Cellular mechanisms for trazodone-induced cardiotoxicity.

abstract：:Coronary heart disease and in particular its most serious form - acute myocardial infarction (AMI) - represents the most common cause of mortality in developed countries. Better prognosis may be achieved by understanding the etiopathogenetic mechanisms of AMI. Therefore, a catecholamine model of myocardial injury, whi...

journal_title：Human & experimental toxicology

authors： Mladenka P,Hrdina R,Bobrovová Z,Semecky V,Vávrová J,Holecková M,Palicka V,Mazurová Y,Nachtigal P

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is the main clinical concern resulted from ischemia-reperfusion injury (IRI). Ample clinical data indicates that AKI is associated with distant organ dysfunctions and poor patients' outcomes. Oxidative stress and inflammation have a critical role in the pathogenesis of organ injurie...

journal_title：Human & experimental toxicology

authors： Bagheri Y,Aghajani S,Hosseinzadeh M,Hoshmandan F,Abdollahpour A,Vahed SZ

更新日期：2020-12-16 00:00:00

abstract：:Indomethacin, a non-steroidal anti-inflammatory drug is known to increase the efficacy and toxicity of methotrexate, the widely used anti-cancer drug in man. The mechanism for this interaction has not been clearly established. However, since these drugs bind with albumin, a possible displacement of methotrexate by ind...

journal_title：Human & experimental toxicology

authors： Raveendran R,Heybroek W,Caulfield M,Lawson M,Abrams SM,Wrigley PF,Slevin M,Turner P

更新日期：1992-07-01 00:00:00

abstract：:4-hydroxynonenal (4-HNE) and 6-hydroxydopamine (6-OHDA)-mediated damage in dopaminergic neurons is well documented. Protective potential of steroidal hormone (17β-estradiol) has also been suggested. However, therapeutic potential of such promising hormone is hampered due to complex brain anatomy and physiology. Thus, ...

journal_title：Human & experimental toxicology

authors： Siddiqui MA,Kashyap MP,Al-Khedhairy AA,Musarrat J,Khanna VK,Yadav S,Pant AB

更新日期：2011-08-01 00:00:00

abstract：:The effects of acute administration of dietary levels of ethanol and the garlic oil extract, diallyl sulphide (DAS), on cytochrome P450 2E1 (CYP2E1) activity in volunteers were studied using the selective probe substrate, chlorzoxazone (CZX). The ratio of the CZX metabolite 6- hydroxychlorzoxazone (6-OHCZX) to CZX was...

journal_title：Human & experimental toxicology

authors： Loizou GD,Cocker J

更新日期：2001-07-01 00:00:00

abstract：:We describe two cases of chemical necrotizing fasciitis in the upper extremities, anterior chest wall and epigastric region of the abdominal wall caused by household insecticide injection. We suggest that surgical debridement can be successfully performed in the subacute period under close observation in hemodynamical...

journal_title：Human & experimental toxicology

authors： Terzi C,Bacakoğlu A,Unek T,Ozkan MH

更新日期：2002-12-01 00:00:00

abstract：:The purpose of the present study is to establish a new animal model of azithromycin (AZ)-induced liver injury and study the molecular pathological change during the process. First, mice were respectively injected intraperitoneally with AZ of different high doses. Our results showed that 800 mg/kg AZ injection signific...

journal_title：Human & experimental toxicology

authors： Li SQ,Wan XD,Zhu S,Han HM,Xu ZS,Lu HJ

更新日期：2016-05-01 00:00:00

abstract：:This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetis...

journal_title：Human & experimental toxicology

authors： El-Ebiary AA,Abuelfadl AA,Sarhan NI,Othman MM

更新日期：2013-06-01 00:00:00

abstract：:There are many discrepancies among the results of studies on the genotoxicity of lead. The aim of the study was to explore lead-induced DNA damage, including oxidative damage, in relation to oxidative stress intensity parameters and the antioxidant defense system in human leukocytes. The study population consisted of ...

journal_title：Human & experimental toxicology

authors： Dobrakowski M,Pawlas N,Kasperczyk A,Kozłowska A,Olewińska E,Machoń-Grecka A,Kasperczyk S

更新日期：2017-07-01 00:00:00

abstract：:Epichlorohydrin (ECH) is an antifertility agent that acts both as an epididymal toxicant and an agent capable of directly affecting sperm motility. This study identified the time course of apoptotic cell death in rat epididymides after ECH treatment. Rats were administrated with a single oral dose of ECH (50 mg/kg). E...

journal_title：Human & experimental toxicology

authors： Lee IC,Kim KH,Kim SH,Baek HS,Moon C,Kim SH,Yun WK,Nam KH,Kim HC,Kim JC

更新日期：2013-06-01 00:00:00

abstract：:Delta-aminolevulinate dehydratase (δ-ALA-D) enzyme is sensitive to pro-oxidant agents, including molecular oxygen. Here, we tested whether hyperoxygenation after total intravenous (i.v.) anesthesia could interact with the type of anesthesia (dexmedetomidine, continuous infusion; 0.5 μg/kg/h or remifentanil, continuous...

journal_title：Human & experimental toxicology

authors： Rocha JB,Heinzmann Bulow NM,Correa EF,Scholze C,Nogueira CW,Barbosa NB

更新日期：2011-04-01 00:00:00

abstract：:Osteosarcoma is characterized by high malignancy and high metastasis rate, resulting in high mortality and disability. MiR-663a has been reported in a variety of tumors to promote tumorigenesis. However, miR-663a has not been reported in the pathogenesis of osteosarcoma. Bioinformatics analysis and experiments includi...

journal_title：Human & experimental toxicology

authors： Zhao S,Xiong W,Xu K

更新日期：2020-12-01 00:00:00

abstract：:The current study was undertaken to evaluate the effect of combined therapy of gabapentin and pantoprazole against forestomach and pylorus ligation-induced gastric esophageal reflux disease (GERD) in albino Wistar rats. Rats were randomly divided into five groups, each group consisting of six rats, fasted for 24 h, un...

journal_title：Human & experimental toxicology

authors： Arya P,Kaithwas G

更新日期：2020-04-01 00:00:00

abstract：:Pharmaceutical research and new drug development rely extensively on animal research. The development of novel agents for intrathecal administration requires preclinical studies of toxic effects in an animal model. We have developed a nonrodent animal model for this purpose. Our sheep model: 1 Is an animal whose neura...

journal_title：Human & experimental toxicology

authors： Hassenbusch SJ,Satterfield WC,Gradert TL

更新日期：1999-02-01 00:00:00

abstract：:The study of Jayjock and Lewis, 'Implication of Hormesis for Industrial Hygiene', represents a challenge for the scientific community to consider hormesis as a possible working hypothesis for redefining risk assessment strategy for low-dose exposures in the realm of industrial hygiene. This invited commentary aims at ...

journal_title：Human & experimental toxicology

authors： Carelli G,Iavicoli I,Castellino N

更新日期：2002-07-01 00:00:00

abstract：:The color of the teeth is an important topic for many people and can be influenced by intrinsic and extrinsic stains. There is an increasing demand for whitening of the teeth year by year. The most popular way of whitening is "bleaching," which is the result of the breakdown of pigments located in the enamel and/or th...

journal_title：Human & experimental toxicology

authors： Karaarslan ES,Özmen ZC,Aytac F,Bicakci AA,Buldur M,Aydogan L,Hologlu F,Özkocak B

更新日期：2019-04-01 00:00:00

abstract：:Hormesis can be considered as a parameter which has a non-monotonic relationship with some endpoint. Since caloric intake is such a parameter, and the impact of this parameter on risk assessment has been fairly well characterized, it can provide clues as to how to integrate the information from a hormetic parameter in...

journal_title：Human & experimental toxicology

authors： Turturro A,Hass B,Hart RW

更新日期：1998-08-01 00:00:00

abstract：:A number of xenobiotics require redox reactions to form the reactive intermediates involved in the ultimate toxic events (e.g., adduct formation). The same mechanisms lead to the formation of reactive oxygen species (ROS), which can themselves exert direct toxicity including, e.g., DNA oxidative damage or glutathione ...

journal_title：Human & experimental toxicology

authors： Pagano G

更新日期：2002-02-01 00:00:00

abstract：:1. This work examines the influence of age on some nephrotoxic signs of gentamicin in normal and diabetic rats (aged 1 and 24 months). 2. Gentamicin (80 mg-1 kg-1 day for 6 days, intramuscularly) produced the typical pattern of nephrotoxicity; significantly increasing the plasma concentrations of creatinine and urea, ...

journal_title：Human & experimental toxicology

authors： Ali BH,Bashir AK,Mugamer IT,Tanira MO

更新日期：1996-01-01 00:00:00

abstract：INTRODUCTION:This study provides an epidemiological description of non-health care facility medication errors involving anticonvulsant drugs. METHODS:A retrospective analysis of National Poison Data System data was conducted on non-health care facility medication errors involving anticonvulsant drugs reported to US Po...

journal_title：Human & experimental toxicology

authors： DeDonato EA,Spiller HA,Casavant MJ,Chounthirath T,Hodges NL,Smith GA

更新日期：2018-06-01 00:00:00

abstract：:The malignancy of non-small cell lung cancer (NSCLC) largely results from its invasive manner. Secreted frizzled-related proteins (SFRPs) have been recently found to suppress the invasiveness of some cancers. On the other hand, the methylation of SFRPs increases protein degradation to reduce the activity of SFRPs, res...

journal_title：Human & experimental toxicology

authors： Zhang X,Rong X,Chen Y,Su L

更新日期：2018-02-01 00:00:00

abstract：:This study evaluated the protective potential of curcumin on the possible side effects of bortezomib (Bt) therapy on normal cells in mice. The mice were segregated into three groups (n = 10) that included normal control, Bt-treated, and Bt + curcumin-treated groups. The Bt treatment resulted in significant decrease in...

journal_title：Human & experimental toxicology

authors： Kumar RR,Malhotra A

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:The objective of the present study was to determine oxidant and antioxidant status in infants with hyperbilirubinemia and/or kernicterus and to find whether there is a relationship between bilirubin level and oxidant/antioxidant status. PATIENTS:The study includes 69 full-term newborns (neonates with hyperbi...

journal_title：Human & experimental toxicology

authors： Doğan M,Peker E,Kirimi E,Sal E,Akbayram S,Erel O,Ocak AR,Tuncer O

更新日期：2011-11-01 00:00:00

abstract：:Results obtained in long-term carcinogenicity studies with animals should be evaluated, first and foremost, by statistical comparisons of the data obtained from the treated group with that from the concurrent control group. Often the results are compared with data from so-called historical control groups in order to t...

journal_title：Human & experimental toxicology

authors： Greim H,Gelbke HP,Reuter U,Thielmann HW,Edler L

更新日期：2003-10-01 00:00:00

abstract：:Pesticides, including organophosphate (OP), organochlorine (OC), and carbamate (CB) compounds, are widely used in agricultural and indoor purposes. OP and CB act as acetyl cholinesterase (AChE) inhibitors that affect lots of organs such as peripheral and central nervous systems, muscles, liver, pancreas, and brain, wh...

journal_title：Human & experimental toxicology

authors： Karami-Mohajeri S,Abdollahi M

更新日期：2011-09-01 00:00:00

abstract：:N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-doxorubicin (PK1) is a novel polymeric anticancer agent containing doxorubicin (approximately 8 wt%) bound to the polymer backbone via a Gly-Phe-Leu-Gly peptidyl linker. The approximate LD50 of PK1 in MF1 mice after a single i.v. injection was 63 mg/kg (doxorubicin-eq...

journal_title：Human & experimental toxicology

authors： Duncan R,Coatsworth JK,Burtles S

更新日期：1998-02-01 00:00:00

abstract：:Lipid peroxidation is one of the main manifestations of oxidative damage and has been found to play an important role in the toxicity and carcinogenicity of many xenobiotics. In the present study, we investigated the possible induction of lipid peroxidation by aluminium in human foreskin fibroblast cultures by assayin...

journal_title：Human & experimental toxicology

authors： Anane R,Creppy EE

更新日期：2001-09-01 00:00:00

abstract：:Exposure to quartz induces pulmonary inflammation and development of fibrosis. In order to study the fibrosing process, we investigated morphology, function and phenotype of alveolar (AMs) and interstitial (IMs) macrophages at an early stage of fibrosis in rats. Rats were exposed by intratracheal instillations of 10 m...

journal_title：Human & experimental toxicology

authors： Zetterberg G,Elmberger G,Johansson A,Lundahl J,Lundborg M,Sköld CM,Tornling G,Camner P,Eklund A

更新日期：2000-07-01 00:00:00

abstract：:The majority of breast cancer patients are resistant to chemotherapy or radiotherapy due to the down-regulation or lack of caspase-3 expression. Capsaicin was found to inhibit cancer cell growth in caspase-3-deficient human breast cancer cells. This study aimed to investigate the growth-inhibitive effect of capsaicin ...

journal_title：Human & experimental toxicology

authors： Chang HC,Chen ST,Chien SY,Kuo SJ,Tsai HT,Chen DR

更新日期：2011-10-01 00:00:00

abstract：:The benefits and costs are discussed for the possibility of using pups generated in breeding studies for additional assessments, such as evaluating immunotoxicity. Such an approach is logistically challenging, but not overwhelming. ...

journal_title：Human & experimental toxicology

authors： Chapin RE

更新日期：2002-09-01 00:00:00