Regulation of oxidative stress-mediated apoptosis by diallyl sulfide in DMBA-exposed Swiss mice.

abstract：:1. Neonatal treatment of rats with vitamin D3 resulted in a change of sexual behavior in adulthood. 2. 2.5 mg vitamin D3 completely inhibited the ejaculation of males without any apparent influence on sexual desire. 250 mg vitamin D3 influenced both the desire and ejaculation. 3. Sexual activity of females was depress...

journal_title：Human & experimental toxicology

authors： Mirzahosseini S,Karabélyos C,Dobozy O,Csaba G

更新日期：1996-07-01 00:00:00

abstract：:Two studies were performed in order to evaluate cytochrome P450 1A2 mediated caffeine metabolism during different nutritional conditions. 1. In the first study, 23 healthy male non-smokers, mean age 25, changed from a customary mixed diet to a standard diet in 6 days. The 6 day's standard diet was based on bread, pota...

journal_title：Human & experimental toxicology

authors： Kall MA,Clausen J

更新日期：1995-10-01 00:00:00

abstract：:Cultures of bovine pulmonary endothelial (BPE) cells were exposed to LC70 doses of ricin or abrin (15.5 and 4.5 pM respectively) over a period of up to 40 h. The viability of the cultures (as determined by the neutral red (NR) dye retention assay) declined after 6 h exposure to the toxins. From 15 h onwards, cellular ...

journal_title：Human & experimental toxicology

authors： Hughes JN,Lindsay CD,Griffiths GD

更新日期：1996-05-01 00:00:00

abstract：:Manganese (Mn) is an essential nutrient required for proper growth and maintenance of numerous biological systems. At high levels it is known to be neurotoxic. While focused research concerning the transport of Mn across the blood-brain barrier (BBB) is on-going, the exact identity of the transporter(s) responsible is...

journal_title：Human & experimental toxicology

authors： Fitsanakis VA,Piccola G,Marreilha dos Santos AP,Aschner JL,Aschner M

更新日期：2007-04-01 00:00:00

abstract：:Personal reflections on radiation hormesis for the past 50 years are presented. The causes of ignoring and rejections of this phenomenon by international and national bodies and by radiation protection establishment are analyzed. The opposition against nuclear weapons and preparations for nuclear war was probably the ...

journal_title：Human & experimental toxicology

authors： Jaworowski Z

更新日期：2010-04-01 00:00:00

abstract：:The epithelial Madin Darby canine kidney (MDCK) cell line and 17 human cell lines were examined for sensitivity to Clostridium perfringens type D epsilon-toxin. MDCK cells were confirmed as being sensitive to the toxin. In addition, the Caucasian renal leiomyoblastoma (G-402) human cell line was identified as being ep...

journal_title：Human & experimental toxicology

authors： Shortt SJ,Titball RW,Lindsay CD

更新日期：2000-02-01 00:00:00

abstract：:The common effects of acetaminophen (paracetamol), isopropylantipyrine (propyphenazone) and caffeine on fetal development were examined in rats. The mixture was given in Tween 80 solution once daily, in a constant proportion of 5:3:1, during days 8-14 of gestation in three different doses. Dose S1 - 3.5 mg/kg acetamin...

journal_title：Human & experimental toxicology

authors： Burdan F

更新日期：2002-01-01 00:00:00

abstract：:Recent studies have proposed the use of low concentrations of phytochemicals and combinations of phytochemicals in chemoprevention to reduce cytotoxicity and simulate normal ingestion through diet. The purpose of the present study was to evaluate whether the DNA damage, chromosome instability, and oxidative stress ind...

journal_title：Human & experimental toxicology

authors： Serpeloni JM,Almeida MR,Mercadante AZ,Bianchi ML,Antunes LM

更新日期：2013-08-01 00:00:00

abstract：:Epichlorohydrin (ECH) is an antifertility agent that acts both as an epididymal toxicant and an agent capable of directly affecting sperm motility. This study identified the time course of apoptotic cell death in rat epididymides after ECH treatment. Rats were administrated with a single oral dose of ECH (50 mg/kg). E...

journal_title：Human & experimental toxicology

authors： Lee IC,Kim KH,Kim SH,Baek HS,Moon C,Kim SH,Yun WK,Nam KH,Kim HC,Kim JC

更新日期：2013-06-01 00:00:00

abstract：:The effects of the environmental toxicant, triethyltin, on Ca2+ mobilization in Madin-Darby canine kidney (MDCK) cells have been examined. Triethyltin induced an increase in cytosolic free Ca2+ levels ([Ca2+]i) at concentrations larger than 2 microM in a concentration-dependent manner. Within 5 min, the [Ca2+]i signal...

journal_title：Human & experimental toxicology

authors： Jiann BP,Chou KJ,Chang HT,Chen WC,Huang JK,Jan CR

更新日期：2002-08-01 00:00:00

abstract：:Lipid peroxidation is one of the main manifestations of oxidative damage and has been found to play an important role in the toxicity and carcinogenicity of many xenobiotics. In the present study, we investigated the possible induction of lipid peroxidation by aluminium in human foreskin fibroblast cultures by assayin...

journal_title：Human & experimental toxicology

authors： Anane R,Creppy EE

更新日期：2001-09-01 00:00:00

abstract：:The study was done to find out whether subacute exposure to supercypermethrin forte (SCM) affected cellular and humoral immunity. Groups of 10 male Wistar rats were given SCM by gavage for 28 days at 12.5 mg kg-1 day-1 (1/14 LD50), 8.75 mg kg-1 day-1 (1/20 LD50) and 4.38 mg kg-1 day-1 (1/40 LD50) and the response of s...

journal_title：Human & experimental toxicology

authors： Tulinská J,Kubová J,Janota S,Nyulassy S

更新日期：1995-05-01 00:00:00

abstract：:This study was designed to evaluate the hepato and neuroprotective activity of Daflon and low-dose γ radiation on thioacetamide (TAA)-induced liver damage and hepatic encephalopathy (HE) in rats. Effect of daily Daflon treatment (100 mg/kg body weight, Per OS (p.o.) for consecutive 3 days) and/or fractionated low-dose...

journal_title：Human & experimental toxicology

authors： Abdel-Rafei M,Amin MM,Hasan HF

更新日期：2017-01-01 00:00:00

abstract：:There are many discrepancies among the results of studies on the genotoxicity of lead. The aim of the study was to explore lead-induced DNA damage, including oxidative damage, in relation to oxidative stress intensity parameters and the antioxidant defense system in human leukocytes. The study population consisted of ...

journal_title：Human & experimental toxicology

authors： Dobrakowski M,Pawlas N,Kasperczyk A,Kozłowska A,Olewińska E,Machoń-Grecka A,Kasperczyk S

更新日期：2017-07-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) and dioxins are potentially toxic compounds which occur widely in the environment. Their effects on the growth and development of infants at the levels currently found in highly industrialised western countries is not well known. This Dutch multicenter study, combining animal and human...

journal_title：Human & experimental toxicology

authors： Sauer PJ,Huisman M,Koopman-Esseboom C,Morse DC,Smits-van Prooije AE,van de Berg KJ,Tuinstra LG,van der Paauw CG,Boersma ER,Weisglas-Kuperus N

更新日期：1994-12-01 00:00:00

abstract：:1. The methods used to evaluate the toxicological effects of PCBs in animals have been reviewed. 2. The data show that Toxic Equivalency Factors (TEFs) could be developed to assess the potential toxicity of PCB mixtures for certain specific target organ effects (such as the liver and immune system) but would be inappr...

journal_title：Human & experimental toxicology

authors： Battershill JM

更新日期：1994-09-01 00:00:00

abstract：:1. Adult male albino rats (CF Strain) were administered i.p. CS2 dissolved in cotton seed oil at doses of 25, 50, 100 and 200 mg/kg b. wt. for a period of 60 days. Effect of CS2 on epididymis, adrenal weight, sperm count and sperm head shape abnormality was studied. 2. Epididymal weight remained unaltered in 25, 50 an...

journal_title：Human & experimental toxicology

authors： Kumar S,Patel KG,Gautam AK,Agarwal K,Shah BA,Saiyed HN

更新日期：1999-12-01 00:00:00

abstract：:Changes required for the explicit recognition of hormesis are outlined for both ecotoxicology and ecological risk assessment (ERA). A major research need is the extension of hormesis beyond chemical stressors to abiotic (e.g., habitat) and biotic stressors (e.g., species introductions, organism interactions). An overr...

journal_title：Human & experimental toxicology

authors： Chapman PM

更新日期：2001-10-01 00:00:00

abstract：:Information on the acute effects associated with the handling of 1,4-dioxane is sparse. Our aim was to evaluate the acute effects of 1,4-dioxane vapours. In a screening study, six healthy volunteers rated symptoms on a visual analogue scale (VAS), while exposed to stepwise increasing levels of 1,4-dioxane, from 1 to 2...

journal_title：Human & experimental toxicology

authors： Ernstgård L,Iregren A,Sjögren B,Johanson G

更新日期：2006-12-01 00:00:00

abstract：:The aim of this study was to determine the safety of azelaic acid (AA) and its derivatives in nanovesicles for pharmaceutical and cosmetic uses. The hydrophilic property of AA was modified by complexing AA with hydroxypropyl-beta-cyclodextrin (AACD). The lipophilic property of AA was improved to diethyl azelate (DA) b...

journal_title：Human & experimental toxicology

authors： Panyosak A,Manosroi J,Rojanasakul Y,Manosroi A

更新日期：2009-06-01 00:00:00

abstract：:Pyrazinamide (PYZ)-an essential component of primary drug regimen used for the treatment and management of multidrug resistant or latent tuberculosis-is well known for its hepatoxicity. However, the mechanism of PYZ-induced hepatotoxicity is still unknown to researchers. Studies have shown that the drug is metabolized...

journal_title：Human & experimental toxicology

authors： Rawat A,Chaturvedi S,Singh AK,Guleria A,Dubey D,Keshari AK,Raj V,Rai A,Prakash A,Kumar U,Kumar D,Saha S

更新日期：2018-04-01 00:00:00

abstract：:Dental amalgams are a commonly used dental restorative material, and amalgams are about 50% mercury (Hg). In our study, urinary Hg levels was examined in children of age 8-18 years, with and without dental amalgam fillings, from a completed clinical trial (parent study) that was designed to evaluate the potential heal...

journal_title：Human & experimental toxicology

authors： Geier DA,Carmody T,Kern JK,King PG,Geier MR

更新日期：2012-01-01 00:00:00

abstract：:This study evaluated the protective potential of curcumin on the possible side effects of bortezomib (Bt) therapy on normal cells in mice. The mice were segregated into three groups (n = 10) that included normal control, Bt-treated, and Bt + curcumin-treated groups. The Bt treatment resulted in significant decrease in...

journal_title：Human & experimental toxicology

authors： Kumar RR,Malhotra A

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Mushroom poisoning is still a significant health-care problem, with the potential to affect blood parameters. The present study analyses the effect of mushroom poisoning on complete blood cell parameters, cell ratios, and cell volume indices and the effect of the mentioned parameters on prognosis/hospital len...

journal_title：Human & experimental toxicology

authors： Doğan M,Karahan I

更新日期：2019-10-01 00:00:00

abstract：:Nickel nanoparticles (Ni-NPs) have been widely used in various industries related to electronics, ceramics, textiles, and nanomedicine. Ambient and occupational exposure to Ni-NPs may bring about potential detrimental effects on animals and humans. Thus, there is a growing effort to identify compounds that can amelior...

journal_title：Human & experimental toxicology

authors： Iqbal S,Jabeen F,Peng C,Ijaz MU,Chaudhry AS

更新日期：2020-11-01 00:00:00

abstract：:HCH isomers, endosulfan, malathion, chlorpyrifos, and methyl-parathion were monitored in human milk samples from Bhopal, Madhya Pradesh. The endosulfan concentrations were highest and exceeded the sigma-HCH, chlorpyrifos, and malathion concentrations by 3.5-, 1.5-, and 8.4-fold, respectively. Through breast milk, infa...

journal_title：Human & experimental toxicology

authors： Sanghi R,Pillai MK,Jayalekshmi TR,Nair A

更新日期：2003-02-01 00:00:00

abstract：:N-nitrosodimethylamine (NDMA) is a xenobiotic widespread in human environment capable of regulating the lifespan of immune cells. In this study, we examined the roles of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/death receptor 5 (DR5) complex and the Fas molecule in the induction of the extri...

journal_title：Human & experimental toxicology

authors： Iwaniuk A,Jabłońska E,Jabłoński J,Ratajczak-Wrona W,Garley M

更新日期：2015-06-01 00:00:00

abstract：:The identification of biomarkers for toxicity prediction is crucial for drug development and safety evaluation. The selective and specific biomarkers for antihistamines-induced cardiotoxicity is not well identified yet. In order to evaluate the mechanism of the life-threatening effects caused by antihistamines, we use...

journal_title：Human & experimental toxicology

authors： Yun JS,Kim SY

更新日期：2015-08-01 00:00:00

abstract：:The effect of fendiline on cytosolic free Ca(2+) concentrations ([Ca(2+)](i)) and proliferation has not been explored in human oral cancer cells. This study examined whether fendiline altered Ca(2+) levels and caused cell death in OC2 human oral cancer cells. [Ca(2+)](i) and cell viability were measured using the fluo...

journal_title：Human & experimental toxicology

authors： Huang C,Huang C,Cheng J,Liu S,Chen I,Tsai J,Chou C,Tseng P,Jan C

更新日期：2009-01-01 00:00:00

abstract：AIM:Diazinon (DZN) is one of the most important organophosphorus compounds used to control pests in agriculture in many countries. Several studies have shown that exposure to DZN may alter protein expression in the liver. In order to further investigate the mechanism of DZN toxicity, differentially expressed ATP-intera...

journal_title：Human & experimental toxicology

authors： Pourtaji A,Robati RY,Lari P,Hosseinzadeh H,Ramezani M,Abnous K

更新日期：2016-10-01 00:00:00