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Sex-specific differences in the regulation of inducible nitric oxide synthase by bisphenol A in neutrophils.

Abstract：

:The aim of the study was to evaluate the effect of bisphenol A (BPA) on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression by neutrophils with regard to sex and nuclear factor-κB (NF-κB) pathway participation in this process. This study demonstrated that BPA intensifies the production of NO and the expression of iNOS in the cytoplasmic fraction of neutrophils of women as well as men. In addition, an enhanced expression of NF-κB in the cytoplasmic and nuclear fraction of neutrophils exposed to BPA was observed in the cells of both sexes. The lipopolysaccharide (LPS) stimulation of neutrophils of both sexes led to an intensification of NO production and expression of all tested proteins. However, simultaneous stimulation of neutrophils of both men and women with LPS and BPA decreased the production of NO and expression of iNOS and NF-κB in both fractions compared to the cells exposed only to xenoestrogen. Moreover, expression of iNOS and NF-κB was higher in female neutrophils than in male cells. This study demonstrated that BPA affects the production of NO with the participation of iNOS by human polymorphonuclear neutrophils. This process is associated with the activation of the NF-κB pathway. In addition, different activity of NF-κB in neutrophils, observed with respect to sex, indicates a different role of this pathway in female and male cells.

journal_name

Hum Exp Toxicol

journal_title

Human & experimental toxicology

authors

Ratajczak-Wrona W,Nowak K,Garley M,Tynecka M,Jablonska E

doi

10.1177/0960327118793188

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

239-246

issue

2

eissn

0960-3271

issn

1477-0903

journal_volume

38

pub_type

杂志文章

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