-3

    authors: Wheeler TS,Sbravati ND,Janorkar AV

    更新日期:2013-10-01 00:00:00

  • Finite Element Model of a Deformable American Football Helmet Under Impact.

    abstract::Despite the use of helmets in American football, brain injuries are still prevalent. To reduce the burden of these injuries, novel impact mitigation systems are needed. The Vicis Zero1 (VZ1) American football helmet is unique in its use of multi-directional buckling structures sandwiched between a deformable outer she...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-020-02472-6

    authors: Giudice JS,Caudillo A,Mukherjee S,Kong K,Park G,Kent R,Panzer MB

    更新日期:2020-05-01 00:00:00

  • A computational study of the effect of false vocal folds on glottal flow and vocal fold vibration during phonation.

    abstract::The false vocal folds are believed to be components of the acoustic filter that is responsible for shaping the voice. However, the effects of false vocal folds on the vocal fold vibration and the glottal aerodynamic during phonation remain unclear. This effect has implications for computational modeling of phonation a...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-008-9630-9

    authors: Zheng X,Bielamowicz S,Luo H,Mittal R

    更新日期:2009-03-01 00:00:00

  • Partial Bone Formation in Additive Manufactured Porous Implants Reduces Predicted Stress and Danger of Fatigue Failure.

    abstract::New porous implant designs made possible by additive manufacturing allow for increased osseointegration, potentially improving implant performance and longevity for patients that require massive bone implants. The aim of this study was to evaluate how implantation and the strain distribution in the implant affect the ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-019-02369-z

    authors: Cheong VS,Fromme P,Coathup MJ,Mumith A,Blunn GW

    更新日期:2020-01-01 00:00:00

  • Evaluation of three animal models for concussion and serious brain injury.

    abstract::Three animal models were evaluated in this study involving head impacts of the rat, including the Marmarou drop-weight and two momentum-exchange techniques. In series 1, 36 Wistar rats were hit on the side of the free-moving head using Marmarou's 450 g impact mass at 4.4, 5.4, and 6.3 m/s. Head acceleration was measur...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-011-0386-2

    authors: Viano DC,Hamberger A,Bolouri H,Säljö A

    更新日期:2012-01-01 00:00:00

  • Geodesic based registration of sensor data and anatomical surface image data.

    abstract::This paper presents two related methods for registering an image of an anatomical object with data from sensors arranged on the object. One method is described with reference to a test case involving a rectangular electrode plaque disposed on a heart surface, which is imaged with MRI. Data from the electrodes is fused...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-007-9350-6

    authors: Hopenfeld B,Ashikaga H,McVeigh ER

    更新日期:2007-10-01 00:00:00

  • Optical Metabolic Imaging for Assessment of Radiation-Induced Injury to Rat Kidney and Mitigation by Lisinopril.

    abstract::The kidney is one of the most radiosensitive organs; it is the primary dose-limiting organ in radiotherapies for upper abdominal cancers. The role of mitochondrial redox state in the development and treatment of renal radiation injury, however, remains ill-defined. This study utilizes 3D optical cryo-imaging to quanti...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-019-02255-8

    authors: Mehrvar S,la Cour MF,Medhora M,Camara AKS,Ranji M

    更新日期:2019-07-01 00:00:00

  • Machine Learning Classification of Verified Head Impact Exposure Strengthens Associations with Brain Changes.

    abstract::Cumulative exposure to head impacts during contact sports can elicit potentially deleterious brain white matter alterations in young athletes. Head impact exposure is commonly quantified using wearable sensors; however, these sensors tend to overestimate the number of true head impacts that occur and may obfuscate pot...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-020-02662-2

    authors: DiCesare CA,Green B,Yuan W,Diekfuss JA,Barber Foss KD,Dudley J,Qin Y,Wang P,Myer GD

    更新日期:2020-12-01 00:00:00

  • Consistent biomechanical phenotyping of common carotid arteries from seven genetic, pharmacological, and surgical mouse models.

    abstract::The continuing lack of longitudinal histopathological and biomechanical data for human arteries in health and disease highlights the importance of studying the many genetic, pharmacological, and surgical models that are available in mice. As a result, there has been a significant increase in the number of reports on t...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-014-0988-6

    authors: Bersi MR,Ferruzzi J,Eberth JF,Gleason RL Jr,Humphrey JD

    更新日期:2014-06-01 00:00:00

  • Left ventricular external constraint: relationship between pericardial, pleural and esophageal pressures during positive end-expiratory pressure and volume loading in dogs.

    abstract::Left ventricular (LV) diastolic filling is limited by the constraining effects exerted by the pericardium (PE) and the lung/chest wall. The aim of the present study was to assess the validity of various estimates of external cardiac constraint, compared to pericardial surface pressure (Ppe) measured lateral to the LV ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/BF02584288

    authors: Kingma I,Smiseth OA,Frais MA,Smith ER,Tyberg JV

    更新日期:1987-01-01 00:00:00

  • The effect of blood flow on the material properties of bone.

    abstract::This project was undertaken to establish if the integral circulation had any effects upon the mechanical behavior of bone. The influence of blood flow in the rabbit tibia on the strain induced at the bone surface when under load was assessed. Recordings were taken from three adult and three immature New Zealand White ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/BF02390377

    authors: McDonald F,Pitt Ford TR

    更新日期:1994-03-01 00:00:00

  • An evaluation of population D-optimal designs via pharmacokinetic simulations.

    abstract::One goal of large scale clinical trials is to determine how a drug is processed by, and cleared from, the human body [i.e., its pharmacokinetic (PK) properties] and how these PK properties differ between individuals in a population (i.e., its population PK properties). Due to the high cost of these studies and the lim...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1114/1.1533074

    authors: Hooker AC,Foracchia M,Dodds MG,Vicini P

    更新日期:2003-01-01 00:00:00

  • Physiological acoustic sensing based on accelerometers: a survey for mobile healthcare.

    abstract::This paper reviews the applications of accelerometers on the detection of physiological acoustic signals such as heart sounds, respiratory sounds, and gastrointestinal sounds. These acoustic signals contain a rich reservoir of vital physiological and pathological information. Accelerometer-based systems enable continu...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审

    doi:10.1007/s10439-014-1111-8

    authors: Hu Y,Kim EG,Cao G,Liu S,Xu Y

    更新日期:2014-11-01 00:00:00

  • Cellular and Nuclear Alignment Analysis for Determining Epithelial Cell Chirality.

    abstract::Left-right (LR) asymmetry is a biologically conserved property in living organisms that can be observed in the asymmetrical arrangement of organs and tissues and in tissue morphogenesis, such as the directional looping of the gastrointestinal tract and heart. The expression of LR asymmetry in embryonic tissues can be ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-015-1431-3

    authors: Raymond MJ Jr,Ray P,Kaur G,Singh AV,Wan LQ

    更新日期:2016-05-01 00:00:00

  • A review of return to play issues and sports-related concussion.

    abstract::Mild traumatic brain injury in sports has become a significant public health concern which has not only received the general public's attention through multiple news media stories involving athletic concussions, but has also resulted in local, state, and national legislative efforts to improve recognition and manageme...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审

    doi:10.1007/s10439-011-0413-3

    authors: Doolan AW,Day DD,Maerlender AC,Goforth M,Gunnar Brolinson P

    更新日期:2012-01-01 00:00:00

  • Analyzing trends in brain interface technology: a method to compare studies.

    abstract::Continued progress in the field of Brain Interface (BI) research has encouraged the rapid expansion of the BI community over the last two decades. As the number of BI researchers and organizations steadily increases, newer and more advanced technologies are constantly produced, evaluated, and reported. Though the BI c...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-005-9055-7

    authors: Jackson MM,Mason SG,Birch GE

    更新日期:2006-05-01 00:00:00

  • Stereolithography 3D Bioprinting Method for Fabrication of Human Corneal Stroma Equivalent.

    abstract::3D bioprinting technology is a promising approach for corneal stromal tissue regeneration. In this study, gelatin methacrylate (GelMA) mixed with corneal stromal cells was used as a bioink. The visible light-based stereolithography (SLA) 3D bioprinting method was utilized to print the anatomically similar dome-shaped ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-020-02537-6

    authors: Mahdavi SS,Abdekhodaie MJ,Kumar H,Mashayekhan S,Baradaran-Rafii A,Kim K

    更新日期:2020-07-01 00:00:00

  • Simulation of neutrophil deformation and transport in capillaries using newtonian and viscoelastic drop models.

    abstract::It is well known that neutrophils take much longer to traverse the pulmonary capillary bed than erythrocytes, and this is likely due to differences in the structure and rheology of the cells. In this study, we simulate the transit of a neutrophil in a capillary using a Newtonian drop model and a viscoelastic drop mode...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-007-9286-x

    authors: Zhou C,Yue P,Feng JJ

    更新日期:2007-05-01 00:00:00

  • Comparison of Laboratory and On-Field Performance of American Football Helmets.

    abstract::The relationship between laboratory and on-field performance of football helmets was assessed for 31 football helmet models selected from those worn by players in the 2015-2019 National Football League (NFL) seasons. Linear impactor tests were conducted with helmets placed on an instrumented Hybrid III head and neck a...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-020-02627-5

    authors: Bailey AM,McMurry TL,Cormier JM,Funk JR,Crandall JR,Mack CD,Myers BS,Arbogast KB

    更新日期:2020-11-01 00:00:00

  • Interaction between high frequency jet ventilation and cardiovascular function.

    abstract::We have studied the interaction of high frequency jet ventilation with cardiovascular pressures and flows. Results in dogs show that the amplitude of all intrathoracic pressures and flows fluctuate with a frequency equal to the difference between the heart rate and ventilator rate. The magnitude of this amplitude vari...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/BF02584287

    authors: Mitzner W,Gioia F,Weinmann GG,Robotham JL,Ehrlich W

    更新日期:1987-01-01 00:00:00

  • Constitutive modeling of pia-arachnoid complex.

    abstract::The pia-arachnoid complex (PAC) covering the brain plays an important role in the mechanical response of the brain during impact or inertial loading. Recent studies have revealed the complicated material behavior of the PAC. In this study, the nonlinear viscoelastic, transversely isotropic material properties of the P...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-013-0948-6

    authors: Jin X,Mao H,Yang KH,King AI

    更新日期:2014-04-01 00:00:00

  • Automatic Detection of Contracting Muscle Regions via the Deformation Field of Transverse Ultrasound Images: A Feasibility Study.

    abstract::Accurate identification of contracting muscles can help us to understand the muscle function in both physiological and pathological conditions. Conventional electromyography (EMG) have limited access to deep muscles, crosstalk, or instability in the recordings. Accordingly, a novel framework was developed to detect co...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-020-02557-2

    authors: Zheng Y,Shin H,Kamper DG,Hu X

    更新日期:2021-01-01 00:00:00

  • Intelligent self-tuning of PID control for the robotic testing system for human musculoskeletal joints test.

    abstract::In this paper, an intelligent proportional-integral-derivative (PID) control method is introduced to the robotic testing system for the biomechanical study of human musculoskeletal joints. For the testing system, the robot is a highly nonlinear and heavily coupled complicated system, and the human spinal specimen also...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1023/b:abme.0000030759.80354.e8

    authors: Tian L

    更新日期:2004-06-01 00:00:00

  • Automatic Model Generation Framework for Computational Simulation of Cochlear Implantation.

    abstract::Recent developments in computational modeling of cochlear implantation are promising to study in silico the performance of the implant before surgery. However, creating a complete computational model of the patient's anatomy while including an external device geometry remains challenging. To address such a challenge, ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-015-1541-y

    authors: Mangado N,Ceresa M,Duchateau N,Kjer HM,Vera S,Dejea Velardo H,Mistrik P,Paulsen RR,Fagertun J,Noailly J,Piella G,González Ballester MÁ

    更新日期:2016-08-01 00:00:00

  • Evaluating the Impact of Calcification on Plaque Vulnerability from the Aspect of Mechanical Interaction Between Blood Flow and Artery Based on MRI.

    abstract::Acute cerebral ischemic events and thrombosis are associated with the rupture/erosion of carotid atherosclerotic plaques. The aim of the present study was to determine the impact of calcification deposition on the wall shear stress (WSS) and stresses within the plaques using 3D fluid-structure interaction (FSI) models...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-020-02655-1

    authors: Benitez J,Fontanarosa D,Wang J,Paritala PK,McGahan T,Lloyd T,Li Z

    更新日期:2020-10-20 00:00:00

  • Multidirectional pelvic floor muscle strength measurement.

    abstract::Pelvic floor muscle (PFM) strength measurement provides useful information for the study of pelvic floor dysfunctions. Vaginal digital palpation, intravaginal pressure measurements, and the use of a dynamometric speculum represent currently available clinical methods for evaluating PFM strength. However, none of these...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1007/s10439-009-9728-8

    authors: Saleme CS,Rocha DN,Del Vecchio S,Silva Filho AL,Pinotti M

    更新日期:2009-08-01 00:00:00

  • Shear stress distribution in the trabeculae of human vertebral bone.

    abstract::The statistical distribution of von Mises stress in the trabeculae of human vertebral cancellous bone was estimated using large-scale finite element models. The goal was to test the hypothesis that average trabecular von Mises stress is correlated to the maximum trabecular level von Mises stress. The hypothesis was pr...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章

    doi:10.1114/1.1318928

    authors: Fyhrie DP,Hoshaw SJ,Hamid MS,Hou FJ

    更新日期:2000-01-01 00:00:00

  • Predictive Virtual Patient Modelling of Mechanical Ventilation: Impact of Recruitment Function.

    abstract::Mechanical ventilation is a life-support therapy for intensive care patients suffering from respiratory failure. To reduce the current rate of ventilator-induced lung injury requires ventilator settings that are patient-, time-, and disease-specific. A common lung protective strategy is to optimise the level of positi...

    journal_title:Annals of biomedical engineering

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10439-019-02253-w

    authors: Morton SE,Knopp JL,Chase JG,Möller K,Docherty P,Shaw GM,Tawhai M

    更新日期:2019-07-01 00:00:00