Abstract:
:The purpose of the present study is to establish a new animal model of azithromycin (AZ)-induced liver injury and study the molecular pathological change during the process. First, mice were respectively injected intraperitoneally with AZ of different high doses. Our results showed that 800 mg/kg AZ injection significantly induced liver injury in the mice, which reflected an ideal process of liver injury and repair. In this study, we analyzed the molecular pathological changes during the process by hematoxylin and eosin staining, immunohistochemistry, Western blot, and quantitative real-time reverse transcription polymerase chain reaction in the liver of mice at 0, 12, 24, 48, and 72 h after 800 mg/kg injection. Our results showed that the expression of heat shock protein 70, proliferating cell nuclear antigen, vascular endothelial growth factor, caspase 3, and cytochrome P450 2E1 were significantly differently expressed during liver injury induced by 800 mg/kg AZ in mice. Our results will be conducive for further study of the pathogenesis and prevention of drug-induced liver injury.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Li SQ,Wan XD,Zhu S,Han HM,Xu ZS,Lu HJdoi
10.1177/0960327115595684subject
Has Abstractpub_date
2016-05-01 00:00:00pages
511-25issue
5eissn
0960-3271issn
1477-0903pii
0960327115595684journal_volume
35pub_type
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