Inhibitory effects of the medicinal herb, Thonningia sanguinea, on liver drug metabolizing enzymes of rats.

abstract：:Accidental ingestion of electrical batteries occurs commonly in children. This rarely is associated with severe morbidity and mortality. Significant symptoms can arise due to leakage of alkali or heavy metals from the battery after degradation in the gastrointestinal tract. The main heavy metal of concern in electrica...

journal_title：Human & experimental toxicology

authors： Mallon PT,White JS,Thompson RL

更新日期：2004-04-01 00:00:00

abstract：:The mechanism of doxorubicin (DOX)-induced cardiotoxicity remains controversial. Wistar rats (n = 66) received DOX injections intraperitoneally and were randomly assigned to 2 experimental protocols: (1) rats were killed before (-24 h, n = 8) and 24 h after (+24 h, n = 8) a single dose of DOX (4 mg/kg body weight) to ...

journal_title：Human & experimental toxicology

authors： Segredo MP,Salvadori DM,Rocha NS,Moretto FC,Correa CR,Camargo EA,de Almeida DC,Reis RA,Freire CM,Braz MG,Tang G,Matsubara LS,Matsubara BB,Yeum KJ,Ferreira AL

更新日期：2014-07-01 00:00:00

abstract：:Rosiglitazone is in the thiazolidinedione class of drugs used in the treatment of type 2 diabetes mellitus. It works as an insulin sensitizer by binding to the peroxisome proliferator-activated receptor gamma. We investigated the effects of prenatally administered rosiglitazone on pyramidal cell numbers and morphologi...

journal_title：Human & experimental toxicology

authors： Sağır D,Eren B,Yılmaz BD,Eren Z,Keleş ON,Gökçe AB

更新日期：2018-08-01 00:00:00

abstract：:Periodontitis is a common infectious disease associated with destruction of periodontal ligaments and alveolar bones. CD4(+) T cell-mediated immune response is involved in the progression of periodontitis. Tobacco consumption increases the risk of periodontal disease. However, the impact of nicotine on the interaction...

journal_title：Human & experimental toxicology

authors： Ge X,Liu YF,Wong Y,Wu LZ,Tan L,Liu F,Wang XJ

更新日期：2016-09-01 00:00:00

abstract：:N-nitrosodimethylamine (NDMA) is a xenobiotic widespread in human environment capable of regulating the lifespan of immune cells. In this study, we examined the roles of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/death receptor 5 (DR5) complex and the Fas molecule in the induction of the extri...

journal_title：Human & experimental toxicology

authors： Iwaniuk A,Jabłońska E,Jabłoński J,Ratajczak-Wrona W,Garley M

更新日期：2015-06-01 00:00:00

abstract：:N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-doxorubicin (PK1) is a novel polymeric anticancer agent containing doxorubicin (approximately 8 wt%) bound to the polymer backbone via a Gly-Phe-Leu-Gly peptidyl linker. The approximate LD50 of PK1 in MF1 mice after a single i.v. injection was 63 mg/kg (doxorubicin-eq...

journal_title：Human & experimental toxicology

authors： Duncan R,Coatsworth JK,Burtles S

更新日期：1998-02-01 00:00:00

abstract：:The purpose of the present study is to establish a new animal model of azithromycin (AZ)-induced liver injury and study the molecular pathological change during the process. First, mice were respectively injected intraperitoneally with AZ of different high doses. Our results showed that 800 mg/kg AZ injection signific...

journal_title：Human & experimental toxicology

authors： Li SQ,Wan XD,Zhu S,Han HM,Xu ZS,Lu HJ

更新日期：2016-05-01 00:00:00

abstract：:Drugs containing 5-acetylsalicylic acid (5-ASA) have been commonly used for inflammatory bowel diseases for more than half a century, but no case about overdose of suppository form of mesalazine which was taken both orally and rectally has been reported in the related literature up to now. In the present case, a 20-ye...

journal_title：Human & experimental toxicology

authors： Koseoglu Z,Satar S,Kara B,Sebe A,Kosenli O

更新日期：2011-07-01 00:00:00

abstract：:The fixed-dose procedure (FDP) was introduced as OECD Test Guideline 420 in 1992, as an alternative to the conventional median lethal dose (LD50) test for the assessment of acute oral toxicity (OECD Test Guideline 401). The FDP uses fewer animals and causes less suffering than the conventional test, while providing in...

journal_title：Human & experimental toxicology

authors： Stalla N,Whitehead A,Ridgway P

更新日期：2002-04-01 00:00:00

abstract：:Lead exposure was assessed in a random cohort of 70 male papier mâché workers and compared with 35 age and sex matched controls. Blood-lead levels in workers were significantly higher than in controls (Mean 68.07 +/- 44.64 ug/dl vs 25.52 +/- 16.56 ug/dl respectively; P < 0.001). Urinary lead was also higher in workers...

journal_title：Human & experimental toxicology

authors： Wahid A,Koul PA,Shah SU,Khan AR,Bhat MS,Malik MA

更新日期：1997-05-01 00:00:00

abstract：:This study was designed to evaluate the hepato and neuroprotective activity of Daflon and low-dose γ radiation on thioacetamide (TAA)-induced liver damage and hepatic encephalopathy (HE) in rats. Effect of daily Daflon treatment (100 mg/kg body weight, Per OS (p.o.) for consecutive 3 days) and/or fractionated low-dose...

journal_title：Human & experimental toxicology

authors： Abdel-Rafei M,Amin MM,Hasan HF

更新日期：2017-01-01 00:00:00

abstract：:Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Attenuation of fibrogenic process can significantly lower the mortality rate. However, pharmaceutical intervention at fibrogenesis stage remains a major task in medicine. So there is a need for a natural compound to treat hepatic fibrosis. This ...

journal_title：Human & experimental toxicology

authors： Thirupathi A,Silveira PC,Nesi RT,Pinho RA

更新日期：2017-02-01 00:00:00

abstract：:The article focuses on flaws in the actual approaches of exposure to a chemical of recipient organisms. It demonstrates the excessive use of arguments based on adverse effects and underlines the necessity to take adaptive effects seriously. Regulators are invited to rethink their inclination to the 'When in doubt, kee...

journal_title：Human & experimental toxicology

authors： Hanekamp JC,Bast A

更新日期：2007-11-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with high morbidity and mortality. miR-182-5p is overexpressed in several fibrosis-related diseases but its effect in pulmonary fibrosis has not been reported yet. To investigate the function of miR-182-5p in pulmonary fibrosis, we establish...

journal_title：Human & experimental toxicology

authors： Chen Y,Zhang Q,Zhou Y,Yang Z,Tan M

更新日期：2020-05-01 00:00:00

abstract：:Acute and chronic arsenic exposure result in toxicity both in human and animal beings and cause many hepatic and renal manifestations. The present study stated that mushroom lectin prevents arsenic-induced apoptosis. Apoptosis was measured by morphological alterations, cell proliferation index (CPI), phagocytic activi...

journal_title：Human & experimental toxicology

authors： Rana T,Bera AK,Das S,Bhattacharya D,Pan D,Bandyopadhyay S,De S,Das SK

更新日期：2011-04-01 00:00:00

abstract：:In responding to Drs Calabrese and Baldwin's question, 'At what point, if ever, should hormesis be employed as the principal dose response default assumption in risk assessment?', we examined the benefits of replacing traditional dose-response with hormesis. In general, hormesis provides more complete useful informati...

journal_title：Human & experimental toxicology

authors： Pickrell JA,Oehme FW

更新日期：2005-05-01 00:00:00

abstract：:The phenomenon of subtoxic stimulation of organism response is not uncommon in aquatic toxicology experiments. We describe the presence of hormesis in both growth and reproduction experiments in aquatic toxicology where these responses are observed in both animals and plants and at different trophic levels of an ecosy...

journal_title：Human & experimental toxicology

authors： Bailer AJ,Oris JT

更新日期：1998-05-01 00:00:00

abstract：:The effects of low lead exposure were investigated in 96 children (7-12 years old) living and studying within a 1 km radius of a lead smelter (exposed population) located in Torreón, Coahuila, México, and compared with 30 children living and studying 4.5 km from the same smelter (control population). Both populations ...

journal_title：Human & experimental toxicology

authors： Calderón-Salinas JV,Valdéz-Anaya B,Mazúñiga-Charles,Albores-Medina A

更新日期：1996-04-01 00:00:00

abstract：:1. Osmolal and anion gaps are helpful in the diagnosis and evaluation of intoxications with methanol and ethylene glycol. Reported reference values for osmolal gap and anion gap are -1 (+/- 6) mosm kg-1 H2O and 16 (+/- 2) mmol l-1, respectively. However, we have repeatedly found unexplained increased gaps in patients ...

journal_title：Human & experimental toxicology

authors： Aabakken L,Johansen KS,Rydningen EB,Bredesen JE,Ovrebø S,Jacobsen D

更新日期：1994-02-01 00:00:00

abstract：:1 The urinary recovery of metabolites of aspirin (ASA) was studied in 45 volunteers who took a therapeutic dose (600 mg) of ASA by mouth and in 37 patients who took ASA in overdose. 2 The main metabolite recovered from the volunteers was the glycine conjugate, salicyluric acid (SUA), which accounted for 75.01 +/- 1.19...

journal_title：Human & experimental toxicology

authors： Patel DK,Hesse A,Ogunbona A,Notarianni LJ,Bennett PN

更新日期：1990-05-01 00:00:00

abstract：:Progesterone (a neurosteroid) is an important modulator of the nervous system functioning. Organophosphorus pesticides like phosphamidon have been shown to adversely affect memory and induce oxidative stress on both acute and chronic exposure. The present study was therefore designed to investigate the effects of prog...

journal_title：Human & experimental toxicology

authors： Sharma AK,Bhattacharya SK,Khanna N,Tripathi AK,Arora T,Mehta AK,Mehta KD,Joshi V

更新日期：2011-10-01 00:00:00

abstract：:Persistent organic pollutants (POPs) are organic (carbon-based) compounds that include synthesized substances (pesticides and polychlorinated biphenyls [PCBs]) and other by-product substances generated as a result of human and natural activity (dioxins and furans). Extensive scientific studies have shown that POPs are...

journal_title：Human & experimental toxicology

authors： Mansour SA

更新日期：2009-09-01 00:00:00

abstract：:Although ingestion of methyl ethyl ketone peroxide (MEKP) is rare, it carries a high risk of morbidity and mortality. This paper reports the first such case from Turkey in which a 70-year-old man unintentionally ingested MEKP in his kitchen. The patient was brought into the emergency department (ED) within 1 hour of i...

journal_title：Human & experimental toxicology

authors： Bozdemir MN,Yildiz M,Seyhanli ES,Gurbuz S,Kilicaslan I,Karlidag T

更新日期：2011-12-01 00:00:00

abstract：:To clarify the reproductive toxicity of polychlorinated biphenyl compounds through determination of testicular lipid peroxidation, reactive oxygen species and enzymatic and non-enzymatic antioxidants in rats exposed to Aroclor 1254. Adult male rats were administered Aroclor 1254 at a dose of 2 mg/kg per day ip for 30 ...

journal_title：Human & experimental toxicology

authors： Murugesan P,Senthilkumar J,Balasubramanian K,Aruldhas MM,Arunakaran J

更新日期：2005-02-01 00:00:00

abstract：:Naringenin is a naturally occurring flavanones and has been found to exhibit free radical scavenging, enzyme inhibition, antioxidants, anti-inflammatory, and anticancer activities. Present study was designed to evaluate the protective role of naringenin against benzo[a]pyrene (B[a]P)-induced oxidative stress and pulmo...

journal_title：Human & experimental toxicology

authors： Ali R,Shahid A,Ali N,Hasan SK,Majed F,Sultana S

更新日期：2017-04-01 00:00:00

abstract：:1-Bromopropane (1-BP) is an increasingly used chemical solvent for cleaning metals and gradually replacing spraying adhesives. Workers exposed to 1-BP (WBP) showed nervous system dysfunction and other symptoms. This study focused on the proteomic change between healthy individuals (HIs), WBP and poisoned patients with...

journal_title：Human & experimental toxicology

authors： Miao R,Ding B,Zhang Y,Zhao R,Li Y,Zhu B

更新日期：2018-01-01 00:00:00

abstract：:1. Adult male albino rats (CF Strain) were administered i.p. CS2 dissolved in cotton seed oil at doses of 25, 50, 100 and 200 mg/kg b. wt. for a period of 60 days. Effect of CS2 on epididymis, adrenal weight, sperm count and sperm head shape abnormality was studied. 2. Epididymal weight remained unaltered in 25, 50 an...

journal_title：Human & experimental toxicology

authors： Kumar S,Patel KG,Gautam AK,Agarwal K,Shah BA,Saiyed HN

更新日期：1999-12-01 00:00:00

abstract：:Severe carbon monoxide (CO) poisoning causes fulminant deaths in common environment as well as neurological sequelae to survivors. Prevention of delayed neurological syndrome (DNS) after exposure to CO, the most important sequela, is based up to date on hyperbaric oxygen administration. Nevertheless, its use remains c...

journal_title：Human & experimental toxicology

authors： Del Moral-Barbudo B,Blancas R,Ballesteros-Ortega D,Quintana-Díaz M,Martínez-González Ó

更新日期：2020-06-01 00:00:00

abstract：:The objective of this study was to evaluate data retrospectively on accidental ingestion of ethylene glycol (EG), based on calls to the Czech Toxicological Information Centre and from toxicological laboratories, in the years 2000-2004. All patients who ingested a known amount of EG and/or subjects with measured serum ...

journal_title：Human & experimental toxicology

authors： Krenová M,Pelclová D

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Chronic obstructive pulmonary disease (COPD) due to sulfur mustard (SM), known as mustard lung, is an important late pulmonary complication of SM poisoning. Due to the possible role of systemic inflammation in mustard lung, we evaluated the serum levels of adiponectin and leptin in these patients. MATERIA...

journal_title：Human & experimental toxicology

authors： Rokni Yazdi H,Lari SM,Attaran D,Ayatollahi H,Mohsenizadeh A

更新日期：2014-06-01 00:00:00