Abstract:
:Personal reflections on radiation hormesis for the past 50 years are presented. The causes of ignoring and rejections of this phenomenon by international and national bodies and by radiation protection establishment are analyzed. The opposition against nuclear weapons and preparations for nuclear war was probably the main factor in inducing the concern for adverse effects of low doses of ionizing radiation, a byproduct of activism against the nuclear weapon tests. UNSCEAR was deeply involved in preparation of the scientific basis for cessation of nuclear test, and contributed to elaboration of the LNT assumption, which is in contradiction with the hormetic phenomenon. However, this authoritative body recognized also the existence of radiation hormesis, termed as 'adaptive response.' The political and vested interests behind exclusion of hormesis from the current risk assessment methodology are discussed.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Jaworowski Zdoi
10.1177/0960327110363974subject
Has Abstractpub_date
2010-04-01 00:00:00pages
263-70issue
4eissn
0960-3271issn
1477-0903pii
29/4/263journal_volume
29pub_type
历史文章,杂志文章,评审abstract::Drugs intended for use in preventing allograft rejection in transplant patients are likely to be administered chronically; thus, it is normally expected that sponsors would conduct nonclinical studies to determine the carcinogenic potential of candidate compounds. For pharmaceuticals other than biologic agents, this w...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,评审
doi:10.1191/096032700678815837
更新日期:2000-04-01 00:00:00
abstract::Mercury, a heavy metal, is widespread and persistent in the environment and has been elucidated as a possible risk factor in cardiovascular diseases. Mercury has been reported to selectively impair the nitric oxide (NO) pathway in the vascular endothelium as a consequence of oxidative stress. Conversely, mercury per s...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327113512341
更新日期:2014-09-01 00:00:00
abstract::Recent years have seen substantial shifts in cultural attitudes towards cannabis for medical and recreational use. However, legalizing recreational marijuana may have adverse effects on individual and public health. As the most widely used illicit agent, cannabis is commonly reported to disrupt learning and memory. Un...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119886037
更新日期:2020-03-01 00:00:00
abstract::This report describes two accidents, involving snakes of the Micrurus corallinus species, where compromising respiratory function was not observed and the specific anti-elapidic serum was the single therapy used, and a third incident, probably involving Micrurus frontalis, where neostigmine was used to remedy respirat...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719201100213
更新日期:1992-03-01 00:00:00
abstract::Cytochrome P450 4B1 (CYP4B1) plays crucial roles in biotransforming of xenobiotics. Its predominant extrahepatic expression has been associated with certain tissue-specific toxicities. However, the expressions of CYP4B1 in various cancers and hence their potential roles in cancer development were inclusive. In this wo...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120905959
更新日期:2020-06-01 00:00:00
abstract::Sepsis, often initiated by an infection, is a state of disrupted inflammatory homeostasis. There is increasing evidence that oxidative stress has an important role in the development of sepsis-induced multiorgan failure. Resveratrol (RV) is a polyphenolic compound found in the skin of red fruits, such as mulberries an...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112467047
更新日期:2013-10-01 00:00:00
abstract::Coronary heart disease and in particular its most serious form - acute myocardial infarction (AMI) - represents the most common cause of mortality in developed countries. Better prognosis may be achieved by understanding the etiopathogenetic mechanisms of AMI. Therefore, a catecholamine model of myocardial injury, whi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109350665
更新日期:2009-10-01 00:00:00
abstract::Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Attenuation of fibrogenic process can significantly lower the mortality rate. However, pharmaceutical intervention at fibrogenesis stage remains a major task in medicine. So there is a need for a natural compound to treat hepatic fibrosis. This ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116638727
更新日期:2017-02-01 00:00:00
abstract::Accumulating evidence has shown that ethanol-induced iron overload plays a crucial role in the development and progression of alcoholic liver disease. We designed the present study to investigate the potential protective effect of quercetin, a naturally occurring iron-chelating antioxidant on alcoholic iron overload a...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327113499168
更新日期:2014-05-01 00:00:00
abstract::The purpose of this study was to characterize the zinc oxide nanoparticles (ZnO-NPs) and their bulk counterpart in suspensions and to access the impact of their acute oral toxicity at doses of 300 and 2000 mg/kg in healthy female Wistar rats. The hematological, biochemical, and urine parameters were accessed at 24 and...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116629530
更新日期:2016-12-01 00:00:00
abstract::In carbon monoxide (CO) poisoning, CO affects the oxygen-carrying capacity of the hemoglobin molecule. Nucleolar-organizing regions (NORs) are genetic loci on chromosomes that are composed of ribosomal DNA and proteins. NORs can be stained with silver. A total of 18 rats were exposed to CO in three different concentra...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327114531994
更新日期:2015-01-01 00:00:00
abstract::Celecoxib has been shown to have antitumor effect in previous studies but the mechanisms are unclear. The effect of celecoxib on cytosolic Ca(2+) concentrations ([Ca(2+)]i) and viability in HA59T human hepatoma cells was explored. The Ca(2+)-sensitive fluorescent dye fura-2 was applied to measure [Ca(2+)]i. Celecoxib ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112472996
更新日期:2014-11-01 00:00:00
abstract::1. Six healthy male volunteers received intravenous injections of 26Al as citrate. Accelerator mass spectrometry and gamma-ray spectrometry were used to determine levels of the tracer in blood and excreta at times up to 5-6 d. 2. There was a rapid clearance from blood (mean 2% of injection remaining after 1 d) and maj...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719501400707
更新日期:1995-07-01 00:00:00
abstract::Tripartite motif-containing protein 24 (TRIM24) has currently emerged as a crucial cancer-related gene present in a wide range of human cancer types. However, the involvement of TRIM24 in acute myeloid leukemia (AML) has not been well investigated. The present study aims to investigate the significance, cellular funct...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120938845
更新日期:2020-12-01 00:00:00
abstract::The objective of this study is to analyze exposures concerning analgesics that were reported to Dokuz Eylul University Drug and Poison Information Center (DPIC) and admitted to the Department of Emergency Medicine in Dokuz Eylul University Hospital (EMDEU) between 1993 and 2004. Demographics of the patients, character...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107076836
更新日期:2007-08-01 00:00:00
abstract:INTRODUCTION:Chronic obstructive pulmonary disease (COPD) due to sulfur mustard (SM), known as mustard lung, is an important late pulmonary complication of SM poisoning. Due to the possible role of systemic inflammation in mustard lung, we evaluated the serum levels of adiponectin and leptin in these patients. MATERIA...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327113504973
更新日期:2014-06-01 00:00:00
abstract::A liquid alcoholic extract of Papaver somniferum named Elixir Paregorico is extensively used for diarrheal diseases in Brazil. Its increased popularity has brought concerns and fears over the safety of this herbal product. Given the lack of investigative clinical studies, in this regard, this study investigated whethe...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327108090274
更新日期:2008-10-01 00:00:00
abstract::1. In humans morphine is metabolised to morphine-3-glucuronide (M3G) which possess no opioid activity, and morphine-6-glucuronide (M6G) which is a potent opioid receptor agonist that probably contribute to the desired as well as toxic effects of morphine. 2. In order to investigate the possible effect of ranitidine on...
journal_title:Human & experimental toxicology
pub_type: 临床试验,杂志文章
doi:10.1177/096032719801700611
更新日期:1998-06-01 00:00:00
abstract::Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with high morbidity and mortality. miR-182-5p is overexpressed in several fibrosis-related diseases but its effect in pulmonary fibrosis has not been reported yet. To investigate the function of miR-182-5p in pulmonary fibrosis, we establish...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119895549
更新日期:2020-05-01 00:00:00
abstract::Arsenic trioxide (As2O3) is utilized for treating patients suffering from hematological malignancies particularly acute promyelocytic leukemia. Unfortunately, the extensive application of this chemotherapeutic agent has been limited due to its adverse effects such as cardiotoxicity. Ellagic acid, as a phenolic compoun...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117701986
更新日期:2018-04-01 00:00:00
abstract::To clarify the reproductive toxicity of polychlorinated biphenyl compounds through determination of testicular lipid peroxidation, reactive oxygen species and enzymatic and non-enzymatic antioxidants in rats exposed to Aroclor 1254. Adult male rats were administered Aroclor 1254 at a dose of 2 mg/kg per day ip for 30 ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327105ht500oa
更新日期:2005-02-01 00:00:00
abstract::Paracetamol overdose is common and microRNA (miR)-122 expression is increased with liver injury. We aimed to measure miR-122 in the setting of an abbreviated paracetamol overdose treatment regimen. We compared miRNA expression in patients treated for paracetamol poisoning with an abbreviated 12-h intravenous acetylcys...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119833740
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) is the main clinical concern resulted from ischemia-reperfusion injury (IRI). Ample clinical data indicates that AKI is associated with distant organ dysfunctions and poor patients' outcomes. Oxidative stress and inflammation have a critical role in the pathogenesis of organ injurie...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120979014
更新日期:2020-12-16 00:00:00
abstract::Recent studies have proposed the use of low concentrations of phytochemicals and combinations of phytochemicals in chemoprevention to reduce cytotoxicity and simulate normal ingestion through diet. The purpose of the present study was to evaluate whether the DNA damage, chromosome instability, and oxidative stress ind...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112468911
更新日期:2013-08-01 00:00:00
abstract::1. Blood lead levels were examined in 127 housepainters in North Carolina between April and September, 1993. Each participant filled out a questionnaire and gave a blood sample. The questionnaire covered the individual's work history, concentrating on paint-removal activities and personal protection, and also covered ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719501400512
更新日期:1995-05-01 00:00:00
abstract::The present study was undertaken to investigate the effects of maternal lead (Pb) exposure on the expression of interleukin (IL) 1β, IL 6, and glial fibrillary acidic protein (GFAP) in hippocampus of mice offspring. Pb exposure initiated from the beginning of gestation to weaning. Lead acetate (PbAc) administered in d...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327114529451
更新日期:2015-04-01 00:00:00
abstract::9-(4'-Aminophenyl)-9H-pyrido [3,4-b] indole (aminophenylnorharman, APNH) is a novel mutagenic heterocyclic amine, produced by the reaction of norharman with aniline in the presence of S9 mix. In the present study, the maternal and developmental toxicity of APNH were investigated in ICR mice administered oral doses of ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327102ht227oa
更新日期:2002-03-01 00:00:00
abstract::Dental amalgams are a commonly used dental restorative material, and amalgams are about 50% mercury (Hg). In our study, urinary Hg levels was examined in children of age 8-18 years, with and without dental amalgam fillings, from a completed clinical trial (parent study) that was designed to evaluate the potential heal...
journal_title:Human & experimental toxicology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/0960327111417264
更新日期:2012-01-01 00:00:00
abstract::Periodontitis is a common infectious disease associated with destruction of periodontal ligaments and alveolar bones. CD4(+) T cell-mediated immune response is involved in the progression of periodontitis. Tobacco consumption increases the risk of periodontal disease. However, the impact of nicotine on the interaction...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115614383
更新日期:2016-09-01 00:00:00
abstract::Diallyl sulfide, a sulfur-containing volatile compound present in garlic (Allium sativum), exerts anticarcinogenic activity in various rodent tumor models. In the present study, apoptosis-inhibiting effects of diallyl sulfide against a carcinogenic polycyclic aromatic hydrocarbon, 7,12-dimethyl benz(a)anthracene (DMBA...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327108088978
更新日期:2008-01-01 00:00:00