Silibinin mitigates zidovudine-induced hepatocellular degenerative changes, oxidative stress and hyperlipidaemia in rats.

abstract：BACKGROUND:The widespread use of synthetic cannabinoids (SCs) among youth has become an important public health problem. Several life-threatening side effects of SC have been reported, including cardiovascular, gastrointestinal, neurological, renal, metabolic, ophthalmologic, and pulmonary effects, besides skin toxicit...

journal_title：Human & experimental toxicology

authors： Guler EM,Bektay MY,Akyildiz AG,Sisman BH,Izzettin FV,Kocyigit A

更新日期：2020-11-01 00:00:00

abstract：:A number of novel serotonergic antidepressants have been introduced to clinical practice over the last decade. These medications are felt to be safe alternatives to the traditional tricyclic antidepressants and monoamine oxidase inhibitors, particularly in the overdose setting. Serious adverse reactions and drug inter...

journal_title：Human & experimental toxicology

authors： Hodgman MJ,Martin TG,Krenzelok EP

更新日期：1997-01-01 00:00:00

abstract：INTRODUCTION:Automatic dishwashing rinse aids are drying aids which contain non-ionic surfactants, usually ethoxylated alcohols, typically at concentrations of ≤30%. OBJECTIVE:To assess the reported toxicity of rinse aids. METHODS:Telephone enquiries to the UK National Poisons Information Service were analysed from J...

journal_title：Human & experimental toxicology

authors： Day R,Bradberry SM,Sandilands EA,Thomas S,Thompson JP,Vale JA

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due ...

journal_title：Human & experimental toxicology

authors： Attaran D,Lari SM,Khajehdaluee M,Ayatollahi H,Towhidi M,Asnaashari A,Marallu HG,Mazloomi M,Mood MB

更新日期：2009-12-01 00:00:00

abstract：:The aim of this study was to compare simultaneously obtained arterial and capillary blood gas (CBG) values in comatose-poisoned patients presented with stable vital signs. Forty-five adult patients with a diagnosis of coma because of poisoning and stable vital signs were included in this prospective study. With respec...

journal_title：Human & experimental toxicology

authors： Eizadi-Mood N,Alfred S,Yaraghi A,Huynh C,Moghadam AS

更新日期：2009-10-01 00:00:00

abstract：:The National Toxicology Program (NTP) Technical Reports online database was reviewed to find chemicals that were reported to show clear evidence of carcinogenicity in the NTP rodent studies and for which data on human exposure could be found. Six representative compounds were selected. Three volatile compounds: ethyl ...

journal_title：Human & experimental toxicology

authors： Waddell WJ

更新日期：2003-09-01 00:00:00

abstract：:Organophosphorus compounds are known to cause the selective release of liver microsomal beta-glucuronidase into plasma. Organophophoruses may induce nitrosative stress leading to the generation of nitrogen free radicals and alterations in scavengers of free radicals in many biological systems. In this study, we invest...

journal_title：Human & experimental toxicology

authors： Soltaninejad K,Shadnia S,Afkhami-Taghipour M,Saljooghi R,Mohammadirad A,Abdollahi M

更新日期：2007-12-01 00:00:00

abstract：:beta-glucuronidase is considered a sensitive biomarker for acute organophosphorus poisoning. In this well-documented study, multiple plasma samples over time were collected. A decrease in plasma concentration of beta-glucuronidase was surprisingly observed, even within normal range. These findings do not support the h...

journal_title：Human & experimental toxicology

authors： Sabbe MB,Desruelles D,Lissens W

更新日期：2008-05-01 00:00:00

abstract：:Pesticides are used in agriculture to protect crops from insects-pests. Most of the field workers of North Indian population are exposed to commonly used insecticides. In the present study, pesticides induced oxidative stress as well as alterations in the level of acetylcholinesterase (AChE) in a total of 70 male heal...

journal_title：Human & experimental toxicology

authors： Sharma RK,Upadhyay G,Siddiqi NJ,Sharma B

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is the main clinical concern resulted from ischemia-reperfusion injury (IRI). Ample clinical data indicates that AKI is associated with distant organ dysfunctions and poor patients' outcomes. Oxidative stress and inflammation have a critical role in the pathogenesis of organ injurie...

journal_title：Human & experimental toxicology

authors： Bagheri Y,Aghajani S,Hosseinzadeh M,Hoshmandan F,Abdollahpour A,Vahed SZ

更新日期：2020-12-16 00:00:00

abstract：:Epichlorohydrin (ECH) is an antifertility agent that acts both as an epididymal toxicant and an agent capable of directly affecting sperm motility. This study identified the time course of apoptotic cell death in rat epididymides after ECH treatment. Rats were administrated with a single oral dose of ECH (50 mg/kg). E...

journal_title：Human & experimental toxicology

authors： Lee IC,Kim KH,Kim SH,Baek HS,Moon C,Kim SH,Yun WK,Nam KH,Kim HC,Kim JC

更新日期：2013-06-01 00:00:00

abstract：:N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-doxorubicin (PK1) is a novel polymeric anticancer agent containing doxorubicin (approximately 8 wt%) bound to the polymer backbone via a Gly-Phe-Leu-Gly peptidyl linker. The approximate LD50 of PK1 in MF1 mice after a single i.v. injection was 63 mg/kg (doxorubicin-eq...

journal_title：Human & experimental toxicology

authors： Duncan R,Coatsworth JK,Burtles S

更新日期：1998-02-01 00:00:00

abstract：:Indomethacin, a non-steroidal anti-inflammatory drug is known to increase the efficacy and toxicity of methotrexate, the widely used anti-cancer drug in man. The mechanism for this interaction has not been clearly established. However, since these drugs bind with albumin, a possible displacement of methotrexate by ind...

journal_title：Human & experimental toxicology

authors： Raveendran R,Heybroek W,Caulfield M,Lawson M,Abrams SM,Wrigley PF,Slevin M,Turner P

更新日期：1992-07-01 00:00:00

abstract：:Dimerized translationally controlled tumor protein (dTCTP) plays a role in allergic diseases. A 7-mer peptide, dimerized translationally binding protein 2 (dTBP2), binds to dTCTP and inhibits dTCTP, suggesting that the 7-mer peptide may have therapeutic potential. We assessed the safety of dTBP2 by examining its cytot...

journal_title：Human & experimental toxicology

authors： Kim M,Jin YB,Lee K,Lee YS

更新日期：2013-11-01 00:00:00

abstract：:Pityriasis rosea (PR) is a common, acute, and self-limited inflammatory skin disease. The typical clinical presentation includes the appearance of a primary "herald" patch followed within days to weeks by the onset of secondary scaly skin eruptions distributed along the skin tension line in most cases. Although PR is ...

journal_title：Human & experimental toxicology

authors： Polat M,Uzun Ö,Örs I,Boran Ç

更新日期：2014-12-01 00:00:00

abstract：:1. The effect of pyridostigmine on cardiorespiratory function after oxime + atropine injection was investigated in tabun poisoned guinea-pigs and without tabun poisoning. 2. The trachea, a carotid artery and jugular vein were cannulated in female urethane-anaesthetised Pirbright-white guinea-pigs. After baseline measu...

journal_title：Human & experimental toxicology

authors： Worek F,Kleine A,Szinicz L

更新日期：1995-08-01 00:00:00

abstract：:Clinical and experimental studies have shown the adverse effects of excess glucocorticoid on testicular testosterone production. The NADPH co-enzyme has been recognized as an important factor that regulates several steps in steroidogenesis, while glucose oxidation acts as a limiting factor on testicular testosterone p...

journal_title：Human & experimental toxicology

authors： Kavitha TS,Parthasarathy C,Sivakumar R,Badrinarayanan R,Balasubramanian K

更新日期：2006-03-01 00:00:00

abstract：:4-hydroxynonenal (4-HNE) and 6-hydroxydopamine (6-OHDA)-mediated damage in dopaminergic neurons is well documented. Protective potential of steroidal hormone (17β-estradiol) has also been suggested. However, therapeutic potential of such promising hormone is hampered due to complex brain anatomy and physiology. Thus, ...

journal_title：Human & experimental toxicology

authors： Siddiqui MA,Kashyap MP,Al-Khedhairy AA,Musarrat J,Khanna VK,Yadav S,Pant AB

更新日期：2011-08-01 00:00:00

abstract：:This study was designed to evaluate the hepato and neuroprotective activity of Daflon and low-dose γ radiation on thioacetamide (TAA)-induced liver damage and hepatic encephalopathy (HE) in rats. Effect of daily Daflon treatment (100 mg/kg body weight, Per OS (p.o.) for consecutive 3 days) and/or fractionated low-dose...

journal_title：Human & experimental toxicology

authors： Abdel-Rafei M,Amin MM,Hasan HF

更新日期：2017-01-01 00:00:00

abstract：:Omeprazole is one of the most used acid-suppressing medications. This fact emphasizes the questions concerning the safety of this compound. Healthy volunteers (n=33) were included in this prospective study. All study subjects were analysed for their CYP2C19 genotype. Of the 33 individuals, 24 were homozygous for the w...

journal_title：Human & experimental toxicology

authors： Sinués B,Fanlo A,Bernal ML,Val M,Mayayo E

更新日期：2004-03-01 00:00:00

abstract：:This study was designed to investigate the effect of agmatine sulfate (AG, CAS2482-00-0) in nicotine (NIC)-induced vascular endothelial dysfunction (VED) in rabbits. NIC was administered to produce VED in rabbits with or without AG for 6 weeks. Serum lipid profile, serum thiobarbituric acid reactive substances, reduce...

journal_title：Human & experimental toxicology

authors： Nader MA,Gamiel NM,El-Kashef H,Zaghloul MS

更新日期：2016-05-01 00:00:00

abstract：:Paraquat (PQ) is a highly toxic herbicide that is used in most of the countries without restriction. The cytotoxic effect of PQ is mediated by radicals, which are the products of PQ reduction in cells. The anti-oxidative action of captopril, an angiotensin-converting enzyme inhibitor, appears to be through its ability...

journal_title：Human & experimental toxicology

authors： Elmi A,Sadeghi Zh,Elmi S,Daraei B,Ghazi-Khansari M

更新日期：2007-10-01 00:00:00

abstract：:The US Environmental Protection Agency (EPA) recently issued a Staff Paper that articulates current risk assessment practices. In section 4.1.3, EPA states, "... effects that appear to be adaptive, non-adverse, or beneficial may not be mentioned." This statement may be perceived as precluding risk assessments based on...

journal_title：Human & experimental toxicology

authors： Mundt KA

更新日期：2006-01-01 00:00:00

abstract：:1. Human volunteer studies are an essential part of drug development but their use in the area of non-pharmaceutical chemicals has so far been very limited. Such studies can have considerable value in the assessment and improvement of the safe use of chemicals. 2. Once metabolic pathways and target metabolites have be...

journal_title：Human & experimental toxicology

authors： Wilks MF,Woollen BH

更新日期：1994-06-01 00:00:00

abstract：:Oxidative stress has an important role in the pathophysiology of many occupational diseases. In this controlled exposure study, the intensity of oxidative stress biomarkers was assessed in the workers of natural sweet and sour gas refineries (SwGR and SoGR, respectively) and compared with controls. In addition, the ro...

journal_title：Human & experimental toxicology

authors： Mandegary A,Sezavar M,Saeedi A,Amirheidari B,Naghibi B

更新日期：2012-12-01 00:00:00

abstract：:Drugs containing 5-acetylsalicylic acid (5-ASA) have been commonly used for inflammatory bowel diseases for more than half a century, but no case about overdose of suppository form of mesalazine which was taken both orally and rectally has been reported in the related literature up to now. In the present case, a 20-ye...

journal_title：Human & experimental toxicology

authors： Koseoglu Z,Satar S,Kara B,Sebe A,Kosenli O

更新日期：2011-07-01 00:00:00

abstract：:In this study we examined the effect of the aqueous extract of Thonningia sanguinea (T.S.) on 7-ethoxyresorufin O-deethylase (EROD, CYP1A1), 7-pentoxyresorufin O-dealkylase (PROD, CYP2B1/2), 7-methoxyresorufin O-demethylase (MROD, CYP1A2), aniline hydroxylase (aniline, CYP2E1), p-nitrophenol hydroxylase (PNPH, CYP2E1)...

journal_title：Human & experimental toxicology

authors： Gyamfi MA,Hokama N,Oppong-Boachie K,Aniya Y

更新日期：2000-11-01 00:00:00

abstract：:Delta-aminolevulinate dehydratase (δ-ALA-D) enzyme is sensitive to pro-oxidant agents, including molecular oxygen. Here, we tested whether hyperoxygenation after total intravenous (i.v.) anesthesia could interact with the type of anesthesia (dexmedetomidine, continuous infusion; 0.5 μg/kg/h or remifentanil, continuous...

journal_title：Human & experimental toxicology

authors： Rocha JB,Heinzmann Bulow NM,Correa EF,Scholze C,Nogueira CW,Barbosa NB

更新日期：2011-04-01 00:00:00

abstract：:Dermal exposure is an important factor in risk characterization. In occupational settings it becomes relatively more important because of the continuous reduction in inhalation exposure. In the public health arena, dermal exposure may also form a significant contribution to the total exposure. Dermal exposure, however...

journal_title：Human & experimental toxicology

authors： Boogaard PJ

更新日期：2008-04-01 00:00:00

abstract：:Endogenous alcohol has been applied for spontaneous ethanol production via different metabolic pathways of the human body. Auto-brewery syndrome describes the patients with alcohol intoxication after ingesting carbohydrate-rich meals. The main objective of this study is to investigate the effect of diabetes mellitus (...

journal_title：Human & experimental toxicology

authors： Hafez EM,Hamad MA,Fouad M,Abdel-Lateff A

更新日期：2017-05-01 00:00:00