Abstract:
:The aim of the present study was to investigate whether cognitive behavioral impairment, induced by nicotine in offspring rats, was associated with the alteration of hippocampal short-term potentiation (STP) and long-term potentiation (LTP) and to discuss the potential underlying mechanism. Young adult offspring rats were randomly divided into three groups. The groups include: control group (CC), nicotine group 1 (NC), in which their mothers received nicotine from gestational day 3 (GD3) to GD18, and nicotine group 2 (CN), in which young adult offspring rats received nicotine from postnatal day 42 (PD42) to PD56. Morris water maze (MWM) test was performed and then field excitatory postsynaptic potentials elicited by the stimulation of perforant pathway were recorded in the hippocampal dentate gyrus region. The results of the MWM test showed that learning and memory were impaired by either prenatal or postnatal nicotine exposure. In addition, it was found that there was no statistical difference of the MWM data between both nicotine treatments. In the electrophysiological test, LTP and STP were significantly inhibited in both NC and CN groups in comparison with the CC group. Notably, STP in CN group was also lower than that in the NC group. These findings suggested that both prenatal and postnatal exposure to nicotine induced learning and memory deficits, while the potential mechanism might be different from each other due to their dissimilar impairments of synaptic plasticity.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Han G,An L,Yang B,Si L,Zhang Tdoi
10.1177/0960327113494902subject
Has Abstractpub_date
2014-02-01 00:00:00pages
203-13issue
2eissn
0960-3271issn
1477-0903pii
0960327113494902journal_volume
33pub_type
杂志文章abstract::The present study was designed to evaluate the protective effects of Juglans regia kernel extract against cigarette smoke extract (CSE)-induced lung toxicities in Wistar rats. Prophylactic treatment of methanolic extract of J. regia kernel at the doses of 50 mg/kg b.wt. and 100 mg/kg b.wt was given by gavage to Wistar...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110374204
更新日期:2011-06-01 00:00:00
abstract::The mechanism of doxorubicin (DOX)-induced cardiotoxicity remains controversial. Wistar rats (n = 66) received DOX injections intraperitoneally and were randomly assigned to 2 experimental protocols: (1) rats were killed before (-24 h, n = 8) and 24 h after (+24 h, n = 8) a single dose of DOX (4 mg/kg body weight) to ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327113512342
更新日期:2014-07-01 00:00:00
abstract::Levo-Carnitine (l-carnitine) is widely used in health and food. This study was to focus on the adverse effects of 8-week oral supplementation of l-carnitine (0.3 and 0.6 g/kg) in female and male Sprague Dawley rats. l-carnitine reduced body and fat weights, as well as serum, liver, and kidney lipid levels in rats. Sim...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115571767
更新日期:2015-11-01 00:00:00
abstract::This study was carried out on rodents, to explore the neurobehavioral effects of acrylonitrile (AN) administered in drinking water. Thirty, male, Sprague-Dawley rats were randomly divided into three groups: two exposure groups (50 and 200 ppm AN), and one control group (tap water without AN). Three tests, including th...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107070563
更新日期:2007-03-01 00:00:00
abstract::Vigabatrin (VGB) is an antiepileptic drug thatincreases brain γ-aminobutyric acid (GABA) levels through irreversible inhibition of GABA transaminase. The aim of this study was to evaluate neurotoxicological effects of VGB measuring motor activity and genotoxic and mutagenic effects after a single and repeated administ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115611970
更新日期:2016-09-01 00:00:00
abstract::Previous studies have shown that environmental exposure to heavy metals has been related to epigenetic changes, such as DNA methylation in receptors involved in pathogenesis of asthma. One of these receptors is beta-2 adrenergic receptor (ADRB2). We conducted this study to examine the association between blood aluminu...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120921436
更新日期:2020-10-01 00:00:00
abstract::1. Neonatal treatment of rats with vitamin D3 resulted in a change of sexual behavior in adulthood. 2. 2.5 mg vitamin D3 completely inhibited the ejaculation of males without any apparent influence on sexual desire. 250 mg vitamin D3 influenced both the desire and ejaculation. 3. Sexual activity of females was depress...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719601500704
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate, the cytotoxicity of orthodontic composites in vitro as a function of degree of conversion (DC) and the light curing units (LCU) employed on mouse fibroblast (L929). MATERIALS AND METHODS:Cured samples of the composites Light bond (Reliance Orthodontic Products, Itasca,...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327113520020
更新日期:2014-10-01 00:00:00
abstract::Sodium hypochlorite (NaClO) is used extensively as a disinfectant or bleaching agent. Most studies describe ingestion or inhalation route of this product with rare complication and fatalities. Despite global daily exposures, data about bleach injection is limited. Here we report intentional infusion of 20 mL, sodium h...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327111432506
更新日期:2012-06-01 00:00:00
abstract::Benzydamine is a nonsteroidal anti-inflammatory drug, currently available as mouthwash, aerosol, dermal cream, vaginal douche preparation, pills and otic drops. Up to now no cases of poisoning due to this drug have been reported. A 6-year-old girl with an accidental poisoning with benzydamine is described. The episode...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032799678840264
更新日期:1999-07-01 00:00:00
abstract:AIM:To assess the systemic inflammatory response (SIR) and the multi-organ damage after large-volume liver radiofrequency ablation (RFA) with or without concurrent Pringle maneuver. METHODS:Wistar rats were subjected to 30% liver RFA (group RFA), liver RFA under 30-min Pringle maneuver (group RFA + P), Pringle only (g...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327111401438
更新日期:2011-11-01 00:00:00
abstract::Diallyl sulfide, a sulfur-containing volatile compound present in garlic (Allium sativum), exerts anticarcinogenic activity in various rodent tumor models. In the present study, apoptosis-inhibiting effects of diallyl sulfide against a carcinogenic polycyclic aromatic hydrocarbon, 7,12-dimethyl benz(a)anthracene (DMBA...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327108088978
更新日期:2008-01-01 00:00:00
abstract::The present study was undertaken to investigate the effects of maternal lead (Pb) exposure on the expression of interleukin (IL) 1β, IL 6, and glial fibrillary acidic protein (GFAP) in hippocampus of mice offspring. Pb exposure initiated from the beginning of gestation to weaning. Lead acetate (PbAc) administered in d...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327114529451
更新日期:2015-04-01 00:00:00
abstract::This study presents the findings of free radical scavenging and antigenotoxic effect of hydroalcoholic extract of Cymbopogon citratus (CCE). The CCE at a concentration of 60 microg/mL resulted in a significant scavenging ability of 2,2-diphenyl-2-picryl hydrazyl (DPPH; (85%), 2,2-azinobis (3-ethyl benzothiazoline-6-su...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109104822
更新日期:2009-04-01 00:00:00
abstract::Derivatives of dehydrocrotonin (DHC; Compound I) with different anti-ulcerogenic properties but less toxicity were produced by reducing the cyclohexenone moiety of DHC with NaBH4 (Compound II), reducing the cyclohexenone and lactone moieties with LiAlH4 (Compound III) and transforming the lactone moiety into an amide ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327102ht246oa
更新日期:2002-05-01 00:00:00
abstract::1. Four different concentrations of quinalphos and methyl parathion were tested on human peripheral lymphocytes over different time periods, for the analysis of chromosomal aberrations and sister chromatid exchanges (SCEs). 2. A significant increase in chromosomal aberrations was observed when cells were treated with ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719000900605
更新日期:1990-11-01 00:00:00
abstract:INTRODUCTION:Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalase activity, malondial...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116661020
更新日期:2017-07-01 00:00:00
abstract::Pesticides are used in agriculture to protect crops from insects-pests. Most of the field workers of North Indian population are exposed to commonly used insecticides. In the present study, pesticides induced oxidative stress as well as alterations in the level of acetylcholinesterase (AChE) in a total of 70 male heal...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112474835
更新日期:2013-11-01 00:00:00
abstract::Cyanate and its active form isocyanate are formed mainly in the process of nonenzymatic urea biodegradation. Cyanate is capable of protein S- and N-carbamoylation, which can affect their activity. The present studies aimed to demonstrate the effect of cyanate on activity of the enzymes implicated in anaerobic cysteine...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110394225
更新日期:2011-10-01 00:00:00
abstract::The aim of this study was to determine the safety of azelaic acid (AA) and its derivatives in nanovesicles for pharmaceutical and cosmetic uses. The hydrophilic property of AA was modified by complexing AA with hydroxypropyl-beta-cyclodextrin (AACD). The lipophilic property of AA was improved to diethyl azelate (DA) b...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109105164
更新日期:2009-06-01 00:00:00
abstract::Resveratrol, a grape skin and red wine-derived polyphenolic phytoalexin, exhibits hormetic action delivering numerous health benefits at lower doses while being detrimental at higher doses. Epidemiologic and clinical trials need to be based on the clear understanding of hormetic health benefits of resveratrol. ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110383626
更新日期:2010-12-01 00:00:00
abstract::Genotoxicants can be identified as aneugens and clastogens through a micronucleus (MN) assay. The current high-content screening-based MN assays usually discriminate an aneugen from a clastogen based on only one parameter, such as the MN size, intensity, or morphology, which yields low accuracies (70-84%) because each...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117695635
更新日期:2018-03-01 00:00:00
abstract::Hormesis can be considered as a parameter which has a non-monotonic relationship with some endpoint. Since caloric intake is such a parameter, and the impact of this parameter on risk assessment has been fairly well characterized, it can provide clues as to how to integrate the information from a hormetic parameter in...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719801700810
更新日期:1998-08-01 00:00:00
abstract::We aimed to investigate the possible roles of nitric oxide (NO) and endothelin on the changes of cardiac muscle function in both hyper- and hypodynamic septic shock periods. Cecal ligation and puncture was performed in 50 Wistar albino rats to induce septic shock. Changes in atrium and right ventricle papillary muscle...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115583363
更新日期:2016-03-01 00:00:00
abstract::Sulfur mustard (SM) represents a potential chemical warfare agent. In order to characterize SM-induced airway epithelial damage, we studied the effects of an intratracheal injection of 0.3 mg/kg of SM in guinea pigs, 5 h, 24 h, 14 days and 35 days after exposure. During the acute period, lesions prevailed in tracheal ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719601501204
更新日期:1996-12-01 00:00:00
abstract::Evidence-based guidelines do not exist for the treatment of patients with chronic mild-moderate digoxin toxicity. We sought to evaluate differences among specialists in the use of digoxin-specific antibody fragments and the decision to admit these patients. A sample of cardiologists, emergency physicians, and medical ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109105405
更新日期:2009-05-01 00:00:00
abstract::Sterigmatocystin (Stg), a major secondary metabolite of Aspergillus versicolor and A. nidulans, is the precursor of aflatoxin B1. In this study, male albino rats were treated with Stg-contaminated diet for 30 days, resulting in reduced levels of glutathione, ascorbic acid, and alpha-tocopherol. The activity of catalas...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032701682692955
更新日期:2001-08-01 00:00:00
abstract::Boophone disticha (B. disticha) has been used systemically in traditional medical practice in Zimbabwe and neighbouring countries for the management of various central nervous system conditions including hysteria. Abuse of the plant by teenagers in Zimbabwe for its claimed hallucinogenic effects has also been reported...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110384524
更新日期:2011-08-01 00:00:00
abstract::The second-generation selective 5-HT2 receptor antagonists and reuptake inhibitors (SARIs) class antidepressants are known to have fewer cardiovascular side effects than the older ones. However, several case reports showed that trazodone, one of the second-generation SARIs, induces QT prolongation, cardiac arrhythmia,...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115595683
更新日期:2016-05-01 00:00:00
abstract::The aim of the present investigation was to check the fluctuation in essential elements, such as Na, K, Mg, Mn, Cu, Zn, Cr and Ni in the brain, spinal cord, liver and kidney of mice during methylmercury chloride (MMC) toxication and therapy with monothiols (N-acetyl-DL-homocysteine thiolactone and glutathione) and vit...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719401301201
更新日期:1994-12-01 00:00:00