Evaluation of severity indexes of patients with paraquat poisoning.


:1. Three indexes for evaluating the severity of paraquat poisoning based on plasma-paraquat concentration are presently in use; the curves of Proudfood et al. and Scherrmann et al. and the SIPP. Their effectiveness in determining the prognosis of patients with paraquat poisoning was evaluated. 2. To determine which index was more accurate, contigency tables of the three indexes were obtained and compared; Proudfoot's curve vs the SIPP Scherrmann's curve vs the SIPP. Proudfoot's curve and the SIPP were applied to patients admitted within 24 h after intoxication. Scherrmann's curve and the SIPP were applied to patients admitted more than 24 h after intoxication. The proportions of patients with true positive and true negative results to total patients were compared by a ratio test. 3. Proudfoot's curve was found to be more accurate than the SIPP for predicting the prognosis of patients admitted within 24 h (P less than 0.05). No significant difference, however, was noted between Scherrmann's curve and the SIPP in determining the prognosis of patients admitted after more than 24 h. 4. In conclusion, Proudfoot's curve proved a better index for predicting the outcome of patients who were admitted within 24 h. However, for the prognosis of patients admitted more than 24 h after the ingestion of paraquat, further study is required.


Hum Exp Toxicol


Suzuki K,Takasu N,Arita S,Ueda A,Okabe T,Ishimatsu S,Tanaka S,Kohama A




Has Abstract


1991-01-01 00:00:00












  • Effects of mono-2-ethylhexyl phthalate on the respiratory tract in BALB/c mice.

    abstract::Airborne mono-2-ethylhexyl phthalate (MEHP) was studied for acute airway effects using a bioassay with BALB/c mice. Concentration- and time-dependent effects were obtained by continuous monitoring of the breathing pattern during exposure to 0.3-43.6 mg/m3 MEHP for 60 min. Additionally, inflammatory effects of MEHP wer...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Larsen ST,Hansen JS,Hammer M,Alarie Y,Nielsen GD

    更新日期:2004-11-01 00:00:00

  • Inconsistent approach to the treatment of chronic digoxin toxicity in the United States.

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    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Kirrane BM,Olmedo RE,Nelson LS,Mercurio-Zappala M,Howland MA,Hoffman RS

    更新日期:2009-05-01 00:00:00

  • Long-term health effects of chemical warfare agents on children following a single heavy exposure.

    abstract::In the 1980s, villages in the Kurdistan region of Iraq were exposed to chemical weapons (CWs), which killed and injured thousands of civilians. There has been no clinical assessment of the long-term effects of CWs exposure on those injured. We report the first such evaluation of CW effects on long-term health of child...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Talabani JM,Ali AI,Kadir AM,Rashid R,Samin F,Greenwood D,Hay A

    更新日期:2018-08-01 00:00:00

  • Effects of lutein and chlorophyll b on GSH depletion and DNA damage induced by cisplatin in vivo.

    abstract::Recent studies have proposed the use of low concentrations of phytochemicals and combinations of phytochemicals in chemoprevention to reduce cytotoxicity and simulate normal ingestion through diet. The purpose of the present study was to evaluate whether the DNA damage, chromosome instability, and oxidative stress ind...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Serpeloni JM,Almeida MR,Mercadante AZ,Bianchi ML,Antunes LM

    更新日期:2013-08-01 00:00:00

  • Safety assessment of nicotinamide riboside, a form of vitamin B3.

    abstract::Nicotinamide riboside (NR) is a naturally occurring form of vitamin B3 present in trace amounts in some foods. Like niacin, it has been shown to be a precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). The safety of Niagen™, a synthetic form of NR, was determined using a bacterial reverse mutage...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Conze DB,Crespo-Barreto J,Kruger CL

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  • Radiotoxicity of h-R3 monoclonal antibody labeled with 188Re administered intracerebrally in rats.

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    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Gonzalez B,Casaco A,Alvarez P,Leon M,Arteaga M,Leon A,Santana E,Bada A,Figueredo R,Hernández R,Iznaga-Escobar N,González F,Perez R

    更新日期:2000-12-01 00:00:00

  • HFA-134a (1,1,1,2-tetrafluoroethane); lack of oncogenicity in rodents after inhalation.

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    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Alexander DJ,Libretto SE,Chevalier HJ,Imamura T,Pappritz G,Wilson J

    更新日期:1995-09-01 00:00:00

  • Fendiline-evoked [Ca2+]i rises and non-Ca2+-triggered cell death in human oral cancer cells.

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    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Huang C,Huang C,Cheng J,Liu S,Chen I,Tsai J,Chou C,Tseng P,Jan C

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  • Colour vision defects in occupational chronic solvent encephalopathy.

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    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Päällysaho J,Näsänen R,Mäntyjärvi M,Kaukiainen A,Sainio M

    更新日期:2007-04-01 00:00:00

  • Critique of dose response in carcinogenesis.

    abstract::A few landmarks in the development of dose response in toxicology are presented, with an explanation of why dose should only be considered on a logarithmic scale. Examples are shown, illustrating that the current practice of labeling dose-response curves for carcinogenesis as supralinear, linear or sublinear, is meani...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章,评审


    authors: Waddell WJ

    更新日期:2006-07-01 00:00:00

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    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Juni RL

    更新日期:2008-02-01 00:00:00

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    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Mundt KA

    更新日期:2006-01-01 00:00:00

  • Impact of polychlorinated biphenyl Aroclor 1254 on testicular antioxidant system in adult rats.

    abstract::To clarify the reproductive toxicity of polychlorinated biphenyl compounds through determination of testicular lipid peroxidation, reactive oxygen species and enzymatic and non-enzymatic antioxidants in rats exposed to Aroclor 1254. Adult male rats were administered Aroclor 1254 at a dose of 2 mg/kg per day ip for 30 ...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Murugesan P,Senthilkumar J,Balasubramanian K,Aruldhas MM,Arunakaran J

    更新日期:2005-02-01 00:00:00

  • Sex-specific differences in the regulation of inducible nitric oxide synthase by bisphenol A in neutrophils.

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    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Ratajczak-Wrona W,Nowak K,Garley M,Tynecka M,Jablonska E

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    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Kassa J,Bajgar J

    更新日期:1996-05-01 00:00:00

  • Changes of acetylcholinesterase activity after long-term exposure to sarin vapors in rats.

    abstract::In our study, rats were exposed to sarin vapors for 240 min at four different concentrations (0.30, 0.43, 0.58 and 0.82 microg/L) in a whole-body inhalation chamber. The acetylcholinesterase activity (AChE, EC was measured in the whole blood, frontal cortex (FC), pontomedullar area (PM) and basal ganglia (BG)...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Bartosova-Sevelova L,Bajgar J

    更新日期:2005-07-01 00:00:00

  • Near-fatal gamma-butyrolactone intoxication--first report in the UK.

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    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Dupont P,Thornton J

    更新日期:2001-01-01 00:00:00

  • Apoptotic cell death in rat epididymis following epichlorohydrin treatment.

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    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Lee IC,Kim KH,Kim SH,Baek HS,Moon C,Kim SH,Yun WK,Nam KH,Kim HC,Kim JC

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  • Dose-dependent toxicity of diphenhydramine overdose.

    abstract:BACKGROUND:Diphenhydramine (DPHM) overdose is a frequent cause of acute poisoning. Although its clinical features are well known, information about the dose-dependent toxicity of DPHM is still scarce. The objective of this study was to investigate the dose-dependent toxicity of DPHM in patients with acute DPHM poisonin...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Radovanovic D,Meier PJ,Guirguis M,Lorent JP,Kupferschmidt H

    更新日期:2000-09-01 00:00:00

  • The ethics of hormesis--no fuss?

    abstract::It has been argued that the phenomenon of hormesis should prompt us to revise current regulatory policy in order to take beneficial effects of small doses of various agents into account. I argue that three problems--the comparative smallness of hormetic effects, the fine-tuning problem, and the problem of aggregated a...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章,评审


    authors: Sandin P

    更新日期:2008-08-01 00:00:00

  • Effects of concentration reduction and partial replacement of paraquat by diquat on human toxicity: a clinical survey.

    abstract::Paraquat poisoning was studied in 174 patients over a 12-month period when a new, low concentration paraquat product (4.5% w/v paraquat ion mixed with 4.5% w/v diquat ion; 63 cases) replaced the original high concentration paraquat product (20% w/v paraquat ion only; 111 cases). In both groups approximately 60% of the...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Yoshioka T,Sugimoto T,Kinoshita N,Shimazu T,Hiraide A,Kuwagata Y

    更新日期:1992-07-01 00:00:00

  • Serum paraoxonase activity and oxidative stress levels in patients with cutaneous anthrax.

    abstract:INTRODUCTION:Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalase activity, malondial...

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    authors: Karadas S,Aslan M,Ceylan MR,Sunnetcioglu M,Bozan N,Kara H,Demir H

    更新日期:2017-07-01 00:00:00

  • A model of chlorpyrifos distribution and its biochemical effects on the liver and kidneys of rats.

    abstract::This study investigated the main target sites of chlorpyrifos (CPF), its effect on biochemical indices, and the pathological changes observed in rat liver and kidney function using gas chromatography/mass spectrometry. Adult female Wistar rats (n = 12) were randomly assigned into two groups (one control and one test g...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Tanvir EM,Afroz R,Chowdhury M,Gan SH,Karim N,Islam MN,Khalil MI

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  • Polyphenols from Juglans regia L. (walnut) kernel modulate cigarette smoke extract induced acute inflammation, oxidative stress and lung injury in Wistar rats.

    abstract::The present study was designed to evaluate the protective effects of Juglans regia kernel extract against cigarette smoke extract (CSE)-induced lung toxicities in Wistar rats. Prophylactic treatment of methanolic extract of J. regia kernel at the doses of 50 mg/kg b.wt. and 100 mg/kg b.wt was given by gavage to Wistar...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Qamar W,Sultana S

    更新日期:2011-06-01 00:00:00

  • Lead exposure in a population of Mexican children.

    abstract::The effects of low lead exposure were investigated in 96 children (7-12 years old) living and studying within a 1 km radius of a lead smelter (exposed population) located in Torreón, Coahuila, México, and compared with 30 children living and studying 4.5 km from the same smelter (control population). Both populations ...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Calderón-Salinas JV,Valdéz-Anaya B,Mazúñiga-Charles,Albores-Medina A

    更新日期:1996-04-01 00:00:00

  • An unusual case of mesalazine intoxication: oral and rectal overloading of the rectal suppository form.

    abstract::Drugs containing 5-acetylsalicylic acid (5-ASA) have been commonly used for inflammatory bowel diseases for more than half a century, but no case about overdose of suppository form of mesalazine which was taken both orally and rectally has been reported in the related literature up to now. In the present case, a 20-ye...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Koseoglu Z,Satar S,Kara B,Sebe A,Kosenli O

    更新日期:2011-07-01 00:00:00

  • Scientific research related to calcium channel blockers poisoning: Bibliometric analysis in Scopus, 1968-2012.

    abstract:PURPOSE:Calcium channel blockers (CCBs) were the most common agents associated with a significant morbidity and mortality rate. The main objective of this study was to examine the publication pattern related to CCBs poisoning at the global level using bibliometric analysis of articles published in SciVerse Scopus onlin...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Zyoud SH,Al-Jabi SW,Sweileh WM,Waring WS

    更新日期:2015-11-01 00:00:00

  • An assessment of the in vitro toxicology of Clostridium perfringens type D epsilon-toxin in human and animal cells.

    abstract::The epithelial Madin Darby canine kidney (MDCK) cell line and 17 human cell lines were examined for sensitivity to Clostridium perfringens type D epsilon-toxin. MDCK cells were confirmed as being sensitive to the toxin. In addition, the Caucasian renal leiomyoblastoma (G-402) human cell line was identified as being ep...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Shortt SJ,Titball RW,Lindsay CD

    更新日期:2000-02-01 00:00:00

  • Protective effects of melatonin and Glycyrrhiza glabra extract on ochratoxin A--induced damages on testes in mature rats.

    abstract::The effect of Glycyrrhiza glabra extract (GgE) as a natural antioxidant and melatonin (MEL) on ochratoxin A (OTA)-induced histopathological damages on the testes and oxidative stress was evaluated in male rats. The animals were assigned into four groups (n = 8) including control and test groups. The rats in control gr...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Malekinejad H,Mirzakhani N,Razi M,Cheraghi H,Alizadeh A,Dardmeh F

    更新日期:2011-02-01 00:00:00

  • Hydrogen sulfide ameliorates cardiovascular dysfunction induced by cecal ligation and puncture in rats.

    abstract::Hydrogen sulfide (H2S) is an endogenously produced gaseous messenger that participates in regulation of cardiovascular functions. This study evaluates the possible protective effect of H2S in cardiovascular dysfunction induced by cecal ligation and puncture (CLP) in rats. After 24 h of induction of CLP, heart rate (HR...

    journal_title:Human & experimental toxicology

    pub_type: 杂志文章


    authors: Abdelrahman RS,El-Awady MS,Nader MA,Ammar EM

    更新日期:2015-10-01 00:00:00