Abstract：
:The effect of fendiline on cytosolic free Ca(2+) concentrations ([Ca(2+)](i)) and proliferation has not been explored in human oral cancer cells. This study examined whether fendiline altered Ca(2+) levels and caused cell death in OC2 human oral cancer cells. [Ca(2+)](i) and cell viability were measured using the fluorescent dyes fura-2 and WST-1, respectively. Fendiline at concentrations above 10 microM increased [Ca(2+)](i) in a concentration-dependent manner. The Ca(2+) signal was reduced partly by removing extracellular Ca(2+). The fendiline-induced Ca(2+) influx was sensitive to blockade of L-type Ca(2+) channel blockers. In Ca(2+)-free medium, after pretreatment with 50 microM fendiline, 1 microM thapsigargin (an endoplasmic reticulum Ca(2+) pump inhibitor)-induced [Ca(2+)](i) rises were inhibited; and conversely, thapsigargin pretreatment nearly abolished fendiline-induced [Ca(2+)](i) rises. Inhibition of phospholipase C with 2 microM U73122 did not change fendiline-induced [Ca(2+)](i) rises. At concentrations between 5 and 25 microM, fendiline killed cells in a concentration-dependent manner. The cytotoxic effect of 15 microM fendiline was not reversed by prechelating cytosolic Ca(2+) with BAPTA/AM. Collectively, in OC2 cells, fendiline induced [Ca(2+)](i) rises by causing Ca(2+) release from the endoplasmic reticulum and Ca(2+) influx from L-type Ca(2+) channels. Furthermore, fendiline-caused cytotoxicity was not via a preceding [Ca(2+)](i) rise.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Huang C,Huang C,Cheng J,Liu S,Chen I,Tsai J,Chou C,Tseng P,Jan Cdoi
10.1177/0960327108097436subject
Has Abstractpub_date
2009-01-01 00:00:00pages
41-8issue
1eissn
0960-3271issn
1477-0903pii
28/1/41journal_volume
28pub_type
杂志文章abstract：BACKGROUND:Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327109354311
更新日期：2009-12-01 00:00:00
abstract：:A liquid alcoholic extract of Papaver somniferum named Elixir Paregorico is extensively used for diarrheal diseases in Brazil. Its increased popularity has brought concerns and fears over the safety of this herbal product. Given the lack of investigative clinical studies, in this regard, this study investigated whethe...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327108090274
更新日期：2008-10-01 00:00:00
abstract：:Occupational chronic solvent encephalopathy (CSE) is associated with a number of neurobehavioural disorders including defects of visual perception. The purpose of this study was to characterize colour vision defects in CSE patients. Colour vision was tested in bright illumination with the Farnsworth-Munsell 100-hue te...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327107076820
更新日期：2007-04-01 00:00:00
abstract：:The time-dependent changes in lead (Pb) concentrations in major tissues, serum and urine, and the Pb biomarker delta-aminolevulinic acid (ALA) concentration in urine were studied in rats after sub-chronic Pb exposure. Female Sprague-Dawley (SD) rats were exposed to Pb in drinking water at concentrations of 100 ppm and...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327109107046
更新日期：2009-10-01 00:00:00
abstract：:Drugs intended for use in preventing allograft rejection in transplant patients are likely to be administered chronically; thus, it is normally expected that sponsors would conduct nonclinical studies to determine the carcinogenic potential of candidate compounds. For pharmaceuticals other than biologic agents, this w...
journal_title：Human & experimental toxicology
pub_type： 杂志文章,评审
doi：10.1191/096032700678815837
更新日期：2000-04-01 00:00:00
abstract：:1. A study was carried out to find out if digoxin and acipimox interact. 2. Six elderly patients on digoxin were each given acipimox 150 mg three daily for a week, after informed consent. Digoxin and acipimox plasma concentrations and urinary excretion were measured after the first dose of acipimox and after a week of...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719201100509
更新日期：1992-09-01 00:00:00
abstract：:Tripartite motif-containing protein 24 (TRIM24) has currently emerged as a crucial cancer-related gene present in a wide range of human cancer types. However, the involvement of TRIM24 in acute myeloid leukemia (AML) has not been well investigated. The present study aims to investigate the significance, cellular funct...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327120938845
更新日期：2020-12-01 00:00:00
abstract：:1. Three indexes for evaluating the severity of paraquat poisoning based on plasma-paraquat concentration are presently in use; the curves of Proudfood et al. and Scherrmann et al. and the SIPP. Their effectiveness in determining the prognosis of patients with paraquat poisoning was evaluated. 2. To determine which in...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719101000104
更新日期：1991-01-01 00:00:00
abstract：:To evaluate in vitro inhibitory effects of four types of histamine H2-receptor antagonist (H2-receptor antagonists), famotidine, roxatidine, cimetidine and ranitidine, on platelet function, we examined aggregating potency and P-selectin levels with agonist-induced aggregation. Ranitidine and cimetidine inhibited, in c...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/096032799678847069
更新日期：1999-08-01 00:00:00
abstract：:Persistent organic pollutants (POPs) are organic (carbon-based) compounds that include synthesized substances (pesticides and polychlorinated biphenyls [PCBs]) and other by-product substances generated as a result of human and natural activity (dioxins and furans). Extensive scientific studies have shown that POPs are...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327109347048
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Diphenhydramine (DPHM) overdose is a frequent cause of acute poisoning. Although its clinical features are well known, information about the dose-dependent toxicity of DPHM is still scarce. The objective of this study was to investigate the dose-dependent toxicity of DPHM in patients with acute DPHM poisonin...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/096032700671040438
更新日期：2000-09-01 00:00:00
abstract：:As an input to dose assessments, measurements have been made of the clearance of Pu and Am after subcutaneous implantation in rats for six particulate materials and one dust from the Maralinga test sites. The tissue distribution of Pu and Am were measured in groups of six animals at one month and 6 months after implan...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719301200410
更新日期：1993-07-01 00:00:00
abstract：:Delta-aminolevulinate dehydratase (δ-ALA-D) enzyme is sensitive to pro-oxidant agents, including molecular oxygen. Here, we tested whether hyperoxygenation after total intravenous (i.v.) anesthesia could interact with the type of anesthesia (dexmedetomidine, continuous infusion; 0.5 μg/kg/h or remifentanil, continuous...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327110372399
更新日期：2011-04-01 00:00:00
abstract：:We describe two cases of chemical necrotizing fasciitis in the upper extremities, anterior chest wall and epigastric region of the abdominal wall caused by household insecticide injection. We suggest that surgical debridement can be successfully performed in the subacute period under close observation in hemodynamical...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/0960327102ht308cr
更新日期：2002-12-01 00:00:00
abstract：:Vulpinic acid, a lichen compound, has been shown to have many beneficial effects and its medicinal value increases day by day. As in atherosclerosis, endothelial damage is the basis of many diseases. The aim of this study is to investigate the effects of vulpinic acid against oxidative stress damage induced by hydroge...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327119833745
更新日期：2019-06-01 00:00:00
abstract：:Pentavalent antimonial (Sb5+) drugs such as meglumine antimoniate (MA) are the mainstay treatment of leishmaniases in developing countries. The effects of these compounds on drug-metabolizing enzymes have not been characterized and their potential pharmacokinetic interactions with other drugs are therefore unknown. Th...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327116637110
更新日期：2017-01-01 00:00:00
abstract：:Sibutramine is an antiobesity drug that inhibits the reuptake of serotonin and noradrenalin in the hypothalamus. A 37-year-old Korean man presented to the emergency room for the oral intake of 280 mg of sibutramine. The patient was in thyrotoxic state. The (99m)Technetium-pertechnetate thyroid scan showed irregular up...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327112468907
更新日期：2013-08-01 00:00:00
abstract：:1. The effect of pyridostigmine on cardiorespiratory function after oxime + atropine injection was investigated in tabun poisoned guinea-pigs and without tabun poisoning. 2. The trachea, a carotid artery and jugular vein were cannulated in female urethane-anaesthetised Pirbright-white guinea-pigs. After baseline measu...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719501400803
更新日期：1995-08-01 00:00:00
abstract：:1. The methods used to evaluate the toxicological effects of PCBs in animals have been reviewed. 2. The data show that Toxic Equivalency Factors (TEFs) could be developed to assess the potential toxicity of PCB mixtures for certain specific target organ effects (such as the liver and immune system) but would be inappr...
journal_title：Human & experimental toxicology
pub_type： 杂志文章,评审
doi：10.1177/096032719401300901
更新日期：1994-09-01 00:00:00
abstract：:The US Environmental Protection Agency (EPA) recently issued a Staff Paper that articulates current risk assessment practices. In section 4.1.3, EPA states, "... effects that appear to be adaptive, non-adverse, or beneficial may not be mentioned." This statement may be perceived as precluding risk assessments based on...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/0960327106ht580oa
更新日期：2006-01-01 00:00:00
abstract：:Recent years have seen substantial shifts in cultural attitudes towards cannabis for medical and recreational use. However, legalizing recreational marijuana may have adverse effects on individual and public health. As the most widely used illicit agent, cannabis is commonly reported to disrupt learning and memory. Un...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327119886037
更新日期：2020-03-01 00:00:00
abstract：:Hexafluorocyclobutene (HFCB), a reactive organohalogen gas, causes overwhelming pulmonary oedema. We investigated its effect on the rat lung surfactant system, comparing its action on type II pneumocytes with air-exposed rats. The inflammatory cell population and protein content of bronchoalveolar lavage fluid was ana...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/096032701678227686
更新日期：2001-05-01 00:00:00
abstract：:Diepoxybutane (DEB)- and mitomycin C (MMC)-associated toxicity was investigated in embryos from the sea urchin (SU) species Sphaerechinus granularis. DEB- and MMC-induced toxicity resulted in S. granularis embryos and larvae at concentrations ranging 10(-5) to 10(-4) M DEB, and 3 x 10(-6) to 3 x 10(-5) M MMC, in terms...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/096032701718890577
更新日期：2001-12-01 00:00:00
abstract：:We have investigated the pituitary-testicular axis in a well-characterized population which was occupationally exposed to mercury vapour. Thyroid stimulating hormone and prolactin were also measured as indices of thyroid and pituitary endocrine function. We found no relation between blood or urine mercury levels or le...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719101000309
更新日期：1991-05-01 00:00:00
abstract：:A key aim of toxicology is the prevention of adverse effects due to toxic hazards. Therefore, the dissemination of toxicology research findings must confront two important challenges: one being the lack of information on the vast majority of potentially toxic industrial chemicals and the other being the strict criteri...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327115601762
更新日期：2015-12-01 00:00:00
abstract：:Omeprazole is one of the most used acid-suppressing medications. This fact emphasizes the questions concerning the safety of this compound. Healthy volunteers (n=33) were included in this prospective study. All study subjects were analysed for their CYP2C19 genotype. Of the 33 individuals, 24 were homozygous for the w...
journal_title：Human & experimental toxicology
pub_type： 临床试验,杂志文章
doi：10.1191/0960327104ht431oa
更新日期：2004-03-01 00:00:00
abstract：:The purpose of the present study is to establish a new animal model of azithromycin (AZ)-induced liver injury and study the molecular pathological change during the process. First, mice were respectively injected intraperitoneally with AZ of different high doses. Our results showed that 800 mg/kg AZ injection signific...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327115595684
更新日期：2016-05-01 00:00:00
abstract：:Cytochrome P450 4B1 (CYP4B1) plays crucial roles in biotransforming of xenobiotics. Its predominant extrahepatic expression has been associated with certain tissue-specific toxicities. However, the expressions of CYP4B1 in various cancers and hence their potential roles in cancer development were inclusive. In this wo...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327120905959
更新日期：2020-06-01 00:00:00
abstract：:This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetis...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327111426584
更新日期：2013-06-01 00:00:00
abstract：INTRODUCTION:Chronic obstructive pulmonary disease (COPD) due to sulfur mustard (SM), known as mustard lung, is an important late pulmonary complication of SM poisoning. Due to the possible role of systemic inflammation in mustard lung, we evaluated the serum levels of adiponectin and leptin in these patients. MATERIA...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327113504973
更新日期：2014-06-01 00:00:00
