Decorporation of thorium-228 from the rat by 3,4,3-LIHOPO and DTPA after simulated wound contamination.

abstract：:Periostin is an extracellular matrix protein from the fasciclin family that guides cellular trafficking and extracellular matrix organization. Periostin stimulates mature cardiomyocytes to reenter the cell cycle. The molecular mechanism behind such stimulation remains to be explored. A DNA microarray technology consti...

journal_title：Human & experimental toxicology

authors： Sözmen M,Devrim AK,Kabak YB,Devrim T

更新日期：2019-02-01 00:00:00

abstract：:Progressive renal dysfunction in 5/6 nephrectomized (NX) rats can be physiologically divided into three stages, coinciding with morphological stages, after definition of physiological parameters for identification of stage. Now, for the establishment of a toxicity screening approach using 5/6 NX rats, our concept, "Di...

journal_title：Human & experimental toxicology

authors： Barata K,Yoshida M,Hokao R,Imai S,Takahashi S,Harada E,Maekawa A

更新日期：2001-02-01 00:00:00

abstract：:Omeprazole is one of the most used acid-suppressing medications. This fact emphasizes the questions concerning the safety of this compound. Healthy volunteers (n=33) were included in this prospective study. All study subjects were analysed for their CYP2C19 genotype. Of the 33 individuals, 24 were homozygous for the w...

journal_title：Human & experimental toxicology

authors： Sinués B,Fanlo A,Bernal ML,Val M,Mayayo E

更新日期：2004-03-01 00:00:00

abstract：:This study evaluated the protective potential of curcumin on the possible side effects of bortezomib (Bt) therapy on normal cells in mice. The mice were segregated into three groups (n = 10) that included normal control, Bt-treated, and Bt + curcumin-treated groups. The Bt treatment resulted in significant decrease in...

journal_title：Human & experimental toxicology

authors： Kumar RR,Malhotra A

更新日期：2015-07-01 00:00:00

abstract：:1. Carbofuran was administered orally to adult male rats at dose levels of 0.1, 0.2, 0.4 or 0.8 mg kg-1 body weight, 5 d wk-1 for 60 days. A dose dependent decrease was observed in body weight of rats treated with 0.2-0.8 mg carbofuran kg-1 body weight. 2. A significant decrease in the weight of epididymides, seminal ...

journal_title：Human & experimental toxicology

authors： Pant N,Prasad AK,Srivastava SC,Shankar R,Srivastava SP

更新日期：1995-11-01 00:00:00

abstract：:Vulpinic acid, a lichen compound, has been shown to have many beneficial effects and its medicinal value increases day by day. As in atherosclerosis, endothelial damage is the basis of many diseases. The aim of this study is to investigate the effects of vulpinic acid against oxidative stress damage induced by hydroge...

journal_title：Human & experimental toxicology

authors： Sahin E,Dabagoglu Psav S,Avan I,Candan M,Sahinturk V,Koparal AT

更新日期：2019-06-01 00:00:00

abstract：:Diallyl sulfide, a sulfur-containing volatile compound present in garlic (Allium sativum), exerts anticarcinogenic activity in various rodent tumor models. In the present study, apoptosis-inhibiting effects of diallyl sulfide against a carcinogenic polycyclic aromatic hydrocarbon, 7,12-dimethyl benz(a)anthracene (DMBA...

journal_title：Human & experimental toxicology

authors： Prasad S,Kalra N,Srivastava S,Shukla Y

更新日期：2008-01-01 00:00:00

abstract：:Derivatives of dehydrocrotonin (DHC; Compound I) with different anti-ulcerogenic properties but less toxicity were produced by reducing the cyclohexenone moiety of DHC with NaBH4 (Compound II), reducing the cyclohexenone and lactone moieties with LiAlH4 (Compound III) and transforming the lactone moiety into an amide ...

journal_title：Human & experimental toxicology

authors： Melo PS,Durán N,Haun M

更新日期：2002-05-01 00:00:00

abstract：:The modulating effect of peroxisome proliferator-activated receptor α ligand on haemodynamic effects of phenylepherine (PE), angiotensin II (AII), endothelin 1 (ET1), acetylcholine (Ach), sodium nitroprusside (SNP) and isoproterenol (ISO) were evaluated in glycerol-induced acute kidney injury in rats. The effect of PE...

journal_title：Human & experimental toxicology

authors： Adedapo AA,Oyekan AO

更新日期：2013-03-01 00:00:00

abstract：:Diabetes mellitus promoted an overproduction of free radicals and an increased incidence of both diabetic nephropathy and liver disease. In this report, we evaluated the effects of Chinese and Brazilian propolis on streptozotocin-induced hepatorenal injury in rats. The results demonstrated that Chinese propolis-treate...

journal_title：Human & experimental toxicology

authors： Zhu W,Li YH,Chen ML,Hu FL

更新日期：2011-09-01 00:00:00

abstract：:Diazinon is one of the most widely used organophosphate insecticides (OPI) in agriculture and public health programs. The aim of this study was to investigate how an OPI, diazinon, affects lipid peroxidation (LPO) and the antioxidant defense system in vitro. For this purpose, two experiments were carried out. In exper...

journal_title：Human & experimental toxicology

authors： Altuntas I,Kilinc I,Orhan H,Demirel R,Koylu H,Delibas N

更新日期：2004-01-01 00:00:00

abstract：:We have investigated the pituitary-testicular axis in a well-characterized population which was occupationally exposed to mercury vapour. Thyroid stimulating hormone and prolactin were also measured as indices of thyroid and pituitary endocrine function. We found no relation between blood or urine mercury levels or le...

journal_title：Human & experimental toxicology

authors： McGregor AJ,Mason HJ

更新日期：1991-05-01 00:00:00

abstract：:The effects of moderate lead exposure on testicular endocrine function were evaluated in a group of 90 males who were occupationally exposed to inorganic lead. Lead concentrations in blood and bone were measured as indices of short-term and long-term, cumulative exposure, respectively. The results of this study show t...

journal_title：Human & experimental toxicology

authors： McGregor AJ,Mason HJ

更新日期：1990-11-01 00:00:00

abstract：:Osteosarcoma is characterized by high malignancy and high metastasis rate, resulting in high mortality and disability. MiR-663a has been reported in a variety of tumors to promote tumorigenesis. However, miR-663a has not been reported in the pathogenesis of osteosarcoma. Bioinformatics analysis and experiments includi...

journal_title：Human & experimental toxicology

authors： Zhao S,Xiong W,Xu K

更新日期：2020-12-01 00:00:00

abstract：:The conventional method for the assessment of acute inhalation toxicity (OECD Test Guideline 403, 1981) uses death of animals as an endpoint to identify the median lethal concentration (LC50). A new OECD Testing Guideline called the Fixed Concentration Procedure (FCP) is being prepared to provide an alternative to Tes...

journal_title：Human & experimental toxicology

authors： Stallard N,Whitehead A,Indans I

更新日期：2003-11-01 00:00:00

abstract：:The present study was designed to evaluate the protective effects of Juglans regia kernel extract against cigarette smoke extract (CSE)-induced lung toxicities in Wistar rats. Prophylactic treatment of methanolic extract of J. regia kernel at the doses of 50 mg/kg b.wt. and 100 mg/kg b.wt was given by gavage to Wistar...

journal_title：Human & experimental toxicology

authors： Qamar W,Sultana S

更新日期：2011-06-01 00:00:00

abstract：:1. A chronic alcoholic with severe metabolic acidosis presents a difficult diagnostic problem. The most common cause is alcoholic ketoacidosis, a syndrome with a typical history but often misleading laboratory findings. This paper will focus on this important and probably underdiagnosed syndrome. 2. The disorder occur...

journal_title：Human & experimental toxicology

authors： Höjer J

更新日期：1996-06-01 00:00:00

abstract：:The regulation of osteoblast proliferation is a key factor in maintaining bone mass. The enhancement of this process can be achieved by stimulating the proliferation of these cells. Mechanical stimulation is one of the important enhancing factors, but the exact cellular mechanisms of mechanical stimulation, i.e., mech...

journal_title：Human & experimental toxicology

authors： Rosenberg N

更新日期：2003-05-01 00:00:00

abstract：:Results obtained in long-term carcinogenicity studies with animals should be evaluated, first and foremost, by statistical comparisons of the data obtained from the treated group with that from the concurrent control group. Often the results are compared with data from so-called historical control groups in order to t...

journal_title：Human & experimental toxicology

authors： Greim H,Gelbke HP,Reuter U,Thielmann HW,Edler L

更新日期：2003-10-01 00:00:00

abstract：:Pharmaceutical research and new drug development rely extensively on animal research. The development of novel agents for intrathecal administration requires preclinical studies of toxic effects in an animal model. We have developed a nonrodent animal model for this purpose. Our sheep model: 1 Is an animal whose neura...

journal_title：Human & experimental toxicology

authors： Hassenbusch SJ,Satterfield WC,Gradert TL

更新日期：1999-02-01 00:00:00

abstract：:This study was designed to evaluate the maternal toxicity and teratogenicity of fenproporex, one of the most widely-used anorectic drugs in many countries, including Brazil. Three periods of exposure were evaluated: (a) 30 days before mating; (b) from gestational day (GD) 0 to 14; and (c) 30 days before mating and dur...

journal_title：Human & experimental toxicology

authors： Moreira CQ,Faria MJ,Baroneza JE,Oliveira RJ,Moreira EG

更新日期：2005-08-01 00:00:00

abstract：:To clarify the reproductive toxicity of polychlorinated biphenyl compounds through determination of testicular lipid peroxidation, reactive oxygen species and enzymatic and non-enzymatic antioxidants in rats exposed to Aroclor 1254. Adult male rats were administered Aroclor 1254 at a dose of 2 mg/kg per day ip for 30 ...

journal_title：Human & experimental toxicology

authors： Murugesan P,Senthilkumar J,Balasubramanian K,Aruldhas MM,Arunakaran J

更新日期：2005-02-01 00:00:00

abstract：:The malignancy of non-small cell lung cancer (NSCLC) largely results from its invasive manner. Secreted frizzled-related proteins (SFRPs) have been recently found to suppress the invasiveness of some cancers. On the other hand, the methylation of SFRPs increases protein degradation to reduce the activity of SFRPs, res...

journal_title：Human & experimental toxicology

authors： Zhang X,Rong X,Chen Y,Su L

更新日期：2018-02-01 00:00:00

abstract：:Although ingestion of methyl ethyl ketone peroxide (MEKP) is rare, it carries a high risk of morbidity and mortality. This paper reports the first such case from Turkey in which a 70-year-old man unintentionally ingested MEKP in his kitchen. The patient was brought into the emergency department (ED) within 1 hour of i...

journal_title：Human & experimental toxicology

authors： Bozdemir MN,Yildiz M,Seyhanli ES,Gurbuz S,Kilicaslan I,Karlidag T

更新日期：2011-12-01 00:00:00

abstract：:Hexafluorocyclobutene (HFCB), a reactive organohalogen gas, causes overwhelming pulmonary oedema. We investigated its effect on the rat lung surfactant system, comparing its action on type II pneumocytes with air-exposed rats. The inflammatory cell population and protein content of bronchoalveolar lavage fluid was ana...

journal_title：Human & experimental toxicology

authors： Jugg B,Jenner J,Hughes JN,Rice P

更新日期：2001-05-01 00:00:00

abstract：:Iodine-125 HIPDM was evaluated as a screening agent for studying multiorgan toxicity due to Cyclosporine-A (CsA) and the results were compared to histopathological findings of the tissues. The rats were injected subcutaneously with 50 mg/kg (body weight) of CsA or with equal volume of the vehicle, Cremophor-EL, for 7 ...

journal_title：Human & experimental toxicology

authors： Shihab-Eldeen A,Owunwanne A,Junaid TA,Yacoub T

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:The widespread use of synthetic cannabinoids (SCs) among youth has become an important public health problem. Several life-threatening side effects of SC have been reported, including cardiovascular, gastrointestinal, neurological, renal, metabolic, ophthalmologic, and pulmonary effects, besides skin toxicit...

journal_title：Human & experimental toxicology

authors： Guler EM,Bektay MY,Akyildiz AG,Sisman BH,Izzettin FV,Kocyigit A

更新日期：2020-11-01 00:00:00

abstract：:1. Groups of 60 male and 60 female B6C3F1 mice or HanIbm Wistar rats were exposed to HFA-134a using snout-only inhalation exposure techniques for periods of one hour daily for at least 104 weeks. HFA-134a was delivered directly from cylinders at vapour concentrations of 2500, 15,000 and 75,000ppm for mice and from met...

journal_title：Human & experimental toxicology

authors： Alexander DJ,Libretto SE,Chevalier HJ,Imamura T,Pappritz G,Wilson J

更新日期：1995-09-01 00:00:00

abstract：:Public health issues have been raised regarding fructose toxicity and its serious metabolic disorders. Deleterious effects of high fructose intake on insulin sensitivity, body weight, lipid homeostasis have been identified. The new millennium has witnessed the emergence of a modern epidemic, the metabolic syndrome (MS...

journal_title：Human & experimental toxicology

authors： Abdelhamid YA,Elyamany MF,Al-Shorbagy MY,Badary OA

更新日期：2020-10-29 00:00:00

abstract：:Severe carbon monoxide (CO) poisoning causes fulminant deaths in common environment as well as neurological sequelae to survivors. Prevention of delayed neurological syndrome (DNS) after exposure to CO, the most important sequela, is based up to date on hyperbaric oxygen administration. Nevertheless, its use remains c...

journal_title：Human & experimental toxicology

authors： Del Moral-Barbudo B,Blancas R,Ballesteros-Ortega D,Quintana-Díaz M,Martínez-González Ó

更新日期：2020-06-01 00:00:00