Abstract：
:Neutrophil functions were studied in 38 lead-exposed workers compared to 34 controls. Both groups were matched according to age, sex, drinking and smoking habits, ethnic origin and drug intake. Blood lead levels were found to be seven times higher in exposed workers than in controls. Phagocytosis assayed by chemiluminescence was found to be slightly but not significantly altered in exposed workers. In contrast, chemotaxis using the agarose technique was significantly depressed. These results are in agreement with previous in-vitro findings. A further assessment of clinical consequences is warranted.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Bergeret A,Pouget E,Tedone R,Meygret T,Cadot R,Descotes Jdoi
10.1177/096032719000900405subject
Has Abstractpub_date
1990-07-01 00:00:00pages
231-3issue
4eissn
0960-3271issn
1477-0903journal_volume
9pub_type
杂志文章abstract：:The objective of the present study was to perform histological and stereological examination of alcohol-induced changes in the optic nerve, considered an extension of white matter of the brain, in rats. This study included 20 male Wistar albino rats aged 60 days and weighing 190-220 g. The rats were divided into three...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327119828123
更新日期：2019-05-01 00:00:00
abstract：:1. Carbofuran was administered orally to adult male rats at dose levels of 0.1, 0.2, 0.4 or 0.8 mg kg-1 body weight, 5 d wk-1 for 60 days. A dose dependent decrease was observed in body weight of rats treated with 0.2-0.8 mg carbofuran kg-1 body weight. 2. A significant decrease in the weight of epididymides, seminal ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719501401106
更新日期：1995-11-01 00:00:00
abstract：:Prolonged zidovudine (AZT) treatment in HIV-infected and AIDS patients is shown to induce liver toxicity leading to complications. Therapeutic regimen that could encounter this adverse effect is unavailable and management of toxicity is often symptomatic or is limited to withdrawal of therapy. In the present investiga...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327114567765
更新日期：2015-11-01 00:00:00
abstract：:The aim of the present investigation was to check the fluctuation in essential elements, such as Na, K, Mg, Mn, Cu, Zn, Cr and Ni in the brain, spinal cord, liver and kidney of mice during methylmercury chloride (MMC) toxication and therapy with monothiols (N-acetyl-DL-homocysteine thiolactone and glutathione) and vit...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719401301201
更新日期：1994-12-01 00:00:00
abstract：:In order to assess the effect of arsenic on the male reproductive impairment in mice, 7-week-old animals were exposed to 7.5 mg sodium arsenite (NaAsO(2))/kg body weight, during 35 days (one spermatogenic cycle). One group of animals was sacrificed after exposure, while another group received distilled water for an ad...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327111405862
更新日期：2012-03-01 00:00:00
abstract：:In this study, genotoxic activities of four halogenated anesthetics (halothane, isoflurane, sevoflurane and desflurane) were investigated in human peripheral blood lymphocytes (PBLs) and sperm cells in vitro by alkaline comet assay. For this purpose, sperm or lymphocyte suspension was exposed to different concentratio...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327112446818
更新日期：2012-12-01 00:00:00
abstract：:As an input to dose assessments, measurements have been made of the clearance of Pu and Am after subcutaneous implantation in rats for six particulate materials and one dust from the Maralinga test sites. The tissue distribution of Pu and Am were measured in groups of six animals at one month and 6 months after implan...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719301200410
更新日期：1993-07-01 00:00:00
abstract：:The effects of low lead exposure were investigated in 96 children (7-12 years old) living and studying within a 1 km radius of a lead smelter (exposed population) located in Torreón, Coahuila, México, and compared with 30 children living and studying 4.5 km from the same smelter (control population). Both populations ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719601500406
更新日期：1996-04-01 00:00:00
abstract：:Acrylamide is oxidized by cytochrome P450 2E1 (CYP2E1) to its epoxide form, glycidamide, which is believed to be responsible for the mutagenic and carcinogenic activities. This study was carried out to investigate the early changes that may be related to the carcinogenic activity of acrylamide in thyroid, adrenal glan...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327111417267
更新日期：2012-05-01 00:00:00
abstract：:This study deals with pesticide exposure profile in some European countries with a specific focus on ethylenebisdithiocarbamates (EBDC). In all, 55 Bulgarian greenhouse workers, 51 Finnish potato farmers, 48 Italian vineyard workers, 42 Dutch floriculture farmers, and 52 Bulgarian zineb producers entered the study. Ea...
journal_title：Human & experimental toxicology
pub_type： 杂志文章,多中心研究
doi：10.1177/0960327108100003
更新日期：2008-09-01 00:00:00
abstract：:1. With DTPA as a comparison, the siderophore analogue 3,4,3-LIHOPO has been examined for its ability to remove 228Th nitrate from the rat after subcutaneous (sc) and intramuscular (im) injection to simulate wound contamination. The commencement of treatment was delayed 30 min, 6 h or 1 d and the animals killed at 7 d...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719501400202
更新日期：1995-02-01 00:00:00
abstract：:Occupational chronic solvent encephalopathy (CSE) is associated with a number of neurobehavioural disorders including defects of visual perception. The purpose of this study was to characterize colour vision defects in CSE patients. Colour vision was tested in bright illumination with the Farnsworth-Munsell 100-hue te...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327107076820
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Diphenhydramine (DPHM) overdose is a frequent cause of acute poisoning. Although its clinical features are well known, information about the dose-dependent toxicity of DPHM is still scarce. The objective of this study was to investigate the dose-dependent toxicity of DPHM in patients with acute DPHM poisonin...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/096032700671040438
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:The present study was designed to highlight the toxic impact of baclofen on both biochemical and histopathological aspects in rats' liver, gastric, lung, kidney, and brain tissues. METHODS:The study was performed on 30 healthy adult male albino rats divided into four groups with 5 rats in each control group,...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327117712369
更新日期：2018-04-01 00:00:00
abstract：:The serial cognitive assessment of ten individuals made between 8 and 26 months after the water at Camelford in Cornwall was accidentally contaminated with aluminium sulphate, showed consistent evidence of impairment of information processing and memory. There was no obvious relationship between these impairments and ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719301200108
更新日期：1993-01-01 00:00:00
abstract：:This report describes two accidents, involving snakes of the Micrurus corallinus species, where compromising respiratory function was not observed and the specific anti-elapidic serum was the single therapy used, and a third incident, probably involving Micrurus frontalis, where neostigmine was used to remedy respirat...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719201100213
更新日期：1992-03-01 00:00:00
abstract：:In the 1980s, villages in the Kurdistan region of Iraq were exposed to chemical weapons (CWs), which killed and injured thousands of civilians. There has been no clinical assessment of the long-term effects of CWs exposure on those injured. We report the first such evaluation of CW effects on long-term health of child...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327117734620
更新日期：2018-08-01 00:00:00
abstract：:Chronic mercury exposure impairs vascular function, leading to the depression of endothelium-dependent vasodilatation. Loss of the nitric oxide (NO) pathway has been implicated, but little is known about effects on other endothelial mediators. This study investigated the mechanisms of endothelial dysfunction in rats s...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327110391389
更新日期：2011-11-01 00:00:00
abstract：:The present study was designed to evaluate the protective effects of Juglans regia kernel extract against cigarette smoke extract (CSE)-induced lung toxicities in Wistar rats. Prophylactic treatment of methanolic extract of J. regia kernel at the doses of 50 mg/kg b.wt. and 100 mg/kg b.wt was given by gavage to Wistar...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327110374204
更新日期：2011-06-01 00:00:00
abstract：:Utilizing information obtained from the X-ray fluorescence linear scanning along a single strand of hair in a recent fatal exposure to dimethylmercury, it was possible to determine the circumstances leading to the fatal result. When the Dartmouth chemistry professor displayed symptoms of mercury toxicity, samples of h...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1191/096032701678766813
更新日期：2001-04-01 00:00:00
abstract：:The Organization for Economic Cooperation and Development (OECD) has promoted Good Laboratory Practice (GLP) since the mid 1970s. This paper describes the development of the concept through international harmonisation, Quality Assurance (QA), and compliance monitoring. Ultimately this process permits Mutual Acceptance...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719301200611
更新日期：1993-11-01 00:00:00
abstract：:This study evaluated the protective potential of curcumin on the possible side effects of bortezomib (Bt) therapy on normal cells in mice. The mice were segregated into three groups (n = 10) that included normal control, Bt-treated, and Bt + curcumin-treated groups. The Bt treatment resulted in significant decrease in...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327114555928
更新日期：2015-07-01 00:00:00
abstract：:Evidence-based guidelines do not exist for the treatment of patients with chronic mild-moderate digoxin toxicity. We sought to evaluate differences among specialists in the use of digoxin-specific antibody fragments and the decision to admit these patients. A sample of cardiologists, emergency physicians, and medical ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327109105405
更新日期：2009-05-01 00:00:00
abstract：:1. Polyvinyl chloride (PVC) cot mattress covers from SIDS cases were investigated as potential sources of soluble (potentially ingestable) antimony in the cot environment. 2. Body fluids (urine, saliva) and proprietary domestic detergents/sterilizing fluids markedly enhanced leaching of antimony from PVC. Release of a...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719801700302
更新日期：1998-03-01 00:00:00
abstract：INTRODUCTION:This study provides an epidemiological description of non-health care facility medication errors involving anticonvulsant drugs. METHODS:A retrospective analysis of National Poison Data System data was conducted on non-health care facility medication errors involving anticonvulsant drugs reported to US Po...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327117721962
更新日期：2018-06-01 00:00:00
abstract：:The renin-angiotensin system (RAS) subserves vital physiological functions and also implicated in certain pathological states. Modulation of this system has been proposed in recent studies to be a promising strategy in treating liver fibrosis. We investigated the effect of the pharmacologic inhibition of RAS with angi...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327111401051
更新日期：2011-11-01 00:00:00
abstract：:The present study was designed to evaluate the cardioprotective potential of lycopene (LCP) against isoproterenol (ISP)-induced myocardial infarction (MI), by assessing hemodynamic, biochemical and histopathological parameters. Wistar male albino rats were orally administered with LCP (0.5, 1.0 and 1.5 mg/kg) or with ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/0960327112454890
更新日期：2013-05-01 00:00:00
abstract：:1. Four different concentrations of quinalphos and methyl parathion were tested on human peripheral lymphocytes over different time periods, for the analysis of chromosomal aberrations and sister chromatid exchanges (SCEs). 2. A significant increase in chromosomal aberrations was observed when cells were treated with ...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719000900605
更新日期：1990-11-01 00:00:00
abstract：:The effects of moderate lead exposure on testicular endocrine function were evaluated in a group of 90 males who were occupationally exposed to inorganic lead. Lead concentrations in blood and bone were measured as indices of short-term and long-term, cumulative exposure, respectively. The results of this study show t...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719000900602
更新日期：1990-11-01 00:00:00
abstract：:Indomethacin, a non-steroidal anti-inflammatory drug is known to increase the efficacy and toxicity of methotrexate, the widely used anti-cancer drug in man. The mechanism for this interaction has not been clearly established. However, since these drugs bind with albumin, a possible displacement of methotrexate by ind...
journal_title：Human & experimental toxicology
pub_type： 杂志文章
doi：10.1177/096032719201100411
更新日期：1992-07-01 00:00:00
