Cyclopiazonic acid augments the hepatic and renal oxidative stress in broiler chicks.

abstract：BACKGROUND:Deliberate self-poisoning (DSP) is a major health problem with increasing incidence mainly among young people. OBJECTIVE:To examine the clinical and toxicological characteristics of DSP, it is compared to unintentional (non-DSP) exposures and those characteristics which might be associated with increased to...

journal_title：Human & experimental toxicology

authors： Bentur Y,Raikhlin-Eisenkraft B,Lavee M

更新日期：2004-07-01 00:00:00

abstract：:1. This study investigated whether the reactive organohalogen gases perfluoroisobutene (PFIB) and phosgene, which cause death by overwhelming pulmonary oedema, affect the surfactant system or type II pneumocytes of rat lung. 2. The progression and type of pulmonary injury in Porton Wistar-derived rats was monitored ov...

journal_title：Human & experimental toxicology

authors： Jugg B,Jenner J,Rice P

更新日期：1999-11-01 00:00:00

abstract：:The isolated and identified triterpenoid, 1-hydroxytetratriacontane-4-one (C34H68O2), obtained from the methanolic leaf extract of Leucas aspera Linn. was explored for the first time for antisnake venom activity. The plant (L. aspera Linn.) extract significantly antagonized the spectacled cobra (Naja naja naja) venom ...

journal_title：Human & experimental toxicology

authors： Venkatesan C,Sarathi M,Balasubramanian G,Thomas J,Balachander V,Babu VS,Bilal SM,Majeed SA,Madan N,Raj NS,Vimal S,Nambi KS,Hameed AS

更新日期：2014-04-01 00:00:00

abstract：:The objective of the present study was to perform histological and stereological examination of alcohol-induced changes in the optic nerve, considered an extension of white matter of the brain, in rats. This study included 20 male Wistar albino rats aged 60 days and weighing 190-220 g. The rats were divided into three...

journal_title：Human & experimental toxicology

authors： Igit T,Colcimen N

更新日期：2019-05-01 00:00:00

abstract：:1. The influence of pharmacological pretreatment (pyridostigmine, benactyzine and trihexyphenidyle), designated PANPAL, on soman-induced cholinergic and stressogenic effects as well as on the efficacy of antidotal treatment (HI-6 plus obidoxime) in rats was studied. 2. PANPAL prophylaxis significantly decreased soman-...

journal_title：Human & experimental toxicology

authors： Kassa J,Bajgar J

更新日期：1996-05-01 00:00:00

abstract：:Recent studies have proposed the use of low concentrations of phytochemicals and combinations of phytochemicals in chemoprevention to reduce cytotoxicity and simulate normal ingestion through diet. The purpose of the present study was to evaluate whether the DNA damage, chromosome instability, and oxidative stress ind...

journal_title：Human & experimental toxicology

authors： Serpeloni JM,Almeida MR,Mercadante AZ,Bianchi ML,Antunes LM

更新日期：2013-08-01 00:00:00

abstract：:In responding to Drs Calabrese and Baldwin's question, 'At what point, if ever, should hormesis be employed as the principal dose response default assumption in risk assessment?', we examined the benefits of replacing traditional dose-response with hormesis. In general, hormesis provides more complete useful informati...

journal_title：Human & experimental toxicology

authors： Pickrell JA,Oehme FW

更新日期：2005-05-01 00:00:00

abstract：:The objective of this study is to analyze exposures concerning analgesics that were reported to Dokuz Eylul University Drug and Poison Information Center (DPIC) and admitted to the Department of Emergency Medicine in Dokuz Eylul University Hospital (EMDEU) between 1993 and 2004. Demographics of the patients, character...

journal_title：Human & experimental toxicology

authors： Hocaoglu N,Kalkan S,Akgun A,Capar S,Tuncok Y

更新日期：2007-08-01 00:00:00

abstract：:Hepatic fibrosis is a leading cause of morbidity and mortality worldwide. Attenuation of fibrogenic process can significantly lower the mortality rate. However, pharmaceutical intervention at fibrogenesis stage remains a major task in medicine. So there is a need for a natural compound to treat hepatic fibrosis. This ...

journal_title：Human & experimental toxicology

authors： Thirupathi A,Silveira PC,Nesi RT,Pinho RA

更新日期：2017-02-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) and dioxins are potentially toxic compounds which occur widely in the environment. Their effects on the growth and development of infants at the levels currently found in highly industrialised western countries is not well known. This Dutch multicenter study, combining animal and human...

journal_title：Human & experimental toxicology

authors： Sauer PJ,Huisman M,Koopman-Esseboom C,Morse DC,Smits-van Prooije AE,van de Berg KJ,Tuinstra LG,van der Paauw CG,Boersma ER,Weisglas-Kuperus N

更新日期：1994-12-01 00:00:00

abstract：:Deregulated cancer cell metabolism plays an important role in cancer progression. Cancer cell metabolism has been in the centre of attention in therapeutical cancer cell targeting. Repurposed chemical agents, such as metformin and aspirin, have been studied extensively as preventive and therapeutic agents. Metformin i...

journal_title：Human & experimental toxicology

authors： Albayrak G,Konac E,Dikmen AU,Bilen CY

更新日期：2018-09-01 00:00:00

abstract：:We have investigated the pituitary-testicular axis in a well-characterized population which was occupationally exposed to mercury vapour. Thyroid stimulating hormone and prolactin were also measured as indices of thyroid and pituitary endocrine function. We found no relation between blood or urine mercury levels or le...

journal_title：Human & experimental toxicology

authors： McGregor AJ,Mason HJ

更新日期：1991-05-01 00:00:00

abstract：:After acknowledging Renn's careful investigation and valuable insights, this paper expands on some issues that have been somewhat neglected in his account. It addresses the relationship between risk, uncertainity and ignorance in risk assessment, focusing in particular on the need to recognize that framing assumptions...

journal_title：Human & experimental toxicology

authors： De Marchi B

更新日期：2003-01-01 00:00:00

abstract：:Recent years have seen substantial shifts in cultural attitudes towards cannabis for medical and recreational use. However, legalizing recreational marijuana may have adverse effects on individual and public health. As the most widely used illicit agent, cannabis is commonly reported to disrupt learning and memory. Un...

journal_title：Human & experimental toxicology

authors： Zhang Z,Li R,Lu H,Zhang X

更新日期：2020-03-01 00:00:00

abstract：:Nicotinamide riboside (NR) is a naturally occurring form of vitamin B3 present in trace amounts in some foods. Like niacin, it has been shown to be a precursor in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). The safety of Niagen™, a synthetic form of NR, was determined using a bacterial reverse mutage...

journal_title：Human & experimental toxicology

authors： Conze DB,Crespo-Barreto J,Kruger CL

更新日期：2016-11-01 00:00:00

abstract：:The aim of this study was to determine the safety of azelaic acid (AA) and its derivatives in nanovesicles for pharmaceutical and cosmetic uses. The hydrophilic property of AA was modified by complexing AA with hydroxypropyl-beta-cyclodextrin (AACD). The lipophilic property of AA was improved to diethyl azelate (DA) b...

journal_title：Human & experimental toxicology

authors： Panyosak A,Manosroi J,Rojanasakul Y,Manosroi A

更新日期：2009-06-01 00:00:00

abstract：:Manganese (Mn) is an essential nutrient required for proper growth and maintenance of numerous biological systems. At high levels it is known to be neurotoxic. While focused research concerning the transport of Mn across the blood-brain barrier (BBB) is on-going, the exact identity of the transporter(s) responsible is...

journal_title：Human & experimental toxicology

authors： Fitsanakis VA,Piccola G,Marreilha dos Santos AP,Aschner JL,Aschner M

更新日期：2007-04-01 00:00:00

abstract：:The manufacture of fibreglass reinforced plastic products may give rise to substantial peak exposures to styrene. Such exposure patterns need further consideration in terms of styrene neurotoxicity. The aim of this study was to evaluate the neurotoxic effects of short-term peak exposures in volunteers, at levels respe...

journal_title：Human & experimental toxicology

authors： Ska B,Vyskocil A,Tardif R,Carrier G,Thuot R,Muray K,Viau C

更新日期：2003-08-01 00:00:00

abstract：:The study of Jayjock and Lewis, 'Implication of Hormesis for Industrial Hygiene', represents a challenge for the scientific community to consider hormesis as a possible working hypothesis for redefining risk assessment strategy for low-dose exposures in the realm of industrial hygiene. This invited commentary aims at ...

journal_title：Human & experimental toxicology

authors： Carelli G,Iavicoli I,Castellino N

更新日期：2002-07-01 00:00:00

abstract：:Boophone disticha (B. disticha) has been used systemically in traditional medical practice in Zimbabwe and neighbouring countries for the management of various central nervous system conditions including hysteria. Abuse of the plant by teenagers in Zimbabwe for its claimed hallucinogenic effects has also been reported...

journal_title：Human & experimental toxicology

authors： Gadaga LL,Tagwireyi D,Dzangare J,Nhachi CF

更新日期：2011-08-01 00:00:00

abstract：:1. Neonatal treatment of rats with vitamin D3 resulted in a change of sexual behavior in adulthood. 2. 2.5 mg vitamin D3 completely inhibited the ejaculation of males without any apparent influence on sexual desire. 250 mg vitamin D3 influenced both the desire and ejaculation. 3. Sexual activity of females was depress...

journal_title：Human & experimental toxicology

authors： Mirzahosseini S,Karabélyos C,Dobozy O,Csaba G

更新日期：1996-07-01 00:00:00

abstract：:The effect of sympathomimetic intervention with dopamine or dobutamine on the myocardial uptake of d-propoxyphene was investigated experimentally in rats. The d-propoxyphene (19 mg kg-1 h-1) was continuously infused, intravenously, over 45 min. After 20 min of infusion the rats were given either dopamine (12.5 microgr...

journal_title：Human & experimental toxicology

authors： Pedersen CB,Strøm J,Angelo HR,Munksgaard A,Høgskilde S,Bredgaard Sørensen M

更新日期：1991-03-01 00:00:00

abstract：:Organophosphorus compounds are known to cause the selective release of liver microsomal beta-glucuronidase into plasma. Organophophoruses may induce nitrosative stress leading to the generation of nitrogen free radicals and alterations in scavengers of free radicals in many biological systems. In this study, we invest...

journal_title：Human & experimental toxicology

authors： Soltaninejad K,Shadnia S,Afkhami-Taghipour M,Saljooghi R,Mohammadirad A,Abdollahi M

更新日期：2007-12-01 00:00:00

abstract：:A retrospective review of medical records was carried out to determine the pattern of drug and chemical poisoning cases admitted to a teaching hospital in Malaysia. Medical records of patients admitted during the period January 1987 to December 1995 were reviewed. They accounted for 0.2% of total admissions during the...

journal_title：Human & experimental toxicology

authors： Ab Rahman AF

更新日期：2002-07-01 00:00:00

abstract：:This study deals with pesticide exposure profile in some European countries with a specific focus on ethylenebisdithiocarbamates (EBDC). In all, 55 Bulgarian greenhouse workers, 51 Finnish potato farmers, 48 Italian vineyard workers, 42 Dutch floriculture farmers, and 52 Bulgarian zineb producers entered the study. Ea...

journal_title：Human & experimental toxicology

authors： Fustinoni S,Campo L,Liesivuori J,Pennanen S,Vergieva T,van Amelsvoort L,Bosetti C,Van Loveren H,Colosio C

更新日期：2008-09-01 00:00:00

abstract：:In order to assess the effect of arsenic on the male reproductive impairment in mice, 7-week-old animals were exposed to 7.5 mg sodium arsenite (NaAsO(2))/kg body weight, during 35 days (one spermatogenic cycle). One group of animals was sacrificed after exposure, while another group received distilled water for an ad...

journal_title：Human & experimental toxicology

authors： Ferreira M,Matos RC,Oliveira H,Nunes B,Pereira Mde L

更新日期：2012-03-01 00:00:00

abstract：:Clobenpropit, an H( 3) receptor antagonist, has been reported to modulate both the release of neurotransmitters and also the activity of histidine decarboxylase (HDC). Therefore, a decarboxylase-positive modulator, namely pyridoxine, was taken for interaction studies with clobenpropit in the electroshock (ES) model of...

journal_title：Human & experimental toxicology

authors： Uma Devi P,Manocha A,Khanam R,Vohora D

更新日期：2011-01-01 00:00:00

abstract：:beta-glucuronidase is considered a sensitive biomarker for acute organophosphorus poisoning. In this well-documented study, multiple plasma samples over time were collected. A decrease in plasma concentration of beta-glucuronidase was surprisingly observed, even within normal range. These findings do not support the h...

journal_title：Human & experimental toxicology

authors： Sabbe MB,Desruelles D,Lissens W

更新日期：2008-05-01 00:00:00

abstract：:The fixed-dose procedure (FDP) was introduced as OECD Test Guideline 420 in 1992, as an alternative to the conventional median lethal dose (LD50) test for the assessment of acute oral toxicity (OECD Test Guideline 401). The FDP uses fewer animals and causes less suffering than the conventional test, while providing in...

journal_title：Human & experimental toxicology

authors： Stalla N,Whitehead A,Ridgway P

更新日期：2002-04-01 00:00:00

abstract：:Tripartite motif-containing protein 24 (TRIM24) has currently emerged as a crucial cancer-related gene present in a wide range of human cancer types. However, the involvement of TRIM24 in acute myeloid leukemia (AML) has not been well investigated. The present study aims to investigate the significance, cellular funct...

journal_title：Human & experimental toxicology

authors： Li C,Xin H,Shi Y,Mu J

更新日期：2020-12-01 00:00:00