Abstract:
:The identification of biomarkers for toxicity prediction is crucial for drug development and safety evaluation. The selective and specific biomarkers for antihistamines-induced cardiotoxicity is not well identified yet. In order to evaluate the mechanism of the life-threatening effects caused by antihistamines, we used DNA microarrays to analyze genomic profiles in H9C2 rat cardiomyocytes that were treated with antihistamines. The gene expression profiles from drug-treated cells revealed changes in the integrin signaling pathway, suggesting that cardiac arrhythmias induced by antihistamine treatment may be mediated by changes in integrin-mediated signaling. It has been reported that integrin plays a role in QT prolongation that may induce cardiac arrhythmia. These results indicate that the integrin-mediated signaling pathway induced by antihistamines is involved in various biological mechanisms that lead to cardiac QT prolongation. Therefore, we suggest that genomic profiling of antihistamine-treated cardiomyocytes has the potential to reveal the mechanism of adverse drug reactions, and this signal pathway is applicable to prediction of in vitro cardiotoxicity induced by antihistamines as a biomarker candidate.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Yun JS,Kim SYdoi
10.1177/0960327114559988subject
Has Abstractpub_date
2015-08-01 00:00:00pages
796-807issue
8eissn
0960-3271issn
1477-0903pii
0960327114559988journal_volume
34pub_type
杂志文章abstract::Serrapeptase (SP) and nattokinase (NK) are proteolytic enzymes belonging to serine proteases. In this study, we hypothesized that SP and NK could modulate certain factors that are associated with Alzheimer's disease (AD) pathophysiology in the experimental model. Oral administration of aluminium chloride (AlCl3) in a ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112467040
更新日期:2013-07-01 00:00:00
abstract::1. A chronic alcoholic with severe metabolic acidosis presents a difficult diagnostic problem. The most common cause is alcoholic ketoacidosis, a syndrome with a typical history but often misleading laboratory findings. This paper will focus on this important and probably underdiagnosed syndrome. 2. The disorder occur...
journal_title:Human & experimental toxicology
pub_type: 杂志文章,评审
doi:10.1177/096032719601500604
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abstract::D-Glucaro(1,4)lactone, a potent beta-glucuronidase inhibitor was attached via the carboxylic acid moiety to polyvinylbenzyl chloride (PVBC) using a bimolecular nucleophilic displacement reaction. First, the caesium salt of D-glucaro(1,4)lactone was prepared by titrating the carboxylic acid to neutrality with aqueous c...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719301200216
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abstract::1. Groups of 60 male and 60 female B6C3F1 mice or HanIbm Wistar rats were exposed to HFA-134a using snout-only inhalation exposure techniques for periods of one hour daily for at least 104 weeks. HFA-134a was delivered directly from cylinders at vapour concentrations of 2500, 15,000 and 75,000ppm for mice and from met...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719501400902
更新日期:1995-09-01 00:00:00
abstract::Okadaic acid (OA) is the main toxin produced by dinoflagellates, which can accumulate in the hepatopancreas of mussels and cause diarrhoetic shellfish poisoning in consumers. This toxin is also a tumour promoter and a specific potent inhibitor of protein phosphatases 1 and 2A. The results in this study show for the fi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719601500307
更新日期:1996-03-01 00:00:00
abstract::The polybrominated diphenyl ether flame retardants decabromodiphenyl ether (BDE-209) and bisphenol A (BPA) are environmental contaminants that can cross the placenta and exert toxicity in the developing fetal nervous system. Copy number variants (CNVs) play a role in a number of genetic disorders and may be implicated...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117710535
更新日期:2018-05-01 00:00:00
abstract::Derivatives of dehydrocrotonin (DHC; Compound I) with different anti-ulcerogenic properties but less toxicity were produced by reducing the cyclohexenone moiety of DHC with NaBH4 (Compound II), reducing the cyclohexenone and lactone moieties with LiAlH4 (Compound III) and transforming the lactone moiety into an amide ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327102ht246oa
更新日期:2002-05-01 00:00:00
abstract::Progressive renal dysfunction in 5/6 nephrectomized (NX) rats can be physiologically divided into three stages, coinciding with morphological stages, after definition of physiological parameters for identification of stage. Now, for the establishment of a toxicity screening approach using 5/6 NX rats, our concept, "Di...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032701666840048
更新日期:2001-02-01 00:00:00
abstract::A retrospective study was conducted on 269 patients with anticholinesterase poisoning who had been admitted to the Internal Medicine and Pediatric Clinics over the past 10 years. Their ages ranged from 17 d to 62 years. In adults, suicide was the most common means of intoxication. Miosis was the most frequent symptom ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719000900503
更新日期:1990-09-01 00:00:00
abstract::In this study, genotoxic activities of four halogenated anesthetics (halothane, isoflurane, sevoflurane and desflurane) were investigated in human peripheral blood lymphocytes (PBLs) and sperm cells in vitro by alkaline comet assay. For this purpose, sperm or lymphocyte suspension was exposed to different concentratio...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112446818
更新日期:2012-12-01 00:00:00
abstract::Clinical and experimental studies have shown the adverse effects of excess glucocorticoid on testicular testosterone production. The NADPH co-enzyme has been recognized as an important factor that regulates several steps in steroidogenesis, while glucose oxidation acts as a limiting factor on testicular testosterone p...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327106ht591oa
更新日期:2006-03-01 00:00:00
abstract::1. 26Al and 67Ga were given as citrates to a healthy male volunteer by intravenous injection. The retention of both tracers was studied by body radioactivity measurement. Levels in blood and excreta were determined by gamma-ray spectrometry and/or accelerator mass spectrometry. 2. More than half of the 26Al had left t...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719501400309
更新日期:1995-03-01 00:00:00
abstract::Dermal exposure is an important factor in risk characterization. In occupational settings it becomes relatively more important because of the continuous reduction in inhalation exposure. In the public health arena, dermal exposure may also form a significant contribution to the total exposure. Dermal exposure, however...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107085830
更新日期:2008-04-01 00:00:00
abstract::Pityriasis rosea (PR) is a common, acute, and self-limited inflammatory skin disease. The typical clinical presentation includes the appearance of a primary "herald" patch followed within days to weeks by the onset of secondary scaly skin eruptions distributed along the skin tension line in most cases. Although PR is ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327113478444
更新日期:2014-12-01 00:00:00
abstract::In vivo antidotal efficacy of new bis- quaternary 2-(hydroxyimino)- N-(pyridin-3yl) acetamide derivatives (HNK series), to counter multiples of lethal doses of nerve agent sarin (GB) and reactivation of acetylcholinesterase (AChE), was evaluated in Swiss albino mice. [Protection index PI; median lethal dose (LD50) of ...
journal_title:Human & experimental toxicology
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doi:10.1177/0960327116637109
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was focused on investigating the possible protective effect of erdosteine against gamma radiation-induced renal lesions in male albino rats. Twenty-eight albino rats were divided into four equal groups as follows: control group, irradiated group (animals subjected to whole-body gamma irradiation ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115574919
更新日期:2016-01-01 00:00:00
abstract::Fructus Psoraleae (FP), widely used in traditional medicine, is increasingly reported to cause serious hepatotoxicity in recent years. However, the main toxic constituents responsible for hepatotoxicity and the underlying mechanisms are poorly understood. In the present study, psoralen, a main and quality-control cons...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120979346
更新日期:2020-12-15 00:00:00
abstract::The pharmacokinetics of the herbicide fluazifop-butyl have been determined in female rats following oral and intravenous dosing, and described by a mathematical model. Penetration of fluazifop-butyl through epidermal membranes has been determined using three different receptor fluids. It is demonstrated how this in vi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719301200302
更新日期:1993-05-01 00:00:00
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117722822
更新日期:2018-06-01 00:00:00
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journal_title:Human & experimental toxicology
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032799678839554
更新日期:1999-11-01 00:00:00
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journal_title:Human & experimental toxicology
pub_type: 历史文章,杂志文章,评审
doi:10.1177/0960327110363974
更新日期:2010-04-01 00:00:00
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327114529451
更新日期:2015-04-01 00:00:00
abstract::1. Four different concentrations of quinalphos and methyl parathion were tested on human peripheral lymphocytes over different time periods, for the analysis of chromosomal aberrations and sister chromatid exchanges (SCEs). 2. A significant increase in chromosomal aberrations was observed when cells were treated with ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719000900605
更新日期:1990-11-01 00:00:00
abstract::Postoperative cognitive dysfunction, which is associated with a wide range of cognitive functions including working memory, long-term memory, information processing, attention, and cognitive flexibility, is a major clinical issue in geriatric surgical patients. The aim of the current study was to determine the protect...
journal_title:Human & experimental toxicology
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更新日期:2017-12-01 00:00:00
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112454890
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:Pesticide poisoning stands as a major public health issue worldwide. The objective of this study was to examine the epidemiologic characteristics of pesticide-related hospitalizations in South Korea. METHODS:Data from the Korea National Hospital Discharge Survey were analyzed to describe the epidemiologic c...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
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更新日期:2012-08-01 00:00:00
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journal_title:Human & experimental toxicology
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更新日期:2000-12-01 00:00:00
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journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327109348082
更新日期:2009-08-01 00:00:00
abstract::The purpose of the present study is to establish a new animal model of azithromycin (AZ)-induced liver injury and study the molecular pathological change during the process. First, mice were respectively injected intraperitoneally with AZ of different high doses. Our results showed that 800 mg/kg AZ injection signific...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115595684
更新日期:2016-05-01 00:00:00