Hepatoprotective role of captopril on paraquat induced hepatotoxicity.

abstract：:The effect of fendiline on cytosolic free Ca(2+) concentrations ([Ca(2+)](i)) and proliferation has not been explored in human oral cancer cells. This study examined whether fendiline altered Ca(2+) levels and caused cell death in OC2 human oral cancer cells. [Ca(2+)](i) and cell viability were measured using the fluo...

journal_title：Human & experimental toxicology

authors： Huang C,Huang C,Cheng J,Liu S,Chen I,Tsai J,Chou C,Tseng P,Jan C

更新日期：2009-01-01 00:00:00

abstract：:1. Polyvinyl chloride (PVC) cot mattress covers from SIDS cases were investigated as potential sources of soluble (potentially ingestable) antimony in the cot environment. 2. Body fluids (urine, saliva) and proprietary domestic detergents/sterilizing fluids markedly enhanced leaching of antimony from PVC. Release of a...

journal_title：Human & experimental toxicology

authors： Jenkins RO,Craig PJ,Goessler W,Irgolic KJ

更新日期：1998-03-01 00:00:00

abstract：:Genotoxicants can be identified as aneugens and clastogens through a micronucleus (MN) assay. The current high-content screening-based MN assays usually discriminate an aneugen from a clastogen based on only one parameter, such as the MN size, intensity, or morphology, which yields low accuracies (70-84%) because each...

journal_title：Human & experimental toxicology

authors： Huang ZH,Li N,Rao KF,Liu CT,Huang Y,Ma M,Wang ZJ

更新日期：2018-03-01 00:00:00

abstract：:Resveratrol, a grape skin and red wine-derived polyphenolic phytoalexin, exhibits hormetic action delivering numerous health benefits at lower doses while being detrimental at higher doses. Epidemiologic and clinical trials need to be based on the clear understanding of hormetic health benefits of resveratrol. ...

journal_title：Human & experimental toxicology

authors： Das DK

更新日期：2010-12-01 00:00:00

abstract：:A sound understanding of the mechanisms determining percutaneous absorption is necessary for toxicological risk assessment of chemicals contacting the skin. As part of a programme investigating these mechanisms we have developed a physiologically based mathematical model. The structure of the model parallels the multi...

journal_title：Human & experimental toxicology

authors： Auton TR,Westhead DR,Woollen BH,Scott RC,Wilks MF

更新日期：1994-01-01 00:00:00

abstract：:Drugs containing 5-acetylsalicylic acid (5-ASA) have been commonly used for inflammatory bowel diseases for more than half a century, but no case about overdose of suppository form of mesalazine which was taken both orally and rectally has been reported in the related literature up to now. In the present case, a 20-ye...

journal_title：Human & experimental toxicology

authors： Koseoglu Z,Satar S,Kara B,Sebe A,Kosenli O

更新日期：2011-07-01 00:00:00

abstract：:4-hydroxynonenal (4-HNE) and 6-hydroxydopamine (6-OHDA)-mediated damage in dopaminergic neurons is well documented. Protective potential of steroidal hormone (17β-estradiol) has also been suggested. However, therapeutic potential of such promising hormone is hampered due to complex brain anatomy and physiology. Thus, ...

journal_title：Human & experimental toxicology

authors： Siddiqui MA,Kashyap MP,Al-Khedhairy AA,Musarrat J,Khanna VK,Yadav S,Pant AB

更新日期：2011-08-01 00:00:00

abstract：:The present study was designed to evaluate the protective effects of Juglans regia kernel extract against cigarette smoke extract (CSE)-induced lung toxicities in Wistar rats. Prophylactic treatment of methanolic extract of J. regia kernel at the doses of 50 mg/kg b.wt. and 100 mg/kg b.wt was given by gavage to Wistar...

journal_title：Human & experimental toxicology

authors： Qamar W,Sultana S

更新日期：2011-06-01 00:00:00

abstract：AIM:To assess the systemic inflammatory response (SIR) and the multi-organ damage after large-volume liver radiofrequency ablation (RFA) with or without concurrent Pringle maneuver. METHODS:Wistar rats were subjected to 30% liver RFA (group RFA), liver RFA under 30-min Pringle maneuver (group RFA + P), Pringle only (g...

journal_title：Human & experimental toxicology

authors： Ypsilantis P,Lambropoulou M,Anagnostopoulos C,Tsigalou C,Vasiliadis C,Kortsaris A,Papadopoulos N,Simopoulos C

更新日期：2011-11-01 00:00:00

abstract：:Comparisons on a linear and the Rozman logarithmic scale for dosage versus carcinogenicity in rodents are presented for methyl eugenol (ME), nitrosodiethylamine (NDEA), ethyl carbamate (EC) and 2-acetylaminofluorene (AAF). Each of these chemicals has been shown to be carcinogenic in experimental animals and, in additi...

journal_title：Human & experimental toxicology

authors： Waddell WJ

更新日期：2005-06-01 00:00:00

abstract：:Okadaic acid (OA) is the main toxin produced by dinoflagellates, which can accumulate in the hepatopancreas of mussels and cause diarrhoetic shellfish poisoning in consumers. This toxin is also a tumour promoter and a specific potent inhibitor of protein phosphatases 1 and 2A. The results in this study show for the fi...

journal_title：Human & experimental toxicology

authors： Matias WG,Creppy EE

更新日期：1996-03-01 00:00:00

abstract：:Generation of reactive oxygen species (ROS) leads to serious tissue injuries. The effect of cyclopiazonic acid (CPA) on oxidative stress markers in the liver and kidneys of broiler chicks was studied. Ten-day-old male broiler chicks (Ross 308) were assigned into the control and test groups, which received normal salin...

journal_title：Human & experimental toxicology

authors： Malekinejad H,Akbari P,Allymehr M,Hobbenaghi R,Rezaie A

更新日期：2011-08-01 00:00:00

abstract：:Endogenous alcohol has been applied for spontaneous ethanol production via different metabolic pathways of the human body. Auto-brewery syndrome describes the patients with alcohol intoxication after ingesting carbohydrate-rich meals. The main objective of this study is to investigate the effect of diabetes mellitus (...

journal_title：Human & experimental toxicology

authors： Hafez EM,Hamad MA,Fouad M,Abdel-Lateff A

更新日期：2017-05-01 00:00:00

abstract：:Hypofibrinogenemia is an important clinical consequence following envenomation by Lachesis muta muta, usually attenuated or prevented by administration of antivenom. The venom of L. m. muta contains both a metalloproteinase fibrinogenase and a serine protease thrombin-like enzyme, and exposure of fibrinogen to iron (F...

journal_title：Human & experimental toxicology

authors： Nielsen VG,Matika RW

更新日期：2017-07-01 00:00:00

abstract：:Tissue-dependent oestrogenic and anti-oestrogenic activity of polycyclic aromatic hydrocarbons (PAHs) has been suggested. In this study, the effect of two PAH mixtures, M1 composed of all 16 priority pollutants and M2 composed of five (noted in the highest levels) compounds, on follicle-stimulating hormone receptor (F...

journal_title：Human & experimental toxicology

authors： Zajda K,Gregoraszczuk EL

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:The present study was designed to highlight the toxic impact of baclofen on both biochemical and histopathological aspects in rats' liver, gastric, lung, kidney, and brain tissues. METHODS:The study was performed on 30 healthy adult male albino rats divided into four groups with 5 rats in each control group,...

journal_title：Human & experimental toxicology

authors： Issa SY,Hafez EM,El-Banna AS,Abdel Rahman SM,AlMazroua MK,El-Hamd MA

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:To investigate the mechanism of apoptosis dependent on the Fas/FasL (Fas ligand) complex in the presence of N-nitrosodimethylamine (NDMA) in human leukocytes. METHODS:Polymorphonuclear neutrophils (PMNs) and peripheral blood mononuclear cells (PBMCs) were isolated form whole blood by density centrifugation. ...

journal_title：Human & experimental toxicology

authors： Iwaniuk A,Grubczak K,Ratajczak-Wrona W,Garley M,Nowak K,Jabłońska E

更新日期：2019-05-01 00:00:00

abstract：:Organophosphorus compounds are known to cause the selective release of liver microsomal beta-glucuronidase into plasma. Organophophoruses may induce nitrosative stress leading to the generation of nitrogen free radicals and alterations in scavengers of free radicals in many biological systems. In this study, we invest...

journal_title：Human & experimental toxicology

authors： Soltaninejad K,Shadnia S,Afkhami-Taghipour M,Saljooghi R,Mohammadirad A,Abdollahi M

更新日期：2007-12-01 00:00:00

abstract：:Utilizing information obtained from the X-ray fluorescence linear scanning along a single strand of hair in a recent fatal exposure to dimethylmercury, it was possible to determine the circumstances leading to the fatal result. When the Dartmouth chemistry professor displayed symptoms of mercury toxicity, samples of h...

journal_title：Human & experimental toxicology

authors： Toribara TY

更新日期：2001-04-01 00:00:00

abstract：:Enterococcus faecalis is a facultative anaerobic gram-positive commensal bacterium common in the gastrointestinal tract of animals and humans. This study aimed to investigate the protective effects of heat-killed E. faecalis EF-2001 (EF-2001) on acute gastric ulcer using a murine model of ethanol (EtOH)-induced acute ...

journal_title：Human & experimental toxicology

authors： Jeon DB,Shin HG,Lee BW,Jeong SH,Kim JH,Ha JH,Park JY,Kwon HJ,Kim WJ,Ryu YB,Lee IC

更新日期：2020-05-01 00:00:00

abstract：:This study was conducted to evaluate the possible genotoxic effects of waste anesthetic gases. Comet assay was performed on peripheral blood lymphocytes of 60 volunteers: 20 healthy unexposed office workers and 40 operation room (OR) personnel at Tanta University Hospital (Egypt). The exposed personnel were anesthetis...

journal_title：Human & experimental toxicology

authors： El-Ebiary AA,Abuelfadl AA,Sarhan NI,Othman MM

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is the main clinical concern resulted from ischemia-reperfusion injury (IRI). Ample clinical data indicates that AKI is associated with distant organ dysfunctions and poor patients' outcomes. Oxidative stress and inflammation have a critical role in the pathogenesis of organ injurie...

journal_title：Human & experimental toxicology

authors： Bagheri Y,Aghajani S,Hosseinzadeh M,Hoshmandan F,Abdollahpour A,Vahed SZ

更新日期：2020-12-16 00:00:00

abstract：:Coronary heart disease and in particular its most serious form - acute myocardial infarction (AMI) - represents the most common cause of mortality in developed countries. Better prognosis may be achieved by understanding the etiopathogenetic mechanisms of AMI. Therefore, a catecholamine model of myocardial injury, whi...

journal_title：Human & experimental toxicology

authors： Mladenka P,Hrdina R,Bobrovová Z,Semecky V,Vávrová J,Holecková M,Palicka V,Mazurová Y,Nachtigal P

更新日期：2009-10-01 00:00:00

abstract：:The purpose of the present study is to establish a new animal model of azithromycin (AZ)-induced liver injury and study the molecular pathological change during the process. First, mice were respectively injected intraperitoneally with AZ of different high doses. Our results showed that 800 mg/kg AZ injection signific...

journal_title：Human & experimental toxicology

authors： Li SQ,Wan XD,Zhu S,Han HM,Xu ZS,Lu HJ

更新日期：2016-05-01 00:00:00

abstract：:Phosphorus flame retardants are a group of chemicals that are used to slow or prevent the spread of fire. These compounds have been detected in different environments including human organism. In the present study, we have investigated DNA-damaging potential and effect on DNA methylation of tris(2-chloroethyl) phospha...

journal_title：Human & experimental toxicology

authors： Bukowski K,Wysokinski D,Mokra K,Wozniak K

更新日期：2019-06-01 00:00:00

abstract：:The aim of the study was to evaluate the effect of bisphenol A (BPA) on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression by neutrophils with regard to sex and nuclear factor-κB (NF-κB) pathway participation in this process. This study demonstrated that BPA intensifies the production o...

journal_title：Human & experimental toxicology

authors： Ratajczak-Wrona W,Nowak K,Garley M,Tynecka M,Jablonska E

更新日期：2019-02-01 00:00:00

abstract：:In order to assess the effect of arsenic on the male reproductive impairment in mice, 7-week-old animals were exposed to 7.5 mg sodium arsenite (NaAsO(2))/kg body weight, during 35 days (one spermatogenic cycle). One group of animals was sacrificed after exposure, while another group received distilled water for an ad...

journal_title：Human & experimental toxicology

authors： Ferreira M,Matos RC,Oliveira H,Nunes B,Pereira Mde L

更新日期：2012-03-01 00:00:00

abstract：:There are many discrepancies among the results of studies on the genotoxicity of lead. The aim of the study was to explore lead-induced DNA damage, including oxidative damage, in relation to oxidative stress intensity parameters and the antioxidant defense system in human leukocytes. The study population consisted of ...

journal_title：Human & experimental toxicology

authors： Dobrakowski M,Pawlas N,Kasperczyk A,Kozłowska A,Olewińska E,Machoń-Grecka A,Kasperczyk S

更新日期：2017-07-01 00:00:00

abstract：:Predictive toxicology plays a critical role in reducing the failure rate of new drugs in pharmaceutical research and development. Despite recent gains in our understanding of drug-induced toxicity, however, it is urgent that the utility and limitations of our current predictive tools be determined in order to identify...

journal_title：Human & experimental toxicology

authors： Naven RT,Louise-May S

更新日期：2015-12-01 00:00:00

abstract：:The purpose of this study was to characterize the zinc oxide nanoparticles (ZnO-NPs) and their bulk counterpart in suspensions and to access the impact of their acute oral toxicity at doses of 300 and 2000 mg/kg in healthy female Wistar rats. The hematological, biochemical, and urine parameters were accessed at 24 and...

journal_title：Human & experimental toxicology

authors： Srivastav AK,Kumar M,Ansari NG,Jain AK,Shankar J,Arjaria N,Jagdale P,Singh D

更新日期：2016-12-01 00:00:00