Abstract:
:Drugs containing 5-acetylsalicylic acid (5-ASA) have been commonly used for inflammatory bowel diseases for more than half a century, but no case about overdose of suppository form of mesalazine which was taken both orally and rectally has been reported in the related literature up to now. In the present case, a 20-year-old male patient who took 14.5 g of mesalazine rectally and orally for suicide purpose is discussed. He was an ulcerative colitis patient and depressed about his illness and routine life traffic. Although it was hard for him to take the suppository form orally because of its bad taste and structure, he took it with the help of water. In the patient's colonoscopy, diffuse hyperemia and edema extending from the anal channel to the proximal rectal mucosa and a 1.5 cm diameter ulcer expanding from anal channel through the rectum were identified. No pathology was found in the upper gastrointestinal endoscopy. Routine laboratory examination was performed and no abnormality was identified in the patient's total blood account, biochemical parameters and full-urine examination. In the control rectoscopy applied to the patient 15 days later, recovery of the ulcer was observed and he was discharged to be followed in the psychiatry clinic.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Koseoglu Z,Satar S,Kara B,Sebe A,Kosenli Odoi
10.1177/0960327110379249subject
Has Abstractpub_date
2011-07-01 00:00:00pages
772-6issue
7eissn
0960-3271issn
1477-0903pii
0960327110379249journal_volume
30pub_type
杂志文章abstract::Organophosphate-induced delayed neuropathy (OPIDN) is a progressive neuropathic disorder that manifests in days to weeks following exposure to an acute dose of organophosphates. The precise mechanism involved in the development of OPIDN is not clear as it develops after many days of the cessation of cholinergic crisis...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112446842
更新日期:2012-12-01 00:00:00
abstract::Cyfluthrin is a pyrethroid insecticide and common household pesticide. The effect of cyfluthrin on Ca2+-related physiology in human osteosarcoma is unclear. This study investigated the effect of cyfluthrin on cytosolic-free Ca2+ concentrations ([Ca2+]i) and viability in MG63 human osteosarcoma cells. Cyfluthrin concen...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120918298
更新日期:2020-09-01 00:00:00
abstract::1. The coumarin anticoagulant difenacoum was detected by high performance liquid chromatography (HPLC) with multi-wavelength UV detection in plasma from a 41 years old man who presented with a severe deficiency of vitamin K-dependent clotting factors of unknown aetiology. A longitudinal toxicological study of the cons...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719701600306
更新日期:1997-03-01 00:00:00
abstract::Pesticides are used in agriculture to protect crops from insects-pests. Most of the field workers of North Indian population are exposed to commonly used insecticides. In the present study, pesticides induced oxidative stress as well as alterations in the level of acetylcholinesterase (AChE) in a total of 70 male heal...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112474835
更新日期:2013-11-01 00:00:00
abstract::This study was designed to evaluate the hepato and neuroprotective activity of Daflon and low-dose γ radiation on thioacetamide (TAA)-induced liver damage and hepatic encephalopathy (HE) in rats. Effect of daily Daflon treatment (100 mg/kg body weight, Per OS (p.o.) for consecutive 3 days) and/or fractionated low-dose...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116637657
更新日期:2017-01-01 00:00:00
abstract::The present study has three purposes; first evaluating cytotoxicity of (E)-4-chloro-2-((3-ethoxy-2-hydroxybenzylidene)amino)phenol (ACES), second deciphering ACES-mediated cellular death mechanism, and third estimating ACES-mediated alterations in the expressions of mitogen-activated protein kinase (MAPK) pathway-rela...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327120924112
更新日期:2020-10-01 00:00:00
abstract::Lipid peroxidation is one of the main manifestations of oxidative damage and has been found to play an important role in the toxicity and carcinogenicity of many xenobiotics. In the present study, we investigated the possible induction of lipid peroxidation by aluminium in human foreskin fibroblast cultures by assayin...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032701682693053
更新日期:2001-09-01 00:00:00
abstract::Rosiglitazone is in the thiazolidinedione class of drugs used in the treatment of type 2 diabetes mellitus. It works as an insulin sensitizer by binding to the peroxisome proliferator-activated receptor gamma. We investigated the effects of prenatally administered rosiglitazone on pyramidal cell numbers and morphologi...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117730883
更新日期:2018-08-01 00:00:00
abstract::We have investigated the pituitary-testicular axis in a well-characterized population which was occupationally exposed to mercury vapour. Thyroid stimulating hormone and prolactin were also measured as indices of thyroid and pituitary endocrine function. We found no relation between blood or urine mercury levels or le...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719101000309
更新日期:1991-05-01 00:00:00
abstract:OBJECTIVE:To investigate the mechanism of apoptosis dependent on the Fas/FasL (Fas ligand) complex in the presence of N-nitrosodimethylamine (NDMA) in human leukocytes. METHODS:Polymorphonuclear neutrophils (PMNs) and peripheral blood mononuclear cells (PBMCs) were isolated form whole blood by density centrifugation. ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119828198
更新日期:2019-05-01 00:00:00
abstract::Diabetes mellitus promoted an overproduction of free radicals and an increased incidence of both diabetic nephropathy and liver disease. In this report, we evaluated the effects of Chinese and Brazilian propolis on streptozotocin-induced hepatorenal injury in rats. The results demonstrated that Chinese propolis-treate...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110387456
更新日期:2011-09-01 00:00:00
abstract::The use of Lucilia sericata larvae on the healing of wounds in diabetics has been reported. However, the role of the excretion/secretion (ES) products of the larvae in treatment of diabetic wounds remains unknown. This study investigated whether application of the ES products of L. sericata on the wound surface could ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117714041
更新日期:2018-05-01 00:00:00
abstract::1. Neonatal treatment of rats with vitamin D3 resulted in a change of sexual behavior in adulthood. 2. 2.5 mg vitamin D3 completely inhibited the ejaculation of males without any apparent influence on sexual desire. 250 mg vitamin D3 influenced both the desire and ejaculation. 3. Sexual activity of females was depress...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719601500704
更新日期:1996-07-01 00:00:00
abstract::Paraquat (PQ) is a highly toxic herbicide that is used in most of the countries without restriction. The cytotoxic effect of PQ is mediated by radicals, which are the products of PQ reduction in cells. The anti-oxidative action of captopril, an angiotensin-converting enzyme inhibitor, appears to be through its ability...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327107084533
更新日期:2007-10-01 00:00:00
abstract::Clinical and experimental studies have shown the adverse effects of excess glucocorticoid on testicular testosterone production. The NADPH co-enzyme has been recognized as an important factor that regulates several steps in steroidogenesis, while glucose oxidation acts as a limiting factor on testicular testosterone p...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/0960327106ht591oa
更新日期:2006-03-01 00:00:00
abstract::Apoptosis induction in cancer cells is one of the most efficient ways to treat cancer and find anticancer compounds. The aim of this study was to evaluate the cytotoxic effects of heat-killed indigenous probiotic bacteria and apoptosis induction in the HT-29 human colon adenocarcinoma cell line. The growth-inhibitory ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327119851255
更新日期:2019-09-01 00:00:00
abstract::Sterigmatocystin (Stg), a major secondary metabolite of Aspergillus versicolor and A. nidulans, is the precursor of aflatoxin B1. In this study, male albino rats were treated with Stg-contaminated diet for 30 days, resulting in reduced levels of glutathione, ascorbic acid, and alpha-tocopherol. The activity of catalas...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032701682692955
更新日期:2001-08-01 00:00:00
abstract::The aim of this study was to compare the number of inactivated-influenza vaccine-related spontaneous abortion and stillbirth (SB) reports in the Vaccine Adverse Event Reporting System (VAERS) database during three consecutive flu seasons beginning 2008/2009 and assess the relative fetal death reports associated with t...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112455067
更新日期:2013-05-01 00:00:00
abstract::1. Six healthy male volunteers received intravenous injections of 26Al as citrate. Accelerator mass spectrometry and gamma-ray spectrometry were used to determine levels of the tracer in blood and excreta at times up to 5-6 d. 2. There was a rapid clearance from blood (mean 2% of injection remaining after 1 d) and maj...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719501400707
更新日期:1995-07-01 00:00:00
abstract::1. The herbicide, paraquat, is accumulated by the energy-dependent polyamine uptake pathway of alveolar type II cells. There it undergoes redox cycling that results in an amplified production of toxic reactive oxygen species and depletion of NADPH and other reducing equivalents. These processes account for the lung be...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719401300808
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Diphenhydramine (DPHM) overdose is a frequent cause of acute poisoning. Although its clinical features are well known, information about the dose-dependent toxicity of DPHM is still scarce. The objective of this study was to investigate the dose-dependent toxicity of DPHM in patients with acute DPHM poisonin...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1191/096032700671040438
更新日期:2000-09-01 00:00:00
abstract::Neutrophil functions were studied in 38 lead-exposed workers compared to 34 controls. Both groups were matched according to age, sex, drinking and smoking habits, ethnic origin and drug intake. Blood lead levels were found to be seven times higher in exposed workers than in controls. Phagocytosis assayed by chemilumin...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719000900405
更新日期:1990-07-01 00:00:00
abstract::We aimed to investigate the possible roles of nitric oxide (NO) and endothelin on the changes of cardiac muscle function in both hyper- and hypodynamic septic shock periods. Cecal ligation and puncture was performed in 50 Wistar albino rats to induce septic shock. Changes in atrium and right ventricle papillary muscle...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327115583363
更新日期:2016-03-01 00:00:00
abstract:CONTEXT:Cardiac dysfunction is one of the most serious consequences of scorpion envenomation. The best tool to evaluate cardiac function is echocardiography, but it is not available at all emergency departments. Many studies aimed to describe biological predictive factors of cardiac dysfunction in scorpion envenomation...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327117722822
更新日期:2018-06-01 00:00:00
abstract::There are many discrepancies among the results of studies on the genotoxicity of lead. The aim of the study was to explore lead-induced DNA damage, including oxidative damage, in relation to oxidative stress intensity parameters and the antioxidant defense system in human leukocytes. The study population consisted of ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327116665674
更新日期:2017-07-01 00:00:00
abstract::The color of the teeth is an important topic for many people and can be influenced by intrinsic and extrinsic stains. There is an increasing demand for whitening of the teeth year by year. The most popular way of whitening is "bleaching," which is the result of the breakdown of pigments located in the enamel and/or th...
journal_title:Human & experimental toxicology
pub_type: 临床试验,杂志文章
doi:10.1177/0960327118817103
更新日期:2019-04-01 00:00:00
abstract::Oxidative stress has an important role in the pathophysiology of many occupational diseases. In this controlled exposure study, the intensity of oxidative stress biomarkers was assessed in the workers of natural sweet and sour gas refineries (SwGR and SoGR, respectively) and compared with controls. In addition, the ro...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327112450898
更新日期:2012-12-01 00:00:00
abstract::Cyanate and its active form isocyanate are formed mainly in the process of nonenzymatic urea biodegradation. Cyanate is capable of protein S- and N-carbamoylation, which can affect their activity. The present studies aimed to demonstrate the effect of cyanate on activity of the enzymes implicated in anaerobic cysteine...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327110394225
更新日期:2011-10-01 00:00:00
abstract::The aim of the present investigation was to check the fluctuation in essential elements, such as Na, K, Mg, Mn, Cu, Zn, Cr and Ni in the brain, spinal cord, liver and kidney of mice during methylmercury chloride (MMC) toxication and therapy with monothiols (N-acetyl-DL-homocysteine thiolactone and glutathione) and vit...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/096032719401301201
更新日期:1994-12-01 00:00:00
abstract::Pityriasis rosea (PR) is a common, acute, and self-limited inflammatory skin disease. The typical clinical presentation includes the appearance of a primary "herald" patch followed within days to weeks by the onset of secondary scaly skin eruptions distributed along the skin tension line in most cases. Although PR is ...
journal_title:Human & experimental toxicology
pub_type: 杂志文章
doi:10.1177/0960327113478444
更新日期:2014-12-01 00:00:00