The ability of Warburgia salutaris extracts to protect against crystalline silica-induced cell injury.

abstract：:The study was done to find out whether subacute exposure to supercypermethrin forte (SCM) affected cellular and humoral immunity. Groups of 10 male Wistar rats were given SCM by gavage for 28 days at 12.5 mg kg-1 day-1 (1/14 LD50), 8.75 mg kg-1 day-1 (1/20 LD50) and 4.38 mg kg-1 day-1 (1/40 LD50) and the response of s...

journal_title：Human & experimental toxicology

authors： Tulinská J,Kubová J,Janota S,Nyulassy S

更新日期：1995-05-01 00:00:00

abstract：:1. Alveolar macrophages efficiently phagocytize particles deposited in the alveolar part of the lung. Phagolysosomal pH in alveolar macrophages from rabbits, dogs, baboons and guinea pigs is around 5 pH units. A low pH is of importance for clearance of inorganic particles and probably also for defence against bacteria...

journal_title：Human & experimental toxicology

authors： Nyberg K,Johansson A,Camner P,Johard U,Eklund A

更新日期：1994-03-01 00:00:00

abstract：:1. With DTPA as a comparison, the siderophore analogue 3,4,3-LIHOPO has been examined for its ability to remove 228Th nitrate from the rat after subcutaneous (sc) and intramuscular (im) injection to simulate wound contamination. The commencement of treatment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d...

journal_title：Human & experimental toxicology

authors： Stradling GN,Gray SA,Pearce MJ,Wilson I,Moody JC,Burgada R,Durbin PW,Raymond KN

更新日期：1995-02-01 00:00:00

abstract：:The aim of this study was focused on investigating the possible protective effect of erdosteine against gamma radiation-induced renal lesions in male albino rats. Twenty-eight albino rats were divided into four equal groups as follows: control group, irradiated group (animals subjected to whole-body gamma irradiation ...

journal_title：Human & experimental toxicology

authors： Elkady AA,Ibrahim IM

更新日期：2016-01-01 00:00:00

abstract：:Cisplatin is an effective anticancer drug used against a variety of cancers. The full therapeutic potential of cisplatin is often hampered due to concurrent development of various side effects in the hosts. Rutin, a naturally occurring bioflavonoid shows several pharmacological activities. It has been earlier reported...

journal_title：Human & experimental toxicology

authors： Prasad R,Prasad SB

更新日期：2020-08-13 00:00:00

abstract：:9-(4'-Aminophenyl)-9H-pyrido [3,4-b] indole (aminophenylnorharman, APNH) is a novel mutagenic heterocyclic amine, produced by the reaction of norharman with aniline in the presence of S9 mix. In the present study, the maternal and developmental toxicity of APNH were investigated in ICR mice administered oral doses of ...

journal_title：Human & experimental toxicology

authors： Naga T,Yoshimura S,Totsuka Y,Wakabayashi K

更新日期：2002-03-01 00:00:00

abstract：:Dimerized translationally controlled tumor protein (dTCTP) plays a role in allergic diseases. A 7-mer peptide, dimerized translationally binding protein 2 (dTBP2), binds to dTCTP and inhibits dTCTP, suggesting that the 7-mer peptide may have therapeutic potential. We assessed the safety of dTBP2 by examining its cytot...

journal_title：Human & experimental toxicology

authors： Kim M,Jin YB,Lee K,Lee YS

更新日期：2013-11-01 00:00:00

abstract：:Mercury, a heavy metal, is widespread and persistent in the environment and has been elucidated as a possible risk factor in cardiovascular diseases. Mercury has been reported to selectively impair the nitric oxide (NO) pathway in the vascular endothelium as a consequence of oxidative stress. Conversely, mercury per s...

journal_title：Human & experimental toxicology

authors： Omanwar S,Saidullah B,Ravi K,Fahim M

更新日期：2014-09-01 00:00:00

abstract：:1. Following the establishment, in the USA, of the first poisons information centre, in 1953, the movement has grown globally. Originally, such a service was intended to meet an emergency need. Its efficacy has still not been objectively audited. 2. The suggestion now is that clinical toxicology has become such a dive...

journal_title：Human & experimental toxicology

authors： Goulding R

更新日期：1991-11-01 00:00:00

abstract：:Pentavalent antimonial (Sb5+) drugs such as meglumine antimoniate (MA) are the mainstay treatment of leishmaniases in developing countries. The effects of these compounds on drug-metabolizing enzymes have not been characterized and their potential pharmacokinetic interactions with other drugs are therefore unknown. Th...

journal_title：Human & experimental toxicology

authors： Coelho DR,De-Oliveira A,Parente T,Leal BS,das Chagas LF,Oliveira TN,Saint'Pierre TD,Paumgartten F

更新日期：2017-01-01 00:00:00

abstract：:1. Adult male albino rats (CF Strain) were administered i.p. CS2 dissolved in cotton seed oil at doses of 25, 50, 100 and 200 mg/kg b. wt. for a period of 60 days. Effect of CS2 on epididymis, adrenal weight, sperm count and sperm head shape abnormality was studied. 2. Epididymal weight remained unaltered in 25, 50 an...

journal_title：Human & experimental toxicology

authors： Kumar S,Patel KG,Gautam AK,Agarwal K,Shah BA,Saiyed HN

更新日期：1999-12-01 00:00:00

abstract：:Fructus Psoraleae (FP), widely used in traditional medicine, is increasingly reported to cause serious hepatotoxicity in recent years. However, the main toxic constituents responsible for hepatotoxicity and the underlying mechanisms are poorly understood. In the present study, psoralen, a main and quality-control cons...

journal_title：Human & experimental toxicology

authors： Huang J,Wang Q,Chen M,Bi Y,Shi H,Zhou K

更新日期：2020-12-15 00:00:00

abstract：:The study of Jayjock and Lewis, 'Implication of Hormesis for Industrial Hygiene', represents a challenge for the scientific community to consider hormesis as a possible working hypothesis for redefining risk assessment strategy for low-dose exposures in the realm of industrial hygiene. This invited commentary aims at ...

journal_title：Human & experimental toxicology

authors： Carelli G,Iavicoli I,Castellino N

更新日期：2002-07-01 00:00:00

abstract：:The fixed-dose procedure (FDP) was introduced as OECD Test Guideline 420 in 1992, as an alternative to the conventional median lethal dose (LD50) test for the assessment of acute oral toxicity (OECD Test Guideline 401). The FDP uses fewer animals and causes less suffering than the conventional test, while providing in...

journal_title：Human & experimental toxicology

authors： Stalla N,Whitehead A,Ridgway P

更新日期：2002-04-01 00:00:00

abstract：:1. Multiple low doses of the direct acting organophosphates, ecothiopate, paraoxon and mipafox produced persistent and additive inhibition of diaphragm acetylcholinesterase. Paraoxon and mipafox had similar effects on brain acetylcholinesterase. There was greater recovery from inhibition between doses for paraoxon and...

journal_title：Human & experimental toxicology

authors： Williams FM,Charlton C,de Blaquière GE,Mutch E,Kelly SS,Blain PG

更新日期：1997-02-01 00:00:00

abstract：:Rosiglitazone is in the thiazolidinedione class of drugs used in the treatment of type 2 diabetes mellitus. It works as an insulin sensitizer by binding to the peroxisome proliferator-activated receptor gamma. We investigated the effects of prenatally administered rosiglitazone on pyramidal cell numbers and morphologi...

journal_title：Human & experimental toxicology

authors： Sağır D,Eren B,Yılmaz BD,Eren Z,Keleş ON,Gökçe AB

更新日期：2018-08-01 00:00:00

abstract：:1. Human volunteer studies are an essential part of drug development but their use in the area of non-pharmaceutical chemicals has so far been very limited. Such studies can have considerable value in the assessment and improvement of the safe use of chemicals. 2. Once metabolic pathways and target metabolites have be...

journal_title：Human & experimental toxicology

authors： Wilks MF,Woollen BH

更新日期：1994-06-01 00:00:00

abstract：:In this study, the effect of a combination of vitamin C, vitamin E and selenium on ethanol-induced duodenal mucosal damage in rats was investigated morphologically and biochemically. The duodenal mucosal injury was produced by oral administration of 1 mL of absolute ethanol to each rat. Animals received vitamin C (250...

journal_title：Human & experimental toxicology

authors： Koyuturk M,Bolkent S,Ozdil S,Arbak S,Yanardag R

更新日期：2004-08-01 00:00:00

abstract：:The effects of acute administration of dietary levels of ethanol and the garlic oil extract, diallyl sulphide (DAS), on cytochrome P450 2E1 (CYP2E1) activity in volunteers were studied using the selective probe substrate, chlorzoxazone (CZX). The ratio of the CZX metabolite 6- hydroxychlorzoxazone (6-OHCZX) to CZX was...

journal_title：Human & experimental toxicology

authors： Loizou GD,Cocker J

更新日期：2001-07-01 00:00:00

abstract：:This study presents the findings of free radical scavenging and antigenotoxic effect of hydroalcoholic extract of Cymbopogon citratus (CCE). The CCE at a concentration of 60 microg/mL resulted in a significant scavenging ability of 2,2-diphenyl-2-picryl hydrazyl (DPPH; (85%), 2,2-azinobis (3-ethyl benzothiazoline-6-su...

journal_title：Human & experimental toxicology

authors： Rao BS,Shanbhoge R,Rao BN,Adiga SK,Upadhya D,Aithal BK,Kumar MR

更新日期：2009-04-01 00:00:00

abstract：:1. The methods used to evaluate the toxicological effects of PCBs in animals have been reviewed. 2. The data show that Toxic Equivalency Factors (TEFs) could be developed to assess the potential toxicity of PCB mixtures for certain specific target organ effects (such as the liver and immune system) but would be inappr...

journal_title：Human & experimental toxicology

authors： Battershill JM

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due ...

journal_title：Human & experimental toxicology

authors： Attaran D,Lari SM,Khajehdaluee M,Ayatollahi H,Towhidi M,Asnaashari A,Marallu HG,Mazloomi M,Mood MB

更新日期：2009-12-01 00:00:00

abstract：:Phagocytes remove and store mercury (Hg) that enters the body. Macrophages and granulocytes respond in opposite ways to Hg: macrophages loose cell viability, and neutrophils become protected from apoptosis. We have investigated the cytology of early intake of Hg by macrophages and neutrophils after a short period (2-4...

journal_title：Human & experimental toxicology

authors： Cunha EM,Oliveira MJ,Ferreira PG,Aguas AP

更新日期：2004-08-01 00:00:00

abstract：:Alcohol levels were measured in 15 cerebrospinal fluid (CSF) samples and 14 blood samples from grade III and IV male alcoholic patients with signs of nervous system involvement, and compared with levels detected in 11 CSF samples and 11 blood samples from abstemious patients or patients with grade I or II alcoholism w...

journal_title：Human & experimental toxicology

authors： Agapejev S,Vassilieff I,Curi PR

更新日期：1992-05-01 00:00:00

abstract：:Delta-aminolevulinate dehydratase (δ-ALA-D) enzyme is sensitive to pro-oxidant agents, including molecular oxygen. Here, we tested whether hyperoxygenation after total intravenous (i.v.) anesthesia could interact with the type of anesthesia (dexmedetomidine, continuous infusion; 0.5 μg/kg/h or remifentanil, continuous...

journal_title：Human & experimental toxicology

authors： Rocha JB,Heinzmann Bulow NM,Correa EF,Scholze C,Nogueira CW,Barbosa NB

更新日期：2011-04-01 00:00:00

abstract：:In vivo antidotal efficacy of new bis- quaternary 2-(hydroxyimino)- N-(pyridin-3yl) acetamide derivatives (HNK series), to counter multiples of lethal doses of nerve agent sarin (GB) and reactivation of acetylcholinesterase (AChE), was evaluated in Swiss albino mice. [Protection index PI; median lethal dose (LD50) of ...

journal_title：Human & experimental toxicology

authors： Swami D,Karade HN,Acharya J,Kumar P

更新日期：2017-01-01 00:00:00

abstract：:The use of Lucilia sericata larvae on the healing of wounds in diabetics has been reported. However, the role of the excretion/secretion (ES) products of the larvae in treatment of diabetic wounds remains unknown. This study investigated whether application of the ES products of L. sericata on the wound surface could ...

journal_title：Human & experimental toxicology

authors： Tombulturk FK,Kasap M,Tuncdemir M,Polat E,Sirekbasan S,Kanli A,Kanigur-Sultuybek G

更新日期：2018-05-01 00:00:00

abstract：:The objective of the present study was to perform histological and stereological examination of alcohol-induced changes in the optic nerve, considered an extension of white matter of the brain, in rats. This study included 20 male Wistar albino rats aged 60 days and weighing 190-220 g. The rats were divided into three...

journal_title：Human & experimental toxicology

authors： Igit T,Colcimen N

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:The objective of the present study was to determine oxidant and antioxidant status in infants with hyperbilirubinemia and/or kernicterus and to find whether there is a relationship between bilirubin level and oxidant/antioxidant status. PATIENTS:The study includes 69 full-term newborns (neonates with hyperbi...

journal_title：Human & experimental toxicology

authors： Doğan M,Peker E,Kirimi E,Sal E,Akbayram S,Erel O,Ocak AR,Tuncer O

更新日期：2011-11-01 00:00:00

abstract：:1. The effect of pyridostigmine on cardiorespiratory function after oxime + atropine injection was investigated in tabun poisoned guinea-pigs and without tabun poisoning. 2. The trachea, a carotid artery and jugular vein were cannulated in female urethane-anaesthetised Pirbright-white guinea-pigs. After baseline measu...

journal_title：Human & experimental toxicology

authors： Worek F,Kleine A,Szinicz L

更新日期：1995-08-01 00:00:00