Effects of lutein and chlorophyll b on GSH depletion and DNA damage induced by cisplatin in vivo.

abstract：:1 The cytotoxicity of dichlorobenzenes in cultured rat liver slices has previously been shown to be strain specific and biotransformation related. 2 In order to extrapolate animal models to humans, the dichlorobenzenes were incubated with human liver slices to try to clarify their hepatotoxic potential in man. 3 The d...

journal_title：Human & experimental toxicology

authors： Fisher R,Barr J,Zukoski CF,Putnam CW,Sipes IG,Gandolfi AJ,Brendel K

更新日期：1991-09-01 00:00:00

abstract：:A key aim of toxicology is the prevention of adverse effects due to toxic hazards. Therefore, the dissemination of toxicology research findings must confront two important challenges: one being the lack of information on the vast majority of potentially toxic industrial chemicals and the other being the strict criteri...

journal_title：Human & experimental toxicology

authors： Grandjean P

更新日期：2015-12-01 00:00:00

abstract：:1. Dettol liquid (chloroxylenol 4.8%, pine oil, isopropyl alcohol), a household disinfectant, has a corrosive action on the gastrointestinal mucosa when swallowed. The incidence of upper gastrointestinal haemorrhage and gastroscopic findings following Dettol poisoning was studied in 89 patients. 2. Five patients (5.6%...

journal_title：Human & experimental toxicology

authors： Chan TY,Sung JJ,Critchley JA

更新日期：1995-01-01 00:00:00

abstract：:Potassium bromate (KBrO3) is a potent nephrotoxic agent. In this paper, we report the chemopreventive effect of Nigella sativa (black cumin) on KBrO3-mediated renal oxidative stress, toxicity and tumor promotion response in rats. KBrO3 (125 mg/kg body weight, intraperitoneally) enhances lipid peroxidation, gamma-gluta...

journal_title：Human & experimental toxicology

authors： Khan N,Sharma S,Sultana S

更新日期：2003-04-01 00:00:00

abstract：:The synthetic catecholamine isoprenaline (ISO) has been used as an inductor in the acute myocardial infarction model for more than a half century. Despite the fact that many articles were published on this topic, precise early haemodynamic pathology remains unknown. Acute haemodynamic changes were measured in rats; fi...

journal_title：Human & experimental toxicology

authors： Filipský T,Zatloukalová L,Mladěnka P,Hrdina R

更新日期：2012-08-01 00:00:00

abstract：:Until quite recently, pentabromodiphenyl ether (PentaBDE) was most commonly used as a flame retardant. Due to the considerably long atmospheric half-life of PentaBDE and its contribution to environmental pollution, it is categorized as a persistent organic pollutant (POP). As the data on the toxicity of PentaBDE is ra...

journal_title：Human & experimental toxicology

authors： Bruchajzer E,Frydrych B,Sporny S,Szymańska JA

更新日期：2011-05-01 00:00:00

abstract：:We have investigated the pituitary-testicular axis in a well-characterized population which was occupationally exposed to mercury vapour. Thyroid stimulating hormone and prolactin were also measured as indices of thyroid and pituitary endocrine function. We found no relation between blood or urine mercury levels or le...

journal_title：Human & experimental toxicology

authors： McGregor AJ,Mason HJ

更新日期：1991-05-01 00:00:00

abstract：:The aim of this study was to compare the number of inactivated-influenza vaccine-related spontaneous abortion and stillbirth (SB) reports in the Vaccine Adverse Event Reporting System (VAERS) database during three consecutive flu seasons beginning 2008/2009 and assess the relative fetal death reports associated with t...

journal_title：Human & experimental toxicology

authors： Goldman GS

更新日期：2013-05-01 00:00:00

abstract：:Pyrazinamide (PYZ)-an essential component of primary drug regimen used for the treatment and management of multidrug resistant or latent tuberculosis-is well known for its hepatoxicity. However, the mechanism of PYZ-induced hepatotoxicity is still unknown to researchers. Studies have shown that the drug is metabolized...

journal_title：Human & experimental toxicology

authors： Rawat A,Chaturvedi S,Singh AK,Guleria A,Dubey D,Keshari AK,Raj V,Rai A,Prakash A,Kumar U,Kumar D,Saha S

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate, the cytotoxicity of orthodontic composites in vitro as a function of degree of conversion (DC) and the light curing units (LCU) employed on mouse fibroblast (L929). MATERIALS AND METHODS:Cured samples of the composites Light bond (Reliance Orthodontic Products, Itasca,...

journal_title：Human & experimental toxicology

authors： Cörekçi B,Irgın C,Halıcıoğlu K,Dursun S,Yavuz MZ

更新日期：2014-10-01 00:00:00

abstract：:The aim of the present study was to investigate whether cognitive behavioral impairment, induced by nicotine in offspring rats, was associated with the alteration of hippocampal short-term potentiation (STP) and long-term potentiation (LTP) and to discuss the potential underlying mechanism. Young adult offspring rats ...

journal_title：Human & experimental toxicology

authors： Han G,An L,Yang B,Si L,Zhang T

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Diphenhydramine (DPHM) overdose is a frequent cause of acute poisoning. Although its clinical features are well known, information about the dose-dependent toxicity of DPHM is still scarce. The objective of this study was to investigate the dose-dependent toxicity of DPHM in patients with acute DPHM poisonin...

journal_title：Human & experimental toxicology

authors： Radovanovic D,Meier PJ,Guirguis M,Lorent JP,Kupferschmidt H

更新日期：2000-09-01 00:00:00

abstract：:This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetis...

journal_title：Human & experimental toxicology

authors： El-Ebiary AA,Abuelfadl AA,Sarhan NI,Othman MM

更新日期：2013-06-01 00:00:00

abstract：:To clarify the reproductive toxicity of polychlorinated biphenyl compounds through determination of testicular lipid peroxidation, reactive oxygen species and enzymatic and non-enzymatic antioxidants in rats exposed to Aroclor 1254. Adult male rats were administered Aroclor 1254 at a dose of 2 mg/kg per day ip for 30 ...

journal_title：Human & experimental toxicology

authors： Murugesan P,Senthilkumar J,Balasubramanian K,Aruldhas MM,Arunakaran J

更新日期：2005-02-01 00:00:00

abstract：:Periostin is an extracellular matrix protein from the fasciclin family that guides cellular trafficking and extracellular matrix organization. Periostin stimulates mature cardiomyocytes to reenter the cell cycle. The molecular mechanism behind such stimulation remains to be explored. A DNA microarray technology consti...

journal_title：Human & experimental toxicology

authors： Sözmen M,Devrim AK,Kabak YB,Devrim T

更新日期：2019-02-01 00:00:00

abstract：:The effect of sympathomimetic intervention with dopamine or dobutamine on the myocardial uptake of d-propoxyphene was investigated experimentally in rats. The d-propoxyphene (19 mg kg-1 h-1) was continuously infused, intravenously, over 45 min. After 20 min of infusion the rats were given either dopamine (12.5 microgr...

journal_title：Human & experimental toxicology

authors： Pedersen CB,Strøm J,Angelo HR,Munksgaard A,Høgskilde S,Bredgaard Sørensen M

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due ...

journal_title：Human & experimental toxicology

authors： Attaran D,Lari SM,Khajehdaluee M,Ayatollahi H,Towhidi M,Asnaashari A,Marallu HG,Mazloomi M,Mood MB

更新日期：2009-12-01 00:00:00

abstract：:The time-dependent changes in lead (Pb) concentrations in major tissues, serum and urine, and the Pb biomarker delta-aminolevulinic acid (ALA) concentration in urine were studied in rats after sub-chronic Pb exposure. Female Sprague-Dawley (SD) rats were exposed to Pb in drinking water at concentrations of 100 ppm and...

journal_title：Human & experimental toxicology

authors： Kang HG,Jeong SH,Cho MR,Cho JH,Bischoff K

更新日期：2009-10-01 00:00:00

abstract：:1. The reactivating and therapeutic efficacy of a new acetylcholinesterase reactivator, designated BI-6 (1-/2-hydroxyiminomethylpyridinium/-4-/carbamoylpyridinium/- 2-butene dibromide), against organophosphate sarin was compared with presently used oximes (pralidoxime, obidoxime, methoxime) and H oximes (HI-6, HLö-7) ...

journal_title：Human & experimental toxicology

authors： Kassa J,Cabal J

更新日期：1999-09-01 00:00:00

abstract：:1. In humans morphine is metabolised to morphine-3-glucuronide (M3G) which possess no opioid activity, and morphine-6-glucuronide (M6G) which is a potent opioid receptor agonist that probably contribute to the desired as well as toxic effects of morphine. 2. In order to investigate the possible effect of ranitidine on...

journal_title：Human & experimental toxicology

authors： Aasmundstad TA,Størset P

更新日期：1998-06-01 00:00:00

abstract：:Sodium hypochlorite (NaClO) is used extensively as a disinfectant or bleaching agent. Most studies describe ingestion or inhalation route of this product with rare complication and fatalities. Despite global daily exposures, data about bleach injection is limited. Here we report intentional infusion of 20 mL, sodium h...

journal_title：Human & experimental toxicology

authors： Rahmani SH,Ahmadi S,Vahdati SS,Moghaddam HH

更新日期：2012-06-01 00:00:00

abstract：:In responding to Drs Calabrese and Baldwin's question, 'At what point, if ever, should hormesis be employed as the principal dose response default assumption in risk assessment?', we examined the benefits of replacing traditional dose-response with hormesis. In general, hormesis provides more complete useful informati...

journal_title：Human & experimental toxicology

authors： Pickrell JA,Oehme FW

更新日期：2005-05-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) and dioxins are potentially toxic compounds which occur widely in the environment. Their effects on the growth and development of infants at the levels currently found in highly industrialised western countries is not well known. This Dutch multicenter study, combining animal and human...

journal_title：Human & experimental toxicology

authors： Sauer PJ,Huisman M,Koopman-Esseboom C,Morse DC,Smits-van Prooije AE,van de Berg KJ,Tuinstra LG,van der Paauw CG,Boersma ER,Weisglas-Kuperus N

更新日期：1994-12-01 00:00:00

abstract：:3,4-Methylenedioxyphenol (sesamol) is effective against acetaminophen-induced liver injury in rats. Whether sesamol's anti-hepatotoxic effect is comparable to that of N-acetylcysteine has never been studied. We investigated the anti-hepatotoxic effects of sesamol and N-acetylcysteine on acetaminophen-induced hepatotox...

journal_title：Human & experimental toxicology

authors： Chandrasekaran VR,Chien SP,Hsu DZ,Liu MY

更新日期：2011-10-01 00:00:00

abstract：:Oxidative stress has an important role in the pathophysiology of many occupational diseases. In this controlled exposure study, the intensity of oxidative stress biomarkers was assessed in the workers of natural sweet and sour gas refineries (SwGR and SoGR, respectively) and compared with controls. In addition, the ro...

journal_title：Human & experimental toxicology

authors： Mandegary A,Sezavar M,Saeedi A,Amirheidari B,Naghibi B

更新日期：2012-12-01 00:00:00

abstract：:Pharmacological potential of curcumin was assessed in PC12 cells against hydrogen peroxide (H(2) O(2)) exposure. In MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] and lactate dehydrogenase (LDH) assays, 24-hour exposure of H(2)O(2) (0.5 mM and above) was found to be cytotoxic. A significant (p < 0...

journal_title：Human & experimental toxicology

authors： Siddiqui MA,Kashyap MP,Kumar V,Tripathi VK,Khanna VK,Yadav S,Pant AB

更新日期：2011-03-01 00:00:00

abstract：:1. Groups of 60 male and 60 female B6C3F1 mice or HanIbm Wistar rats were exposed to HFA-134a using snout-only inhalation exposure techniques for periods of one hour daily for at least 104 weeks. HFA-134a was delivered directly from cylinders at vapour concentrations of 2500, 15,000 and 75,000ppm for mice and from met...

journal_title：Human & experimental toxicology

authors： Alexander DJ,Libretto SE,Chevalier HJ,Imamura T,Pappritz G,Wilson J

更新日期：1995-09-01 00:00:00

abstract：:1. Six healthy male volunteers received intravenous injections of 26Al as citrate. Accelerator mass spectrometry and gamma-ray spectrometry were used to determine levels of the tracer in blood and excreta at times up to 5-6 d. 2. There was a rapid clearance from blood (mean 2% of injection remaining after 1 d) and maj...

journal_title：Human & experimental toxicology

authors： Talbot RJ,Newton D,Priest ND,Austin JG,Day JP

更新日期：1995-07-01 00:00:00

abstract：:Pharmaceutical research and new drug development rely extensively on animal research. The development of novel agents for intrathecal administration requires preclinical studies of toxic effects in an animal model. We have developed a nonrodent animal model for this purpose. Our sheep model: 1 Is an animal whose neura...

journal_title：Human & experimental toxicology

authors： Hassenbusch SJ,Satterfield WC,Gradert TL

更新日期：1999-02-01 00:00:00

abstract：:1. The herbicide, paraquat, is accumulated by the energy-dependent polyamine uptake pathway of alveolar type II cells. There it undergoes redox cycling that results in an amplified production of toxic reactive oxygen species and depletion of NADPH and other reducing equivalents. These processes account for the lung be...

journal_title：Human & experimental toxicology

authors： Chen N,Bowles MR,Pond SM

更新日期：1994-08-01 00:00:00