Abstract:
:Phosphorus flame retardants are a group of chemicals that are used to slow or prevent the spread of fire. These compounds have been detected in different environments including human organism. In the present study, we have investigated DNA-damaging potential and effect on DNA methylation of tris(2-chloroethyl) phosphate (TCEP) and tris(1-chloro-2-propyl) phosphate (TCPP) in human peripheral blood mononuclear cells (PBMCs). In order to determine DNA damage and repair, the alkaline and neutral versions of the comet assay were used. The level of DNA methylation was determined with specific antibodies against methylated DNA. PBMCs were exposed to TCEP and TCPP at the concentrations in the range of 1-1000 µM for 24 h. We have observed that TCEP and TCPP induced DNA damage-DNA breaks and alkali-labile sites. All DNA damages were effectively repaired during 120-min repair incubation. The results have also shown that TCEP and TCPP decreased the level of DNA methylation in PBMCs. In the case of TCEP, this effect was observed at a very low concentration of 1 µM.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Bukowski K,Wysokinski D,Mokra K,Wozniak Kdoi
10.1177/0960327119839174subject
Has Abstractpub_date
2019-06-01 00:00:00pages
724-733issue
6eissn
0960-3271issn
1477-0903journal_volume
38pub_type
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