Rat alveolar and interstitial macrophages in the fibrosing stage following quartz exposure.

abstract：:1. A chronic alcoholic with severe metabolic acidosis presents a difficult diagnostic problem. The most common cause is alcoholic ketoacidosis, a syndrome with a typical history but often misleading laboratory findings. This paper will focus on this important and probably underdiagnosed syndrome. 2. The disorder occur...

journal_title：Human & experimental toxicology

authors： Höjer J

更新日期：1996-06-01 00:00:00

abstract：:There is compelling evidence in support of positive associations between zinc (Zn) deficiency and high accumulation of cadmium (Cd) in biological samples of different cancerous patients. The incidence of mouth cancer has been increased among people who possess habit of drinking alcohol, tobacco smoking and chewing wit...

journal_title：Human & experimental toxicology

authors： Kazi TG,Wadhwa SK,Afridi HI,Kazi N,Kandhro GA,Baig JA,Shah AQ,Kolachi NF,Khan S

更新日期：2010-03-01 00:00:00

abstract：:Three patients admitted to the Accident and Emergency Unit of Lagos University Teaching Hospital (LUTH) after eating a cassava based meal 'Gari' died shortly after admission. The patients vomited and complained of abdominal pain immediately after the meal. They were unconscious with renal failure and died of cardiopul...

journal_title：Human & experimental toxicology

authors： Akintonwa A,Tunwashe OL

更新日期：1992-01-01 00:00:00

abstract：:Paraquat poisoning was studied in 174 patients over a 12-month period when a new, low concentration paraquat product (4.5% w/v paraquat ion mixed with 4.5% w/v diquat ion; 63 cases) replaced the original high concentration paraquat product (20% w/v paraquat ion only; 111 cases). In both groups approximately 60% of the...

journal_title：Human & experimental toxicology

authors： Yoshioka T,Sugimoto T,Kinoshita N,Shimazu T,Hiraide A,Kuwagata Y

更新日期：1992-07-01 00:00:00

abstract：:This study was designed to evaluate the hepato and neuroprotective activity of Daflon and low-dose γ radiation on thioacetamide (TAA)-induced liver damage and hepatic encephalopathy (HE) in rats. Effect of daily Daflon treatment (100 mg/kg body weight, Per OS (p.o.) for consecutive 3 days) and/or fractionated low-dose...

journal_title：Human & experimental toxicology

authors： Abdel-Rafei M,Amin MM,Hasan HF

更新日期：2017-01-01 00:00:00

abstract：:Tissue-dependent oestrogenic and anti-oestrogenic activity of polycyclic aromatic hydrocarbons (PAHs) has been suggested. In this study, the effect of two PAH mixtures, M1 composed of all 16 priority pollutants and M2 composed of five (noted in the highest levels) compounds, on follicle-stimulating hormone receptor (F...

journal_title：Human & experimental toxicology

authors： Zajda K,Gregoraszczuk EL

更新日期：2020-03-01 00:00:00

abstract：:Phagocytes remove and store mercury (Hg) that enters the body. Macrophages and granulocytes respond in opposite ways to Hg: macrophages loose cell viability, and neutrophils become protected from apoptosis. We have investigated the cytology of early intake of Hg by macrophages and neutrophils after a short period (2-4...

journal_title：Human & experimental toxicology

authors： Cunha EM,Oliveira MJ,Ferreira PG,Aguas AP

更新日期：2004-08-01 00:00:00

abstract：:Alcohol levels were measured in 15 cerebrospinal fluid (CSF) samples and 14 blood samples from grade III and IV male alcoholic patients with signs of nervous system involvement, and compared with levels detected in 11 CSF samples and 11 blood samples from abstemious patients or patients with grade I or II alcoholism w...

journal_title：Human & experimental toxicology

authors： Agapejev S,Vassilieff I,Curi PR

更新日期：1992-05-01 00:00:00

abstract：:The aim of the present investigation was to check the fluctuation in essential elements, such as Na, K, Mg, Mn, Cu, Zn, Cr and Ni in the brain, spinal cord, liver and kidney of mice during methylmercury chloride (MMC) toxication and therapy with monothiols (N-acetyl-DL-homocysteine thiolactone and glutathione) and vit...

journal_title：Human & experimental toxicology

authors： Bapu C,Purohit RC,Sood PP

更新日期：1994-12-01 00:00:00

abstract：:The article focuses on flaws in the actual approaches of exposure to a chemical of recipient organisms. It demonstrates the excessive use of arguments based on adverse effects and underlines the necessity to take adaptive effects seriously. Regulators are invited to rethink their inclination to the 'When in doubt, kee...

journal_title：Human & experimental toxicology

authors： Hanekamp JC,Bast A

更新日期：2007-11-01 00:00:00

abstract：:Indomethacin, a non-steroidal anti-inflammatory drug is known to increase the efficacy and toxicity of methotrexate, the widely used anti-cancer drug in man. The mechanism for this interaction has not been clearly established. However, since these drugs bind with albumin, a possible displacement of methotrexate by ind...

journal_title：Human & experimental toxicology

authors： Raveendran R,Heybroek W,Caulfield M,Lawson M,Abrams SM,Wrigley PF,Slevin M,Turner P

更新日期：1992-07-01 00:00:00

abstract：:Levo-Carnitine (l-carnitine) is widely used in health and food. This study was to focus on the adverse effects of 8-week oral supplementation of l-carnitine (0.3 and 0.6 g/kg) in female and male Sprague Dawley rats. l-carnitine reduced body and fat weights, as well as serum, liver, and kidney lipid levels in rats. Sim...

journal_title：Human & experimental toxicology

authors： Liu L,Zhang DM,Wang MX,Fan CY,Zhou F,Wang SJ,Kong LD

更新日期：2015-11-01 00:00:00

abstract：:Stem cell transplantation has indicated great promise for cell therapy in a wide range of diseases, but poor and insufficient viability of cells within damaged tissues has limited its potential therapeutic effects. 17 β-Estradiol (E2) is a steroid hormone that plays an important role in expression of many genes and re...

journal_title：Human & experimental toxicology

authors： Mirzamohammadi S,Mehrabani M,Tekiyehmaroof N,Sharifi AM

更新日期：2016-03-01 00:00:00

abstract：:Accidental ingestion of electrical batteries occurs commonly in children. This rarely is associated with severe morbidity and mortality. Significant symptoms can arise due to leakage of alkali or heavy metals from the battery after degradation in the gastrointestinal tract. The main heavy metal of concern in electrica...

journal_title：Human & experimental toxicology

authors： Mallon PT,White JS,Thompson RL

更新日期：2004-04-01 00:00:00

abstract：:Sibutramine mesylate is a new anti-obesity drug. It is a crystalline salt of sibutramine developed to improve the solubility of sibutramine hydrochloride. Methanesulfonic acid was used as a salt-forming acid instead of hydrochloric acid, resulting in a greatly improved solubility of 1000 mg/mL in water. Sibutramine me...

journal_title：Human & experimental toxicology

authors： Kim EJ,Park EK,Suh KH

更新日期：2005-03-01 00:00:00

abstract：:Two studies were performed in order to evaluate cytochrome P450 1A2 mediated caffeine metabolism during different nutritional conditions. 1. In the first study, 23 healthy male non-smokers, mean age 25, changed from a customary mixed diet to a standard diet in 6 days. The 6 day's standard diet was based on bread, pota...

journal_title：Human & experimental toxicology

authors： Kall MA,Clausen J

更新日期：1995-10-01 00:00:00

abstract：:The effects of acute administration of dietary levels of ethanol and the garlic oil extract, diallyl sulphide (DAS), on cytochrome P450 2E1 (CYP2E1) activity in volunteers were studied using the selective probe substrate, chlorzoxazone (CZX). The ratio of the CZX metabolite 6- hydroxychlorzoxazone (6-OHCZX) to CZX was...

journal_title：Human & experimental toxicology

authors： Loizou GD,Cocker J

更新日期：2001-07-01 00:00:00

abstract：:The objective of the present study was to perform histological and stereological examination of alcohol-induced changes in the optic nerve, considered an extension of white matter of the brain, in rats. This study included 20 male Wistar albino rats aged 60 days and weighing 190-220 g. The rats were divided into three...

journal_title：Human & experimental toxicology

authors： Igit T,Colcimen N

更新日期：2019-05-01 00:00:00

abstract：:The present study was undertaken to investigate the effects of maternal lead (Pb) exposure on the expression of interleukin (IL) 1β, IL 6, and glial fibrillary acidic protein (GFAP) in hippocampus of mice offspring. Pb exposure initiated from the beginning of gestation to weaning. Lead acetate (PbAc) administered in d...

journal_title：Human & experimental toxicology

authors： Li N,Liu X,Zhang P,Qiao M,Li H,Li X,Zhang H,Yu Z

更新日期：2015-04-01 00:00:00

abstract：:Okadaic acid (OA) is the main toxin produced by dinoflagellates, which can accumulate in the hepatopancreas of mussels and cause diarrhoetic shellfish poisoning in consumers. This toxin is also a tumour promoter and a specific potent inhibitor of protein phosphatases 1 and 2A. The results in this study show for the fi...

journal_title：Human & experimental toxicology

authors： Matias WG,Creppy EE

更新日期：1996-03-01 00:00:00

abstract：:Vulpinic acid, a lichen compound, has been shown to have many beneficial effects and its medicinal value increases day by day. As in atherosclerosis, endothelial damage is the basis of many diseases. The aim of this study is to investigate the effects of vulpinic acid against oxidative stress damage induced by hydroge...

journal_title：Human & experimental toxicology

authors： Sahin E,Dabagoglu Psav S,Avan I,Candan M,Sahinturk V,Koparal AT

更新日期：2019-06-01 00:00:00

abstract：:After acknowledging Renn's careful investigation and valuable insights, this paper expands on some issues that have been somewhat neglected in his account. It addresses the relationship between risk, uncertainity and ignorance in risk assessment, focusing in particular on the need to recognize that framing assumptions...

journal_title：Human & experimental toxicology

authors： De Marchi B

更新日期：2003-01-01 00:00:00

abstract：:Sepsis, often initiated by an infection, is a state of disrupted inflammatory homeostasis. There is increasing evidence that oxidative stress has an important role in the development of sepsis-induced multiorgan failure. Resveratrol (RV) is a polyphenolic compound found in the skin of red fruits, such as mulberries an...

journal_title：Human & experimental toxicology

authors： Aydin S,Bacanli M,Taner G,Şahin T,Başaran AA,Başaran N

更新日期：2013-10-01 00:00:00

abstract：:Seafood is considered by nutritionists to be a high source of omega 3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) which are involved in prevention of cardiovascular diseases. The aim of the present study is firstly to detect the presence of organochlorine pesticides and heavy metals in some fresh seafood of ...

journal_title：Human & experimental toxicology

authors： Al-Malki AL,Moselhy SS

更新日期：2011-10-01 00:00:00

abstract：:Sulphur is an essential micronutrient required by the body in low concentrations, but its high intake can lead to a serious health hazard. Sulphur compounds are reported to induce several toxic responses in animals, but so far no reports are available on the toxic effects of elemental sulphur, following dietary supple...

journal_title：Human & experimental toxicology

authors： Arora A,Shukla Y

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:The mortality rate associated with human glufosinate poisoning is high. We evaluated the usefulness of serum ammonia and sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation II (APACHE II) scores for early prediction of in-hospital mortality in glufosinate ammonium po...

journal_title：Human & experimental toxicology

authors： Lee J,Lee Y,Kim YS,Choi JG,Go TH,Kim H,Cha YS

更新日期：2019-09-01 00:00:00

abstract：:Although ingestion of methyl ethyl ketone peroxide (MEKP) is rare, it carries a high risk of morbidity and mortality. This paper reports the first such case from Turkey in which a 70-year-old man unintentionally ingested MEKP in his kitchen. The patient was brought into the emergency department (ED) within 1 hour of i...

journal_title：Human & experimental toxicology

authors： Bozdemir MN,Yildiz M,Seyhanli ES,Gurbuz S,Kilicaslan I,Karlidag T

更新日期：2011-12-01 00:00:00

abstract：:This descriptive and retrospective study was conducted at the poisoning ward of Imam teaching hospital, Sari, Iran, with the aim of evaluating the pattern of poisoning. Hence, the medical profiles of 2057 patients, who were admitted, were carefully reviewed during the period from April 2006 to March 2008 for 2 years. ...

journal_title：Human & experimental toxicology

authors： Ahmadi A,Pakravan N,Ghazizadeh Z

更新日期：2010-09-01 00:00:00

abstract：:Pesticides are used in agriculture to protect crops from insects-pests. Most of the field workers of North Indian population are exposed to commonly used insecticides. In the present study, pesticides induced oxidative stress as well as alterations in the level of acetylcholinesterase (AChE) in a total of 70 male heal...

journal_title：Human & experimental toxicology

authors： Sharma RK,Upadhyay G,Siddiqi NJ,Sharma B

更新日期：2013-11-01 00:00:00

abstract：:Dimethylacetamide (DMAc) is a skin-penetrating solvent able to induce hepatic damage after chronic exposure. Previous research has indicated that metabolism may be saturated at its present TLV/TWA (10 ppm). Biological monitoring of monomethylacetamide (MMAc), the primary metabolite of DMAc, might therefore underestima...

journal_title：Human & experimental toxicology

authors： Palmen NG,Evelo CT,Borm PJ,Henderson PT

更新日期：1993-03-01 00:00:00