Abstract:
:Manganese (Mn) is an essential nutrient required for proper growth and maintenance of numerous biological systems. At high levels it is known to be neurotoxic. While focused research concerning the transport of Mn across the blood-brain barrier (BBB) is on-going, the exact identity of the transporter(s) responsible is still debated. The transferrin receptor (TfR) and the divalent metal transporter-1 (DMT-1) have long been thought to play a role in brain Mn deposition. However, evidence suggests that Mn may also be transported by other proteins. One model system of the BBB, rat brain endothelial (RBE4) cells, are known to express many proteins suspected to be involved in metal transport. This review will discuss the biological importance of Mn, and then briefly describe several proteins that may be involved in transport of this metal across the BBB. The latter section will examine the potential usefulness of RBE4 cells in characterizing various aspects of Mn transport, and basic culture techniques involved in working with these cells. It is hoped that ideas put forth in this article will stimulate further investigations into the complex nature of Mn transport, and address the importance as well as the limitation of in vitro models in answering these questions.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Fitsanakis VA,Piccola G,Marreilha dos Santos AP,Aschner JL,Aschner Mdoi
10.1177/0960327107070496subject
Has Abstractpub_date
2007-04-01 00:00:00pages
295-302issue
4eissn
0960-3271issn
1477-0903pii
26/4/295journal_volume
26pub_type
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