Effects of TNF-α antagonist infliximab on fructose-induced metabolic syndrome in rats.

abstract：:Iodine-125 HIPDM was evaluated as a screening agent for studying multiorgan toxicity due to Cyclosporine-A (CsA) and the results were compared to histopathological findings of the tissues. The rats were injected subcutaneously with 50 mg/kg (body weight) of CsA or with equal volume of the vehicle, Cremophor-EL, for 7 ...

journal_title：Human & experimental toxicology

authors： Shihab-Eldeen A,Owunwanne A,Junaid TA,Yacoub T

更新日期：1996-11-01 00:00:00

abstract：:Naringenin is a naturally occurring flavanones and has been found to exhibit free radical scavenging, enzyme inhibition, antioxidants, anti-inflammatory, and anticancer activities. Present study was designed to evaluate the protective role of naringenin against benzo[a]pyrene (B[a]P)-induced oxidative stress and pulmo...

journal_title：Human & experimental toxicology

authors： Ali R,Shahid A,Ali N,Hasan SK,Majed F,Sultana S

更新日期：2017-04-01 00:00:00

abstract：:Predictive toxicology plays a critical role in reducing the failure rate of new drugs in pharmaceutical research and development. Despite recent gains in our understanding of drug-induced toxicity, however, it is urgent that the utility and limitations of our current predictive tools be determined in order to identify...

journal_title：Human & experimental toxicology

authors： Naven RT,Louise-May S

更新日期：2015-12-01 00:00:00

abstract：:Changes required for the explicit recognition of hormesis are outlined for both ecotoxicology and ecological risk assessment (ERA). A major research need is the extension of hormesis beyond chemical stressors to abiotic (e.g., habitat) and biotic stressors (e.g., species introductions, organism interactions). An overr...

journal_title：Human & experimental toxicology

authors： Chapman PM

更新日期：2001-10-01 00:00:00

abstract：:1. Multiple low doses of the direct acting organophosphates, ecothiopate, paraoxon and mipafox produced persistent and additive inhibition of diaphragm acetylcholinesterase. Paraoxon and mipafox had similar effects on brain acetylcholinesterase. There was greater recovery from inhibition between doses for paraoxon and...

journal_title：Human & experimental toxicology

authors： Williams FM,Charlton C,de Blaquière GE,Mutch E,Kelly SS,Blain PG

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:Mushroom poisoning is still a significant health-care problem, with the potential to affect blood parameters. The present study analyses the effect of mushroom poisoning on complete blood cell parameters, cell ratios, and cell volume indices and the effect of the mentioned parameters on prognosis/hospital len...

journal_title：Human & experimental toxicology

authors： Doğan M,Karahan I

更新日期：2019-10-01 00:00:00

abstract：:This study evaluated the protective potential of curcumin on the possible side effects of bortezomib (Bt) therapy on normal cells in mice. The mice were segregated into three groups (n = 10) that included normal control, Bt-treated, and Bt + curcumin-treated groups. The Bt treatment resulted in significant decrease in...

journal_title：Human & experimental toxicology

authors： Kumar RR,Malhotra A

更新日期：2015-07-01 00:00:00

abstract：:The National Toxicology Program (NTP) Technical Reports online database was reviewed to find chemicals that were reported to show clear evidence of carcinogenicity in the NTP rodent studies and for which data on human exposure could be found. Six representative compounds were selected. Three volatile compounds: ethyl ...

journal_title：Human & experimental toxicology

authors： Waddell WJ

更新日期：2003-09-01 00:00:00

abstract：:The aim of the present investigation was to check the fluctuation in essential elements, such as Na, K, Mg, Mn, Cu, Zn, Cr and Ni in the brain, spinal cord, liver and kidney of mice during methylmercury chloride (MMC) toxication and therapy with monothiols (N-acetyl-DL-homocysteine thiolactone and glutathione) and vit...

journal_title：Human & experimental toxicology

authors： Bapu C,Purohit RC,Sood PP

更新日期：1994-12-01 00:00:00

abstract：:Tripartite motif-containing protein 24 (TRIM24) has currently emerged as a crucial cancer-related gene present in a wide range of human cancer types. However, the involvement of TRIM24 in acute myeloid leukemia (AML) has not been well investigated. The present study aims to investigate the significance, cellular funct...

journal_title：Human & experimental toxicology

authors： Li C,Xin H,Shi Y,Mu J

更新日期：2020-12-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) and dioxins are potentially toxic compounds which occur widely in the environment. Their effects on the growth and development of infants at the levels currently found in highly industrialised western countries is not well known. This Dutch multicenter study, combining animal and human...

journal_title：Human & experimental toxicology

authors： Sauer PJ,Huisman M,Koopman-Esseboom C,Morse DC,Smits-van Prooije AE,van de Berg KJ,Tuinstra LG,van der Paauw CG,Boersma ER,Weisglas-Kuperus N

更新日期：1994-12-01 00:00:00

abstract：:There are many discrepancies among the results of studies on the genotoxicity of lead. The aim of the study was to explore lead-induced DNA damage, including oxidative damage, in relation to oxidative stress intensity parameters and the antioxidant defense system in human leukocytes. The study population consisted of ...

journal_title：Human & experimental toxicology

authors： Dobrakowski M,Pawlas N,Kasperczyk A,Kozłowska A,Olewińska E,Machoń-Grecka A,Kasperczyk S

更新日期：2017-07-01 00:00:00

abstract：:The principal impediment to gene therapy is the development of efficient, nontoxic gene carriers that can handle and deliver foreign genetic materials into various cell types, including healthy and cancerous cells. Poly-l-lysine (PLL) polymers are one of the most favorable gene carriers among nonviral vectors, and PLL...

journal_title：Human & experimental toxicology

authors： Alinejad-Mofrad E,Malaekeh-Nikouei B,Gholami L,Mousavi SH,Sadeghnia HR,Mohajeri M,Darroudi M,Oskuee RK

更新日期：2019-08-01 00:00:00

abstract：:The polybrominated diphenyl ether flame retardants decabromodiphenyl ether (BDE-209) and bisphenol A (BPA) are environmental contaminants that can cross the placenta and exert toxicity in the developing fetal nervous system. Copy number variants (CNVs) play a role in a number of genetic disorders and may be implicated...

journal_title：Human & experimental toxicology

authors： Du L,Sun W,Li XM,Li XY,Liu W,Chen D

更新日期：2018-05-01 00:00:00

abstract：:HCH isomers, endosulfan, malathion, chlorpyrifos, and methyl-parathion were monitored in human milk samples from Bhopal, Madhya Pradesh. The endosulfan concentrations were highest and exceeded the sigma-HCH, chlorpyrifos, and malathion concentrations by 3.5-, 1.5-, and 8.4-fold, respectively. Through breast milk, infa...

journal_title：Human & experimental toxicology

authors： Sanghi R,Pillai MK,Jayalekshmi TR,Nair A

更新日期：2003-02-01 00:00:00

abstract：:Progressive renal dysfunction in 5/6 nephrectomized (NX) rats can be physiologically divided into three stages, coinciding with morphological stages, after definition of physiological parameters for identification of stage. Now, for the establishment of a toxicity screening approach using 5/6 NX rats, our concept, "Di...

journal_title：Human & experimental toxicology

authors： Barata K,Yoshida M,Hokao R,Imai S,Takahashi S,Harada E,Maekawa A

更新日期：2001-02-01 00:00:00

abstract：:Seafood is considered by nutritionists to be a high source of omega 3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) which are involved in prevention of cardiovascular diseases. The aim of the present study is firstly to detect the presence of organochlorine pesticides and heavy metals in some fresh seafood of ...

journal_title：Human & experimental toxicology

authors： Al-Malki AL,Moselhy SS

更新日期：2011-10-01 00:00:00

abstract：:Trichloroethylene (TCE) was exposed in the presence of the spin trap N-tert-butyl-alpha-phenyl nitrone (PBN, 0.1 M) to ionizing radiation from two different sources in an attempt to determine the origin of the spin-trapped radicals generating the EPR spectra in precision cut liver slices. TCE samples were irradiated w...

journal_title：Human & experimental toxicology

authors： Carmichael AJ,Steel-Goodwin L

更新日期：1997-06-01 00:00:00

abstract：:Phosphorus flame retardants are a group of chemicals that are used to slow or prevent the spread of fire. These compounds have been detected in different environments including human organism. In the present study, we have investigated DNA-damaging potential and effect on DNA methylation of tris(2-chloroethyl) phospha...

journal_title：Human & experimental toxicology

authors： Bukowski K,Wysokinski D,Mokra K,Wozniak K

更新日期：2019-06-01 00:00:00

abstract：:The present study was undertaken to investigate the effects of maternal lead (Pb) exposure on the expression of interleukin (IL) 1β, IL 6, and glial fibrillary acidic protein (GFAP) in hippocampus of mice offspring. Pb exposure initiated from the beginning of gestation to weaning. Lead acetate (PbAc) administered in d...

journal_title：Human & experimental toxicology

authors： Li N,Liu X,Zhang P,Qiao M,Li H,Li X,Zhang H,Yu Z

更新日期：2015-04-01 00:00:00

abstract：:This study presents the findings of free radical scavenging and antigenotoxic effect of hydroalcoholic extract of Cymbopogon citratus (CCE). The CCE at a concentration of 60 microg/mL resulted in a significant scavenging ability of 2,2-diphenyl-2-picryl hydrazyl (DPPH; (85%), 2,2-azinobis (3-ethyl benzothiazoline-6-su...

journal_title：Human & experimental toxicology

authors： Rao BS,Shanbhoge R,Rao BN,Adiga SK,Upadhya D,Aithal BK,Kumar MR

更新日期：2009-04-01 00:00:00

abstract：:1. This study examines the effect of treating rats with gentamicin (80 mg kg-1 day-1 intramuscularly (i.m.), for 6 days) alone or with either L-thyroxine or the anti-thyroid drug carbimazole. 2. Gentamicin produced significant increases in serum creatinine and urea concentrations, and significantly reduced the activit...

journal_title：Human & experimental toxicology

authors： Ali BH,Bashir AA,Tanira MO

更新日期：1995-01-01 00:00:00

abstract：:Diallyl sulfide, a sulfur-containing volatile compound present in garlic (Allium sativum), exerts anticarcinogenic activity in various rodent tumor models. In the present study, apoptosis-inhibiting effects of diallyl sulfide against a carcinogenic polycyclic aromatic hydrocarbon, 7,12-dimethyl benz(a)anthracene (DMBA...

journal_title：Human & experimental toxicology

authors： Prasad S,Kalra N,Srivastava S,Shukla Y

更新日期：2008-01-01 00:00:00

abstract：:Many industrial and agricultural chemicals have steroid hormone agonist or antagonist activities and disrupt hormone-regulated gene expression. The widely-used agricultural insecticide, diazinon, was evaluated using MCF-7 cells - a breast cancer-derived, estrogen-dependent, human cell line - to examine the capacity of...

journal_title：Human & experimental toxicology

authors： Mankame T,Hokanson R,Fudge R,Chowdhary R,Busbee D

更新日期：2006-02-01 00:00:00

abstract：:Vulpinic acid, a lichen compound, has been shown to have many beneficial effects and its medicinal value increases day by day. As in atherosclerosis, endothelial damage is the basis of many diseases. The aim of this study is to investigate the effects of vulpinic acid against oxidative stress damage induced by hydroge...

journal_title：Human & experimental toxicology

authors： Sahin E,Dabagoglu Psav S,Avan I,Candan M,Sahinturk V,Koparal AT

更新日期：2019-06-01 00:00:00

abstract：:The purpose of this study was to characterize the zinc oxide nanoparticles (ZnO-NPs) and their bulk counterpart in suspensions and to access the impact of their acute oral toxicity at doses of 300 and 2000 mg/kg in healthy female Wistar rats. The hematological, biochemical, and urine parameters were accessed at 24 and...

journal_title：Human & experimental toxicology

authors： Srivastav AK,Kumar M,Ansari NG,Jain AK,Shankar J,Arjaria N,Jagdale P,Singh D

更新日期：2016-12-01 00:00:00

abstract：:The majority of households in rural India still rely on unprocessed solid biomass for domestic energy. The aim of this study was to investigate whether chronic exposure to biomass smoke causes activation of leukocytes and the formation of leukocyte-platelet aggregates. We conducted flow cytometric analysis of beta2 Ma...

journal_title：Human & experimental toxicology

authors： Ray MR,Mukherjee S,Roychoudhury S,Bhattacharya P,Banerjee M,Siddique S,Chakraborty S,Lahiri T

更新日期：2006-11-01 00:00:00

abstract：:A number of xenobiotics require redox reactions to form the reactive intermediates involved in the ultimate toxic events (e.g., adduct formation). The same mechanisms lead to the formation of reactive oxygen species (ROS), which can themselves exert direct toxicity including, e.g., DNA oxidative damage or glutathione ...

journal_title：Human & experimental toxicology

authors： Pagano G

更新日期：2002-02-01 00:00:00

abstract：:The pharmacokinetics of the herbicide fluazifop-butyl have been determined in female rats following oral and intravenous dosing, and described by a mathematical model. Penetration of fluazifop-butyl through epidermal membranes has been determined using three different receptor fluids. It is demonstrated how this in vi...

journal_title：Human & experimental toxicology

authors： Auton TR,Ramsey JD,Woollen BH

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Deliberate self-poisoning (DSP) is a major health problem with increasing incidence mainly among young people. OBJECTIVE:To examine the clinical and toxicological characteristics of DSP, it is compared to unintentional (non-DSP) exposures and those characteristics which might be associated with increased to...

journal_title：Human & experimental toxicology

authors： Bentur Y,Raikhlin-Eisenkraft B,Lavee M

更新日期：2004-07-01 00:00:00