Abstract:
:This study was designed to investigate the effect of agmatine sulfate (AG, CAS2482-00-0) in nicotine (NIC)-induced vascular endothelial dysfunction (VED) in rabbits. NIC was administered to produce VED in rabbits with or without AG for 6 weeks. Serum lipid profile, serum thiobarbituric acid reactive substances, reduced glutathione, superoxide dismutase generation, serum nitrite/nitrate, serum vascular cellular adhesion molecule-1 (VCAM-1), and aortic nuclear factor κB (NF-κB) levels were analyzed.Treatment with AG markedly improves lipid profile and prevented NIC-induced VED and oxidative stress. The mechanism of AG in improving NIC-induced VED may be due to the significant reduction in serum VCAM-1 levels and aortic NF-κB. Thus, it may be concluded that AG reduces the oxidative stress, nitric oxide production, VCAM-1 levels, and aortic NF-κB expression, thereby consequently improving the integrity of vascular endothelium.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Nader MA,Gamiel NM,El-Kashef H,Zaghloul MSdoi
10.1177/0960327115597311subject
Has Abstractpub_date
2016-05-01 00:00:00pages
573-82issue
5eissn
0960-3271issn
1477-0903pii
0960327115597311journal_volume
35pub_type
杂志文章abstract::This report describes two accidents, involving snakes of the Micrurus corallinus species, where compromising respiratory function was not observed and the specific anti-elapidic serum was the single therapy used, and a third incident, probably involving Micrurus frontalis, where neostigmine was used to remedy respirat...
journal_title:Human & experimental toxicology
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