Abstract:
:Coronary heart disease and in particular its most serious form - acute myocardial infarction (AMI) - represents the most common cause of mortality in developed countries. Better prognosis may be achieved by understanding the etiopathogenetic mechanisms of AMI. Therefore, a catecholamine model of myocardial injury, which has appeared to be very similar to AMI in human in some aspect, was used. Male Wistar:Han rats were randomly divided into two groups: control group (saline) and isoprenaline group (ISO; synthetic catecholamine, 100 mg.kg(- 1) subcutaneously [s.c.]). After 24 hours, functional parameters were measured, biochemical markers in the blood and metals content in the heart tissue were analysed and histological examination was performed. ISO caused marked myocardial injury that was associated with myocardial calcium overload. Close correlation between myocardial impairment (i.e. serum TnT, stroke volume index and wet ventricles weight) and the levels of myocardial calcium was observed. Direct reactive oxygen species (ROS) involvement was documented only by non-significant increase in malonyldialdehyde 24 hours after ISO injury. Moreover, myocardial element analysis revealed no significant changes as for the content of zinc and iron while selenium and copper increased in the ISO group although it reached statistical significance only for the latter.
journal_name
Hum Exp Toxicoljournal_title
Human & experimental toxicologyauthors
Mladenka P,Hrdina R,Bobrovová Z,Semecky V,Vávrová J,Holecková M,Palicka V,Mazurová Y,Nachtigal Pdoi
10.1177/0960327109350665subject
Has Abstractpub_date
2009-10-01 00:00:00pages
631-40issue
10eissn
0960-3271issn
1477-0903pii
0960327109350665journal_volume
28pub_type
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