Abstract：
:Brain tumors are often incurable despite current aggressive treatment modalities. Regional intracerebral administration of labeled monoclonal antibodies (Mabs) can maximize the radioisotope and Mab concentration to tumor sites while reducing systemic toxicity. h-R3 is a humanized antiepidermal growth factor receptor Mab that successfully targets the epidermal growth factor receptor, which is overexpressed in glioblastomas. We studied the acute local and systemic toxicity effects of intraventricular 188Re-h-R3 in rats. Forty rats were distributed into four groups with five animals of each sex in each group. A single 5 -microl dose (2.5 microl into the left and 2.5 microl into the right lateral ventricles) of neutral solution containing 50 microg of h- R3 labeled with 49.5 +/- 1.7,284 +/- 13.7 or 579 +/- 23.7 muCi of 188Re were stereotactically administered to each animal. Control animals received vehicle alone. Each animal was observed twice daily for detection of toxicity signs. Body weights were recorded on days 0, 7 and 14. Blood samples for analysis of hematological and clinical chemistry parameters were taken on days 0 and 14. Necropsy and histopathological studies were carried out after completion of the study. All animals, but one, remained clinically stable. Toxicities included local radionecrosis, discrete increase in ALAT and creatinine blood values at higher dose level. We concluded that a single intraventricular administration of relatively large doses of 188Re-h-R3 is tolerable and causes minimal local and systemic toxicity effects in rats. Nevertheless, further studies are necessary to discard learning and behavioral problems.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Gonzalez B,Casaco A,Alvarez P,Leon M,Arteaga M,Leon A,Santana E,Bada A,Figueredo R,Hernández R,Iznaga-Escobar N,González F,Perez Rdoi
10.1191/096032700675323269subject
Has Abstractpub_date
2000-12-01 00:00:00pages
684-92issue
12eissn
0960-3271issn
1477-0903journal_volume
19pub_type
杂志文章abstract：:1. Human volunteer studies are an essential part of drug development but their use in the area of non-pharmaceutical chemicals has so far been very limited. Such studies can have considerable value in the assessment and improvement of the safe use of chemicals. 2. Once metabolic pathways and target metabolites have be...
journal_title：Human & experimental toxicology
pub_type： 杂志文章,评审
doi：10.1177/096032719401300604
更新日期：1994-06-01 00:00:00
abstract：UNLABELLED:A single dose of monocrotaline, a pyrrolizidine alkaloid, was injected into rats in order to produce 25 (Group I) and 45 (Group II) days later a progressive and so called delayed liver injury. The present study investigated the prostanoid production of Kupffer cells and endothelial cells separated from Monoc...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719801701007
更新日期：1998-10-01 00:00:00
abstract：AIM:Diazinon (DZN) is one of the most important organophosphorus compounds used to control pests in agriculture in many countries. Several studies have shown that exposure to DZN may alter protein expression in the liver. In order to further investigate the mechanism of DZN toxicity, differentially expressed ATP-intera...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327115619771
更新日期：2016-10-01 00:00:00
abstract：:The common effects of acetaminophen (paracetamol), isopropylantipyrine (propyphenazone) and caffeine on fetal development were examined in rats. The mixture was given in Tween 80 solution once daily, in a constant proportion of 5:3:1, during days 8-14 of gestation in three different doses. Dose S1 - 3.5 mg/kg acetamin...
journal_title：Human & experimental toxicology
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doi：10.1191/0960327102ht224oa
更新日期：2002-01-01 00:00:00
abstract：:Seafood is considered by nutritionists to be a high source of omega 3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) which are involved in prevention of cardiovascular diseases. The aim of the present study is firstly to detect the presence of organochlorine pesticides and heavy metals in some fresh seafood of ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327110396535
更新日期：2011-10-01 00:00:00
abstract：:1. Neonatal treatment of rats with vitamin D3 resulted in a change of sexual behavior in adulthood. 2. 2.5 mg vitamin D3 completely inhibited the ejaculation of males without any apparent influence on sexual desire. 250 mg vitamin D3 influenced both the desire and ejaculation. 3. Sexual activity of females was depress...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719601500704
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:The mortality rate associated with human glufosinate poisoning is high. We evaluated the usefulness of serum ammonia and sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation II (APACHE II) scores for early prediction of in-hospital mortality in glufosinate ammonium po...
journal_title：Human & experimental toxicology
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abstract：:The time-dependent changes in lead (Pb) concentrations in major tissues, serum and urine, and the Pb biomarker delta-aminolevulinic acid (ALA) concentration in urine were studied in rats after sub-chronic Pb exposure. Female Sprague-Dawley (SD) rats were exposed to Pb in drinking water at concentrations of 100 ppm and...
journal_title：Human & experimental toxicology
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doi：10.1177/0960327109107046
更新日期：2009-10-01 00:00:00
abstract：:1. Six healthy male volunteers received intravenous injections of 26Al as citrate. Accelerator mass spectrometry and gamma-ray spectrometry were used to determine levels of the tracer in blood and excreta at times up to 5-6 d. 2. There was a rapid clearance from blood (mean 2% of injection remaining after 1 d) and maj...
journal_title：Human & experimental toxicology
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doi：10.1177/096032719501400707
更新日期：1995-07-01 00:00:00
abstract：:Nickel nanoparticles (Ni-NPs) have been widely used in various industries related to electronics, ceramics, textiles, and nanomedicine. Ambient and occupational exposure to Ni-NPs may bring about potential detrimental effects on animals and humans. Thus, there is a growing effort to identify compounds that can amelior...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327120930125
更新日期：2020-11-01 00:00:00
abstract：:Silver nanoparticles are used in many commercial products in daily life. Exposure to nanosilver has hepatotoxic effects in animals. This study investigated the cytotoxicity associated with polyvinylpyrrolidone-coated nanosilver (23.44 ± 4.92 nm in diameter) exposure in the human hepatoma cell line (HepG2) and normal h...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327118769718
更新日期：2018-12-01 00:00:00
abstract：:1. Dettol liquid (chloroxylenol 4.8%, pine oil, isopropyl alcohol), a household disinfectant, has a corrosive action on the gastrointestinal mucosa when swallowed. The incidence of upper gastrointestinal haemorrhage and gastroscopic findings following Dettol poisoning was studied in 89 patients. 2. Five patients (5.6%...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719501400104
更新日期：1995-01-01 00:00:00
abstract：:Alcohol levels were measured in 15 cerebrospinal fluid (CSF) samples and 14 blood samples from grade III and IV male alcoholic patients with signs of nervous system involvement, and compared with levels detected in 11 CSF samples and 11 blood samples from abstemious patients or patients with grade I or II alcoholism w...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719201100313
更新日期：1992-05-01 00:00:00
abstract：:1. A modified mouse liver slice culture technique was established and the viability of the system was assessed on the basis of leakage of cytosolic enzymes viz. lactate dehydrogenase (LDH), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartic aminotransferase (AST) and slice histology. 2. This system w...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719601500202
更新日期：1996-02-01 00:00:00
abstract：:1 The cytotoxicity of dichlorobenzenes in cultured rat liver slices has previously been shown to be strain specific and biotransformation related. 2 In order to extrapolate animal models to humans, the dichlorobenzenes were incubated with human liver slices to try to clarify their hepatotoxic potential in man. 3 The d...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719101000510
更新日期：1991-09-01 00:00:00
abstract：:Gamma-hydroxybutyrate (GHB) is a compound used in the treatment of alcohol withdrawal, narcolepsy, and for induction of anaesthesia. It is also contained in many products illegally marketed as "dietary supplements" and is increasingly being recognised as a potential drug of abuse. We report the case of a 44-year-old m...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/096032701666142043
更新日期：2001-01-01 00:00:00
abstract：:1. Multiple low doses of the direct acting organophosphates, ecothiopate, paraoxon and mipafox produced persistent and additive inhibition of diaphragm acetylcholinesterase. Paraoxon and mipafox had similar effects on brain acetylcholinesterase. There was greater recovery from inhibition between doses for paraoxon and...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719701600201
更新日期：1997-02-01 00:00:00
abstract：:In Southern Africa, the medicinal plant Warburgia salutaris is commonly used for the treatment of inflammatory and other diseases. The methanol extracts of W. salutaris were investigated with regard to a) production of proinflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma; b) a...
journal_title：Human & experimental toxicology
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doi：10.1177/0960327108099536
更新日期：2008-11-01 00:00:00
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journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327110382130
更新日期：2011-08-01 00:00:00
abstract：:N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-doxorubicin (PK1) is a novel polymeric anticancer agent containing doxorubicin (approximately 8 wt%) bound to the polymer backbone via a Gly-Phe-Leu-Gly peptidyl linker. The approximate LD50 of PK1 in MF1 mice after a single i.v. injection was 63 mg/kg (doxorubicin-eq...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719801700204
更新日期：1998-02-01 00:00:00
abstract：:1 The concentrations of a range of organochlorine pesticide residues have been determined in 168 samples of human milk collected between January 1997 and May 1998 in the UK. 2 Of the 18 residues sought, only p,p'-DTT, p,p'-DDE, dieldrin, HCB, beta-HCH and gamma-HCH were detected. 3 The continuing trend of a reduction ...
journal_title：Human & experimental toxicology
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doi：10.1191/096032799678839392
更新日期：1999-10-01 00:00:00
abstract：:Hexafluorocyclobutene (HFCB), a reactive organohalogen gas, causes overwhelming pulmonary oedema. We investigated its effect on the rat lung surfactant system, comparing its action on type II pneumocytes with air-exposed rats. The inflammatory cell population and protein content of bronchoalveolar lavage fluid was ana...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/096032701678227686
更新日期：2001-05-01 00:00:00
abstract：:Trichothecenes are mycotoxins produced by various species of fungi which can occur on various agricultural products. Among these compounds, T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS) and deoxynivalenol (DON) are the most naturally encountered and potent trichothecenes. Consumption of trichothecene contaminated fo...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719701601108
更新日期：1997-11-01 00:00:00
abstract：:1. Four different concentrations of quinalphos and methyl parathion were tested on human peripheral lymphocytes over different time periods, for the analysis of chromosomal aberrations and sister chromatid exchanges (SCEs). 2. A significant increase in chromosomal aberrations was observed when cells were treated with ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719000900605
更新日期：1990-11-01 00:00:00
abstract：:Pesticides are used in agriculture to protect crops from insects-pests. Most of the field workers of North Indian population are exposed to commonly used insecticides. In the present study, pesticides induced oxidative stress as well as alterations in the level of acetylcholinesterase (AChE) in a total of 70 male heal...
journal_title：Human & experimental toxicology
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doi：10.1177/0960327112474835
更新日期：2013-11-01 00:00:00
abstract：:Apoptosis induction in cancer cells is one of the most efficient ways to treat cancer and find anticancer compounds. The aim of this study was to evaluate the cytotoxic effects of heat-killed indigenous probiotic bacteria and apoptosis induction in the HT-29 human colon adenocarcinoma cell line. The growth-inhibitory ...
journal_title：Human & experimental toxicology
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doi：10.1177/0960327119851255
更新日期：2019-09-01 00:00:00
abstract：:A retrospective study was conducted on 269 patients with anticholinesterase poisoning who had been admitted to the Internal Medicine and Pediatric Clinics over the past 10 years. Their ages ranged from 17 d to 62 years. In adults, suicide was the most common means of intoxication. Miosis was the most frequent symptom ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719000900503
更新日期：1990-09-01 00:00:00
abstract：:Changes required for the explicit recognition of hormesis are outlined for both ecotoxicology and ecological risk assessment (ERA). A major research need is the extension of hormesis beyond chemical stressors to abiotic (e.g., habitat) and biotic stressors (e.g., species introductions, organism interactions). An overr...
journal_title：Human & experimental toxicology
pub_type： 杂志文章,评审
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更新日期：2001-10-01 00:00:00
abstract：:Prolonged zidovudine (AZT) treatment in HIV-infected and AIDS patients is shown to induce liver toxicity leading to complications. Therapeutic regimen that could encounter this adverse effect is unavailable and management of toxicity is often symptomatic or is limited to withdrawal of therapy. In the present investiga...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327114567765
更新日期：2015-11-01 00:00:00
abstract：:Cytochrome P450 4B1 (CYP4B1) plays crucial roles in biotransforming of xenobiotics. Its predominant extrahepatic expression has been associated with certain tissue-specific toxicities. However, the expressions of CYP4B1 in various cancers and hence their potential roles in cancer development were inclusive. In this wo...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327120905959
更新日期：2020-06-01 00:00:00
